Study to overcome metastasis and targeted drug-resistance of lung cancer
| Project/Area Number |
24390209
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
YANO Seiji 金沢大学, がん進展制御研究所, 教授 (30294672)
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| Co-Investigator(Kenkyū-buntansha) |
EBI Hiromichi 金沢大学, がん進展制御研究所, 助教 (00645145)
OHTSUBO Koshiro 金沢大学, 大学病院, 講師 (60361987)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 分子標的薬耐性 / 脳転移 / 骨転移 / がん性胸膜炎 / 転移 / イメージング / がん性胸水 / がん性髄膜炎 / 肺がん / ALK阻害薬耐性 / BIM遺伝子多型 / EGFR阻害薬耐性 / mTOR阻害薬 / 個別化医療 / ボリノスタット |
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| Outline of Final Research Achievements |
To elucidate mechanism of targeted drug resistance in metastatic lesions, we established in vivo imaging models for pleural carcinomatosis and bone/brain metastases, which are resistant to targeted drugs, of EGFR mutant or ALK fusion positive lung cancer cell lines. We found that resistant tumors consist of a heterogeneous mixture of functionally distinct cancer cells with different resistant mechanisms. Moreover, our observation indicated that we should be careful for toxicity of combined therapy which overcome targeted drug resistance caused by multiple mechanisms.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Fibrosis in Preeclamptic Placentas Is Associated with Stromal Fibroblasts Activated by the Transforming Growth Factor-β1 Signaling Pathway.2018
Author(s)
J. Asai, H. Takenaka, S. Hirakawa, J. Sakabe, A. Hagura, S. Kishimoto, K. Maruyama, K. Kajiya, S. Kinoshita, Y. Tokura, N. Katoh
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Journal Title
American Journal of Pathology
Volume: 181
Pages: 1180-1189
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinical significance of epidermal growth factor receptor tyrosine kinase inhibitors: Sensitivity and resistance.2014
Author(s)
Okamoto T, Miyazaki Y, Ogura T, Chida K, Kohno N, Kohno S, Taniguchi H, Akagawa S, Mochizuki Y, Yamauchi K, Takahashi H, Johkoh T, Homma S, Kishi K, Ikushima S, Konno S, Mishima M, Ohta K, Nishioka Y, Yoshimura N, Munakata M, Watanabe K, Miyashita Y, Inase N.
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Journal Title
Respir Investig
Volume: 51
Pages: 191-199
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Therapeutic antitumor efficacy of anti-epidermal growth factor receptor antibody, cetuximab, against malignant pleural mesothelioma.2012
Author(s)
Kurai J, Chikumi HT, Hamada H, Yano S, , Hashimoto K, Takata M, Sako T, Yamaguchi K, Kinoshita N, Watanabe M, Touge H, Makino H, Igishi Shimizu E
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Journal Title
Int J Oncol
Volume: 41
Pages: 1610-1618
DOI
Related Report
Peer Reviewed
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