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Constructive Understanding of the Platelet Function for the Onset of Myocardial Infarction.

Research Project

Project/Area Number 24390202
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokai University

Principal Investigator

GOTO Shinya  東海大学, 医学部, 教授 (50225653)

Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords血小板細胞 / 血栓 / 数理モデル / 抗血小板薬 / シミュレーション / 血小板 / von Willebrand因子 / 心筋梗塞 / 抗血栓薬 / 構成論 / 分子動力学
Outline of Final Research Achievements

Platelet cell play crucial roles for the onset of thrombotic diseases such as acute myocardial infarction. We aim to construct the physiological function of platelet cell on computer with the use of simulation technology. Platelet adhesion under blood flow condition, activation locally started at site of platelet adhesion, transduction of activation signals and energy metabolism, local release of vaso-active substances from dense or alpha granules, the impact of local blood flow conditions on the distribution of locally released substances, local activation of coagulation on the surface of platelet membrane, are all implemented in our platelet cell simulator. Platelet adhesion at site of endothelial injury was mediated exclusively by platelet glycoprotein Ib binding with von Willebrand factor. All physical interaction among atoms constructing GPIb, VWF and waters were solved to predict dynamic three-dimensional structure and binding force between GPIb and VWF.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (48 results)

All 2017 2016 2015 2014 2013 2012

All Journal Article (30 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 29 results,  Open Access: 19 results,  Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 8 results) Book (6 results)

  • [Journal Article] Evidence-Based Carotid Interventions for Stroke Prevention: State-of-the-art Review2017

    • Author(s)
      2.Morris DR, Ayabe K, Inoue T, Sakai N, Halliday A, Bulbulia R, and Goto S.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 24 Issue: 4 Pages: 373-387

    • DOI

      10.5551/jat.38745

    • NAID

      130005529928

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prevention of Stroke with Ticagrelor in Patients with Prior Myocardial Infarction: Insights from PEGASUS-TIMI 542016

    • Author(s)
      Bonaca MP, Goto S, Bhatt DL, Steg P, Storey RF, Cohen M, Goodrich E, Mauri L, Ophuis TO, Ruda M, J, Seung KB, Hu D, Dalby AJ, Jensen E, Held P, Morrow DA, Braunwald E, Sabatine MS.
    • Journal Title

      Circulation

      Volume: 134 Issue: 12 Pages: 861-871

    • DOI

      10.1161/circulationaha.116.024637

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Persistence and Discontinuation of Oral Anticoagulant: Remaining Issues Not Addressed by Phase III Clinical Trial2016

    • Author(s)
      Ayabe K, Goto S, and Goto S
    • Journal Title

      J Am Heart Assoc

      Volume: 5 Issue: 2

    • DOI

      10.1161/jaha.116.003258

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two-year outcomes of patients with newly diagnosed atrial fibrillation: results from GARFIELD-AF2016

    • Author(s)
      Bassand JP, Accetta G, Camm AJ, Cools F, Fitzmaurice DA, Fox KA, Goldhaber SZ, Goto S, Haas S, Hacke W, Kayani G, Mantovani LG, Misselwitz F, Ten Cate H, Turpie AG, Verheugt FW, Kakkar AK.
    • Journal Title

      Eur Heart J

      Volume: 37 Issue: 38 Pages: 2882-2889

    • DOI

      10.1093/eurheartj/ehw233

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting thrombin long-term after an acute coronary syndrome: Opportunities and challenges.2016

    • Author(s)
      De Caterina, R. & Goto, S.
    • Journal Title

      Vascul Pharmacol

      Volume: 81 Pages: 1-14

    • DOI

      10.1016/j.vph.2016.03.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prediction of Molecular Interaction between Platelet Glycoprotein Ibα and von Willebrand Factor using Molecular Dynamics Simulations2016

    • Author(s)
      Shiozaki S, Takagi S, and Goto S
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 4 Pages: 455-464

    • DOI

      10.5551/jat.32458

    • NAID

      130005141415

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 542015

    • Author(s)
      Bonaca, M. P. Bhatt, D. L. Steg, P. G. Storey, R. F. Cohen, M. Im, K. Oude Ophuis, T. Budaj, A. Goto, S. Lopez-Sendon, J. Diaz, R. Dalby, A. Van de Werf, F. Ardissino, D. Montalescot, G. Aylward, P. Magnani, G. Jensen, E. C. Held, P. Braunwald, E. Sabatine, M. S.
    • Journal Title

      Eur Heart J

      Volume: in press Issue: 14 Pages: 1133-1142

    • DOI

      10.1093/eurheartj/ehv531

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Platelets: Small in Size But Essential in the Regulation of Vascular Homeostasis – Translation From Basic Science to Clinical Medicine –2015

    • Author(s)
      Goto S, Hasebe T, Takagi S
    • Journal Title

      Circulation Journal

      Volume: 79 Issue: 9 Pages: 1871-1881

    • DOI

      10.1253/circj.CJ-14-1434

    • NAID

      130005095321

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adhesive Forces between A1 Domain of von Willebrand Factor and N-terminus Domain of Glycoprotein Ibα Measured by Atomic Force Microscopy2015

    • Author(s)
      Tobimatsu H, Nishibuchi Y, Sudo R, Goto S and Tanishita
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 22 Issue: 10 Pages: 1091-1099

    • DOI

      10.5551/jat.28423

    • NAID

      130005101337

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction.2015

    • Author(s)
      Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Ophuis TO, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS
    • Journal Title

      N Engl J Med

      Volume: in press Issue: 19 Pages: 1791-1800

    • DOI

      10.1056/nejmoa1500857

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adhesive forcpe between Al domain of von Willeb'rand Factor and N-terminus domain of Glycopnotein lbalpha measured by AFM.2015

    • Author(s)
      Tomimatsu H, Nishibuchi Y, Sudo R, Goto S and Tanishita K
    • Journal Title

      J Arteriosclr Thromb

      Volume: in press Issue: 2_suppl_1

    • DOI

      10.1161/circoutcomes.114.001556

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Virtual Platelets Implementing the Functions of Three Platelet Membrane Proteins with Different Adhesive Characteristics2015

    • Author(s)
      Tomita A, Tamura N, Nanazawa Y, Shiozaki S, and Goto S.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 22 Issue: 2 Pages: 201-210

    • DOI

      10.5551/jat.26203

    • NAID

      130004694072

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selection of a Suitable Patient Population for New Antiplatelet Therapy From the Large Clinical Trial Database of the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events-Thrombolysis in Myocardial Infarction 50 (TRA-2P-TIMI50) Trial.2015

    • Author(s)
      Goto, S. & Goto, S
    • Journal Title

      Circulation

      Volume: 131 Issue: 12 Pages: 1041-1043

    • DOI

      10.1161/circulationaha.115.015471

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial commenton ‘A novel approach indirectly comparing benefit: risk across oral antithrombotic therapies inpatients with atrial fibrillation’.Are the evidences of current dose-adjusted anticoagulationwith warfarin stroke prevention for patients with atrial fibrillation sufficient enough to compare with newly developed non-vitamin K oral anticoagulants?2015

    • Author(s)
      Goto, S. & Goto, S.
    • Journal Title

      European Heart Journal – Cardiovascular Pharmacotherapy

      Volume: 1 Issue: 2 Pages: 83-85

    • DOI

      10.1093/ehjcvp/pvu017

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between diabetes and a high ankle-brachial index on mortality risk.2015

    • Author(s)
      Potier L, Roussel R, Labreuche J, Marre M, Cacoub P, Röther J, Wilson PW, Goto S, Bhatt DL, Steg PG
    • Journal Title

      Eur J Prev Cardiol

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolic syndrome, diabetes mellitus, or both and cardiovascular risk in outpatients with or at risk for atherothrombosis.2014

    • Author(s)
      Udell JA, Steg PG, Scirica BM, Eagle KA, Ohman EM, Goto S, Alsheikh-Ali AA, Porath A, Corbalan R, Umez-Eronini AA, Hoffman EB, Wilson PW, Bhatt DL
    • Journal Title

      Eur J Prev Cardiol.

      Volume: 21 Issue: 12 Pages: 1531-40

    • DOI

      10.1177/2047487313500541

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] World Heart Federation expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI.2014

    • Author(s)
      Levine GN, Jeong YH, Goto S, Anderson JL, Huo Y, Mega JL, Taubert K, and Smith Jr. SC
    • Journal Title

      Nat Rev Cardiol

      Volume: 11 Issue: 10 Pages: 597-606

    • DOI

      10.1038/nrcardio.2014.104

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and Safety of Apixaban Compared with Warfarin for Stroke Prevention in Patients with Atrial Fibrillation from East Asia: A Sub-Analysis of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial.2014

    • Author(s)
      11.Goto S, Zhu J, Liu L, Oh BH, Wojdyla DM, Aylward P, Bahit C, Gersh BJ, Hanna M, Horowitz J, Lopes RD, Wallentin L, Xavier D, Alexander JH
    • Journal Title

      Am Heart J

      Volume: 168 Issue: 3 Pages: 303-309

    • DOI

      10.1016/j.ahj.2014.06.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renin-Angiotensin System Antagonists and clinical outcomes in stable coronary artery disease without heart failure.2014

    • Author(s)
      Sorbets E, Labreuche J, Simon T, Delome L, Danchin N, Amarenco P, Goto S, Meune C, Eagle KA. Bhatt DL, Steg PG
    • Journal Title

      European Heart Journal

      Volume: 35 Issue: 26 Pages: 1760-1768

    • DOI

      10.1093/eurheartj/ehu078

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rivaroxaban versus warfarin in Japanese patients with non-valvular atrial fibrillation in relation to hypertension: a subgroup analysis of the J-ROCKET AF trial.2014

    • Author(s)
      Matsumoto M, Hori M, Tanahashi N, Momomura 4, Uchiyama S, Goto S, Izumi T, Koretsune Y, Kajikawa M, Kato M, Ueda H, Iekushi K, Yamanaka S, Tajiri M
    • Journal Title

      Hypertens Res.

      Volume: 37 Issue: 5 Pages: 457-462

    • DOI

      10.1038/hr.2014.1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New ischemic stroke and outcomes with vorapaxar versus placebo: results from the TRA 2 °P-TIMI 50 trial.2014

    • Author(s)
      Bonaca MP, Scirica BM, Braunwald E, Wiviott SD, Goto S, Nilsen DW, Bonarjee V, Murphy SA, Morrow DA.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 64 Pages: 2318-2326

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Platelet repellent properties of hydrogel coatings on polyurethane-coated glass surfaces.2014

    • Author(s)
      Baghai M, Tamura N, Beyersdorf F, Henze M, Prucker O, Rühe J, Goto S, Zieger B, Heilmann C.
    • Journal Title

      ASAIO J

      Volume: 60 Issue: 5 Pages: 587-593

    • DOI

      10.1097/mat.0000000000000118

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term cardiovascular outcomes in patients with atrial fibrillation and atherothrombosis in the REACH Registry2014

    • Author(s)
      Ruff CT, Bhatt DL, Steg PG, Gersh BJ, Alberts MJ, Hoffman EB, Ohman EM, Eagle KA, Lip GY, Goto S
    • Journal Title

      Int J Cardiol

      Volume: 170 Issue: 3 Pages: 413-418

    • DOI

      10.1016/j.ijcard.2013.11.030

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Net Clinical Benefit of Rivaroxaban versus Warfarin in Japanese Patients with Nonvalvular Atrial Fibrillation: A Subgroup Analysis of J-ROCKET AF2014

    • Author(s)
      Uchiyama S, Hori M, Matsumoto M, Tanahashi N, Momomura SI, Goto S, Izumi T, Koretsune Y, Kajikawa M, Kato M, Ueda H, Iekushi K, Yamanaka S, Tajiri M
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: in press Issue: 5 Pages: 1142-1147

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.10.001

    • Related Report
      2013 Annual Research Report
  • [Journal Article] New antithrombotics for secondary prevention of acute coronary syndrome2014

    • Author(s)
      Goto S and Tomita A
    • Journal Title

      Clin Cardiol

      Volume: 37 Issue: 3 Pages: 178-87

    • DOI

      10.1002/clc.22233

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NSAID use and association with cardiovascular outcomes in outpatients with stable atherothrombotic disease2013

    • Author(s)
      Kohli P, Steg PG, Cannon CP, Smith SC Jr, Eagle KA, Ohman EM, Alberts MJ, Hoffman E, Guo J, Simon T, Sorbets E, Goto S, Bhatt DL
    • Journal Title

      Am J Med

      Volume: 127 Issue: 1 Pages: 53-60

    • DOI

      10.1016/j.amjmed.2013.08.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rivaroxaban versus warfarin in Japanese patients with nonvalvular atrial fibrillation in relation to the CHADS2 score: a subgroup analysis of the J-ROCKET AF trial2013

    • Author(s)
      Hori, M. Matsumoto, M. Tanahashi, N. Momomura, S. Uchiyama, S. Goto, S. Izumi, T. Koretsune, Y. Kajikawa, M. Kato, M. Ueda, H. Iekushi, K. Yamanaka, S. Tajiri, M
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 23 Issue: 2 Pages: 379-383

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.07.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A history of stroke/transient ischemic attack indicates high risks of cardiovascular event and hemorrhagic stroke in patients with coronary artery disease.2013

    • Author(s)
      Ducrocq G, Amarenco P, Labreuche J, Alberts MJ, Mas JL, Ohman EM, Goto S, Lavallee P, Bhatt DL,
    • Journal Title

      Circulation.

      Volume: 127 Issue: 6 Pages: 730-738

    • DOI

      10.1161/circulationaha.112.141572

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High on-treatment platelet reactivity (HPR) : what does it mean, and does it matter?2013

    • Author(s)
      Goto S
    • Journal Title

      Thromb Haeraost

      Volume: 109 Issue: 02 Pages: 177-178

    • DOI

      10.1160/th12-12-0910

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] beta-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease2012

    • Author(s)
      Bangalore S, Steg G, Deedwania P, Crowley K, Eagle KA, Goto S, Oilman EM, Cannon CP, Smith SC, Zeymer U, Hoffman EB, Messerli FH, Bhatt DL, REACH Registry Investigators.
    • Journal Title

      JAMA

      Volume: 208 Issue: 13 Pages: 1340-1349

    • DOI

      10.1001/jama.2012.12559

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] APPLICATION OF HIGH PERFORMANCE COMPUTING TECHNOLOGY FOR CARDIOLOGY2016

    • Author(s)
      Shinya Goto
    • Organizer
      77th Italian Society of Cardiology
    • Place of Presentation
      Rome Cavalieri (Rome, Italy)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Consensus Statement of the Use of Antithrombotic Therapy in East Asian Patients: From Evidence to Clinical Application2015

    • Author(s)
      Goto S
    • Organizer
      Korean Society of Interventional Cardiology
    • Place of Presentation
      Lotte Hotel Jeju
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NOACs in ACS2014

    • Author(s)
      後藤信哉
    • Organizer
      第28回日本冠疾患学会
    • Place of Presentation
      ステーションカンファレンス東京
    • Year and Date
      2014-12-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 血栓形成: 血栓性物質と血流の観点から2014

    • Author(s)
      後藤信哉
    • Organizer
      第36回日本血栓止血学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-05-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Interpretation of the Global Clinical Trial Data for Local Clinical Practice in East Asian Region: Management of Atrial Fibrillation2014

    • Author(s)
      Goto S
    • Organizer
      The Annual Scientific Meeting of Taiwan Heart Rhythm Society
    • Place of Presentation
      Taipei
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 日本循環器学会教育講演 : 新規経口抗凝固薬の考え方-適正使用のために-2013

    • Author(s)
      後藤信哉
    • Organizer
      第41回日本循環器学会教育講演
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] Keynote Lecture : Future Perspective of Antithrombotic Therapy in the Field of Cardiology : How can We Select Suitable Patients for Potentially Harmful Intervention?2013

    • Author(s)
      Goto
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規経口抗凝固薬をどう使うか?有効かつ安全な使い方2013

    • Author(s)
      後藤信哉
    • Organizer
      第61回日本心臓病学会教育講演
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヒト血管内の血流と血小板細胞から みたバイオレオロジー2013

    • Author(s)
      後藤信哉
    • Organizer
      第15回レオロジーフォーラム特別講演
    • Place of Presentation
      山形
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ー高齢者にはワルファリンが好ましいとの立場ー2013

    • Author(s)
      後藤信哉
    • Organizer
      第28回日本老年医学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Antiplatelet Therapy: “How can We Select Suitable Patients for Potentially Harmful Intervention?”2013

    • Author(s)
      Goto S
    • Organizer
      79th Annual Meeting of German Society of Cardiology
    • Place of Presentation
      Manheim, Germany
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Goto S : Special Session. Discussant for the Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease (LoDoCo Trial).2012

    • Author(s)
      Goto S
    • Organizer
      Annual Scientific Session of American Heart Assoication 2012,
    • Place of Presentation
      Los Angeles
    • Year and Date
      2012-11-05
    • Related Report
      2012 Annual Research Report
  • [Book] 理屈がわかる抗凝固・抗血小板療法2016

    • Author(s)
      後藤信哉
    • Total Pages
      134
    • Publisher
      中外医学社
    • Related Report
      2016 Annual Research Report
  • [Book] Vascular Engineering2016

    • Author(s)
      Goto S
    • Total Pages
      393
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] 止血、血栓ハンドブック2015

    • Author(s)
      鈴木重統、後藤信哉、松野一彦
    • Total Pages
      422
    • Publisher
      西村書店
    • Related Report
      2015 Annual Research Report
  • [Book] 止血血栓ハンドブック2015

    • Author(s)
      鈴木重統、後藤信哉、松野一彦
    • Total Pages
      420
    • Publisher
      西村書店
    • Related Report
      2014 Annual Research Report
  • [Book] 血栓形成と凝固、線溶2013

    • Author(s)
      浦野哲盟、後藤信哉
    • Total Pages
      217
    • Publisher
      メディカルサイエンスインターナショナル
    • Related Report
      2013 Annual Research Report
  • [Book] 血栓形成と凝固、線溶2013

    • Author(s)
      浦野哲盟, 後藤信哉
    • Total Pages
      232
    • Publisher
      メディカルサイエンスインターナショナル .
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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