Development of a novel antibody therapy based on antibody-dependent cellular cytotoxicity activity against lung cancer and mesothelioma and identification of the immunological biomarkers

• Project/Area Number: 24390210
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: NISHIOKA Yasuhiko 徳島大学, ヘルスバイオサイエンス研究部, 教授 (70274199)
• Co-Investigator(Kenkyū-buntansha): KATO Yukinari 東北大学, 医学(系)研究科(研究院), 教授 (00571811) ; KAKIUCHI Soji 徳島大学, 病院, 講師 (50380100) ; GOTO Hisatsugu 徳島大学, 大学院ヘルスバイオサイエンス研究部, 講師 (00437641)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 抗体療法 / ADCC / ポドプラニン / 肺癌 / 悪性胸膜中皮腫 / 免疫療法 / バイオマーカー / 抗体治療

Outline of Final Research Achievements

We developed novel antibodies against podoplanin expressing in lung squamous cell carcinoma and mesothelioma. We generated a human-rat chimeric anti-podoplanin antibody NZ-8 which showed higher anti-tumor activity in mouse xenograft model based on antibody-dependent cellular and complement- dependent cytotoxicity as compared to those of the rat antibody NZ-1. The binding activity of NZ-8 seemed to be higher against podoplanin expressing in tumor cells rather than normal cells such as alveolar cells or podocytes, indicating the advantage for clinical use of NZ-8. We finally developed the chimeric antibody NZ-12 showing the higher anti-tumor activity than NZ-8. Furthermore, gene expression analyses in xenograft tumors treated with NZ-1 identified the candidate genes related with the biological activity of NZ-1/NZ-8.

Research Products

• [Journal Article] New wave of immunotherapy against lung cancer rolls in to clinic (2014)
  • Author(s): Nishioka Y
  • Journal Title: Transl Lung Cancer Res Volume: 3 Pages: 1-1
  • Open Access
• [Journal Article] Early growth response 4 is involved in cell proliferation of small cell lung cancer through transcriptional activation of its downstream genes (2014)
  • Author(s): Matsuo T, Dat le T, Komatsu M, Yoshimaru T, Daizumoto K, Sone S, Nishioka Y, Katagiri T
  • Journal Title: PLoS One Volume: 9 Issue: 11 Pages: e113606-e113606
  • DOI: 10.1371/journal.pone.0113606
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The molecular biology of lung cancer brain metastasis: an overview of current comprehensions and future perspectives (2014)
  • Author(s): Hanibuchi M, Kim SJ, Fidler IJ, Nishioka Y
  • Journal Title: J Med Invest Volume: 61 Pages: 241-253
  • NAID: 130004822728
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of surfactant protein A in non-infectious lung diseases (2014)
  • Author(s): Goto H, Mitsuhashi A, Nishioka Y
  • Journal Title: J Med Invest Volume: 61 Pages: 1-6
  • NAID: 130004822696
  • Peer Reviewed / Open Access
• [Journal Article] 新薬の最近の話題「デノスマブ」 (2014)
  • Author(s): 後東久嗣, 西岡安彦
  • Journal Title: 分子呼吸器病 Volume: 18 Pages: 109-111
  • NAID: 40021326748
• [Journal Article] New wave of immunotherapy against lung cancer rolls in to clinic. (2014)
  • Author(s): Nishioka Y
  • Journal Title: Transl Lung Cancer Res Volume: 3 Pages: 1-1
• [Journal Article] Surfactant protein a suppresses lung cancer progression by regulating the polarization of tumor-associated macrophages. (2013)
  • Author(s): Mitsuhashi A, Yano S, et al.
  • Journal Title: Am J Pathol Volume: 182 Issue: 5 Pages: 1843-53
  • DOI: 10.1016/j.ajpath.2013.01.030
  • Peer Reviewed
• [Journal Article] A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody (2013)
  • Author(s): Abe S, Morita Y, Kaneko MK, Hanibuchi M, Tsujimoto Y, Goto H, Kakiuchi S, Aono Y, Huang J, Sato S, Kishuku M, Taniguchi Y, Azuma M, Kawazoe K, Sekido Y, Yano S, Akiyama SI, Sone S, Minakuchi K, Kato Y, Nishioka Y
  • Journal Title: J Immunol Volume: 190 Issue: 12 Pages: 6239-6249
  • DOI: 10.4049/jimmunol.1300448
  • Peer Reviewed
• [Journal Article] Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target. (2013)
  • Author(s): Huang J, Tabata S, Kakiuchi S, The Van T, Goto H, Hanibuchi M, Nishioka Y
  • Journal Title: Oncotarget Volume: 4 Pages: 1172-1184
  • Peer Reviewed
• [Journal Article] Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR activating and gatekeeper mutations. (2013)
  • Author(s): Yamada T, Yano S, et al.
  • Journal Title: Oncogene Volume: 32 Issue: 37 Pages: 4427-35
  • DOI: 10.1038/onc.2012.446
  • NAID: 120004997024
  • Peer Reviewed
• [Journal Article] ヒト肺癌多臓器転移モデルとmacrophage stimulatuing protein (2013)
  • Author(s): 佐藤正大, 西岡安彦, 曽根三郎
  • Journal Title: THE LUNG perspectives Volume: 21 Pages: 72-77
• [Journal Article] 分子標的治療と免疫療法 (2013)
  • Author(s): 西岡安彦
  • Journal Title: 癌と化学療法 Volume: 40 Pages: 1004-1008
• [Journal Article] imeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity (2013)
  • Author(s): Kaneko MK, Kunita A, Abe S, Tsujimoto Y, Fukayama M, Goto K, Sawa Y, Nishioka Y, Kato Y
  • Journal Title: Cancer Sci Volume: 103 Issue: 11 Pages: 1913-1919
  • DOI: 10.1111/j.1349-7006.2012.02385.x
  • Peer Reviewed
• [Journal Article] Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironme (2013)
  • Author(s): Sato S, Hanibuchi M, Kuramoto T, Yamamori N, Goto H, Ogawa H, Mitsuhashi A, Van TT, Kakiuchi S, Akiyama SI, Nishioka Y, Sone S
  • Journal Title: Clin Exp Metastasis Volume: 30 Issue: 3 Pages: 333-344
  • DOI: 10.1007/s10585-012-9540-y
  • Peer Reviewed
• [Journal Article] A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody. (2013)
  • Author(s): Abe S, et al.
  • Journal Title: J Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] E7050, a Met kinase inhibitor, reverses three different mechanisms of hepatocyte growth factor-induced resistance to tyrosine kinase inhibitors in EGFR mutant lung cancer cells (2012)
  • Author(s): Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Uenaka T, Yano S
  • Journal Title: Clin Cancer Res Volume: 18 Issue: 6 Pages: 1663-71
  • DOI: 10.1158/1078-0432.ccr-11-1171
  • Peer Reviewed
• [Journal Article] Erlotinib prevents experimental metastases of human small cell lung cancer cells with no epidermal growth factor receptor expression (2012)
  • Author(s): abr AG, Goto H, Hanibuchi M, Ogawa H, Kuramoto T, Suzuki M, Saijo A, Kakiuchi S, Trung VT, Sakaguchi S, Mori
  • Journal Title: Clin Exp Metastasis Volume: 29 Issue: 3 Pages: 207-216
  • DOI: 10.1007/s10585-011-9443-3
  • Peer Reviewed
• [Journal Article] Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile nalysis of non-small cell lung cancer in mic (2012)
  • Author(s): Dat LT, Matsuo T, Yoshimaru T, Kakiuchi S, Goto H, Hanibuchi M, Kuramoto T, Nishioka Y, Sone S, Katagiri T
  • Journal Title: Int J Oncol Volume: 40 Pages: 1455-1469
  • DOI: 10.3892/ijo.2012.1348
  • Peer Reviewed
• [Journal Article] がん分子標的薬に合併する間質性肺炎 (2012)
  • Author(s): 青野純典, 他.
  • Journal Title: Medical Science Digest Volume: 38 Pages: 396-399
• [Journal Article] a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model (2012)
  • Author(s): Van TT, Hanibuchi M, Goto H, Kuramoto T, Yukishige S, Kakiuchi S, Sato S, Sakaguchi S, Dat LT, Nishioka Y, Akiyama SI, Sone S, SU666
  • Journal Title: Respirology Volume: 17 Issue: 6 Pages: 984-990
  • DOI: 10.1111/j.1440-1843.2012.02193.x
  • Peer Reviewed
• [Journal Article] Dual inhibition of met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer (2012)
  • Author(s): Takeuchi S, Wang W, Li Q, Yamada T, Kita K, Donev IS, Nakamura T, Matsumoto K, Shimizu E, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano
  • Journal Title: Am J Pathol Volume: 181 Issue: 3 Pages: 1034-1043
  • DOI: 10.1016/j.ajpath.2012.05.023
  • Peer Reviewed
• [Journal Article] Akiyama S, Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells (2012)
  • Author(s): Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S
  • Journal Title: Oncol Rep Volume: 28 Pages: 895-902
  • DOI: 10.3892/or.2012.1887
  • Peer Reviewed
• [Journal Article] Malignant pleural effusion : further translational research is crucial. (2012)
  • Author(s): Nishioka Y
  • Journal Title: Transl Lung Cancer Res Volume: 1 Pages: 167-169
  • Peer Reviewed
• [Journal Article] がん分子標的治療における一体化開発の現状と展望 (2012)
  • Author(s): 西岡安彦
  • Journal Title: がん分子標的治療 Volume: 10 Pages: 267-275
• [Journal Article] Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity. (2012)
  • Author(s): Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y
  • Journal Title: Mol Cancer Ther Volume: 11 Issue: 12 Pages: 2578-2587
  • DOI: 10.1158/1535-7163.mct-12-0640
  • Peer Reviewed
• [Journal Article] mTOR阻害薬による肺障害とその対応 (2012)
  • Author(s): 柿内聡司, 他.
  • Journal Title: 分子呼吸器病 Volume: 17 Pages: 42-45
• [Presentation] がん免疫療法の過去と未来：エビデンスが示した新たな可能性 (2014)
  • Author(s): 西岡安彦
  • Organizer: 第62回日本口腔学会 中国・四国地方部会
  • Place of Presentation: 徳島大学歯学部大講義室（徳島県徳島市）
  • Year and Date: 2014-10-25
  • Invited
• [Presentation] ベバシズマブに対する獲得耐性メカニズムとしての線維細胞（fibrocytes）の役割 (2014)
  • Author(s): 後東久嗣, 三橋惇志, 西條敦郎, 柿内聡司, 埴淵昌毅, 上原久典, 矢野聖二, 西岡安彦
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-27
• [Presentation] がん特異的抗ポドプラニン抗体の樹立 (2014)
  • Author(s): 加藤幸成, 金子美華, 小笠原諭, 西岡安彦
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-27
• [Presentation] 加藤幸成, 西岡安彦. 血小板凝集因子Podoplaninに対するがん特異的抗体の開発 (2014)
  • Author(s): 加藤幸成, 西岡安彦
  • Organizer: 第23回日本がん転移学会学術集会
  • Place of Presentation: 金沢市文化ホール（石川県金沢市）
  • Year and Date: 2014-07-11
  • Invited
• [Presentation] 肺癌多臓器転移モデルにおけるsphere形成癌幹細胞様分画の役割 (2014)
  • Author(s): 後東久嗣, 三橋惇志, 倉本卓哉, 田畑祥, 西條敦郎, 柿内聡司, 埴淵昌毅, 上原久典, 西岡安彦
  • Organizer: 第23回日本がん転移学会学術集会
  • Place of Presentation: 金沢市文化ホール（石川県金沢市）
  • Year and Date: 2014-07-10
• [Presentation] ヒト小細胞肺癌骨転移に対するRANKL標的治療におけるIGF-1の関与 (2014)
  • Author(s): 山子泰斗, 後東久嗣, 三橋惇志, 倉本卓哉, 田畑祥, 西條敦郎, 柿内聡司, 埴淵昌毅, 小川博久, 上原久典, 西岡安彦
  • Organizer: 第23回日本がん転移学会学術集会
  • Place of Presentation: 金沢市文化ホール（石川県金沢市）
  • Year and Date: 2014-07-10
• [Presentation] ベバシズマブに対する獲得耐性メカニズムとしての線維細胞（fibrocytes）の役割 (2014)
  • Author(s): 後東久嗣, 三橋惇志, 西條敦郎, 倉本卓哉, 田畑祥, 埴淵昌毅, 柿内聡司, 青野純典, 上原久典, 西岡安彦
  • Organizer: 第18回日本がん分子標的治療学会学術集会
  • Place of Presentation: 仙台市情報・産業プラザ（宮城県仙台市）
  • Year and Date: 2014-06-27
  • Invited
• [Presentation] 胸膜中皮腫同所移植モデルにおける抗ポドプラニン抗体の抗腫瘍効果 (2014)
  • Author(s): 大塚憲司, 阿部真治, 埴淵昌毅, 木宿昌俊, 川添和義, 加藤幸成, 西岡安彦
  • Organizer: 第18回日本がん分子標的治療学会学術集会
  • Place of Presentation: 仙台市情報・産業プラザ（宮城県仙台市）
  • Year and Date: 2014-06-26
• [Presentation] The role of fibrocytes in the resistance to anti-angiogenic therapy in malignant pleural mesothelioma and lung cancer (2014)
  • Author(s): Hisatsugu Goto, Atsushi Mitsuhashi, Atsuro Saijo, Trung The Van, Yoshinori Aono, Hirohisa Ogawa, Soji Kakiuchi, Masaki Hanibuchi, Seiji Yano, Keisuke Izumi, Yasuhiko Nishioka
  • Organizer: ATS 2014 International Conference
  • Place of Presentation: San Diego Convention Center （U.S.A.）
  • Year and Date: 2014-05-21
• [Presentation] 肺がん・中皮腫における血管新生阻害薬耐性 (2014)
  • Author(s): 西岡安彦
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-04-26
  • Invited
• [Presentation] 当院における間質性肺炎合併肺癌の治療の現状 (2014)
  • Author(s): 柿内聡司, 大塚憲司, 佐藤正大, 西條敦郎, 坂口暁, 後東久嗣, 埴淵昌毅, 西岡安彦
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-04-26
• [Presentation] Surfactant protein A suppresses lung cancer progression by regulating tumor-associated macrophage polarization. (2013)
  • Author(s): Sawaka Yukishige, et al.
  • Organizer: Ninth AACR-Japanese Cancer Association Joint Conference
  • Place of Presentation: Hyatt Regency Maui (U.S.A.)
  • Year and Date: 2013-02-24
• [Presentation] Acquired resistance to anti-VEGF therapy via angiogenic switch in orthotopically implanted human malignant pleural mesothelioma in SCID mice (2013)
  • Author(s): Atsushi Mitsuhashi, et al.
  • Organizer: Ninth AACR-Japanese Cancer Association Joint Conference
  • Place of Presentation: Hyatt Regency Maui (U.S.A.)
  • Year and Date: 2013-02-24
• [Presentation] 悪性胸膜中皮腫に対するヒトキメラ型抗ポドプラニン抗体療法の検討. (2012)
  • Author(s): 阿部真治, 他.
  • Organizer: 第25回日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 倉敷市芸文館 (岡山県)
  • Year and Date: 2012-12-14
• [Presentation] 抗ポドプラニン抗体NZ-1の悪性胸膜中皮腫に対する抗体依存性細胞障害活性と抗腫瘍効果. (2012)
  • Author(s): 埴淵昌毅, 他.
  • Organizer: 第53回日本肺癌学会総会
  • Place of Presentation: 岡山コンベンションセンター (岡山県)
  • Year and Date: 2012-11-09
• [Presentation] Eradication of experimental brain metastases of human non-small cell lung cancer by macitentan, a dual antagonist of the endothelin A and B receptor, combined with paclitaxel. (2012)
  • Author(s): Masaki Hanibuchi, et al.
  • Organizer: Markers in Cancer 2012 : A Joint Meeting by ASCO, EORTC and NCI
  • Place of Presentation: Westin Diplomat (U.S.A.)
  • Year and Date: 2012-10-12
• [Presentation] Role of thymidine catabolism in survival of human cancer cells. (2012)
  • Author(s): Sho Tabata, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-20
• [Presentation] LBMTF, a novel transcriptional factor involved in lung cancer bone metastasis. (2012)
  • Author(s): Tan Dat Le, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] Anti-podoplanin antibodies suppress tumor metastasis via neutralization and antibody-dependent cellular cytotoxicity. (2012)
  • Author(s): Yukinari Kato, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] Antitumor effects of anti-podoplanin rat-human chimeric antibody NZ-8 against malignant mesothelioma. (2012)
  • Author(s): Yasuhiko Nishioka, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through down-regulation of NF-kappa-B activity. (2012)
  • Author(s): Takuya Kuramoto, et al.
  • Organizer: 14th International Biennial Congress of the Metastasis Research Society
  • Place of Presentation: Brisbane Convention Centre (Australia)
  • Year and Date: 2012-09-04
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model. (2012)
  • Author(s): Hisatsugu Goto, et al.
  • Organizer: 14th International Biennial Congress of the Metastasis Research Society
  • Place of Presentation: Brisbane Convention Centre (Australia)
  • Year and Date: 2012-09-04
• [Presentation] Antitumor effects of anti-podoplanin antibody NZ-1 against malignant mesothelioma. (2012)
  • Author(s): Yasuhiko Nishioka, et al.
  • Organizer: 14th International Biennial Congress of the Metastasis Research Society
  • Place of Presentation: Brisbane Convention Centre (Australia)
  • Year and Date: 2012-09-03
• [Presentation] ヒトキメラ型抗ポドプラニン抗体による転移抑制効果の検討. (2012)
  • Author(s): 辻本雄太, 他.
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: オリエンタルホテル広島 (広島県)
  • Year and Date: 2012-07-12
• [Presentation] ヒトキメラ型抗ポドプラニン抗体による転移抑制機序の解明. (2012)
  • Author(s): 加藤幸成, 他.
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場 (福岡県)
  • Year and Date: 2012-06-28
• [Presentation] 悪性胸膜中皮腫に対するヒトキメラ型抗ポドプラニン抗体NZ-8の抗腫瘍効果. (2012)
  • Author(s): 西岡安彦, 他.
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場 (福岡県)
  • Year and Date: 2012-06-28
• [Presentation] Antitumor effects of anti-podoplanin antibody NZ-1 against malignant mesothelioma via ADCC. (2012)
  • Author(s): Yasuhiko Nishioka, et al.
  • Organizer: ATS 2012 International Conference
  • Place of Presentation: Moscone Center (U.S.A.)
  • Year and Date: 2012-05-23
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in an experimental lung metastasis model. (2012)
  • Author(s): Hisatsugu Goto, et al.
  • Organizer: ATS 2012 International Conference
  • Place of Presentation: Moscone Center (U.S.A.)
  • Year and Date: 2012-05-23
• [Presentation] Antibody-dependent cellular cytotoxicity against mesothelioma cells mediated by anti-HM 1.24 antibodies. (2012)
  • Author(s): Jun Huang, et al.
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター (兵庫県)
  • Year and Date: 2012-04-22
• [Presentation] Surfactant protein A suppresses progression of human lung adenocarcinoma in nude mice via modulating host immune response. (2012)
  • Author(s): Atsushi Mitsuhashi, et al.
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター (兵庫県)
  • Year and Date: 2012-04-21
• [Presentation] 悪性胸膜中皮腫に対する抗ポドプラニン抗体NZ-1の抗腫瘍効果に関する検討. (2012)
  • Author(s): 阿部真治, 他.
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター (兵庫県)
  • Year and Date: 2012-04-20
• [Presentation] Dll4-Fc, an inhibitor of Dll4-notch signaling, suppresses liver metastasis of small cell lung cancer cells through down-regulation of NF-kappa-B activity. (2012)
  • Author(s): Takuya Kuramoto, et al.
  • Organizer: AACR Annual Meeting 2012
  • Place of Presentation: McCormick Place West (U.S.A.)
  • Year and Date: 2012-04-02
• [Presentation] Therapeutic efficacy of RNA interference targeting focal adhesion kinase against orthotropic xenograft of human malignant pleural mesothelioma in SCID mice.
  • Author(s): Jun Huang, Dai-Shun Liu, Soji Kakiuchi, Hisatsugu Goto, Masaki Hanibuchi, Yasuhiko Nishioka
  • Organizer: AACR Annual Meeting 2013
  • Place of Presentation: Walter E. Washington Convention Center (U.S.A.)
• [Presentation] Surfactant protein A suppresses lung cancer progression by regulating tumor-associated macrophage polarization.
  • Author(s): Hisatsugu Goto, Atsushi Mitsuhashi, Takuya Kuramoto, Sho Tabata, Sawaka Yukishige, Masaki Hanibuchi, Soji Kakiuchi, Atsuro Saijo, Yoshinori Aono, Hisanori Uehara, Seiji Yano, Julie G. Ledford, Saburo Sone, Yasuhiko Nishioka
  • Organizer: ATS 2013 Conference
  • Place of Presentation: Pennsylvania Convention Center (U.S.A.)
• [Presentation] Phase Ii study of S-1 with patient-reported outcome evaluation in elderly patients with advanced non-small cell lung cancer.
  • Author(s): Hisatsugu Goto, Fumitaka Ogushi, Takashi Haku, Tomoyuki Urata, Takanori Kanematsu, Soji Kakiuchi, Masaki Hanibuchi, Saburo Sone, Yasuhiko Nishioka
  • Organizer: 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: パシフィコ横浜 (神奈川県)
• [Presentation] Therapeutic efficacy of endothelin receptor blockade on experimental brain metastases of human non-small cell lung cancer.
  • Author(s): Masaki Hanibuchi, Sun-Jin Kim, Kenji Otsuka, Atsushi Mitsuhashi, Hisatsugu Goto, Yasuhiko Nishioka, Isaiah J. Fidler
  • Organizer: 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: パシフィコ横浜 (神奈川県)
• [Presentation] Therapeutic efficacy of RNA interference targeting focal adhesion kinase against orthotropic xenograft of human malignant pleural mesothelioma in SCID mice.
  • Author(s): Jun Huang, Dai-Shun Liu, Soji Kakiuchi, Hisatsugu Goto, Masaki Hanibuchi, Yasuhiko Nishioka
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム (東京都)
• [Presentation] ヒトNK細胞を介した抗ポドプラニン抗体NZ-8の悪性胸膜中皮腫に対する抗腫瘍効果.
  • Author(s): 阿部真治, 加藤幸成, 金子美華, 木宿昌俊, 川添和義, 東満美, 埴淵昌毅, 水口和生, 西岡安彦
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム (東京都)
• [Presentation] 悪性胸膜中皮腫同所移植マウスモデルにおける抗VEGF治療耐性化メカニズムの検討.
  • Author(s): 三橋惇志, 後東久嗣, 西條敦郎, 倉本卓哉, 田畑祥, 埴淵昌毅, 矢野聖二, 曽根三郎, 西岡安彦
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館 (京都府)
• [Presentation] 悪性中皮腫におけるPAPPAの機能解析と分子標的治療法開発の検討.
  • Author(s): 黄俊, 田畑祥, 埴淵昌毅, 西岡安彦
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館 (京都府)
• [Presentation] Endothelin受容体拮抗剤による肺癌脳転移抑制効果の検討.
  • Author(s): 埴淵昌毅, 大塚憲司, 後東久嗣, 倉本卓哉, 三橋惇志, 西岡安彦, 曽根三郎, Fidler Isaiah J.
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館 (京都府)
• [Presentation] がん分子標的治療の基礎と臨床.
  • Author(s): 西岡安彦
  • Organizer: 日本放射線腫瘍学会 第15回放射線腫瘍学夏季セミナー
  • Place of Presentation: あわぎんホール (徳島県)
  • Invited
• [Presentation] Translational Research.
  • Author(s): 西岡安彦
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 東北大学百周年記念会館 川内萩ホール (宮城県)
  • Invited