| Budget Amount *help |
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
In order to visualize amyloid deposition in the myocardium, patients underwent a cardiac positron-emission tomography（PET） study with [11C]-BF-227. The PET images revealed significantly robust retention of [11C]-BF-227 in the patients' hearts compared with that of the normal control. In any of the amyloidgenic disorders, such as transthyretin-related systemic amyloidosis and Alzheimer’s disease, it is surmised that the monomer of the amyloid protein itself is not very toxic, whereas misfolded oligomers could cause damage to human organs. It is therefore truly important to detect the accumulation of real amyloid fibrils for the early and accurate diagnosis of amyloidosis. It is therefore truly important to detect the accumulation of real amyloid fibrils for the early and accurate diagnosis of amyloidosis. To our knowledge, this is the first report showing the usefulness of beta-pleated sheet structure-specific PET in investing visceral organ amyloidosis.
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