| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
Platelet cell play crucial roles for the onset of thrombotic diseases such as acute myocardial infarction. We aim to construct the physiological function of platelet cell on computer with the use of simulation technology. Platelet adhesion under blood flow condition, activation locally started at site of platelet adhesion, transduction of activation signals and energy metabolism, local release of vaso-active substances from dense or alpha granules, the impact of local blood flow conditions on the distribution of locally released substances, local activation of coagulation on the surface of platelet membrane, are all implemented in our platelet cell simulator. Platelet adhesion at site of endothelial injury was mediated exclusively by platelet glycoprotein Ib binding with von Willebrand factor. All physical interaction among atoms constructing GPIb, VWF and waters were solved to predict dynamic three-dimensional structure and binding force between GPIb and VWF.
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