An epidemiological study on peripheral arterial disease using a new instrument for measuring blood pressure and pulse wave
| Project/Area Number |
24390171
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Marumo Mikio 兵庫医科大学, 医学部, 講師 (40333950)
Higashiyama Aya 国立研究開発法人国立循環器病研究センター, 研究開発基盤センター, 室長 (20533003)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 末梢動脈疾患 / リスク要因 / 疫学 / 下肢末梢動脈疾患 / 動脈硬化 / 糖尿病 / 喫煙 / 血中脂質異常 / 内蔵型肥満 |
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| Outline of Final Research Achievements |
The percentage of subjects showing low levels of ankle-brachial systolic pressure index (ABI) was low in a general population but was greatly increased when ABI was measured after leg exercise. The percentage of subjects showing low levels of ABI after leg exercise was significantly higher in current smokers than in lifetime nonsmokers, while the percentages of subjects showing low levels of ABI at rest were comparable in current smokers and lifetime nonsmokers. Therefore, measurement of ABI after leg exercise is useful for finding subclinical patients with peripheral arterial disease (PAD) among smokers. We proposed cardiometabolic index (CMI) as a new index to discriminate diabetes mellitus. CMI is defined as a product of triglycerides-to-HDL cholesterol ratio and weight-to-height ratio. In patients with PAD, CMI and blood uric acid level were associated with leg exercise-induced decrease in ABI and are thus suggested to be useful markers for progression of leg ischemia.
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Report
(5 results)
Research Products
(16 results)
