| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Outline of Final Research Achievements |
To develop stem cell therapy for human intestinal diseases, it is essential to assess whether intestinal stem cells in culture retain their tissue regeneration capabilities. During the term of this grant support, we developed a new mouse recipient model of colonic mucosal injury, which allows us to assess the time-course changes and behaviors of transplanted stem cells. By combining the cell transplantation technique developed in our laboratory, we investigated whether cultured intestinal stem cells are capable of regenerating epithelia in vivo, and how they behave when transplanted onto the colon. We found that stem cells of the adult colon and small intestine and also epithelial progenitors of the fetal small intestine are all capable of reconstituting self-renewing epithelia when transplanted. This study provides evidence that cultured intestinal stem cells could be a source for cell therapy of intestinal diseases.
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