Molecular regulation of cardiac function by the automatic nervous system

• Project/Area Number: 24390200
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yokohama City University
• Principal Investigator: ISHIKAWA Yoshihiro 横浜市立大学, 医学(系)研究科(研究院), 教授 (40305470)
• Co-Investigator(Kenkyū-buntansha): UMEMURA Masanari 横浜市立大学, 医学部, 助教 (50595353) ; 藤田 孝之 横浜市立大学, 医学部, 講師 (40468202) ; 横山 詩子 横浜市立大学, 医学部, 講師 (70404994) ; 市川 泰弘 横浜市立大学, 医学部, 助教 (10555121)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 交感神経 / セカンドメッセンジャー / 心臓 / 機能制御 / 自律神経 / 心機能制御 / cAMP / カテコラミン / 分子 / ｃＡＭＰ

Outline of Final Research Achievements

Adenylyl cyclase is a target enzyme of catecholamine signal, which produces cAMP in the cell. This second messenger classically is known to activate protein kinase A, which is known as cAMP-dependent kinase. Recently, however, a second target enzyme, known as “Epac”, has been widely recognized. This enzyme is distinct from the classic PKA and is known to regulate the activity of various small G proteins. In thus study, we compared the role of Epac with that of PKA, in order to understand the cAMP signal network. We particularly carefully examined it from the stand point of the regulation of cardiac function and the development of pathophysiology. This study, accordingly, successfully prevailed new mechanisms of cAMP signaling in the heart.

Research Products

• [Int'l Joint Research] Oak Ridge National Laboratory(米国)
• [Journal Article] Use of Three-dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery (2016)
  • Author(s): P. Chetprayoon, M. Matsusaki, U. Yokoyama, T. Tejima, Y. Ishikawa, M. Akashi
  • Journal Title: Angew. Chem. Int. Ed. Volume: 55 Issue: 14 Pages: 4461-4466
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  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. (2015)
  • Author(s): Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim J-H, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Sigh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I and Ishikawa Y.
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 9194-9194
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  • Peer Reviewed / Open Access
• [Journal Article] Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach (2015)
  • Author(s): Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y
  • Journal Title: The Journal of Physiological Sciences Volume: 65(2) Issue: 2 Pages: 195-200
  • DOI: 10.1007/s12576-014-0354-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes. (2015)
  • Author(s): Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, SuitaK, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, and Ishikawa Y.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 458 Issue: 3 Pages: 531-535
  • DOI: 10.1016/j.bbrc.2015.01.149
  • Peer Reviewed / Open Access
• [Journal Article] Epac1 deficiency attenuated vascular smooth muscle cell migration and neointimal formation. (2015)
  • Author(s): Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, Ishikawa Y.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 35(12) Issue: 12 Pages: 2617-2625
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through β1- and α1-adrenergic receptor-mediated signaling in mice. (2015)
  • Author(s): Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y.
  • Journal Title: PLoS One. Volume: 23;10(7) Issue: 7 Pages: e0133664-e0133664
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  • Peer Reviewed / Open Access
• [Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function. (2015)
  • Author(s): Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 310(1) Issue: 1 Pages: 92-103
  • DOI: 10.1152/ajpheart.00411.2015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Establishment of successively transplantable rabbit VX2 cancer cells that express enhanced green fluorescent protein (2014)
  • Author(s): Oshiro H, Fukumura H, Nagahama K, Sato I, Sugiura K, Iobe H, Okiyama E, Nagao T, Nagashima Y, Aoki I, Yamanaka S, Murakami A, Maegawa J, Chishima T, Ichikawa Y, Ishikawa Y, Nagai T, Nomura M, Ohashi K and Okudela K
  • Journal Title: Med Mol Morphol Volume: 印刷中 Issue: 1 Pages: 13-23
  • DOI: 10.1007/s00795-014-0071-2
  • Peer Reviewed / Open Access
• [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling. (2014)
  • Author(s): Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
  • Journal Title: Circulation. Volume: 129 Issue: 4 Pages: 487-496
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  • Peer Reviewed / Open Access
• [Journal Article] Store-operated Ca2 entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. (2014)
  • Author(s): Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Lai-Hua Xie LH, Feng X, 1, Itoh K, Makino A, Fujita T, Yokoyama U, Iw atsubo M, Chen S, Goydos JS, I shikawa Y, and Iwatsubo K
  • Journal Title: PLoS ONE. Volume: 9 Issue: 2 Pages: e89292-e89292
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  • Peer Reviewed / Open Access
• [Journal Article] Hyperthermia generated with ferucarbotran (Resovis®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells. (2014)
  • Author(s): Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T Fujita T, Yokoyama U, Okumura S, Feng X, Ito K, Miyajima A, Makino A, Iwai M, Eguchi H, I wai T, and Ishikawa Y.
  • Journal Title: J. Physiol. Sci. Volume: 64 Issue: 3 Pages: 177-183
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  • Peer Reviewed / Open Access
• [Journal Article] Decreased serum osmolality promotes ductus arteriosus constriction. (2014)
  • Author(s): Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y.
  • Journal Title: Cardiovascular Research Volume: 104(2) Issue: 2 Pages: 326-36
  • DOI: 10.1093/cvr/cvu199
  • Peer Reviewed / Open Access
• [Journal Article] Three-Dimensional Multilayers of Smooth Muscle Cells as a New Experimental Model for Vascular Elastic Fiber Formation Studies. (2014)
  • Author(s): Ishiwata R, Yokoyama U, Matsusaki M, Yoshiya A, Kadowaki K, Ichikaww Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Mitsuru Akashi M, and Ishikawa Y.
  • Journal Title: Atherosclerosis. Volume: 233 Issue: 2 Pages: 590-600
  • DOI: 10.1016/j.atherosclerosis.2014.01.045
  • Peer Reviewed / Open Access
• [Journal Article] Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8. (2014)
  • Author(s): Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun, AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, and Ishikawa Y.
  • Journal Title: PLoS ONE. Volume: 9 Issue: 3 Pages: e91980-e91980
  • DOI: 10.1371/journal.pone.0091980
  • Peer Reviewed / Open Access
• [Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses. (2014)
  • Author(s): Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
  • Journal Title: J Clin Invest. Volume: 124 Issue: 6 Pages: 2785-2801
  • DOI: 10.1172/jci64784
  • Peer Reviewed / Open Access
• [Journal Article] Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3. (2014)
  • Author(s): Tsutsumi YM, Tsutsumi R, Hamaguchi E, Sakai Y, Kasai A, Ishikawa Y, Yokoyama U, and Tanaka K.
  • Journal Title: Cardiovasc Diabetol. Volume: 13 Issue: 1 Pages: 132-132
  • DOI: 10.1186/s12933-014-0132-9
  • Peer Reviewed / Open Access
• [Journal Article] Geranylgeranylacetone protects the heart via caveloae and caveolin-3. (2014)
  • Author(s): Tsutsumi YM, Tsutsumi R, Hirokawa YT, Sakai Y, Hamaguchi E, Ishikawa Y, Yokoyama U, Kasai A, Kambe N, and Tanaka K.
  • Journal Title: Life Sciences. Volume: 101 Issue: 1-2 Pages: 43-48
  • DOI: 10.1016/j.lfs.2014.02.019
  • Peer Reviewed / Open Access
• [Journal Article] Epacl increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling. (2014)
  • Author(s): Baljinnyam E, Umemura M, C huang C, De Lorenzo M, Iwatsubo M, Chen S, Goydos J, Ishikawa Y, Whitelock J, and Iwatsubo K.
  • Journal Title: Pigment Cell & Melanoma Research. Volume: (Epub ahead of print) Issue: 4 Pages: 611-620
  • DOI: 10.1111/pcmr.12250
  • Peer Reviewed
• [Journal Article] A Case of R-II-B Type Single Coronary Artery Evaluated by Multi-Detector Computed Tomography and Coronary Angiography. (2014)
  • Author(s): Narikawa M, Kiyokuni M, Umemura M, Kawashima C, Doi H, Hisa A, Tomari S, Mitsuhashi T, Ishikawa Y and Endo T.
  • Journal Title: J Clin Exp Cardiolog, Volume: 5 Pages: 10-10
  • Peer Reviewed
• [Journal Article] Impaired NO Production and Increased Blood Pressure in Systemic Heterozygous ATP2B1 Null Mice. (2014)
  • Author(s): Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto y, Ichihara N, Saka S, Toya Y, Yasuda G, Tabara Y, Miki T, Ueshima H, Ishikawa Y, and Umemura S
  • Journal Title: J Hypertension. Volume: 32 Issue: 7 Pages: 1415-1423
  • DOI: 10.1097/hjh.0000000000000206
  • Peer Reviewed / Open Access
• [Journal Article] Role of Cyclic AMP Sensor Epac1 in Masseter Muscle Hypertrophy and Myosin Heavy Chain Transition Induced by 2-Adrenoceptor Stimulation. (2014)
  • Author(s): Ohnuki Y, Umeki D, Mototani Y, Jin H, Cai W, Shiozawa K, Suita K, Saeki Y, Fujita T, Ishikawa Y, and Okumura S.
  • Journal Title: J. Physiol. Volume: 592 Issue: 24 Pages: 5461-5475
  • DOI: 10.1113/jphysiol.2014.282996
  • Peer Reviewed
• [Journal Article] Obstructive Sleep Apnea and Hypertension:A New Way to Go. (2014)
  • Author(s): Ishikawa Y.
  • Journal Title: J Sleep Disorders Ther. Volume: 3 Pages: 4-4
  • Peer Reviewed
• [Journal Article] Disruption of Epac1 decreasesphosphorylation of phospholamban and protects theheart against stresses. (2014)
  • Author(s): Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin HL, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita Km Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, and Ishikawa Y.
  • Journal Title: J. Clin. Invest. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension. (2013)
  • Author(s): Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, Azushima K, Uneda K, Tsurumi-Ikeya Y, Kobayashi R, Matsuda M, Uchida S, Toya Y, Kobori H, Nishiyama A, Yamashita A, Ishikawa Y, Umemura S.
  • Journal Title: Kidney Int. Volume: 86(3) Issue: 3 Pages: 570-81
  • DOI: 10.1038/ki.2014.95
  • Peer Reviewed / Open Access
• [Journal Article] The prostanoid EP4 receptor and its signaling pathway. (2013)
  • Author(s): Yokoyama U, Iwatsubo K, Umemura M, Fujita T, and Ishikawa Y.
  • Journal Title: Pharmacol Rev. Volume: 65 Issue: 3 Pages: 1010-1052
  • DOI: 10.1124/pr.112.007195
  • Peer Reviewed
• [Journal Article] Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the Sirtl/FoxO3a Pathway. (2013)
  • Author(s): Lai L, et al.
  • Journal Title: Circulation. Volume: 127 Issue: 16 Pages: 1692-1701
  • DOI: 10.1161/circulationaha.112.001212
  • Peer Reviewed
• [Journal Article] A role for Piezo2 in EPAC1-dependent mechanical allodynia. (2013)
  • Author(s): Eijkelkamp N, Linley JE, Torres JM, Bee L, Dickenson AH, Gringhuis M, Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ, Cox JJ, and Wood, J N.
  • Journal Title: Nature Commun. Volume: 4 Issue: 1 Pages: 1682-1682
  • DOI: 10.1038/ncomms2673
  • Peer Reviewed
• [Journal Article] Hight-dose zoledronic acid narrows the periodontal space in rats. (2013)
  • Author(s): Okamoto Y, Hirota M, Monden Y, Murata S, Koyama C, Mitsudo K, Iwai T, Ishikawa Y, and Tohnai I.
  • Journal Title: Int J Oral Maxillofac Surg. Volume: 2 Issue: 5 Pages: 627-631
  • DOI: 10.1016/j.ijom.2012.11.011
  • Peer Reviewed
• [Journal Article] Balancing GRK2/ Epac1levels prevents and relieves chronic pain. (2013)
  • Author(s): Wang H, Heijnen CJ, van Velth oven CTJ, Willemen HLDM, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, and Kavelaars A.
  • Journal Title: J. Clin. Invest. Volume: 123 Issue: 12 Pages: 5023-5034
  • DOI: 10.1172/jci66241
  • Peer Reviewed
• [Journal Article] Adenylyl cyclase type 5 in cardiac disease, metabolism and aging. (2013)
  • Author(s): Vatner SF, Park M, Yan L, Lee G, Lai L, Iwatsubo K, Ishikawa Y, Pessin J, and Vatner DE
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 305 Issue: 1 Pages: H1-H8
  • DOI: 10.1152/ajpheart.00080.2013
  • Peer Reviewed
• [Journal Article] Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase. (2012)
  • Author(s): Iwatsubo K, Bravo C, Uechi M, Baljinnyam E, Nakamura T, Umemura M, Lai L, Gao S, Yan L, Park M, Qiu H, Okumura S, Iwatwsubo M, Vatner DE, Vatner SF, and Ishikawa Y.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 302 Issue: 12 Pages: H2622-H2628
  • DOI: 10.1152/ajpheart.00190.2012
  • Peer Reviewed
• [Journal Article] Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity. (2012)
  • Author(s): Jiao Q, et al.
  • Journal Title: Cell Calcium. Volume: 51 Issue: 1 Pages: 31-39
  • DOI: 10.1016/j.ceca.2011.10.003
  • Peer Reviewed
• [Journal Article] Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus Without Inducing Intimal Thickening (2012)
  • Author(s): Ichikawa Y, et al.
  • Journal Title: Circulation Journal Volume: 76 Issue: 10 Pages: 2456-2464
  • DOI: 10.1253/circj.CJ-12-0215
  • NAID: 10030875150
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells show Significant Blood Pressure Elevation. (2012)
  • Author(s): Kobayashi Y, et al.
  • Journal Title: Hypertension. Volume: 59 Issue: 4 Pages: 854-860
  • DOI: 10.1161/hypertensionaha.110.165068
  • Peer Reviewed
• [Journal Article] Acute myocardial infarction with isolated conus branch occlusion. (2012)
  • Author(s): Umemura M, et al.
  • Journal Title: J Electrocardiol. Volume: 45 Issue: 3 Pages: 285-287
  • DOI: 10.1016/j.jelectrocard.2011.11.006
  • Peer Reviewed
• [Journal Article] Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells. (2012)
  • Author(s): Fukumura H, et al.
  • Journal Title: J. Physiol. Sci. Volume: 62 Pages: 251-257
  • Peer Reviewed
• [Journal Article] Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight (2012)
  • Author(s): Bai Y, et al.
  • Journal Title: Journal of Pharmacological Sciences Volume: 119 Issue: 4 Pages: 381-389
  • DOI: 10.1254/jphs.12102FP
  • NAID: 10031071685
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Acute pulmonary embolism induced by renal obstruction with benign prostatic hyperplasia. (2012)
  • Author(s): Umemura M, et al.
  • Journal Title: Journal of Cardiology Cases. Volume: 5 Issue: 1 Pages: e39-e43
  • DOI: 10.1016/j.jccase.2011.10.004
  • Peer Reviewed
• [Journal Article] Morphological and Histological Evaluations of 3D-Layered Blood Vessel Constructs Prepared by Hierarchical Cell Manipulation. (2012)
  • Author(s): Matsusaki M, et al.
  • Journal Title: J Biomater Sci Polym Ed. Volume: 23 Issue: 1-4 Pages: 63-79
  • DOI: 10.1163/092050610x541953
  • Peer Reviewed
• [Journal Article] Inhibition of EP4 signaling attelluates aortic aneurysm formation (2012)
  • Author(s): Yokoyama U
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e36724-e36724
  • DOI: 10.1371/journal.pone.0036724
  • Peer Reviewed
• [Presentation] ビダラビンの不整脈治療における有用性 (2016)
  • Author(s): 藤田孝之、吹田憲治、蔡 文倩、金 慧玲、日高 祐子、石川 義弘
  • Organizer: 第93回日本生理学会大会合同大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-22
• [Presentation] Kato Y, Yokoyama U, Ishikawa Y. The role of Epac1 in the regulatory mechanisms of vascular smooth muscle cell migration and neointimal formation. (2016)
  • Author(s): Kato Y, Yokoyama U, Ishikawa Y.
  • Organizer: 第93回日本生理学会大会合同大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-22
• [Presentation] Periodic hydrodynamic pressurization promotes layered structure of human arterial smooth muscle cells. (2016)
  • Author(s): Tonooka Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
  • Organizer: 第93回日本生理学会大会合同大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-22
• [Presentation] Fabrication of layered elastic fibers in rat arterial constructs by periodic hydrodynamic pressurization. (2016)
  • Author(s): Gonda Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
  • Organizer: 第93回日本生理学会大会合同大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-22
• [Presentation] 分子標的薬であるヴォトリエントの磁性化 (2016)
  • Author(s): 青山春樹, 梅村将就, 佐藤格, 大竹誠, 小田香世子, 成川雅俊, 秋本大輔, 中鍛冶里奈, 勝亦真弓, 江口晴樹, 石川義弘.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-09
• [Presentation] Magnetized methotrexate for novel anti-cancer therapy. (2016)
  • Author(s): Katsumata Ｍ, Umemura M, Sato I, Ohtake M, Oda K, Akimoto T, Nakakaji R, Narikawa M, Aoyama H, Eguchi H and Ishikawa Y.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-09
• [Presentation] The Role of Inflammatory (2016)
  • Author(s): Ishikwa Y.
  • Organizer: The 4th International Conference on PreHypertension & Cardio Metabolic Syndrome.
  • Place of Presentation: Hilton Molino Stucky Venice
  • Year and Date: 2016-03-03
  • Int'l Joint Research
• [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリング. (2015)
  • Author(s): 齋藤純一, 横山詩子,益田宗孝, 麻生俊英, 石川義弘.
  • Organizer: 第14回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル華の湯（福島県郡山市）
  • Year and Date: 2015-12-18
• [Presentation] 有機磁性体化合物による神経膠芽腫に対する化学温熱同時療法の開発. (2015)
  • Author(s): 大竹誠, 梅村将就, 佐藤 格, 秋本大輔, 江口晴樹, 石川義弘, 川原信隆.
  • Organizer: 第74回日本脳神経外科学術総会
  • Place of Presentation: ロイトン札幌、さっぽろ芸術文化の館、札幌市教育文化会館（北海道札幌市）
  • Year and Date: 2015-10-14
• [Presentation] Novel thermo-chemotherapy of oral cancer using a new magnetic anti-cancer drug. (2015)
  • Author(s): Sato I, Umemura M, Mitsudo K, Nakashima H, Kioi M, Eguchi H, Ohtake M, Oda, Tohnai I and Ishikawa Y.
  • Organizer: The 18th European Cancer Congress.
  • Place of Presentation: Messe Wien Exhibition &Congress Center, Vienna, Austria
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] Simultaneous hyperthermic-chemotherapy using a single anti-cancer compound with intrinsic magnetism in glioblastoma animal model. (2015)
  • Author(s): Ohtake M, Umemura M, Sato I, Akimoto T, Nagasako A, Eguchi H, Kawahara N, Ishikawa Y
  • Organizer: The 18th European Cancer Congress.
  • Place of Presentation: Messe Wien Exhibition &Congress Center, Vienna, Austria
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] 口腔癌に対する新規磁性抗癌剤を用いたハイパーサーミアの開発. (2015)
  • Author(s): 佐藤 格, 光藤健司, 梅村将就, 江口春樹, 中鍛冶里奈, 小泉敏之, 中島英行, 來生 知, 石川義弘, 藤内 祝
  • Organizer: 第32回日本ハイパーサーミア学会学術大会
  • Place of Presentation: KKRホテル大阪（大阪府大阪市）
  • Year and Date: 2015-09-04
• [Presentation] 未熟児動脈管開存症治療におけるアミノ酸輸液組成の重要性 The effect of amino acids on patent ductus arteriosus in preterm infants.The effect of amino acids on patent ductus arteriosus in preterm infants. The effect of amino acids on patent ductus arteriosus in preterm infants. (2015)
  • Author(s): 横山詩子, 藤田秀次郎, 青木理加, 岩崎志穂, 麻生俊英, 益田宗孝, 関和男, 石川義弘
  • Organizer: 第51回日本小児循環器学会総会・学術集会
  • Place of Presentation: ホテル日航東京（東京都港区）
  • Year and Date: 2015-07-16
• [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリング. (2015)
  • Author(s): 齋藤純一, 横山詩子, 市川泰広, 益田宗孝, 麻生俊英, 石川義弘
  • Organizer: 第51回日本小児循環器学会総会・学術集会
  • Place of Presentation: ホテル日航東京（東京都港区）
  • Year and Date: 2015-07-16
• [Presentation] 平滑筋におけるPGE2-EP4シグナルは腹部大動脈瘤の発症を促進する. (2015)
  • Author(s): 石渡遼, 横山詩子, 市川泰弘, 石川義弘.
  • Organizer: 第132回日本薬理学会関東部会
  • Place of Presentation: 明海大学浦安キャンパス（千葉県浦安市）
  • Year and Date: 2015-07-04
• [Presentation] 交感神経活性化による心房細動/心房粗動の延長におけるアドレナリン受容体の役割. (2015)
  • Author(s): 長谷川希望, 藤田孝之, 吹田憲治, 祭 文倩, 金 慧玲, 日高祐子, Rajesh Prajapati, 石川義弘
  • Organizer: 第36回循環制御医学会総会
  • Place of Presentation: ウィンク愛知（愛知県名古屋市）
  • Year and Date: 2015-06-05
• [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of Dihydroartemisinin (DHA)-induced heart. (2015)
  • Author(s): Cai W, Fujita T, Hidaka Y, Jin H, Hasegawa N, Ishikawa Y.
  • Organizer: 第79回日本循環器学会学術集会.
  • Place of Presentation: 大阪国際会議場、リーガロイヤルホテル、堂島リバーフォーラム、ＡＢＣホール（大阪府）
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of Dihydroartemisinin(DHA)-induced heart. (2015)
  • Author(s): Cai W, Fujita T, Hidaka Y, Jin H, Hasegawa N, Ishikawa Y.
  • Organizer: The 79th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪・堂島リバーフォーラム・ＡＢＣホール（大阪府大阪市）
  • Year and Date: 2015-04-24
• [Presentation] Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma. (2015)
  • Author(s): Oda K, Umemura M, Baljinntam E, Yamaguchi Y, Aihara M, Iwatsubo K, Ishikawa Y.
  • Organizer: The 106th American Association for Cancer Research Annual meeting.
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18 – 2015-04-22
• [Presentation] Methotrexate derivative with intrinsic magnetism. (2015)
  • Author(s): Umemura M, Katsumata M, Sato I, Nagasako A, Aoyama H, Makino A, Ohatake M, Oda K, Eguchi H, Ishikawa Y.
  • Organizer: The 106th American Association for Cancer Research Annual meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18 – 2015-04-22
• [Presentation] Simultaneous hyperthermic-chemotherapy for glioblastoma using a single anti-cancer compound with magnetism. (2015)
  • Author(s): Ohtake M, Umemura M, Sato I, Oda K, Nagasako A, Makino A, Aoyama H, Katsumata M, Eguchi H, Kawahara N , Ishikawa Y
  • Organizer: The 106th American Association for Cancer Research Annual meeting.
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-18 – 2015-04-22
• [Presentation] Methotrexate derivative with intrinsic magnetism. (2015)
  • Author(s): Umemura M, Katsumata M, Sato I, Nagasako A, Aoyama H, Makino A, Ohatake M, Oda K, Eguchi H, Ishikawa Y
  • Organizer: The 106th American Association for Cancer Research Annual meeting
  • Place of Presentation: Pensylvania Convention Center, Philadelphia,USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma. (2015)
  • Author(s): Oda K, Umemura M, Katsumata M, Aoyama H, Makino A, Ohtake M, Sato I, Nagasako A, Yamaguchi Y, Nagashima Y, Aihara M, Ishikawa Y.
  • Organizer: The 106th American Association for Cancer Research Annual meeting,
  • Place of Presentation: Pensylvania Convention Center, Philadelphia,USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Simultaneous hyperthermic-chemotherapy for glioblastoma using a single anti-cancer compound with intrinsic magnetism. (2015)
  • Author(s): Ohtake M, Umemura M, Sato I, Oda K, Nagasako A, Makino A, Aoyama H, Katsumata M, Eguchi H, Kawahara N, Ishikawa Y
  • Organizer: The 106th American Association for Cancer Research Annual meeting,
  • Place of Presentation: Pensylvania Convention Center, Philadelphia,USA
  • Year and Date: 2015-04-18
  • Int'l Joint Research
• [Presentation] Plasminogen activator may promote intimal thickening in the ductus arteriosus. (2015)
  • Author(s): Nicho N, Yokoyama U, Saitoh J, Yanai C, Ichikawa Y, Masuda M, Aso T, Ishikawa Y.
  • Organizer: The 118th Annual Meeting of the Japan Pediatric Society.
  • Place of Presentation: 大阪国際会議場・リーガロイヤルホテル大阪（大阪府大阪市）
  • Year and Date: 2015-04-17
• [Presentation] New Method for Evaluation of Nano-Drug Carriers by 3D-Arterial Wall Models for Atherosclerosis Treatment. (2015)
  • Author(s): Chetprayoon P, Matsusaki M, Yokoyama U, Ishikawa Y, Akashi M.
  • Organizer: Annual meeting of Society for Biomaterials.
  • Place of Presentation: The Charlotte Convention Center, North Carolina,USA
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] A novel methotrexate derivative with intrinsic magnetism. (2015)
  • Author(s): Katsumata M, Umemura M, Sato I, Ohtake M, Oda K, Nagasako A, Makino A, Aoyama H, Eguchi H, Ishikawa Y.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Magnetized paclitaxel derivative for novel triple negative breast cancer therapy. (2015)
  • Author(s): Makino A, Umemura M, Sato I, Katsumata M, Nagasako A, Oda K, Ohtake M, Aoyama H, Eguchi H, Ishikawa Y.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸国際会議場・展示場（兵庫県）
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] A novel methotrexate derivative with intrinsic magnetism. (2015)
  • Author(s): Katsumata M, Umemura M, Sato I, Ohtake M, Oda K, Nagasako A, Makino A, Aoyama H, Eguchi H, Ishikawa Y.
  • Organizer: 第88回日本薬理学会
  • Place of Presentation: 名古屋国際会議場（愛知県）
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] プロスタグランディンE－EP4はfibulin-1を介して生理的・病的血管内膜肥厚の形成に関与する． (2014)
  • Author(s): 矢内千春, 横山詩子, 熊谷 駿, 手島隆之, 佐藤綾美, 石川義弘
  • Organizer: 第13回日本心臓血管発生研究会
  • Place of Presentation: 磐梯熱海温泉 ホテル 華の湯(福島県）
  • Year and Date: 2014-10-17 – 2014-10-18
• [Presentation] 抗ヘルペス薬による心房細動抑制． (2014)
  • Author(s): 吹田憲治, 藤田孝之, 奥村 敏, 石川義弘
  • Organizer: 第131回日本薬理学会関東部会
  • Place of Presentation: 横浜市立大学医学部ﾍﾎﾞﾝﾎｰﾙ（神奈川県）
  • Year and Date: 2014-10-11
• [Presentation] A novel paclitaxel with intrinsic magnetism (2014)
  • Author(s): Makino A, Umemura M, Sato I, Oda K, Otake M, Nagasako A, Eguchi H, Ishikawa Y.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Development of combination therapy with cisplatin and hyperthermia generated with ferucarbotran (Resovist) in an alternating magnetic field for oral cancer. (2014)
  • Author(s): Sato I, Mitsudo K, Umemura M, Nakashima H, Kioi M, Eguchi H, Ishikawa Y,Tohnai.I
  • Organizer: The 6th Asian Congress of Hyperthermic Oncology (ACHO)
  • Place of Presentation: 福井県民ホール、福井市地域交流プラザ（福井県）
  • Year and Date: 2014-09-05 – 2014-09-06
• [Presentation] EPAC1 plays an important role in regulation of renin and AQP2 expression in the kidney of mice. (2014)
  • Author(s): Jin H, Fujita T, Cai W, Hidaka Y, Sagara S, Kubota K, Suita K, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Prostaglandin E2-EP4 plays a protective role against cardiac fibrosis. (2014)
  • Author(s): Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Cardiac overexpression ofure. Chronic Treatment with Dihydroartemisinin, a TCTP Down-regulating Agent, Results in Cardiac Dysfunction in Mice． (2014)
  • Author(s): Cai W, Fujita T, Hidaka Y, Jin H, K. Sagara S, Kubota K, Suita K, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced atrial fibrillation in mice. (2014)
  • Author(s): Suita K, Fujita T, Cai W, Hidaka Y, Jin H, Jin M, Okumura S, Ishikawa Y.
  • Organizer: European Society of Cardiorogy Congress.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] 体液量調節におけるEPAC1の役割についての検討. (2014)
  • Author(s): Jin H, Fujita T, Cai W, Hidaka Y, Sagara S, Suita K, Ishikawa Y
  • Organizer: 第５７会日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] ヒト大動脈瘤組織におけるPGE2-EP4誘導性分泌タンパク質の網羅的解析. (2014)
  • Author(s): 石渡 遼, 横山詩子, 荒川憲昭, 安田章沢, 郷田素彦, 鈴木伸一, 益田宗孝, 石川義弘
  • Organizer: 第35回日本循環制医学会総会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県）
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] 心臓型アデニル酸シクラーゼの選択的阻害剤ビダラビンによる心房細動抑制. (2014)
  • Author(s): 吹田憲治, 藤田孝之, 蔡 文倩, 金 慧玲, 奥村 敏, 石川義弘
  • Organizer: 第35回日本循環制御医学会総会
  • Place of Presentation: 九州大学医学部百年講堂（福岡県）
  • Year and Date: 2014-07-04
• [Presentation] MRI造影剤フェルカルボトランを用いた新しい温熱化学療法の開発. (2014)
  • Author(s): 佐藤 格, 光藤健司, 梅村将就, 宮島章嘉, 中島英行, 來生 知, 石川義弘, 藤内 祝.
  • Organizer: 第38回日本頭頚部癌学会
  • Place of Presentation: 東京ファッションタウンビルホール(東京都）
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] Nuclear Factor kappa B Inhibition Promotes Closure of the Rat Ductus Arteriosus. (2014)
  • Author(s): Kajimura I, Yokoyama U, Ishikawa Y, Minamisawa S.
  • Organizer: Experimental Biology Annual Meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-25 – 2014-04-30
• [Presentation] Prostaglandin E2 receptor EP4 signaling in vascular smooth muscle cells decreases aortic elasticity. (2014)
  • Author(s): Ichikawa Y, Yokoyama U, Ishikawa Y.
  • Organizer: Experimental Biology Annual Meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-25 – 2014-04-30
• [Presentation] Development of thermochemotherapy using cisplatin and ferucarbotran (Resovist®) in head and neck cancer. (2014)
  • Author(s): Sato I, Umemura M, Mitsudo K, Feng X, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y
  • Organizer: The 105th American Association for Cancer Research Annual meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] A novel treatment for triple-negative breast cancer using intrinsic magnetized paclitaxel. (2014)
  • Author(s): Umemura M, Makino A, Sato I, Feng X, Iwai M, Oda K, Miyajima A, Otake M, Nagasako A, Matsuo K, Eguchi H, and Ishikawa Y
  • Organizer: The 105th American Association for Cancer Research Annual meeting.
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] Store-operated Ca2+ entry (SOCE) regulates melanoma progression. (2013)
  • Author(s): Umemura M, Baljinnyam E, Lorenzo M.S.De, Feske S, Xie L, Ishikawa Y, Iwatsubo K.
  • Organizer: The 104 American Association for Cancer Research Annual meeting
  • Place of Presentation: Washington DC,USA
• [Presentation] Application of a novel nano-magnetic anti-cancer drug to hyperthermia. (2013)
  • Author(s): Umemura M, Fukumura H, Sato I, Feng X, Izuka H, Eguchi H, Ishikawa Y
  • Organizer: The 104 American Association for Cancer Research Annual meeting
  • Place of Presentation: Washington DC,USA
• [Presentation] Targeted drug delivery system and magnetic resonance imaging with intrinsic ferromagnetic nano-particle compound. (2013)
  • Author(s): Eguchi H, Hirata K, Kurotani R, Fukumura H, Singh D.J, Yamamoto M, Sato I, Umemura M, Yamamoto M, Nagashima Y, Ishikawa Y
  • Organizer: The 104 American Association for Cancer Research Annual meeting
  • Place of Presentation: Washington DC,USA
• [Presentation] Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug. The 104 American Association for Cancer Research Annual meeting, (2013)
  • Author(s): Sato I, Mitsudo K, Umemura M, Feng X, Fukumura H, Eguchi H, Nakashima H, Kioi M, Tohnai I, Ishikawa Y
  • Organizer: The 104 American Association for Cancer Research Annual meeting
  • Place of Presentation: Washington DC,USA
• [Presentation] Novel thermo-chemotherapy using a new magnetic anti-cancer drug. (2013)
  • Author(s): Sato I, Umemura M, Mitsudo K, Feng X, Baba J, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y
  • Organizer: The 104 American Association for Cancer Research Annual meeting.
  • Place of Presentation: Washington DC,USA
• [Presentation] Inhibitor of cardiac adenylyl cyclase prevents atrial fibrillation in mice. (2013)
  • Author(s): Suita K, Cai W, Jin H, Jin M, Fujita T, Okumura S, Ishikawa Y
  • Organizer: HD Physiology, the 2nd International Symposium
  • Place of Presentation: 丸ノ内ＭＵＰＬＡＺＡ（東京都）
• [Presentation] Mouse Overexpressing Prostaglandin E Receptor EP4 in Vascular Smooth Muscle Cells Decreased Elasticity of the Aorta. (2013)
  • Author(s): Ichikawa Y, Yokoyama U, Jin M, Ishikawa Y
  • Organizer: The 7th TAKAO International symposium
  • Place of Presentation: 国立オリンピック記念青少年総合センター（東京都）
• [Presentation] Prostaglandin E2-EP4 signaling promotes secretion of the lipid-relating proteoglycan buglycan in human coronary arteries during development. (2013)
  • Author(s): Kumagaya S, Yokoyama U, Sato A, Nishihara H, Inoue T, Minamisawa S, Ishikawa Y
  • Organizer: The 7th TAKAO International symposium
  • Place of Presentation: 国立オリンピック記念青少年総合センター（東京都）
• [Presentation] Prostaglandin E2-EP4 signaling inhibits vascular elastic fiber formation in the ductus arteriosus. (2013)
  • Author(s): Ishiwata R, Yokoyama U, Jin M, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y
  • Organizer: The 7th TAKAO International symposium.
  • Place of Presentation: 国立オリンピック記念青少年総合センター（東京都）
• [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of doxorubicin-induced heart failure. (2013)
  • Author(s): Fujita T, Cai W, Hidaka Y, Jin H, Jin M, Suita K, Ishikawa Y
  • Organizer: European Socirty of Cardiology.
  • Place of Presentation: Amsterdam ,Netherladns
• [Presentation] A novel nano-magnetic particle with cytotoxic and a novel technology of designing intrinsic ferromagnetism compound. (2013)
  • Author(s): Umemura M, Eguchi H, Ishikawa Y
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] A conventional anti-cancer drug designed artificially with ferromagnetic, EI2573M. (2013)
  • Author(s): Iwai M, Umemura M, Sato I, Nagasako A, Feng X, Hoshino Y, Inoue S, Aoki I, Eguchi H, Ishikawa Y
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Therapeutic Effect of EP4 Antagonist on Advanced Abdominal Aortic Aneurysm. (2013)
  • Author(s): Yokoyama U, Ishiwata R, Arakawa N, Suzuki S, Masuda M, Ishikawa Y.
  • Organizer: The 86th Scientific Session, American Heart Association.
  • Place of Presentation: Dallas, USA
• [Presentation] Decreased Serum Osmolality Augments the Closure of the Ductus Arteriosus in Neonates. (2013)
  • Author(s): Yokoyama U, Aoki R, Ichikawa Y, Iwasaki S, Seki K, Nishimaki S, Yokota S, Minamisawa S, Ishikawa Y
  • Organizer: The 86th Scientific Session, American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Prostaglandin E2 Receptor EP4 Signaling in Vascular Smooth Muscle Decreased Elasticity of the Aorta. (2013)
  • Author(s): Ichikawa Y, Yokoyama U, Iwamoto M, Yokota S, Minamisawa S, Ishikawa Y
  • Organizer: The 86th Scientific Session, American Heart Association.
  • Place of Presentation: Dallas, USA
• [Presentation] Anti-fibrotic Effect of Prostaglandin E2-EP4 in the Heart. (2013)
  • Author(s): Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y
  • Organizer: The 86th Scientific Session, American Heart Association.
  • Place of Presentation: Dallas, USA
• [Presentation] 温熱治療における新規磁性抗がん剤の役割 (2013)
  • Author(s): 石川義弘
  • Organizer: 第30回日本ハイパーサーミア学会
  • Place of Presentation: 横浜シンポジア（神奈川県）
  • Invited
• [Presentation] 新規抗癌剤を用いた口腔癌に対するハイパーサーミアの開発. (2013)
  • Author(s): 佐藤 格, 光藤健司, 梅村将就, 江口晴樹, 石川義弘, 藤内 祝
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] EP4シグナル制御による大動脈瘤の治療開発 (2013)
  • Author(s): 石渡 遼, 横山詩子, 石川義弘
  • Organizer: 新学術領域 「自然炎症」+「脂質マシナリー」若手ワークショップ
  • Place of Presentation: ルネッサンスリゾート鳴門（徳島県）
• [Presentation] 出生後血清浸透圧変化からみた動脈管開存症発症リスク因子の検討. (2013)
  • Author(s): 青木理加, 横山詩子, 藤田秀次郎, 市川泰広, 岩崎志穂, 関 和男, 西巻 滋, 横田俊平, 石川義弘
  • Organizer: 第49回日本周産期新生児学会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] .大動脈瘤進展におけるプロスタグランディンE-EP4の役割. (2013)
  • Author(s): 石渡 遼, 横山詩子, 石川義弘
  • Organizer: 第6回大動脈分子病態研究会
  • Place of Presentation: 久留米大学循環器病研究所（福岡県）
• [Presentation] 抗がん作用を有する新規磁性微粒子を用いたハイパーサーミアへの応用. (2013)
  • Author(s): 佐藤 格, 光藤健司, 梅村将就, 來生 知, 中島英行, 馮 先鋒, 江口晴樹, 石川義弘, 藤内 祝
  • Organizer: 第30回ハイパーサーミア学会.
  • Place of Presentation: 横浜シンポジア（神奈川県）
• [Presentation] Prostaglandin Eシグナルによるlysyl oxidase分解亢進が動脈管弾性線維の形成不良を引き起こす. (2013)
  • Author(s): 南沢 享, 横山詩子, 青木浩樹, 中邨智之, 石川義弘
  • Organizer: 生理研研究会―心血管膜輸送分子の構造・機能・病態の統合的研究戦略,
  • Place of Presentation: 自然科学研究機構生理学研究所（愛知県）
• [Presentation] 心臓型アデニル酸シクラーゼの選択的阻害剤ビダラビンによる不整脈治療の可能性. (2013)
  • Author(s): 吹田憲治, 藤田孝之, 石川義弘
  • Organizer: 生理学研究所研究会, ―心血管膜輸送分子の構造・機能・病態の統合的研究戦略,
  • Place of Presentation: 自然科学研究機構生理学研究所（愛知県）
• [Presentation] 新生児期における浸透圧感受性TRPチャネルの役割. (2013)
  • Author(s): 横山詩子, 青木理加, 南沢 享, 石川義弘
  • Organizer: 筋生理の集い
  • Place of Presentation: 東京慈恵会医科大学（東京都）
• [Presentation] Prostaglandin E2 receptor EP4 in coronary smooth muscle cells may play a role in intimal thickening that precedes atherosclerosis (2012)
  • Author(s): Kumagaya S, Yokoyama U, Iwai K, Nishihara H, Inoue T, Mimamisawa S, Ishikawa Y
  • Organizer: 第2回生命医科ポスター交流会
  • Place of Presentation: 東京女子医科大学・早稲田大学連携先端生命医科学研究教育施設(TWlns)(東京都)
  • Year and Date: 2012-08-10
• [Presentation] cAMPシグナルとニコチン受容体 (2012)
  • Author(s): 石川義弘
  • Organizer: 第27回喫煙科学研究財団平成23年度助成研究発表会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2012-07-22
• [Presentation] 酸素による動脈管リモデリング (2012)
  • Author(s): 金美花, 横山詩子, 石渡遼, 石川義弘
  • Organizer: 平成24年度生理学若手研究者フォーラム「生体機能へのアプローチ」
  • Place of Presentation: 順天堂大学(東京都)
  • Year and Date: 2012-06-30
• [Presentation] Phosphodiesterase Type 3 Inhibitor, Milrinone, Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening. (2012)
  • Author(s): Ichikawa Y Yokoyama U, Masuda M, Asou T, Ishikawa Y
  • Organizer: The 8^<th> Congress of Asian Society for Pediatric Research.
  • Place of Presentation: Seoul, Korea
• [Presentation] Rat SMCs within 3D Cellular Mutilayers Exhibit Contractile Phenotypes and Layered elastic fibe. (2012)
  • Author(s): Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
  • Organizer: The 8^<th> Congress of Asian Society for Pediatric Research.
  • Place of Presentation: Seoul, Korea
• [Presentation] Prostaglandin E2 receptor EP4 expressed in coronary smooth muscle cells may play a role in intimal thickening that precedes atheroscleros IS. (2012)
  • Author(s): Kumagaya S, Yokoyama U, Iwai K, Nishihara H, Inoue T, Mimamisawa S, Ishikawa Y
  • Organizer: The 8^<th> Congress of Asian Society for Pediatric Research
  • Place of Presentation: Seoul, Korea
• [Presentation] Plasma Hypoosmolarity after Birth Promotes Closure of the Ductus Arteriosus. (2012)
  • Author(s): Aoki R, Yokoyama U, Ichikawa Y, Minamisawa S, Ishikawa Y
  • Organizer: The 86^<th> American heart association basic cardio vascular science 2012 Scientific session.
  • Place of Presentation: New Orleans, USA
• [Presentation] Hyperthermnia and nanotechnology/nanomedicine Magnetic anti-cancer compound in hyperthermic therapy (2012)
  • Author(s): Ishikawa Y
  • Organizer: ICHO&JCTM 2012.
  • Place of Presentation: 国立京都国際会議場(京都府)(招待講演)
• [Presentation] Development of simultaneous hyperthermo-chemotherapy using a drug. (2012)
  • Author(s): Sato I, Mitsudo K, Baba J, Iida M, Nakashima H, Koizumi T, Kioi M, Eguchi H, Ishikawa Y, Tohnai I
  • Organizer: ICHO&JCTM 2012.
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] A new cancer treatment strategy with magnetic anti-cancer compound with hyperthermia. (2012)
  • Author(s): Feng X, Fukumura H, Sato I, Eguchi H, Ishikawa Y
  • Organizer: The 11th International Congress of Hyperthermic Oncology, The 29th Japanese Congress of Ther mal Medicine.
  • Place of Presentation: 国立京都国際会議場(京都府)
• [Presentation] Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening (2012)
  • Author(s): Ichikawa Y, Yokoyama U, Masuda M, Asou T, Ishikawa Y
  • Organizer: The 86^<th> American Heart Association Scientific Session.
  • Place of Presentation: Los Angeles, USA
• [Presentation] Oxygenation-induced postnatal remodeling of the ductus arteriosus. (2012)
  • Author(s): Jin MH, Yokoyama U, Ishiwata R, Minamisawa S, Ishikawa Y
  • Organizer: The 8^<th> Congress of Asian Society for Pediatric Research.
  • Place of Presentation: Seoul, Korea
• [Presentation] Disruption of Epacl decreases phosphorylation of phospholamban and protects the heart against stress. (2012)
  • Author(s): Okumura S, Jin M, Ohnuki Y, Namekata I, Kurotani R, Fujita T, Jin HL, Cai W, Bai Y, Suita K, Tsunematsu T, Tanaka H, Ishikawa Y
  • Organizer: The 86^<th> American Heart Association ScientificSessions.
  • Place of Presentation: Los Angeles, USA
• [Presentation] 大動脈瘤形成におけるプロスタグランディンE受容体EP4の役割の検討 (2012)
  • Author(s): 片山雄三, 横山詩子, 岩本眞理, 根本寛子, 笠間啓一郎, 鈴木伸一, 磯松幸尚, 内田敬二, 井元清隆, 石川義弘, 益田宗孝
  • Organizer: 第42回日本心臓血管外科学会学術集会
  • Place of Presentation: 秋田大学(秋田県)
• [Presentation] 物理的作用を活用した高機能ドラッグデリバリーシステム, 磁性抗癌剤を用いた癌治療 (2012)
  • Author(s): 石川義弘
  • Organizer: 第51回日本生体医工学大会
  • Place of Presentation: 福岡国際会議場(福岡県)
• [Presentation] 出生後における肺の弾性線維形成の検討 (2012)
  • Author(s): 市川泰広, 横山詩子, 岩本眞理, 南沢享, 石川義弘
  • Organizer: 第48回日本小児循環器学会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] ラット動脈管リモデリングにおけるprostaglandin E2- Nuclear Factor kappa B経路の活性化 (2012)
  • Author(s): 梶村いちげ, 横山詩子, 石川義弘, 南沢享
  • Organizer: 第48回日本小児循環器学会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] アミノ酸輸液の組成の違いが動脈管閉鎖に及ぼす作用の検討 (2012)
  • Author(s): 藤田秀次郎, 横山詩子, 青木理加, 小郷寛史, 岩崎志穂, 西巻滋, 関和男, 石川義弘
  • Organizer: 第48回日本周産期・新生児医学会学術集会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
• [Presentation] CaとcAMPシグナル (2012)
  • Author(s): 石川義弘
  • Organizer: 文部科学省平成24年度新学術領域研究「統合的多階層生体機能学領域の確立とその応用」5回全体会議
  • Place of Presentation: 福岡大学(福岡県)
• [Presentation] Store-operated Ca2+ entry regulates proliferation and cell cycle in me lanoma. (2012)
  • Author(s): Umemura M, Erdne B, Lai-HuaX, Marianas D.L, Ishikawa Y, Umemura S, Iwatsubo K
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌 他(北海道)
• [Book] Bioactive Lipid Mediators. (2015)
  • Author(s): Yokoyama U, Ishiwata R, Ishikawa Y.
  • Total Pages: 426
  • Publisher: Springer
• [Book] オックスフォード・生理学 原書４版 (2015)
  • Author(s): 岡野栄之、鯉渕典之、植村慶一 監訳
  • Total Pages: 896
  • Publisher: 丸善出版社
• [Book] 標準生理学 第8版 第29章「赤血球」 (2014)
  • Author(s): 石川義弘
  • Total Pages: 1140
  • Publisher: 医学書院
• [Book] 標準生理学 第8版 第39章「局所循環」 (2014)
  • Author(s): 石川義弘
  • Total Pages: 1140
  • Publisher: 医学書院
• [Book] 遺伝子医学ＭＯＯＫ２４ 最新生理活性脂質研究 - 実験手法，基礎的知識とその応用 - 「大動脈瘤の進展とPGE2」. (2013)
  • Author(s): 横山詩子、金 美花、石川義弘
  • Total Pages: 312
  • Publisher: メディカルドゥ社
• [Book] TPP問題の核心 公平な医療を受けるため「国民皆保険」を守れ, まだ知らされていない壊国TPP-主権侵害の招待を暴く- (2012)
  • Author(s): 石川義弘
  • Publisher: 創森社
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学教室 ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学 ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/index.html
• [Remarks] 横浜市立大学大学院医学研究科 循環制御医学ホームページ
  • URL: http://www-user.yokohama-cu.ac.jp/~seiri1/index.html
• [Remarks]
• [Patent(Industrial Property Rights)] 非解離性大動脈瘤の疾患活動性の判定方法. (2015)
  • Inventor(s): 横山詩子、石川義弘。荒川憲昭、吉村耕一
  • Industrial Property Rights Holder: 横浜市立大学、山口大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-25
• [Patent(Industrial Property Rights)] 三次元細胞集合体の作製方法. (2015)
  • Inventor(s): 横山詩子, 石川義弘, 金子真, 佐久間臣耶, 新井史人.
  • Industrial Property Rights Holder: 横浜市立大学、大阪大学、名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-09-29
  • Overseas
• [Patent(Industrial Property Rights)] グルタミン酸による動脈管開存症の予防または治療 (2015)
  • Inventor(s): 横山詩子、石川義弘、藤田秀次郎
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-02-07
  • Overseas
• [Patent(Industrial Property Rights)] 三次元細胞集合体の作製方法 (2015)
  • Inventor(s): 横山詩子、石川義弘、金子真、佐久間臣耶、新井史人
  • Industrial Property Rights Holder: 横浜市立大学、大阪大学、名古屋大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-033064
  • Filing Date: 2015-02-23
• [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法 (2014)
  • Inventor(s): 横山詩子、石川義弘、明石満、松崎典弥
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-10-09
  • Overseas
• [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法 (2013)
  • Inventor(s): 横山詩子、石川義弘、明石満、松崎典弥
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学、国立大学法人大阪大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-212966
  • Filing Date: 2013-10-10