International comparative research for common risk factors of chronic obstructive lung disease and coronary artery atherosclerosis

• Project/Area Number: 24390174
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Miyamoto Yoshihiro 国立研究開発法人国立循環器病研究センター, 病院, 部長 (10312224)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567) ; NAKANO Yasutaka 滋賀医科大学, 医学部, 准教授 (00362377)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
• Keywords: 疫学 / 国際比較研究

Outline of Final Research Achievements

Chronic obstructive pulmonary disease (COPD) is the third largest cause of death in the world. Because of high smoking rates in the middle-aged Japanese, the number of COPD patients rapidly increased in our super aging society. However, in the statistics of 2009, COPD is only 1.3 % of the total cause of death in Japan. Rates of smoking in men in Japan have been twice as high as in men in the US at least for the past 3 decades. If confirmed, elucidating factors responsible for low COPD rate in Japan could lead to its prevention. Then, by comparing the prevalence of COPD between that of Japanese smoking man and that of US people using the urban residents’ cohort study, the Suita study and the Multi-Ethnic Study of Atherosclerosis study. To get the research informed consent from 101 people, we have conducted a survey to 61 people. As an interim report, the prevalence of COPD might be not so lower than US people.

Research Products

• [Int'l Joint Research] ピッツバーグ大学/コロンビア大学/アイオワ大学(米国)
• [Journal Article] Clinical predictors of atheroma progression despite optimal glycemic control in early-stage diabetic patients with coronary artery disease: Insight from the DIANA study. (2014)
  • Author(s): Kataoka Y, Yasuda S, Miyamoto Y, Sase K, Kosuge M, Kimura K, Yoshimasa Y, Miyazaki S, investigators Ds.
  • Journal Title: J Atheroscler Thromb Volume: 21(5) Pages: 509-18
  • NAID: 130004444735
  • Peer Reviewed / Open Access
• [Journal Article] High-intensity signals in coronary plaques on noncontrast t1-weighted magnetic resonance imaging as a novel determinant of coronary events (2014)
  • Author(s): Noguchi, T. Kawasaki, T.Tanaka, A. Yasuda, S.Goto, Y. Ishihara, M.Nishimura, K. Miyamoto, Y.Node, K. Koga, N.
  • Journal Title: Journal of the American College of Cardiology Volume: 63 Issue: 10 Pages: 989-999
  • DOI: 10.1016/j.jacc.2013.11.034
  • Peer Reviewed / Open Access
• [Journal Article] Do differences in risk factors explain the lower rates of coronary heart disease in Japanese versus U.S. women? (2013)
  • Author(s): Sekikawa, A. Willcox, B. J.Usui, T. Carr, J. J.Barinas-Mitchell, E. J.Masaki, K. H. Watanabe, M.Tracy, R. P. Bertolet, M. H.Evans, R. W. Nishimura, K.Sutton-Tyrrell, K. Kuller, L. H.Miyamoto, Y.
  • Journal Title: Journal of Women's Health Volume: 22 Issue: 11 Pages: 966-977
  • DOI: 10.1089/jwh.2012.4087
  • Peer Reviewed
• [Journal Article] Alcohol consumption and cardiovascular disease incidence in men with and without hypertension: the Suita study. (2013)
  • Author(s): Higashiyama A, Okamura T Watanabe M, Kokubo Y, Wakabayashi l, Okayama A, Miyamoto Y.
  • Journal Title: Hypertens Res Volume: 36 Issue: 1 Pages: 58-64
  • DOI: 10.1038/hr.2012.133
  • NAID: 10031163286
  • Peer Reviewed
• [Journal Article] Small Dense Low-Density Lipoproteins Cholesterol can Predict Incident Cardiovascular Disease in an Urban Japanese Cohort: The Suita Study (2013)
  • Author(s): Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 20 Issue: 2 Pages: 195-203
  • DOI: 10.5551/jat.14936
  • NAID: 130004845433
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Defining Patients at Extremely High Risk for Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia (2012)
  • Author(s): Sugisawa T, Okamura T, Makino H, Watanabe M, Kishimoto I, Miyamoto Y, Iwamoto N, Yamamoto A, Yokoyama S, Harada-Shiba M
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 19 Issue: 4 Pages: 369-375
  • DOI: 10.5551/jat.11536
  • NAID: 130004444603
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Impact of diabetes mellitus on outcomes in Japanese patients undergoing coronary artery bypass grafting (2012)
  • Author(s): Minakata K, Bando K, Takanashi S, Konishi H, Miyamoto Y, Ueshima K, Sato t Ueda Y, Okita Y, Masuda l, Okabayashi H, Yaku H, Yasuno S, Muranaka H, Kasahara M, Miyata S, Okamura Y, Nasu M, Tanemoto K, Arinaga K, Hisashi Y Sakata R
  • Journal Title: Investigators JS Volume: 53 Issue: 3 Pages: 275-84
  • DOI: 10.1016/j.jjcc.2011.12.009
  • NAID: 10031187746
  • Peer Reviewed
• [Journal Article] Does High-Sensitivity C-Reactive Protein or Low-Density Lipoprotein Cholesterol Show a Stronger Relationship with the Cardio-Ankle Vascular Index in Healthy Community Dwellers?: the KOBE Study (2012)
  • Author(s): Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Nishimura K, Sugiyama D, Kadota A, Imano H, Miyamatsu N, Miyamoto Y, Okamura T.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 19 Issue: 11 Pages: 1027-1034
  • DOI: 10.5551/jat.13599
  • NAID: 130004444557
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Presentation] 肥満症診断におけるウエスト周囲長のカットオフ値決定に関するメタ解析 (2012)
  • Author(s): 宮本恵宏
  • Organizer: 第33回日本肥満学会・シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2012-10-11
• [Presentation] 動脈硬化性疾患の臨床研究と都市部疫学研究 (2012)
  • Author(s): 宮本恵宏
  • Organizer: 第44回日本動脈硬化学会総会・学術集会・シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-19