| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
In the first project, a probiotic strain, Clostridium butyricum (CB), induced FOXP3+ regulatory T cells (iTreg) in the colon of normal mice. Although CB suppressed the development of acute DSS colitis, CB did not induce iTreg, but did IL-10-producing macrophages. The preventive effect of CB was not observed in DSS-administered macrophage-specific IL-10 KO mice. In addition, CB-monoassociated mice did not develop DSS colitis (Cell Host & Microbe 2013).
In the second project, surprisingly, mice treated with vancomycin and biotin-deficient diet suffered from broad alopecia on the back with dysbiosis composed of a specific lactobacillus strain that reached to 60% dominancy. Also, these mice produced a large amount of a specific amines that seemed to be the key metabolites to induce alopecia.
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