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Molecular regulation of cardiac function by the automatic nervous system

Research Project

Project/Area Number 24390200
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionYokohama City University

Principal Investigator

ISHIKAWA Yoshihiro  横浜市立大学, 医学(系)研究科(研究院), 教授 (40305470)

Co-Investigator(Kenkyū-buntansha) UMEMURA Masanari  横浜市立大学, 医学部, 助教 (50595353)
藤田 孝之  横浜市立大学, 医学部, 講師 (40468202)
横山 詩子  横浜市立大学, 医学部, 講師 (70404994)
市川 泰弘  横浜市立大学, 医学部, 助教 (10555121)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords交感神経 / セカンドメッセンジャー / 心臓 / 機能制御 / 自律神経 / 心機能制御 / cAMP / カテコラミン / 分子 / cAMP
Outline of Final Research Achievements

Adenylyl cyclase is a target enzyme of catecholamine signal, which produces cAMP in the cell. This second messenger classically is known to activate protein kinase A, which is known as cAMP-dependent kinase. Recently, however, a second target enzyme, known as “Epac”, has been widely recognized. This enzyme is distinct from the classic PKA and is known to regulate the activity of various small G proteins. In thus study, we compared the role of Epac with that of PKA, in order to understand the cAMP signal network. We particularly carefully examined it from the stand point of the regulation of cardiac function and the development of pathophysiology. This study, accordingly, successfully prevailed new mechanisms of cAMP signaling in the heart.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (147 results)

All 2016 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (40 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 40 results,  Open Access: 18 results,  Acknowledgement Compliant: 3 results) Presentation (90 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results) Book (6 results) Remarks (4 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 3 results)

  • [Int'l Joint Research] Oak Ridge National Laboratory(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Use of Three-dimensional Arterial Models To Predict the In Vivo Behavior of Nanoparticles for Drug Delivery2016

    • Author(s)
      P. Chetprayoon, M. Matsusaki, U. Yokoyama, T. Tejima, Y. Ishikawa, M. Akashi
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Issue: 14 Pages: 4461-4466

    • DOI

      10.1002/anie.201509752

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging.2015

    • Author(s)
      Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim J-H, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Sigh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I and Ishikawa Y.
    • Journal Title

      Sci. Rep.

      Volume: 5 Issue: 1 Pages: 9194-9194

    • DOI

      10.1038/srep09194

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach2015

    • Author(s)
      Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65(2) Issue: 2 Pages: 195-200

    • DOI

      10.1007/s12576-014-0354-3

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Coupling of beta1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.2015

    • Author(s)
      Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, SuitaK, Sato I, Umemura M, Yokoyama U, Sato M, Fujita T, and Ishikawa Y.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 458 Issue: 3 Pages: 531-535

    • DOI

      10.1016/j.bbrc.2015.01.149

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epac1 deficiency attenuated vascular smooth muscle cell migration and neointimal formation.2015

    • Author(s)
      Kato Y, Yokoyama U, Yanai C, Ishige R, Kurotaki D, Umemura M, Fujita T, Kubota T, Okumura S, Sata M, Tamura T, Ishikawa Y.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 35(12) Issue: 12 Pages: 2617-2625

    • DOI

      10.1161/atvbaha.115.306534

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Norepinephrine-induced adrenergic activation strikingly increased the atrial fibrillation duration through β1- and α1-adrenergic receptor-mediated signaling in mice.2015

    • Author(s)
      Suita K, Fujita T, Hasegawa N, Cai W, Jin H, Hidaka Y, Prajapati R, Umemura M, Yokoyama U, Sato M, Okumura S, Ishikawa Y.
    • Journal Title

      PLoS One.

      Volume: 23;10(7) Issue: 7 Pages: e0133664-e0133664

    • DOI

      10.1371/journal.pone.0133664

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterozygous deletion of sarcolipin maintains normal cardiac function.2015

    • Author(s)
      Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 310(1) Issue: 1 Pages: 92-103

    • DOI

      10.1152/ajpheart.00411.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Establishment of successively transplantable rabbit VX2 cancer cells that express enhanced green fluorescent protein2014

    • Author(s)
      Oshiro H, Fukumura H, Nagahama K, Sato I, Sugiura K, Iobe H, Okiyama E, Nagao T, Nagashima Y, Aoki I, Yamanaka S, Murakami A, Maegawa J, Chishima T, Ichikawa Y, Ishikawa Y, Nagai T, Nomura M, Ohashi K and Okudela K
    • Journal Title

      Med Mol Morphol

      Volume: 印刷中 Issue: 1 Pages: 13-23

    • DOI

      10.1007/s00795-014-0071-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling.2014

    • Author(s)
      Yokoyama U, Minamisawa S, Sh ioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki II, Nakamura T, and Ishikawa Y
    • Journal Title

      Circulation.

      Volume: 129 Issue: 4 Pages: 487-496

    • DOI

      10.1161/circulationaha.113.004726

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Store-operated Ca2 entry (SOCE) Regulates Melanoma Proliferation and Cell Migration.2014

    • Author(s)
      Umemura M, Baljinnyam E, Feske S, De Lorenzo MS, Lai-Hua Xie LH, Feng X, 1, Itoh K, Makino A, Fujita T, Yokoyama U, Iw atsubo M, Chen S, Goydos JS, I shikawa Y, and Iwatsubo K
    • Journal Title

      PLoS ONE.

      Volume: 9 Issue: 2 Pages: e89292-e89292

    • DOI

      10.1371/journal.pone.0089292

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperthermia generated with ferucarbotran (Resovis®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells.2014

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Kioi M, Nakashima H, Iwai T Fujita T, Yokoyama U, Okumura S, Feng X, Ito K, Miyajima A, Makino A, Iwai M, Eguchi H, I wai T, and Ishikawa Y.
    • Journal Title

      J. Physiol. Sci.

      Volume: 64 Issue: 3 Pages: 177-183

    • DOI

      10.1007/s12576-014-0309-8

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased serum osmolality promotes ductus arteriosus constriction.2014

    • Author(s)
      Aoki R, Yokoyama U, Ichikawa Y, Taguri M, Kumagaya S, Ishiwata R, Yanai C, Fujita S, Umemura M, Fujita T, Okumura S, Sato M, Minamisawa S, Asou T, Masuda M, Iwasaki S, Nishimaki S, Seki K, Yokota S, Ishikawa Y.
    • Journal Title

      Cardiovascular Research

      Volume: 104(2) Issue: 2 Pages: 326-36

    • DOI

      10.1093/cvr/cvu199

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-Dimensional Multilayers of Smooth Muscle Cells as a New Experimental Model for Vascular Elastic Fiber Formation Studies.2014

    • Author(s)
      Ishiwata R, Yokoyama U, Matsusaki M, Yoshiya A, Kadowaki K, Ichikaww Y, Umemura M, Fujita T, Minamisawa S, Shimoda H, Mitsuru Akashi M, and Ishikawa Y.
    • Journal Title

      Atherosclerosis.

      Volume: 233 Issue: 2 Pages: 590-600

    • DOI

      10.1016/j.atherosclerosis.2014.01.045

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection of cardiomyocytes from the hypoxia-mediated injury by a peptide targeting the activator of G-protein signaling 8.2014

    • Author(s)
      Sato M, Hiraoka M, Suzuki H, Sakima M, Mamun, AA, Yamane Y, Fujita T, Yokoyama U, Okumura S, and Ishikawa Y.
    • Journal Title

      PLoS ONE.

      Volume: 9 Issue: 3 Pages: e91980-e91980

    • DOI

      10.1371/journal.pone.0091980

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses2014

    • Author(s)
      Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
    • Journal Title

      J Clin Invest.

      Volume: 124 Issue: 6 Pages: 2785

    • DOI

      10.1172/jci64784

    • URL

      https://localhost/en/publications/36b42ba8-faa2-4af8-8b0f-f7a856c64b49

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3.2014

    • Author(s)
      Tsutsumi YM, Tsutsumi R, Hamaguchi E, Sakai Y, Kasai A, Ishikawa Y, Yokoyama U, and Tanaka K.
    • Journal Title

      Cardiovasc Diabetol.

      Volume: 13 Issue: 1 Pages: 132-132

    • DOI

      10.1186/s12933-014-0132-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Geranylgeranylacetone protects the heart via caveloae and caveolin-3.2014

    • Author(s)
      Tsutsumi YM, Tsutsumi R, Hirokawa YT, Sakai Y, Hamaguchi E, Ishikawa Y, Yokoyama U, Kasai A, Kambe N, and Tanaka K.
    • Journal Title

      Life Sciences.

      Volume: 101 Issue: 1-2 Pages: 43-48

    • DOI

      10.1016/j.lfs.2014.02.019

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epacl increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling.2014

    • Author(s)
      Baljinnyam E, Umemura M, C huang C, De Lorenzo M, Iwatsubo M, Chen S, Goydos J, Ishikawa Y, Whitelock J, and Iwatsubo K.
    • Journal Title

      Pigment Cell & Melanoma Research.

      Volume: (Epub ahead of print) Issue: 4 Pages: 611-620

    • DOI

      10.1111/pcmr.12250

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of R-II-B Type Single Coronary Artery Evaluated by Multi-Detector Computed Tomography and Coronary Angiography.2014

    • Author(s)
      Narikawa M, Kiyokuni M, Umemura M, Kawashima C, Doi H, Hisa A, Tomari S, Mitsuhashi T, Ishikawa Y and Endo T.
    • Journal Title

      J Clin Exp Cardiolog,

      Volume: 5 Pages: 10-10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired NO Production and Increased Blood Pressure in Systemic Heterozygous ATP2B1 Null Mice.2014

    • Author(s)
      Fujiwara A, Hirawa N, Fujita M, Kobayashi Y, Okuyama Y, Yatsu K, Katsumata M, Yamamoto y, Ichihara N, Saka S, Toya Y, Yasuda G, Tabara Y, Miki T, Ueshima H, Ishikawa Y, and Umemura S
    • Journal Title

      J Hypertension.

      Volume: 32 Issue: 7 Pages: 1415-1423

    • DOI

      10.1097/hjh.0000000000000206

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Cyclic AMP Sensor Epac1 in Masseter Muscle Hypertrophy and Myosin Heavy Chain Transition Induced by 2-Adrenoceptor Stimulation.2014

    • Author(s)
      Ohnuki Y, Umeki D, Mototani Y, Jin H, Cai W, Shiozawa K, Suita K, Saeki Y, Fujita T, Ishikawa Y, and Okumura S.
    • Journal Title

      J. Physiol.

      Volume: 592 Issue: 24 Pages: 5461-5475

    • DOI

      10.1113/jphysiol.2014.282996

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Obstructive Sleep Apnea and Hypertension:A New Way to Go.2014

    • Author(s)
      Ishikawa Y.
    • Journal Title

      J Sleep Disorders Ther.

      Volume: 3 Pages: 4-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of Epac1 decreasesphosphorylation of phospholamban and protects theheart against stresses.2014

    • Author(s)
      Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin HL, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita Km Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, and Ishikawa Y.
    • Journal Title

      J. Clin. Invest.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension.2013

    • Author(s)
      Ohsawa M, Tamura K, Wakui H, Maeda A, Dejima T, Kanaoka T, Azushima K, Uneda K, Tsurumi-Ikeya Y, Kobayashi R, Matsuda M, Uchida S, Toya Y, Kobori H, Nishiyama A, Yamashita A, Ishikawa Y, Umemura S.
    • Journal Title

      Kidney Int.

      Volume: 86(3) Issue: 3 Pages: 570-81

    • DOI

      10.1038/ki.2014.95

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prostanoid EP4 receptor and its signaling pathway.2013

    • Author(s)
      Yokoyama U, Iwatsubo K, Umemura M, Fujita T, and Ishikawa Y.
    • Journal Title

      Pharmacol Rev.

      Volume: 65 Issue: 3 Pages: 1010-1052

    • DOI

      10.1124/pr.112.007195

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the Sirtl/FoxO3a Pathway.2013

    • Author(s)
      Lai L, et al.
    • Journal Title

      Circulation.

      Volume: 127 Issue: 16 Pages: 1692-1701

    • DOI

      10.1161/circulationaha.112.001212

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A role for Piezo2 in EPAC1-dependent mechanical allodynia.2013

    • Author(s)
      Eijkelkamp N, Linley JE, Torres JM, Bee L, Dickenson AH, Gringhuis M, Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ, Cox JJ, and Wood, J N.
    • Journal Title

      Nature Commun.

      Volume: 4 Issue: 1 Pages: 1682-1682

    • DOI

      10.1038/ncomms2673

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hight-dose zoledronic acid narrows the periodontal space in rats.2013

    • Author(s)
      Okamoto Y, Hirota M, Monden Y, Murata S, Koyama C, Mitsudo K, Iwai T, Ishikawa Y, and Tohnai I.
    • Journal Title

      Int J Oral Maxillofac Surg.

      Volume: 2 Issue: 5 Pages: 627-631

    • DOI

      10.1016/j.ijom.2012.11.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Balancing GRK2/ Epac1levels prevents and relieves chronic pain.2013

    • Author(s)
      Wang H, Heijnen CJ, van Velth oven CTJ, Willemen HLDM, Ishikawa Y, Zhang X, Sood AK, Vroon A, Eijkelkamp N, and Kavelaars A.
    • Journal Title

      J. Clin. Invest.

      Volume: 123 Issue: 12 Pages: 5023-5034

    • DOI

      10.1172/jci66241

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenylyl cyclase type 5 in cardiac disease, metabolism and aging.2013

    • Author(s)
      Vatner SF, Park M, Yan L, Lee G, Lai L, Iwatsubo K, Ishikawa Y, Pessin J, and Vatner DE
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 305 Issue: 1 Pages: H1-H8

    • DOI

      10.1152/ajpheart.00080.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase.2012

    • Author(s)
      Iwatsubo K, Bravo C, Uechi M, Baljinnyam E, Nakamura T, Umemura M, Lai L, Gao S, Yan L, Park M, Qiu H, Okumura S, Iwatwsubo M, Vatner DE, Vatner SF, and Ishikawa Y.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 302 Issue: 12 Pages: H2622-H2628

    • DOI

      10.1152/ajpheart.00190.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity.2012

    • Author(s)
      Jiao Q, et al.
    • Journal Title

      Cell Calcium.

      Volume: 51 Issue: 1 Pages: 31-39

    • DOI

      10.1016/j.ceca.2011.10.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus Without Inducing Intimal Thickening2012

    • Author(s)
      Ichikawa Y, et al.
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 10 Pages: 2456-2464

    • DOI

      10.1253/circj.CJ-12-0215

    • NAID

      10030875150

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mice Lacking Hypertension Candidate Gene ATP2B1 in Vascular Smooth Muscle Cells show Significant Blood Pressure Elevation.2012

    • Author(s)
      Kobayashi Y, et al.
    • Journal Title

      Hypertension.

      Volume: 59 Issue: 4 Pages: 854-860

    • DOI

      10.1161/hypertensionaha.110.165068

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute myocardial infarction with isolated conus branch occlusion.2012

    • Author(s)
      Umemura M, et al.
    • Journal Title

      J Electrocardiol.

      Volume: 45 Issue: 3 Pages: 285-287

    • DOI

      10.1016/j.jelectrocard.2011.11.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells.2012

    • Author(s)
      Fukumura H, et al.
    • Journal Title

      J. Physiol. Sci.

      Volume: 62 Pages: 251-257

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological Stimulation of Type 5 Adenylyl Cyclase Stabilizes Heart Rate Under Both Microgravity and Hypergravity Induced by Parabolic Flight2012

    • Author(s)
      Bai Y, et al.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 119 Issue: 4 Pages: 381-389

    • DOI

      10.1254/jphs.12102FP

    • NAID

      10031071685

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute pulmonary embolism induced by renal obstruction with benign prostatic hyperplasia.2012

    • Author(s)
      Umemura M, et al.
    • Journal Title

      Journal of Cardiology Cases.

      Volume: 5 Issue: 1 Pages: e39-e43

    • DOI

      10.1016/j.jccase.2011.10.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and Histological Evaluations of 3D-Layered Blood Vessel Constructs Prepared by Hierarchical Cell Manipulation.2012

    • Author(s)
      Matsusaki M, et al.
    • Journal Title

      J Biomater Sci Polym Ed.

      Volume: 23 Issue: 1-4 Pages: 63-79

    • DOI

      10.1163/092050610x541953

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of EP4 signaling attelluates aortic aneurysm formation2012

    • Author(s)
      Yokoyama U
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e36724-e36724

    • DOI

      10.1371/journal.pone.0036724

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] ビダラビンの不整脈治療における有用性2016

    • Author(s)
      藤田孝之、吹田憲治、蔡 文倩、金 慧玲、日高 祐子、石川 義弘
    • Organizer
      第93回日本生理学会大会合同大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Kato Y, Yokoyama U, Ishikawa Y. The role of Epac1 in the regulatory mechanisms of vascular smooth muscle cell migration and neointimal formation.2016

    • Author(s)
      Kato Y, Yokoyama U, Ishikawa Y.
    • Organizer
      第93回日本生理学会大会合同大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Periodic hydrodynamic pressurization promotes layered structure of human arterial smooth muscle cells.2016

    • Author(s)
      Tonooka Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      第93回日本生理学会大会合同大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Fabrication of layered elastic fibers in rat arterial constructs by periodic hydrodynamic pressurization.2016

    • Author(s)
      Gonda Y, Yokoyama U, Koretake R, Sakuma S, Kaneko M, Ishikawa Y.
    • Organizer
      第93回日本生理学会大会合同大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分子標的薬であるヴォトリエントの磁性化2016

    • Author(s)
      青山春樹, 梅村将就, 佐藤格, 大竹誠, 小田香世子, 成川雅俊, 秋本大輔, 中鍛冶里奈, 勝亦真弓, 江口晴樹, 石川義弘.
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Magnetized methotrexate for novel anti-cancer therapy.2016

    • Author(s)
      Katsumata M, Umemura M, Sato I, Ohtake M, Oda K, Akimoto T, Nakakaji R, Narikawa M, Aoyama H, Eguchi H and Ishikawa Y.
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Role of Inflammatory2016

    • Author(s)
      Ishikwa Y.
    • Organizer
      The 4th International Conference on PreHypertension & Cardio Metabolic Syndrome.
    • Place of Presentation
      Hilton Molino Stucky Venice
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリング.2015

    • Author(s)
      齋藤純一, 横山詩子,益田宗孝, 麻生俊英, 石川義弘.
    • Organizer
      第14回日本心臓血管発生研究会
    • Place of Presentation
      磐梯熱海温泉 ホテル華の湯(福島県郡山市)
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有機磁性体化合物による神経膠芽腫に対する化学温熱同時療法の開発.2015

    • Author(s)
      大竹誠, 梅村将就, 佐藤 格, 秋本大輔, 江口晴樹, 石川義弘, 川原信隆.
    • Organizer
      第74回日本脳神経外科学術総会
    • Place of Presentation
      ロイトン札幌、さっぽろ芸術文化の館、札幌市教育文化会館(北海道札幌市)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Novel thermo-chemotherapy of oral cancer using a new magnetic anti-cancer drug.2015

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Nakashima H, Kioi M, Eguchi H, Ohtake M, Oda, Tohnai I and Ishikawa Y.
    • Organizer
      The 18th European Cancer Congress.
    • Place of Presentation
      Messe Wien Exhibition &Congress Center, Vienna, Austria
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous hyperthermic-chemotherapy using a single anti-cancer compound with intrinsic magnetism in glioblastoma animal model.2015

    • Author(s)
      Ohtake M, Umemura M, Sato I, Akimoto T, Nagasako A, Eguchi H, Kawahara N, Ishikawa Y
    • Organizer
      The 18th European Cancer Congress.
    • Place of Presentation
      Messe Wien Exhibition &Congress Center, Vienna, Austria
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔癌に対する新規磁性抗癌剤を用いたハイパーサーミアの開発.2015

    • Author(s)
      佐藤 格, 光藤健司, 梅村将就, 江口春樹, 中鍛冶里奈, 小泉敏之, 中島英行, 來生 知, 石川義弘, 藤内 祝
    • Organizer
      第32回日本ハイパーサーミア学会学術大会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 未熟児動脈管開存症治療におけるアミノ酸輸液組成の重要性 The effect of amino acids on patent ductus arteriosus in preterm infants.The effect of amino acids on patent ductus arteriosus in preterm infants. The effect of amino acids on patent ductus arteriosus in preterm infants.2015

    • Author(s)
      横山詩子, 藤田秀次郎, 青木理加, 岩崎志穂, 麻生俊英, 益田宗孝, 関和男, 石川義弘
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト動脈管における内膜肥厚部の遺伝子プロファイリング.2015

    • Author(s)
      齋藤純一, 横山詩子, 市川泰広, 益田宗孝, 麻生俊英, 石川義弘
    • Organizer
      第51回日本小児循環器学会総会・学術集会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 平滑筋におけるPGE2-EP4シグナルは腹部大動脈瘤の発症を促進する.2015

    • Author(s)
      石渡遼, 横山詩子, 市川泰弘, 石川義弘.
    • Organizer
      第132回日本薬理学会関東部会
    • Place of Presentation
      明海大学浦安キャンパス(千葉県浦安市)
    • Year and Date
      2015-07-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 交感神経活性化による心房細動/心房粗動の延長におけるアドレナリン受容体の役割.2015

    • Author(s)
      長谷川希望, 藤田孝之, 吹田憲治, 祭 文倩, 金 慧玲, 日高祐子, Rajesh Prajapati, 石川義弘
    • Organizer
      第36回循環制御医学会総会
    • Place of Presentation
      ウィンク愛知(愛知県名古屋市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of Dihydroartemisinin (DHA)-induced heart.2015

    • Author(s)
      Cai W, Fujita T, Hidaka Y, Jin H, Hasegawa N, Ishikawa Y.
    • Organizer
      第79回日本循環器学会学術集会.
    • Place of Presentation
      大阪国際会議場、リーガロイヤルホテル、堂島リバーフォーラム、ABCホール(大阪府)
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of Dihydroartemisinin(DHA)-induced heart.2015

    • Author(s)
      Cai W, Fujita T, Hidaka Y, Jin H, Hasegawa N, Ishikawa Y.
    • Organizer
      The 79th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪・堂島リバーフォーラム・ABCホール(大阪府大阪市)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma.2015

    • Author(s)
      Oda K, Umemura M, Baljinntam E, Yamaguchi Y, Aihara M, Iwatsubo K, Ishikawa Y.
    • Organizer
      The 106th American Association for Cancer Research Annual meeting.
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Methotrexate derivative with intrinsic magnetism.2015

    • Author(s)
      Umemura M, Katsumata M, Sato I, Nagasako A, Aoyama H, Makino A, Ohatake M, Oda K, Eguchi H, Ishikawa Y.
    • Organizer
      The 106th American Association for Cancer Research Annual meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Simultaneous hyperthermic-chemotherapy for glioblastoma using a single anti-cancer compound with magnetism.2015

    • Author(s)
      Ohtake M, Umemura M, Sato I, Oda K, Nagasako A, Makino A, Aoyama H, Katsumata M, Eguchi H, Kawahara N , Ishikawa Y
    • Organizer
      The 106th American Association for Cancer Research Annual meeting.
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Methotrexate derivative with intrinsic magnetism.2015

    • Author(s)
      Umemura M, Katsumata M, Sato I, Nagasako A, Aoyama H, Makino A, Ohatake M, Oda K, Eguchi H, Ishikawa Y
    • Organizer
      The 106th American Association for Cancer Research Annual meeting
    • Place of Presentation
      Pensylvania Convention Center, Philadelphia,USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transient receptor potential cation channel 3 (TRPC3) regulates tumor proliferation and migration of BRAF wild type human malignant melanoma.2015

    • Author(s)
      Oda K, Umemura M, Katsumata M, Aoyama H, Makino A, Ohtake M, Sato I, Nagasako A, Yamaguchi Y, Nagashima Y, Aihara M, Ishikawa Y.
    • Organizer
      The 106th American Association for Cancer Research Annual meeting,
    • Place of Presentation
      Pensylvania Convention Center, Philadelphia,USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Simultaneous hyperthermic-chemotherapy for glioblastoma using a single anti-cancer compound with intrinsic magnetism.2015

    • Author(s)
      Ohtake M, Umemura M, Sato I, Oda K, Nagasako A, Makino A, Aoyama H, Katsumata M, Eguchi H, Kawahara N, Ishikawa Y
    • Organizer
      The 106th American Association for Cancer Research Annual meeting,
    • Place of Presentation
      Pensylvania Convention Center, Philadelphia,USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasminogen activator may promote intimal thickening in the ductus arteriosus.2015

    • Author(s)
      Nicho N, Yokoyama U, Saitoh J, Yanai C, Ichikawa Y, Masuda M, Aso T, Ishikawa Y.
    • Organizer
      The 118th Annual Meeting of the Japan Pediatric Society.
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル大阪(大阪府大阪市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] New Method for Evaluation of Nano-Drug Carriers by 3D-Arterial Wall Models for Atherosclerosis Treatment.2015

    • Author(s)
      Chetprayoon P, Matsusaki M, Yokoyama U, Ishikawa Y, Akashi M.
    • Organizer
      Annual meeting of Society for Biomaterials.
    • Place of Presentation
      The Charlotte Convention Center, North Carolina,USA
    • Year and Date
      2015-04-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A novel methotrexate derivative with intrinsic magnetism.2015

    • Author(s)
      Katsumata M, Umemura M, Sato I, Ohtake M, Oda K, Nagasako A, Makino A, Aoyama H, Eguchi H, Ishikawa Y.
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Magnetized paclitaxel derivative for novel triple negative breast cancer therapy.2015

    • Author(s)
      Makino A, Umemura M, Sato I, Katsumata M, Nagasako A, Oda K, Ohtake M, Aoyama H, Eguchi H, Ishikawa Y.
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場(兵庫県)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel methotrexate derivative with intrinsic magnetism.2015

    • Author(s)
      Katsumata M, Umemura M, Sato I, Ohtake M, Oda K, Nagasako A, Makino A, Aoyama H, Eguchi H, Ishikawa Y.
    • Organizer
      第88回日本薬理学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] プロスタグランディンE-EP4はfibulin-1を介して生理的・病的血管内膜肥厚の形成に関与する.2014

    • Author(s)
      矢内千春, 横山詩子, 熊谷 駿, 手島隆之, 佐藤綾美, 石川義弘
    • Organizer
      第13回日本心臓血管発生研究会
    • Place of Presentation
      磐梯熱海温泉 ホテル 華の湯(福島県)
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗ヘルペス薬による心房細動抑制.2014

    • Author(s)
      吹田憲治, 藤田孝之, 奥村 敏, 石川義弘
    • Organizer
      第131回日本薬理学会関東部会
    • Place of Presentation
      横浜市立大学医学部ヘボンホール(神奈川県)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel paclitaxel with intrinsic magnetism2014

    • Author(s)
      Makino A, Umemura M, Sato I, Oda K, Otake M, Nagasako A, Eguchi H, Ishikawa Y.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of combination therapy with cisplatin and hyperthermia generated with ferucarbotran (Resovist) in an alternating magnetic field for oral cancer.2014

    • Author(s)
      Sato I, Mitsudo K, Umemura M, Nakashima H, Kioi M, Eguchi H, Ishikawa Y,Tohnai.I
    • Organizer
      The 6th Asian Congress of Hyperthermic Oncology (ACHO)
    • Place of Presentation
      福井県民ホール、福井市地域交流プラザ(福井県)
    • Year and Date
      2014-09-05 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] EPAC1 plays an important role in regulation of renin and AQP2 expression in the kidney of mice.2014

    • Author(s)
      Jin H, Fujita T, Cai W, Hidaka Y, Sagara S, Kubota K, Suita K, Ishikawa Y.
    • Organizer
      European Society of Cardiorogy Congress.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 plays a protective role against cardiac fibrosis.2014

    • Author(s)
      Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y.
    • Organizer
      European Society of Cardiorogy Congress.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cardiac overexpression ofure. Chronic Treatment with Dihydroartemisinin, a TCTP Down-regulating Agent, Results in Cardiac Dysfunction in Mice.2014

    • Author(s)
      Cai W, Fujita T, Hidaka Y, Jin H, K. Sagara S, Kubota K, Suita K, Ishikawa Y.
    • Organizer
      European Society of Cardiorogy Congress.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced atrial fibrillation in mice.2014

    • Author(s)
      Suita K, Fujita T, Cai W, Hidaka Y, Jin H, Jin M, Okumura S, Ishikawa Y.
    • Organizer
      European Society of Cardiorogy Congress.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 体液量調節におけるEPAC1の役割についての検討.2014

    • Author(s)
      Jin H, Fujita T, Cai W, Hidaka Y, Sagara S, Suita K, Ishikawa Y
    • Organizer
      第57会日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト大動脈瘤組織におけるPGE2-EP4誘導性分泌タンパク質の網羅的解析.2014

    • Author(s)
      石渡 遼, 横山詩子, 荒川憲昭, 安田章沢, 郷田素彦, 鈴木伸一, 益田宗孝, 石川義弘
    • Organizer
      第35回日本循環制医学会総会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 心臓型アデニル酸シクラーゼの選択的阻害剤ビダラビンによる心房細動抑制.2014

    • Author(s)
      吹田憲治, 藤田孝之, 蔡 文倩, 金 慧玲, 奥村 敏, 石川義弘
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂(福岡県)
    • Year and Date
      2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] MRI造影剤フェルカルボトランを用いた新しい温熱化学療法の開発.2014

    • Author(s)
      佐藤 格, 光藤健司, 梅村将就, 宮島章嘉, 中島英行, 來生 知, 石川義弘, 藤内 祝.
    • Organizer
      第38回日本頭頚部癌学会
    • Place of Presentation
      東京ファッションタウンビルホール(東京都)
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nuclear Factor kappa B Inhibition Promotes Closure of the Rat Ductus Arteriosus.2014

    • Author(s)
      Kajimura I, Yokoyama U, Ishikawa Y, Minamisawa S.
    • Organizer
      Experimental Biology Annual Meeting.
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-25 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prostaglandin E2 receptor EP4 signaling in vascular smooth muscle cells decreases aortic elasticity.2014

    • Author(s)
      Ichikawa Y, Yokoyama U, Ishikawa Y.
    • Organizer
      Experimental Biology Annual Meeting.
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-25 – 2014-04-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of thermochemotherapy using cisplatin and ferucarbotran (Resovist®) in head and neck cancer.2014

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Feng X, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y
    • Organizer
      The 105th American Association for Cancer Research Annual meeting.
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] A novel treatment for triple-negative breast cancer using intrinsic magnetized paclitaxel.2014

    • Author(s)
      Umemura M, Makino A, Sato I, Feng X, Iwai M, Oda K, Miyajima A, Otake M, Nagasako A, Matsuo K, Eguchi H, and Ishikawa Y
    • Organizer
      The 105th American Association for Cancer Research Annual meeting.
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Store-operated Ca2+ entry (SOCE) regulates melanoma progression.2013

    • Author(s)
      Umemura M, Baljinnyam E, Lorenzo M.S.De, Feske S, Xie L, Ishikawa Y, Iwatsubo K.
    • Organizer
      The 104 American Association for Cancer Research Annual meeting
    • Place of Presentation
      Washington DC,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Application of a novel nano-magnetic anti-cancer drug to hyperthermia.2013

    • Author(s)
      Umemura M, Fukumura H, Sato I, Feng X, Izuka H, Eguchi H, Ishikawa Y
    • Organizer
      The 104 American Association for Cancer Research Annual meeting
    • Place of Presentation
      Washington DC,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeted drug delivery system and magnetic resonance imaging with intrinsic ferromagnetic nano-particle compound.2013

    • Author(s)
      Eguchi H, Hirata K, Kurotani R, Fukumura H, Singh D.J, Yamamoto M, Sato I, Umemura M, Yamamoto M, Nagashima Y, Ishikawa Y
    • Organizer
      The 104 American Association for Cancer Research Annual meeting
    • Place of Presentation
      Washington DC,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug. The 104 American Association for Cancer Research Annual meeting,2013

    • Author(s)
      Sato I, Mitsudo K, Umemura M, Feng X, Fukumura H, Eguchi H, Nakashima H, Kioi M, Tohnai I, Ishikawa Y
    • Organizer
      The 104 American Association for Cancer Research Annual meeting
    • Place of Presentation
      Washington DC,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel thermo-chemotherapy using a new magnetic anti-cancer drug.2013

    • Author(s)
      Sato I, Umemura M, Mitsudo K, Feng X, Baba J, Nakashima H, Kioi M, Eguchi H, Tohnai I, Ishikawa Y
    • Organizer
      The 104 American Association for Cancer Research Annual meeting.
    • Place of Presentation
      Washington DC,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibitor of cardiac adenylyl cyclase prevents atrial fibrillation in mice.2013

    • Author(s)
      Suita K, Cai W, Jin H, Jin M, Fujita T, Okumura S, Ishikawa Y
    • Organizer
      HD Physiology, the 2nd International Symposium
    • Place of Presentation
      丸ノ内MUPLAZA(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mouse Overexpressing Prostaglandin E Receptor EP4 in Vascular Smooth Muscle Cells Decreased Elasticity of the Aorta.2013

    • Author(s)
      Ichikawa Y, Yokoyama U, Jin M, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 signaling promotes secretion of the lipid-relating proteoglycan buglycan in human coronary arteries during development.2013

    • Author(s)
      Kumagaya S, Yokoyama U, Sato A, Nishihara H, Inoue T, Minamisawa S, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2-EP4 signaling inhibits vascular elastic fiber formation in the ductus arteriosus.2013

    • Author(s)
      Ishiwata R, Yokoyama U, Jin M, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, Minamisawa S, Ishikawa Y
    • Organizer
      The 7th TAKAO International symposium.
    • Place of Presentation
      国立オリンピック記念青少年総合センター(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cardiac overexpression of Translationally Controlled Tumor Protein (TCTP) prevents the development of doxorubicin-induced heart failure.2013

    • Author(s)
      Fujita T, Cai W, Hidaka Y, Jin H, Jin M, Suita K, Ishikawa Y
    • Organizer
      European Socirty of Cardiology.
    • Place of Presentation
      Amsterdam ,Netherladns
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel nano-magnetic particle with cytotoxic and a novel technology of designing intrinsic ferromagnetism compound.2013

    • Author(s)
      Umemura M, Eguchi H, Ishikawa Y
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A conventional anti-cancer drug designed artificially with ferromagnetic, EI2573M.2013

    • Author(s)
      Iwai M, Umemura M, Sato I, Nagasako A, Feng X, Hoshino Y, Inoue S, Aoki I, Eguchi H, Ishikawa Y
    • Organizer
      The 72nd Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Therapeutic Effect of EP4 Antagonist on Advanced Abdominal Aortic Aneurysm.2013

    • Author(s)
      Yokoyama U, Ishiwata R, Arakawa N, Suzuki S, Masuda M, Ishikawa Y.
    • Organizer
      The 86th Scientific Session, American Heart Association.
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Decreased Serum Osmolality Augments the Closure of the Ductus Arteriosus in Neonates.2013

    • Author(s)
      Yokoyama U, Aoki R, Ichikawa Y, Iwasaki S, Seki K, Nishimaki S, Yokota S, Minamisawa S, Ishikawa Y
    • Organizer
      The 86th Scientific Session, American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2 Receptor EP4 Signaling in Vascular Smooth Muscle Decreased Elasticity of the Aorta.2013

    • Author(s)
      Ichikawa Y, Yokoyama U, Iwamoto M, Yokota S, Minamisawa S, Ishikawa Y
    • Organizer
      The 86th Scientific Session, American Heart Association.
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-fibrotic Effect of Prostaglandin E2-EP4 in the Heart.2013

    • Author(s)
      Ishiwata R, Yokoyama U, Inoue S, Ichikawa Y, Ishikawa Y
    • Organizer
      The 86th Scientific Session, American Heart Association.
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 温熱治療における新規磁性抗がん剤の役割2013

    • Author(s)
      石川義弘
    • Organizer
      第30回日本ハイパーサーミア学会
    • Place of Presentation
      横浜シンポジア(神奈川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 新規抗癌剤を用いた口腔癌に対するハイパーサーミアの開発.2013

    • Author(s)
      佐藤 格, 光藤健司, 梅村将就, 江口晴樹, 石川義弘, 藤内 祝
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] EP4シグナル制御による大動脈瘤の治療開発2013

    • Author(s)
      石渡 遼, 横山詩子, 石川義弘
    • Organizer
      新学術領域 「自然炎症」+「脂質マシナリー」若手ワークショップ
    • Place of Presentation
      ルネッサンスリゾート鳴門(徳島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 出生後血清浸透圧変化からみた動脈管開存症発症リスク因子の検討.2013

    • Author(s)
      青木理加, 横山詩子, 藤田秀次郎, 市川泰広, 岩崎志穂, 関 和男, 西巻 滋, 横田俊平, 石川義弘
    • Organizer
      第49回日本周産期新生児学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] .大動脈瘤進展におけるプロスタグランディンE-EP4の役割.2013

    • Author(s)
      石渡 遼, 横山詩子, 石川義弘
    • Organizer
      第6回大動脈分子病態研究会
    • Place of Presentation
      久留米大学循環器病研究所(福岡県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗がん作用を有する新規磁性微粒子を用いたハイパーサーミアへの応用.2013

    • Author(s)
      佐藤 格, 光藤健司, 梅村将就, 來生 知, 中島英行, 馮 先鋒, 江口晴樹, 石川義弘, 藤内 祝
    • Organizer
      第30回ハイパーサーミア学会.
    • Place of Presentation
      横浜シンポジア(神奈川県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin Eシグナルによるlysyl oxidase分解亢進が動脈管弾性線維の形成不良を引き起こす.2013

    • Author(s)
      南沢 享, 横山詩子, 青木浩樹, 中邨智之, 石川義弘
    • Organizer
      生理研研究会―心血管膜輸送分子の構造・機能・病態の統合的研究戦略,
    • Place of Presentation
      自然科学研究機構生理学研究所(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 心臓型アデニル酸シクラーゼの選択的阻害剤ビダラビンによる不整脈治療の可能性.2013

    • Author(s)
      吹田憲治, 藤田孝之, 石川義弘
    • Organizer
      生理学研究所研究会, ―心血管膜輸送分子の構造・機能・病態の統合的研究戦略,
    • Place of Presentation
      自然科学研究機構生理学研究所(愛知県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新生児期における浸透圧感受性TRPチャネルの役割.2013

    • Author(s)
      横山詩子, 青木理加, 南沢 享, 石川義弘
    • Organizer
      筋生理の集い
    • Place of Presentation
      東京慈恵会医科大学(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prostaglandin E2 receptor EP4 in coronary smooth muscle cells may play a role in intimal thickening that precedes atherosclerosis2012

    • Author(s)
      Kumagaya S, Yokoyama U, Iwai K, Nishihara H, Inoue T, Mimamisawa S, Ishikawa Y
    • Organizer
      第2回生命医科ポスター交流会
    • Place of Presentation
      東京女子医科大学・早稲田大学連携先端生命医科学研究教育施設(TWlns)(東京都)
    • Year and Date
      2012-08-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] cAMPシグナルとニコチン受容体2012

    • Author(s)
      石川義弘
    • Organizer
      第27回喫煙科学研究財団平成23年度助成研究発表会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2012-07-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 酸素による動脈管リモデリング2012

    • Author(s)
      金美花, 横山詩子, 石渡遼, 石川義弘
    • Organizer
      平成24年度生理学若手研究者フォーラム「生体機能へのアプローチ」
    • Place of Presentation
      順天堂大学(東京都)
    • Year and Date
      2012-06-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] Phosphodiesterase Type 3 Inhibitor, Milrinone, Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening.2012

    • Author(s)
      Ichikawa Y Yokoyama U, Masuda M, Asou T, Ishikawa Y
    • Organizer
      The 8^<th> Congress of Asian Society for Pediatric Research.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Rat SMCs within 3D Cellular Mutilayers Exhibit Contractile Phenotypes and Layered elastic fibe.2012

    • Author(s)
      Ishiwata R, Yokoyama U, Kadowaki K, Matsusaki M, Akashi M, Ishikawa Y, Minamisawa S
    • Organizer
      The 8^<th> Congress of Asian Society for Pediatric Research.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Prostaglandin E2 receptor EP4 expressed in coronary smooth muscle cells may play a role in intimal thickening that precedes atheroscleros IS.2012

    • Author(s)
      Kumagaya S, Yokoyama U, Iwai K, Nishihara H, Inoue T, Mimamisawa S, Ishikawa Y
    • Organizer
      The 8^<th> Congress of Asian Society for Pediatric Research
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Plasma Hypoosmolarity after Birth Promotes Closure of the Ductus Arteriosus.2012

    • Author(s)
      Aoki R, Yokoyama U, Ichikawa Y, Minamisawa S, Ishikawa Y
    • Organizer
      The 86^<th> American heart association basic cardio vascular science 2012 Scientific session.
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hyperthermnia and nanotechnology/nanomedicine Magnetic anti-cancer compound in hyperthermic therapy2012

    • Author(s)
      Ishikawa Y
    • Organizer
      ICHO&JCTM 2012.
    • Place of Presentation
      国立京都国際会議場(京都府)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of simultaneous hyperthermo-chemotherapy using a drug.2012

    • Author(s)
      Sato I, Mitsudo K, Baba J, Iida M, Nakashima H, Koizumi T, Kioi M, Eguchi H, Ishikawa Y, Tohnai I
    • Organizer
      ICHO&JCTM 2012.
    • Place of Presentation
      国立京都国際会議場(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A new cancer treatment strategy with magnetic anti-cancer compound with hyperthermia.2012

    • Author(s)
      Feng X, Fukumura H, Sato I, Eguchi H, Ishikawa Y
    • Organizer
      The 11th International Congress of Hyperthermic Oncology, The 29th Japanese Congress of Ther mal Medicine.
    • Place of Presentation
      国立京都国際会議場(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Inhibition of Phosphodiesterase Type 3 Dilates the Rat Ductus Arteriosus without Inducing Intimal Thickening2012

    • Author(s)
      Ichikawa Y, Yokoyama U, Masuda M, Asou T, Ishikawa Y
    • Organizer
      The 86^<th> American Heart Association Scientific Session.
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Oxygenation-induced postnatal remodeling of the ductus arteriosus.2012

    • Author(s)
      Jin MH, Yokoyama U, Ishiwata R, Minamisawa S, Ishikawa Y
    • Organizer
      The 8^<th> Congress of Asian Society for Pediatric Research.
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
  • [Presentation] Disruption of Epacl decreases phosphorylation of phospholamban and protects the heart against stress.2012

    • Author(s)
      Okumura S, Jin M, Ohnuki Y, Namekata I, Kurotani R, Fujita T, Jin HL, Cai W, Bai Y, Suita K, Tsunematsu T, Tanaka H, Ishikawa Y
    • Organizer
      The 86^<th> American Heart Association ScientificSessions.
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 大動脈瘤形成におけるプロスタグランディンE受容体EP4の役割の検討2012

    • Author(s)
      片山雄三, 横山詩子, 岩本眞理, 根本寛子, 笠間啓一郎, 鈴木伸一, 磯松幸尚, 内田敬二, 井元清隆, 石川義弘, 益田宗孝
    • Organizer
      第42回日本心臓血管外科学会学術集会
    • Place of Presentation
      秋田大学(秋田県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 物理的作用を活用した高機能ドラッグデリバリーシステム, 磁性抗癌剤を用いた癌治療2012

    • Author(s)
      石川義弘
    • Organizer
      第51回日本生体医工学大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 出生後における肺の弾性線維形成の検討2012

    • Author(s)
      市川泰広, 横山詩子, 岩本眞理, 南沢享, 石川義弘
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラット動脈管リモデリングにおけるprostaglandin E2- Nuclear Factor kappa B経路の活性化2012

    • Author(s)
      梶村いちげ, 横山詩子, 石川義弘, 南沢享
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] アミノ酸輸液の組成の違いが動脈管閉鎖に及ぼす作用の検討2012

    • Author(s)
      藤田秀次郎, 横山詩子, 青木理加, 小郷寛史, 岩崎志穂, 西巻滋, 関和男, 石川義弘
    • Organizer
      第48回日本周産期・新生児医学会学術集会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] CaとcAMPシグナル2012

    • Author(s)
      石川義弘
    • Organizer
      文部科学省平成24年度新学術領域研究「統合的多階層生体機能学領域の確立とその応用」5回全体会議
    • Place of Presentation
      福岡大学(福岡県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Store-operated Ca2+ entry regulates proliferation and cell cycle in me lanoma.2012

    • Author(s)
      Umemura M, Erdne B, Lai-HuaX, Marianas D.L, Ishikawa Y, Umemura S, Iwatsubo K
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌 他(北海道)
    • Related Report
      2012 Annual Research Report
  • [Book] Bioactive Lipid Mediators.2015

    • Author(s)
      Yokoyama U, Ishiwata R, Ishikawa Y.
    • Total Pages
      426
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] オックスフォード・生理学 原書4版2015

    • Author(s)
      岡野栄之、鯉渕典之、植村慶一 監訳
    • Total Pages
      896
    • Publisher
      丸善出版社
    • Related Report
      2015 Annual Research Report
  • [Book] 標準生理学 第8版 第29章「赤血球」2014

    • Author(s)
      石川義弘
    • Total Pages
      1140
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 標準生理学 第8版 第39章「局所循環」2014

    • Author(s)
      石川義弘
    • Total Pages
      1140
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] 遺伝子医学MOOK24 最新生理活性脂質研究 - 実験手法,基礎的知識とその応用 - 「大動脈瘤の進展とPGE2」.2013

    • Author(s)
      横山詩子、金 美花、石川義弘
    • Total Pages
      312
    • Publisher
      メディカルドゥ社
    • Related Report
      2013 Annual Research Report
  • [Book] TPP問題の核心 公平な医療を受けるため「国民皆保険」を守れ, まだ知らされていない壊国TPP-主権侵害の招待を暴く-2012

    • Author(s)
      石川義弘
    • Publisher
      創森社
    • Related Report
      2012 Annual Research Report
  • [Remarks] 横浜市立大学大学院医学研究科 循環制御医学教室 ホームページ

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 横浜市立大学大学院医学研究科 循環制御医学 ホームページ

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 横浜市立大学大学院医学研究科 循環制御医学ホームページ

    • URL

      http://www-user.yokohama-cu.ac.jp/~seiri1/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 非解離性大動脈瘤の疾患活動性の判定方法.2015

    • Inventor(s)
      横山詩子、石川義弘。荒川憲昭、吉村耕一
    • Industrial Property Rights Holder
      横浜市立大学、山口大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-25
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 三次元細胞集合体の作製方法.2015

    • Inventor(s)
      横山詩子, 石川義弘, 金子真, 佐久間臣耶, 新井史人.
    • Industrial Property Rights Holder
      横浜市立大学、大阪大学、名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-09-29
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] グルタミン酸による動脈管開存症の予防または治療2015

    • Inventor(s)
      横山詩子、石川義弘、藤田秀次郎
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-02-07
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 三次元細胞集合体の作製方法2015

    • Inventor(s)
      横山詩子、石川義弘、金子真、佐久間臣耶、新井史人
    • Industrial Property Rights Holder
      横浜市立大学、大阪大学、名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-033064
    • Filing Date
      2015-02-23
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法2014

    • Inventor(s)
      横山詩子、石川義弘、明石満、松崎典弥
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学、国立大学法人大阪大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-10-09
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 三次元組織体及びその製造方法2013

    • Inventor(s)
      横山詩子、石川義弘、明石満、松崎典弥
    • Industrial Property Rights Holder
      公立大学法人横浜市立大学、国立大学法人大阪大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-212966
    • Filing Date
      2013-10-10
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2022-01-27  

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