| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
To determine the roles of viral proteins and inflammation in hepatocarcinogenesis, the HCV core gene transgenic mice were mated with ①liver-specific AID-KO mice, and ②liver-specific activation-induced cytidine deaminase (AID) Tg mice. In HCV-Tg/AID-/- mice, the incidence of HCC was not different from that in HCV-Tg/AID+/+ mice, showing that AID does not play a central role in HCV-associated hepatocarcinogenesis. On the other hand, in HCV-Tg/AID+++/+++ mice, 90% of those mice developed HCC, showing a synergy of inflammation-induced genetic aberrations and the viral oncoprotein in hepatocarcinogenesis.
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