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Sympathetic activation in heart failure: Elucidation of a novel framework and the control mechanisms

Research Project

Project/Area Number 24390198
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyushu University

Principal Investigator

Hirooka Yoshitaka  九州大学, 循環器病未来医療研究センター, 教授 (90284497)

Co-Investigator(Kenkyū-buntansha) 井手 友美  九州大学, 医学(系)研究科(研究院), 講師 (90380625)
岸 拓弥  九州大学, 循環器病未来医療研究センター, 准教授 (70423514)
伊藤 浩司  九州大学, 医学(系)研究科(研究院), 共同研究員 (10452757)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords血圧 / 心不全 / 交感神経系 / 脳 / レニン-アンジオテンシン系 / 慢性炎症 / 免疫系 / レニンーアンジオテンシン系 / レニン-アンジオテンシン系 / 循環器・高血圧 / 生理学 / 薬理学
Outline of Final Research Achievements

We investigated mechanisms involved in the regulation of sympathetic activation in heart failure The findings are as follows. Alteration of innate immunity and immune cells proportion contribute to sympathetic activation. Activation of astrocytes and microglia play a role in activation of the sympathetic nervous system. Renal denervation attenuated enhanced sympathetic drive via inhibition of hypothalamic activity. Cardiac sympathetic afferent reflex plays an important role in the progression of cardiac hypertrophy during the phase of pressure overload. As an initial step of heart failure, epithelial Na channel activation in the hypothalamus contributes to blood pressure elevation resulted from acquired salt sensitivity. These findings support a novel framework including neural, humoral, cytokines and other cell factors.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (107 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (24 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 22 results,  Acknowledgement Compliant: 5 results,  Open Access: 2 results) Presentation (74 results) (of which Int'l Joint Research: 6 results,  Invited: 21 results) Book (8 results) Remarks (1 results)

  • [Journal Article] Arterial pressure labiality is improved by sodium-glucose cotransporter 2 inhibitor in streptozocin-induced diabetic rats.2017

    • Author(s)
      Yoshikawa T, Kishi T, Sahinohara K, Takesue K, Shibata R, Inoguchi T, Sunagawa K, Tsutsui H, Hirooka Y.
    • Journal Title

      Hypertens Res

      Volume: 印刷中 Issue: 7 Pages: 646-651

    • DOI

      10.1038/hr.2017.14

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Renal denervation enhances GABA-ergic input into the PVN leading to blood pressure lowering in chronic kidney disease.2017

    • Author(s)
      Nishihara M, Takesue K, Hirooka Y.
    • Journal Title

      Auton Neurosci

      Volume: 204 Pages: 88-97

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Activation of microglia within paraventricular nucleus of hypothalamus in NOT involved in maintenance of established hypertension.2017

    • Author(s)
      Takesue K, Kishi T, Hirooka Y, Sunagawa K.
    • Journal Title

      J Cardiol

      Volume: 69 Pages: 84-88

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 本態性高血圧の成因としての交感神経系.2016

    • Author(s)
      廣岡 良隆
    • Journal Title

      血圧

      Volume: 26 Pages: 403-407

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 高血圧のカテーテル・デバイス治療の現状と未来.2016

    • Author(s)
      廣岡 良隆
    • Journal Title

      Pharama Medica

      Volume: 34 Pages: 47-52

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Activation of microglia within paraventricular nucleus of hypothalamus is NOT involved in maintenance of established hypertension.2016

    • Author(s)
      Takesue K, Kishi T, Hirooka Y, Sunagawa K.
    • Journal Title

      J Cardiol.

      Volume: In Press Issue: 1 Pages: 84-88

    • DOI

      10.1016/j.jjcc.2016.01.004

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating angiotensin II deteriorates left ventricular function with sympathoexcitation via brain angiotensin II receptor.2015

    • Author(s)
      Shinohara K, Kishi T, Hirooka Y, Sunagawa K.
    • Journal Title

      Physiol Rep.

      Volume: 3 Issue: 8 Pages: e12514-e12514

    • DOI

      10.14814/phy2.12514

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combining irbesartan and trichlormethiazide enhances blood pressure reduction via inhibition of sympathetic activity without adverse effects on metabolism in hypertensive rats with metabolic syndrome.2015

    • Author(s)
      Nishihara M, Hirooka Y, Sunagawa K.
    • Journal Title

      Clin Exp Hypertens.

      Volume: 37 Issue: 1 Pages: 33-38

    • DOI

      10.3109/10641963.2014.897719

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of brain angiotensin II type 1 receptor inhibits the development of atrial fibrillation in hypertensive rats.2015

    • Author(s)
      Nagayama T, Hirooka Y, Kishi T, Mukai Y, Inoue S, Takase S, Takemoto M, Chishaki A, Sunagawa K.
    • Journal Title

      American Journal of Hypertension

      Volume: 28 Issue: 4 Pages: 444-451

    • DOI

      10.1093/ajh/hpu196

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Decreased proportion of Foxp3+CD4+ regulatory T cells contributes to the development of hypertension in genetically hypertensive rats.2015

    • Author(s)
      Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
    • Journal Title

      Journal of Hypertension

      Volume: 33 Issue: 4 Pages: 773-783

    • DOI

      10.1097/hjh.0000000000000469

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Corticosterone-activated mineralocorticoid receptor contributes to salt-induced sympathoexcitation in pressure overload mice.2014

    • Author(s)
      Ito K, Hirooka Y, Sunagawa K.
    • Journal Title

      Clin Exp Hypertens.

      Volume: 36 Issue: 8 Pages: 550-556

    • DOI

      10.3109/10641963.2014.881841

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with myocardial infarction-induced heart failure.2014

    • Author(s)
      Isegawa K, Hirooka Y, Katsuki M, Kishi T, Sunagawa K.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 307 Issue: 10 Pages: H1448-H1455

    • DOI

      10.1152/ajpheart.00462.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Duration of electrically induced atrial fibrillation is augmented by high voltage of stimulus with higher blood pressure in hypertensive rats.2014

    • Author(s)
      Nagayama T, Hirooka Y, Chishaki A, Takemoto M, Mukai Y, Inoue S, Kishi T, Sunagawa K.
    • Journal Title

      Int J Hypertens.

      Volume: 2014 Pages: 980505-980505

    • DOI

      10.1155/2014/980505

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Benefit of azilsartan on blood pressure elevation around rest-to-active phase in spontaneously hypertensive rats.2014

    • Author(s)
      Isegawa K, Hirooka Y, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
    • Journal Title

      Clin Exp Hypertens.

      Volume: 37 Issue: 1 Pages: 45-50

    • DOI

      10.3109/10641963.2014.897721

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan reduces mortality and left ventricular hypertrophy with sympathoinhibition in rats with hypertension and heart failure.2014

    • Author(s)
      Kishi T, Hirooka Y, Sunagawa K.
    • Journal Title

      Am J Hypertens.

      Volume: 27 Issue: 2 Pages: 260-267

    • DOI

      10.1093/ajh/hpt188

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central neuregulin-1/ErbB signaling modulates cardiac function via sympathetic activity in pressure overload-induced heart failure.2014

    • Author(s)
      Matsukawa R, Hirooka Y, Ito K, Honda N, Sunagawa K.
    • Journal Title

      Journal of Hypertension

      Volume: 32 Pages: 817-825

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats.2013

    • Author(s)
      Nakano M, Hirooka Y, Matsukawa R, Ito K, Sunagawa K.
    • Journal Title

      Hypertens Res.

      Volume: 36 Issue: 3 Pages: 277-284

    • DOI

      10.1038/hr.2012.174

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of hypothalamic angiotensin type 1 receptors in pressure overload-induced mineralocorticoid receptor activation and salt-induced sympathoexcitation.2013

    • Author(s)
      Ito K, Hirooka Y, Nakano M, Honda N, Matsukawa R, Sunagawa K.
    • Journal Title

      Hypertens Res.

      Volume: 36 Issue: 6 Pages: 513-519

    • DOI

      10.1038/hr.2012.221

    • NAID

      10031189655

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partially silencing brain toll-like receptor 4 prevents in part left ventricular remodeling with sympathoinhibition in rats with myocardial infarction-induced heart failure.2013

    • Author(s)
      Ogawa K, Hirooka Y, Kishi T, Ide T, Sunagawa K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 7 Pages: e69053-e69053

    • DOI

      10.1371/journal.pone.0069053

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moxonidine-induced central sympathoinhibition improves prognosis in rats with hypertensive heart failure.2013

    • Author(s)
      Honda N, Hirooka Y, Ito K, Matsukawa R, Shinohara K, Kishi T, Yasukawa K, Utsumi H, Sunagawa K.
    • Journal Title

      J Hypertens

      Volume: 31 Issue: 11 Pages: 2300-2308

    • DOI

      10.1097/hjh.0b013e328364a2a1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis.2013

    • Author(s)
      Matsukawa R, Hirooka Y, Ito K, Sunagawa K.
    • Journal Title

      Am J Hypertens

      Volume: 26 Issue: 1 Pages: 51-57

    • DOI

      10.1093/ajh/hps005

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential clinical application of recently discovered brain mechanisms involved in hypertension.2013

    • Author(s)
      Hirooka Y, Kishi T, Ito K, Sunagawa K.
    • Journal Title

      Hypertension

      Volume: 62 Pages: 995-1002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of Nitric Oxide-Mediated γ-Amino Butyric Acid Release in Rostral Ventrolateral Medulla Is Involved in Superoxide-Induced Sympathoexcitation of Hypertensive Rats2012

    • Author(s)
      Shinohara K, Hirooka Y, et al.
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 12 Pages: 2814-2821

    • DOI

      10.1253/circj.CJ-12-0399

    • NAID

      10031126053

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central mechanisms of abnormal sympathoexcitation in chronic heart failure2012

    • Author(s)
      Kishi T, Hirooka Y, et al.
    • Journal Title

      Cardiovascular Research and Practice

      Volume: 2012 Pages: 847172-847172

    • DOI

      10.1155/2012/847172

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Brain macrophages switch pre-hypertensive rats to the development hypertensive state via delivery of peripheral inflammatory information.2017

    • Author(s)
      Iyonaga T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Reduced uterine perfusion pressure-induced preeclampsia acquires the salt-sensitivity characteristics of postpartum hypertension.2017

    • Author(s)
      Matasuura T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Pharmacological transformation of hypothalamic microglia attenuates the development of hypertension in genetically hypertensive rats.2017

    • Author(s)
      Takesue K, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Disruptive arterial pressure stability is improved by sodium-glucose co-transporter 2 inhibitor in streptozocin-induced diabetic rats.2017

    • Author(s)
      Yoshikawa T, Shinohara K, Kishi T, Tsutsui H, Hirooka Y.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高血圧・心不全における交感神経活性化及び機序解明の進歩.2016

    • Author(s)
      廣岡 良隆
    • Organizer
      第69回日本自律神経学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Pressure overlaod-induced cardiac hypertrophy increases TRPV1 in heart and BDNF in NTS, suggesting baroreflex disruption via the brain-to-heart axis.2016

    • Author(s)
      Shibata R, Shinohara K, Ito K, Kishi T, Tsutsui H, Hirooka Y.
    • Organizer
      第20回日本心不全学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Renal denervation exerts antihypertensive effect via enhancing GABA-ergic input paraventricular nucleus of hypothalamus with chronic kidney disease.2016

    • Author(s)
      Takesue K, Nishihara M, Tsutsui H, Hirooka Y.
    • Organizer
      第20回日本心不全学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳卒中易発症自然発症高血圧ラットにおいて視床下部室傍核の活性化ミクログリアは高血圧発症早期の血圧上昇を促進する.2016

    • Author(s)
      武居 講,篠原 啓介,岸 拓弥,廣岡 良隆
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] SGLT2阻害薬はストレプトゾシン誘発性糖尿病ラットの血圧制御機能を改善する.2016

    • Author(s)
      吉川 智子,篠原 啓介,岸 拓弥,廣岡 良隆,筒井 裕之
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Immunity and sympathetic nervous system in hypertension.2016

    • Author(s)
      Hirooka Y.
    • Organizer
      The 17th International SHR Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-09-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Astrocytes are beyond supporting players on enhanced sympathetic outflow in heart failure.2016

    • Author(s)
      Hirooka Y.
    • Organizer
      FASEB Scientific Research Conference.
    • Place of Presentation
      Saxton River, VT, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 高血圧における交感神経活性化と免疫系との関連.2016

    • Author(s)
      廣岡 良隆
    • Organizer
      第37回日本循環制御医学会総会
    • Place of Presentation
      富山
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 基礎研究からみた病態を考慮した腎デナベーションの有効性.2016

    • Author(s)
      廣岡 良隆
    • Organizer
      第5回臨床高血圧フォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 高血圧発症・進展における自律神経制御異常.2015

    • Author(s)
      廣岡 良隆
    • Organizer
      CVMW2015
    • Place of Presentation
      神戸国際会議場(神戸市中央区)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Immunity and sympathetic nervous system in hypertension.2015

    • Author(s)
      Hirooka Y.
    • Organizer
      The 8th Federation of Asian and Oceanian Physiological Societies Congress
    • Place of Presentation
      Bangkok(Thailand)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hypothalamic activated microglia with morphological changes accelerate blood pressure elevation during the hypertension development phase in stroke-prone hypertensive rats.2015

    • Author(s)
      Takesue K, Kishi T, Hirooka Y.
    • Organizer
      Scientific Sessions 2015
    • Place of Presentation
      Orlando(USA)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activation of hypothalamic mineralocorticoid receptor-independent epithelial sodium channels leads to salt sensitive hypertension in mouse model of metabolic syndrome.2015

    • Author(s)
      Kunita-Takanezawa M, Ito K, Kishi T, Hirooka Y.
    • Organizer
      Scientific Sessions 2015
    • Place of Presentation
      Orlando(USA)
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pressure overload-induced cardiac hypertrophy increases brain-derived neurotrophic factor in nucleus tractus solitarius suggesting disruption of the baroreflex via heart-to-brain axis.2015

    • Author(s)
      Takenaka R, Ito K, Kishi T, Hirooka Y.
    • Organizer
      第19回日本心不全学会学術集会
    • Place of Presentation
      グランフロント大阪 ナレッジキャピタルコングレコンベンションセンター(大阪市北区)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高血圧のデバイス治療.2015

    • Author(s)
      廣岡 良隆
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(松山市道後町)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] メタボリック症候群モデルマウスにおける食塩感受性高血圧の脳内機序においてミネラルコルチコイド受容体非依存性の脳内上皮性Naチャネル活性化が重要である.2015

    • Author(s)
      髙根澤 睦,伊藤 浩司,岸 拓弥,廣岡 良隆
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(松山市道後町)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳視床下部室傍核ミクログリア形態変化の自然発症高血圧ラット発症早期メカニズムにおける重要性.2015

    • Author(s)
      武居 講,岸 拓弥,廣岡 良隆
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(松山市道後町)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Brain angiotensin type 1 receptor activation plays a crucial role in immune-inflammatory mechanisms of central sympathoexcitation in hypertension and heart failure.2015

    • Author(s)
      Hirooka Y.
    • Organizer
      9th Meeting of the International Society for Autonomic Neuroscience (ISAN 2015), EFAS, AAS, JSNR
    • Place of Presentation
      Stresa(Italy)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 脳内アンジオテンシンII受容体—酸化ストレス系が交感神経活性化の原因である.2015

    • Author(s)
      岸 拓弥,廣岡 良隆,砂川 賢二
    • Organizer
      第36回日本循環制御医学会総会
    • Place of Presentation
      ウインクあいち5F小ホール(名古屋市中村区)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Current status and expectation of baroreflex activation therapy and vagal nerve stimulation in heart failure.2015

    • Author(s)
      Hirooka Y.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      リーガロイヤルホテル大阪(大阪市北区)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Angiotensin II type 1 receptor expression in astrocytes is upregulated leading to increased mortality in mice with heart failure.2015

    • Author(s)
      Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      グランフロント大阪 ナレッジキャピタルコングレコンベンションセンター(大阪市北区)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Decreased proportion of regulatory T cells contributes to the development of hypertension and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats.2015

    • Author(s)
      Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      グランフロント大阪 イベントラボ(大阪市北区)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 食事性肥満モデルマウスを用いたメタボリック症候群における食塩感受性高血圧の脳内機序の検討.2014

    • Author(s)
      髙根澤 睦,伊藤 浩司,廣岡 良隆,砂川 賢二
    • Organizer
      第50回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      和歌山県立医科大学 生涯研修センター
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳卒中易発症高血圧自然発症ラットの高血圧発症・進展過程に制御性T細胞の減少および脾臓交感神経入力が関与する.2014

    • Author(s)
      甲木 雅人,廣岡 良隆,砂川 賢二
    • Organizer
      第50回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      和歌山県立医科大学 生涯研修センター
    • Year and Date
      2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 心不全と交感神経・圧受容器反射感受性.2014

    • Author(s)
      廣岡 良隆
    • Organizer
      第18回日本心血管内分泌代謝学会学術集会
    • Place of Presentation
      横浜市開港記念会館
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Central nervous system mechanisms involved in RDN and BAT.2014

    • Author(s)
      Hirooka Y.
    • Organizer
      American Heart association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] In vivo induction of regulatory T cells delays the development of hypertension in stroke-prone spontaneously hypertensive rats.2014

    • Author(s)
      Katsuki M, Hirooka Y, Sunagwa K.
    • Organizer
      American Heart association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Brain angiotensin II type 1 receptor blockade ameliorates the development of atrial fibrillation via sympathoinhibition independent of depressor response in hypertensive rats.2014

    • Author(s)
      Nagayama T, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      American Heart association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Genetic ablation of astrocyte-specific angiotensin II type 1 receptors improves prognosis of myocardial infarction-induced heart failure.2014

    • Author(s)
      Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      American Heart association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳からみた高血圧症.2014

    • Author(s)
      廣岡 良隆
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 交感神経系.2014

    • Author(s)
      廣岡 良隆
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Decreased Foxp3+CD4+regulatory T cells contribute to the development of hypertension in genetically hypertensive rats.2014

    • Author(s)
      Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第37回日本高血圧学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Targeted deletion of astrocyte-specific angiotensin II type 1 receptor strikingly improves prognosis of myocardial infarction-induced heart failure.2014

    • Author(s)
      Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第18回日本心不全学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Involvement of decreases in regulatory T cells and splenic sympathetic nerve in the development of hypertension in genetically hypertensive rats.2014

    • Author(s)
      Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      High Blood Pressure Research Scientific Sessions 2014
    • Place of Presentation
      San Francisco
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] メタボリック症候群モデルマウスにおける食塩感受性高血圧は脳内上皮型Naチャネル活性化を介している.2014

    • Author(s)
      髙根澤 睦,伊藤 浩司,廣岡 良隆,砂川 賢二
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢性循環制御機構の解明と展望.2014

    • Author(s)
      廣岡 良隆
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 脳卒中易発症性自然発症高血圧ラットの高血圧形成過程において制御性T細胞の減少と脾臓交感神経が関与する.2014

    • Author(s)
      甲木 雅人,廣岡 良隆,岸 拓弥,砂川 賢二
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中枢性AT1受容体の阻害は高血圧ラットの心房細動持続時間を降圧度非依存性に抑制する.2014

    • Author(s)
      長山 友美,岸 拓弥,廣岡 良隆,樗木 晶子,向井 靖,井上 修二朗,砂川 賢二
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] アストロサイト特異的AT1受容体阻害は心筋梗塞後の左室リモデリングを抑制する.2014

    • Author(s)
      伊勢川 健吾,廣岡 良隆,岸 拓弥,砂川 賢二
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Decreased T-regulatory cells are associated with blood pressure elevation and sympathoexcitation in hypertensive rats.2014

    • Author(s)
      Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego
    • Year and Date
      2014-04-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Astrocyte-specific angiotensin II type 1 receptor knockout by using Cre-loxp system attenuates left ventricular remodeling after myocardial infarction.2014

    • Author(s)
      Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      Experimental Biology 2014
    • Place of Presentation
      San Diego
    • Year and Date
      2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Decreases in T-regulatory lymphocytes precede blood pressure elevation in stroke-prone spontaneously hypertensive rats.2014

    • Author(s)
      Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Renal nerve denervation exerts antihypertensive effects via enhancing GABA-ergic input to paraventricular nucleus in hypertensive mice with chronic kidney disease.2014

    • Author(s)
      Nishihara M, Hirooka Y, Sunagawa K.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeted deletion of angiotensin II type 1 receptor in astrocytes inhibits left ventricular remodeling after myocardial infarction in mice.2014

    • Author(s)
      Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] AT1 receptors and Oxidative Stress in the RVLM Are the Possible Therapeutic Target for Hypertension2013

    • Author(s)
      Hirooka Y
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] Central sympathoinhibition by moxonidine suppresses brain oxidative stress, prevents cardiac remodeling and improves prognosis in rats with hypertensive heart failure2013

    • Author(s)
      Honda N, Hirooka Y, et al.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Circulating angiotensin II leads to left ventricular diastolic dysfunction through sympathoexcitation with intrinsic brain AT1 receptor activation2013

    • Author(s)
      Shinohara K, Hirooka Y, et al.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Central sympathoinhibition induced by blockade of brain AT1 receptors ameliorates the reduction of splenic regulatory T cells in hypertensive rats2013

    • Author(s)
      Katsuki M, Hirooka Y, et al.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Aldosterone-independent MR activation in the choroid plexus increases Na^+ in cerebrospinal fluid and induces synpathoexcitation instroke-prone spontaneously hypertensive rats2013

    • Author(s)
      Nakano M, Hirooka Y, et al.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Device therapy in hypertension.(Organizer and Symposium speaker)2013

    • Author(s)
      Hirooka Y
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 高血圧から心不全に至る交感神経系の役割.(シンポジスト)2013

    • Author(s)
      廣岡 良隆
    • Organizer
      第49回高血圧関連疾患モデル学会学術集会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Splenic T regulatory lymphocytes are reduced in genetically hypertensive rats associated with sympathoinhibition.2013

    • Author(s)
      Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      High Blood Pressure Research Scientific Sessions 2013
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Combining irbesartan and trichlormethiazide elicits strong blood pressure reduction associated with sympathoinhibition and beneficial metabolic profiles in hypertensive rats with metabolic syndrome.2013

    • Author(s)
      Nishihara M, Hirooka Y, Sunagawa K.
    • Organizer
      High Blood Pressure Research Scientific Sessions 2013
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Different role of oxidative stress in paraventricular nucleus and rostral ventrolateral medulla in cardiovascular regulation in awake spontaneously hypertensive rats. (YIA受賞)2013

    • Author(s)
      Nishihara M, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腎除神経は高血圧性心不全ラットにおいて利尿作用により心機能障害を抑制し、生命予後を改善する.2013

    • Author(s)
      本田 修浩、廣岡 良隆、伊藤 浩司、砂川 賢二
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] アジルサルタンは高血圧モデルラットにおいて強力な平均血圧低下作用に加え睡眠→覚醒時の血圧上昇を抑制する.2013

    • Author(s)
      伊勢川 健吾、廣岡 良隆、岸 拓弥、砂川 賢二
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] イルベサルタンとトリクロルメチアジドの併用療法は高血圧を合併するメタボリックシンドロームモデル動物の脂質糖代謝へ影響を与えず交感神経活動を抑制し強力な降圧効果を有する.2013

    • Author(s)
      西原 正章、廣岡 良隆、砂川 賢二
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Central sympathoinhibition by moxonidine attenuates brain oxidative stress, prevented cardiac dysfunction and improved prognosis in rats with hypertensive heart failure.2013

    • Author(s)
      Honda N, Hirooka Y, Ito K, Matsukawa R, Sunagawa K.
    • Organizer
      Scientific Sessions 2013
    • Place of Presentation
      Dallas, TX, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Brain angiotensin II type 1 receptors in astrocytes, not neurons, are upregulated in mice with myocardial infarction-induced heart failure.2013

    • Author(s)
      Isegawa K, Hirooka Y, Kishi T, Sunagawa K.
    • Organizer
      第17回日本心不全学会学術集会
    • Place of Presentation
      大宮
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mineralocorticoid receptors (MR)/epithelial Na Channels (ENaCs)pathway activation in choroid plexus exaggerates salt-induced hypertension with sympathoexcitation in stroke-prone spontaneously hypertensive rats2012

    • Author(s)
      Nakano M, Hirooka Y, et al.
    • Organizer
      Scientific Sessions 2012
    • Place of Presentation
      Los Angels, CA, USA
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cardiac sympathetic afferents stimulation increases brain ENaCs, thereby concomitant salt loading leads to sympathoexcitation2012

    • Author(s)
      Ito K, Hirooka Y, et al.
    • Organizer
      Scientific Sessions 2012
    • Place of Presentation
      Los Angels, CA, USA
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Brain senses the circulating angiotensin II substantially leading to leftventricular diastolic dysfunction through the central Sympathoexcitation2012

    • Author(s)
      Shinohara K, Hirooka Y, et al.
    • Organizer
      Scientific Sessions 2012
    • Place of Presentation
      Los Angels, CA, USA
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reduced splenic and circulating T regulatory cells contribute to sympathoexcitation through central AT1 receptors in hypertensive rats2012

    • Author(s)
      Katsuki M, Hirooka Y, et al.
    • Organizer
      Scientific Sessions 2012
    • Place of Presentation
      Los Angels, CA, USA
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Brain AT1 receptors as a therapeutic target for hypertension via oxidative stress and inflammatory response2012

    • Author(s)
      Hirooka Y
    • Organizer
      The 29th Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      福岡
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanisms involved in activation of the sympathetic nervous system in hypertension : oxidative stress in the brainstem and hypothalamus2012

    • Author(s)
      Hirooka Y
    • Organizer
      The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      神戸
    • Year and Date
      2012-09-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Targeting the ATI receptors in the RVLM for therapeutic aspects2012

    • Author(s)
      Hirooka Y
    • Organizer
      Satellite Meeting of the International Society of Hypertension
    • Place of Presentation
      Palm Cove, Queens land, Australia
    • Year and Date
      2012-09-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高血圧におけるRVLM機能異常と酸化ストレス2012

    • Author(s)
      廣岡良隆
    • Organizer
      第35回日本高血圧学会・SHR学会合同シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Central NRG-1/ErbB signaling has a pivotal role in the regulation of sympathetic nerve activity in pressure overload-induced heart failure2012

    • Author(s)
      Matsukawa R, Hirooka Y, et al.
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高血圧・心不全の病態における循環中枢異常による交感神経活性化2012

    • Author(s)
      廣岡良隆
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2012-09-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] The brain AT1R are responsible for sympathoexcitation associated with brain MR activation in mice with pressure overload after salt loading2012

    • Author(s)
      Ito K, Hirooka Y, et al.
    • Organizer
      Scientific Sessions 2012
    • Place of Presentation
      Los Angels, CA, USA
    • Year and Date
      2012-01-05
    • Related Report
      2012 Annual Research Report
  • [Book] Oxidative Stress and Central Regulation of Blood Pressure in "Studies on Atherosclerosis"2017

    • Author(s)
      Hirooka Y, Sunagawa K.
    • Total Pages
      138
    • Publisher
      Springer Sciences
    • Related Report
      2016 Annual Research Report
  • [Book] Annual Review循環器20162016

    • Author(s)
      廣岡 良隆
    • Total Pages
      280
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 血圧変動 エビデンス&プラクティス2016

    • Author(s)
      廣岡 良隆
    • Total Pages
      215
    • Publisher
      先端医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 中枢性血圧調節機構 「Annual Review 循環器 2016」(分担執筆)2016

    • Author(s)
      廣岡 良隆
    • Total Pages
      286
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 治療抵抗性高血圧に腎デナベーションは有効ではないのか?(SYMPLICITY IIIを受けて).「EBM循環器疾患の治療 2015-2016」(分担執筆)2015

    • Author(s)
      廣岡 良隆
    • Total Pages
      468
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 二次性高血圧「高血圧診療Q&A 155」2014

    • Author(s)
      廣岡 良隆
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] Central and peripheral nervous system in “Nitric Oxide Synthase Inhibitors: From Animal Studies to Clinical Implications”, edited by Tunctan B.2013

    • Author(s)
      Hirooka Y
    • Total Pages
      286
    • Publisher
      Transworld Research Network
    • Related Report
      2013 Annual Research Report
  • [Book] Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications2012

    • Author(s)
      Hirooka Y
    • Total Pages
      661
    • Publisher
      Transworld Research Network(Central and peripheral nervous system)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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