PET imaging using a novel tracer to detect amyloidosis
| Project/Area Number |
24390179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | アミロイド / PET / トランスサイレチン / 心筋 |
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| Outline of Final Research Achievements |
In order to visualize amyloid deposition in the myocardium, patients underwent a cardiac positron-emission tomography（PET） study with [11C]-BF-227. The PET images revealed significantly robust retention of [11C]-BF-227 in the patients' hearts compared with that of the normal control. In any of the amyloidgenic disorders, such as transthyretin-related systemic amyloidosis and Alzheimer’s disease, it is surmised that the monomer of the amyloid protein itself is not very toxic, whereas misfolded oligomers could cause damage to human organs. It is therefore truly important to detect the accumulation of real amyloid fibrils for the early and accurate diagnosis of amyloidosis. It is therefore truly important to detect the accumulation of real amyloid fibrils for the early and accurate diagnosis of amyloidosis. To our knowledge, this is the first report showing the usefulness of beta-pleated sheet structure-specific PET in investing visceral organ amyloidosis.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis2014
Author(s)
Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
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Journal Title
Jpn J Radiol
Volume: 32
Issue: 3
Pages: 138-144
DOI
NAID
Related Report
Peer Reviewed / Open Access
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