Exploration of specific biomarkers for carbonyl stress inducible disease.

• Project/Area Number: 24390211
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: ITO Sadayoshi 東北大学, 医学(系)研究科(研究院), 教授 (40271613)
• Co-Investigator(Kenkyū-buntansha): MORI Takefumi 東北大学, 大学院医学系研究科, 准教授 (40375001) ; NIWANO Yoshimi 東北大学, 大学院歯学研究科, 教授 (40375184) ; SATO Emiko 東北大学, 大学院薬学研究科, 助教 (20466543)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
• Keywords: カルボニルストレス / メチルグリオキサール / 高血圧 / 腎障害 / レニンアンジオテンシン系 / (プロ)レニン受容体 / 免疫応答 / ERK / 腹膜中皮細胞 / 免疫細胞 / 炎症反応 / 慢性腎臓病 (CKD) / バイオマーカー探索 / グリオキシラーゼ1 (GLO1) / モデル動物 / 初代培養細胞 / 慢性腎臓病(CKD) / グリオキシラーゼ1(GLO1)

Outline of Final Research Achievements

Administration of methylglyoxal (MG) to Dahl salt sensitive rats increased blood pressure, renal injury and cardiac-fibrosis. Simultaneously treatment with angiotensin II (AngII) receptor blocker (ARB) ameliorated MG induced blood pressure increase, renal injury and cardiac injury. These results indicate that renin angiotensin system (RAS) partially contribute hypertension and organ injury induced by carbonyl stress.
Since RAS is involved in inflammation, we evaluated the contribution of (pro)renin receptor [(P)RR] to inflammatory reaction. Renin stimulation induced ERK phosphorylation, COX-2 mRNA expression and IL-6 secretion in human peripheral blood mononuclear cells. (P)RR siRNA treatment ameliorated ERK phosphorylation induced by renin stimulation in human leukemic monocyte lymphoma cells. These results indicates that (P)RR could contribute inflammatory response in human inflammatory cells.

Research Products

• [Journal Article] Elucidation of the etiology and characteristics of pink urine in young healthy subjects (2015)
  • Author(s): Ogawa S, Takiguchi J, Nako K, Okamura M, Sakamoto T, Kabayama S, Mori T, Kinouchi Y, Ito S
  • Journal Title: Clin Exp Nephrol Volume: In Press
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension. (2015)
  • Author(s): Cowley AW Jr, Abe M, Mori T, O'Connor PM, Ohsaki Y, Zheleznova NN
  • Journal Title: Am J Physiol Renal Physiol Volume: 308 Issue: 3 Pages: F179-F197
  • DOI: 10.1152/ajprenal.00455.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A functional (pro)renin receptor is expressed in human lymphocytes and monocytes. (2015)
  • Author(s): Narumi K, Hirose T, Sato E, Mori T, Kisu K, Ishikawa M, Totsune K, Ishii T, Ichihara A, Nguyen G, Sato H, Ito S.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 308 Issue: 5 Pages: F487-F499
  • DOI: 10.1152/ajprenal.00206.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diurnal variations of blood glucose by continuous blood glucose monitoring in peritoneal dialysis patients with diabetes. (2014)
  • Author(s): Mori T, Chida M, Oba I, Koizumi K, Furusho M, Tanno M, Naganuma E, Ito S.
  • Journal Title: Adv Perit Dial Volume: 30 Pages: 54-59
  • Peer Reviewed
• [Journal Article] Impact of hydration and nutrition status on the Watson formula in peritoneal dialysis patients. (2014)
  • Author(s): Furusho M, Weng J, Mori T, Wang T
  • Journal Title: Adv Perit Dial Volume: 30 Pages: 110-114
  • Peer Reviewed
• [Journal Article] Expression of (pro)renin receptor and its upregulation by high salt intake in the rat nephron. (2014)
  • Author(s): Rong R, Ito O, Mori N, Muroya Y, Tamura Y, Mori T, Ito S, Takahashi K, Totsune K, Kohzuki M
  • Journal Title: Peptides. Volume: 63C Pages: 156-162
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Predictors of decreasing glomerular filtration rate and prevalence of chronic kidney disease after treatment of primary aldosteronism: Renal outcome of 213 cases. (2014)
  • Author(s): Iwakura Y, Morimoto R, Kudo M, Ono Y, Takase K, Seiji K, Arai Y, Nakamura Y, Sasano H, Ito S, Satoh F
  • Journal Title: J Clin Endocrinol Metab Volume: In Press
  • Peer Reviewed
• [Journal Article] Effect of a hydrogen (H2 )-enriched solution on the albumin redox of hemodialysis patients. (2014)
  • Author(s): Terawaki H, Zhu WJ, Matsuyama Y, Terada T, Takahashi Y, Sakurai K, Kabayama S, Miyazaki M, Itami N, Nakazawa R, Ito S, Era S, Nakayama M
  • Journal Title: Hemodial Int Volume: In Press Issue: 2 Pages: 459-466
  • DOI: 10.1111/hdi.12112
  • Peer Reviewed
• [Journal Article] Effects of exercise training on nitric oxide synthase in the kidney of spontaneously hypertensive rats (2013)
  • Author(s): Ito D, Ito O, Cao P, Mori N, Suda T, Muroya Y, Takashima K, Ito S, Kohzuki M
  • Journal Title: Clin Exp Pharma Physiol Volume: 40 Issue: 2 Pages: 74-82
  • DOI: 10.1111/1440-1681.12040
  • Peer Reviewed
• [Journal Article] Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. (2013)
  • Author(s): Terawaki H, Nakayama M, Miyazawa E, Murata Y, Nakayama K, Matsushima M, Miyazaki M, Sato H, Sato M, Sato T, Taguma Y, Ito S
  • Journal Title: Clin Exp Nephrol Volume: 17(4) Issue: 4 Pages: 549-553
  • DOI: 10.1007/s10157-012-0742-z
  • NAID: 10031195319
  • Peer Reviewed
• [Journal Article] Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats. (2013)
  • Author(s): Chen x, Mori T, Guo Q, Hu C, Ohsaki Y, Yoneki Y, Zhu W, Jiang Y, Endo S, Nakayama K, Ogawa S, Nakayama M, Miyata T, Ito S
  • Journal Title: Hypertens Res. Volume: (印刷中) Issue: 4 Pages: 361-367
  • DOI: 10.1038/hr.2012.204
  • Peer Reviewed
• [Journal Article] Identification of the Stages of Diabetic Nephropathy at Which Angiotensin II Receptor Blockers Most Effectively Suppress Albuminuria (2013)
  • Author(s): Ogawa S, Matsushima M, Mori T, Okamura M, Senda M, Sakamoto T, Nako K, Ito S
  • Journal Title: Am J Hypertens Volume: 26(9) Issue: 9 Pages: 1064-1069
  • DOI: 10.1093/ajh/hpt085
  • Peer Reviewed
• [Journal Article] Erratum to: Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. (2013)
  • Author(s): Terawaki H, Nakayama M, Miyazawa E, Murata Y, Nakayama K, Matsushima M, Miyazaki M, Sato H, Sato M, Sato T, Taguma Y, Ito S
  • Journal Title: Clin Exp Nephrol Volume: 17(4) Pages: 554-554
  • Peer Reviewed
• [Journal Article] A Decline in Glomerular Filtration Rate Rather than Renal Arterial Stenotic Lesions, per se, Predicts Cardiovascular-Renal Events in Type 2 Diabetic Patients (2013)
  • Author(s): Ogawa S, Nako K, Okamura M, Senda M, Sakamoto T, Abe T, Ito S
  • Journal Title: Circ J Volume: 77(11) Pages: 2816-2822
  • NAID: 10031196836
  • Peer Reviewed
• [Journal Article] Beneficial Role of Tolvaptan in the Control of Body Fluids Without Reductions in Residual Renal Function in Patients Undergoing Peritoneal Dialysis (2013)
  • Author(s): Mori T, Oba I, Koizumi K, Kodama M, Shimanuki M, Tanno M, Chida M, Saito M, Kiyomoto H, Miyazaki M, Ogawa S, Sato H, Ito S
  • Journal Title: Advances in Peritoneal Dialysis Volume: 29 Pages: 33-37
  • Peer Reviewed
• [Journal Article] Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water. (2013)
  • Author(s): Zhu WJ, Nakayama M, Mori T, Hao K, Terawaki H, Katoh J, Kabayama S, Ito S
  • Journal Title: Med Gas Res Volume: 3(1) Issue: 1 Pages: 26-26
  • DOI: 10.1186/2045-9912-3-26
  • Peer Reviewed
• [Journal Article] Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. (2013)
  • Author(s): Terawaki H, Nakayama M, Miyazawa E, Murata y Nakayama K, Matsushima M, Miyazaki M, Sato H, Sato M, Sato T, Taguma y Ito S
  • Journal Title: Clin Exp Nephrol. Volume: (印刷中)
  • NAID: 10031195319
  • Peer Reviewed
• [Journal Article] Cardiorenal syndrome an evolutionary point of view (2012)
  • Author(s): Ito S
  • Journal Title: Hypertension Volume: 60 Issue: 3 Pages: 589-595
  • DOI: 10.1161/hypertensionaha.111.188706
  • Peer Reviewed
• [Journal Article] Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan. (2012)
  • Author(s): Ito S, Naritomi H, Ogihara T, Shimada K, Shimamoto K, Tanaka H, Yoshiike N
  • Journal Title: Hypertension Research Volume: 35(8) Issue: 8 Pages: 867-873
  • DOI: 10.1038/hr.2012.59
  • Peer Reviewed
• [Journal Article] Role of speci丘c T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation. (2012)
  • Author(s): Hu C, Mori T, Lu Y, Guo Q, Sun Y, Yoneki Y, Ohsaki Y, Nakamichi T, Oba I, Sato E, Ogawa S, Dickinson BC, Chang CJ, Miyata T, Sato H, ItoS
  • Journal Title: J Hypertens Volume: 30(8) Issue: 8 Pages: 1620-1631
  • DOI: 10.1097/hjh.0b013e3283550e9f
  • Peer Reviewed
• [Journal Article] Albuminuria indicates the pressure-associated injury of juxtamedullary nephrons and cerebral strain vessels in spontaneously hypertensive stroke-prone rats. (2012)
  • Author(s): Nagasawa T, Mori T Ohsaki Y, Yoneki Y Guo Q, Sato E, Oba I, ItoS
  • Journal Title: Hypertens Res Volume: 35(10) Issue: 10 Pages: 1024-1031
  • DOI: 10.1038/hr.2012.112
  • Peer Reviewed
• [Journal Article] Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats (2012)
  • Author(s): Guo Q, 他
  • Journal Title: Hypertens Res Volume: 35 Issue: 1 Pages: 48-54
  • DOI: 10.1038/hr.2011.140
  • Peer Reviewed
• [Journal Article] A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS). (2012)
  • Author(s): Akiyama Y.
  • Journal Title: Toxins Volume: 4 Issue: 11 Pages: 1309-1322
  • DOI: 10.3390/toxins4111309
  • Peer Reviewed
• [Presentation] 腹膜透析患者における血糖変動とインスリン分泌 (2015)
  • Author(s): 12.森建文、千田真貴子、小泉賢治、大場郁子、佐藤真一、永沼絵理、倉澤奈穂、土川未歩子、伊藤貞嘉
  • Organizer: 第5回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 都市センターホテル（東京）
  • Year and Date: 2015-03-21
• [Presentation] ブドウ糖分解産物による腹膜傷害と腹膜中皮細胞の移植の検討 (2015)
  • Author(s): 大場郁子、森建文、大崎雄介、高橋知香、伊藤貞嘉
  • Organizer: 第5回日本腎臓リハビリテーション学会学術集会
  • Place of Presentation: 都市センターホテル（東京）
  • Year and Date: 2015-03-21
• [Presentation] Glucose and Insulin Response to Peritoneal Dialysis Fluid in Diabetic and Non-diabetic Peritoneal Dialysis Patients (2015)
  • Author(s): Mori T, Chida M, Oba I, Koizumi K, Sato S, Naganuma E, Kurasawa N, Ito S
  • Organizer: 35th Annual Dialysis Conference
  • Place of Presentation: Louisiana, USA
  • Year and Date: 2015-02-02
• [Presentation] Association Between Home Blood Pressure and Body Composition by Bio-impedance Monitoring in Patients Undergoing Peritoneal Dialysis. (2015)
  • Author(s): Kurasawa N, Mori T, Naganuma E, Sato E, Oba I, Koizumi K, Sato S, Ito S
  • Organizer: 35th Annual Dialysis Conference
  • Place of Presentation: Louisiana, USA
  • Year and Date: 2015-02-02
• [Presentation] CKDにおける臓器連関と体液調節機序 (2014)
  • Author(s): 森建文、大場郁子、小泉賢治、大崎雄介、伊藤貞嘉
  • Organizer: 第44回日本腎臓学会東部学術大会
  • Place of Presentation: ベルサール新宿グランド（東京）
  • Year and Date: 2014-10-24
  • Invited
• [Presentation] 尿混濁（尿酸析出）と尿pH、肥満、高血圧の関連とそのメカニズムの解明 (2014)
  • Author(s): 小川晋、滝口純子、岡村将史、奈古一宏、坂本拓矢、樺山繁、森建文、木内喜孝、伊藤貞嘉
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2014-10-17
• [Presentation] 糖尿病合併腹膜透析患者における血糖変動 (2014)
  • Author(s): 千田真貴子、森建文、小泉賢治、大場郁子、永沼絵里、倉澤菜穂、伊藤貞嘉
  • Organizer: 第20回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 山形国際ホテル（山形）
  • Year and Date: 2014-09-07
• [Presentation] 腹膜透析排液における可溶性(プロ)レニン受容体のバイオマーカーとしての意義 (2014)
  • Author(s): 大場郁子、森建文、植木有理子、高橋知香、廣瀬卓男、小泉賢治、千田真貴子、倉澤菜穂、永沼絵里、伊藤貞嘉
  • Organizer: 第20回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 山形国際ホテル（山形）
  • Year and Date: 2014-09-06
• [Presentation] 心不全を伴う腹膜透析におけるV2受容体拮抗薬による残腎機能を保持した体液調整と左心室重量係数に対する効果 (2014)
  • Author(s): 小泉賢治、森建文、大場郁子、伊藤貞嘉
  • Organizer: 第20回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 山形国際ホテル（山形）
  • Year and Date: 2014-09-06
• [Presentation] 二次性高血圧の鑑別 (2014)
  • Author(s): 森建文
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜）
  • Year and Date: 2014-07-06
  • Invited
• [Presentation] 腹膜透析におけるGlyoxalase1を介した腹膜保護戦略 (2014)
  • Author(s): 大場 郁子、森 建文、大崎 雄介、宮田 敏男、伊藤 貞嘉
  • Organizer: 第59回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Year and Date: 2014-06-13
• [Presentation] 慢性腎臓病における脳腎連関のメカニズム (2014)
  • Author(s): 森建文
  • Organizer: 第59回日本透析医学会学術集会・総会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Year and Date: 2014-06-13
  • Invited
• [Presentation] Solubleform of (pro)renin receptor is excreted from mesothelial cells to peritoneal dialysis effluent of peritoneal dialysis patients. (2014)
  • Author(s): Oba I, Mori T, Takahashi C, Ohsaki Y, Sato E, Koizumi K, Furusho M, Chida M, Naganuma E, Ito S
  • Organizer: Experimental Biology 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-30
• [Presentation] (Pro)Renin Receptor in Peritoneal Dialysis Patients. (2013)
  • Author(s): Ikuko Oba, Takefumi Mori, Chika Takahashi, Kaori Narumi, Yusuke Ohsaki, Makiko Chida, Kenji Koizumi, Masahide Furushoi, Mizuho Tanno, Mayumi Kodama,Sadayoshi Ito
  • Organizer: International Society of Peritoneal Dialysis Asian-Pacific Chapter Meeting
  • Place of Presentation: Taipei, China
• [Presentation] 若年層の生活習慣病予備群では腎内レニン・アンジオテンシン系、酸化ストレスおよび炎症が亢進しているのか? (2012)
  • Author(s): 佐藤恵美子、森建文、中道淑美、大場郁子、佐藤博、飛田渉、伊藤貞嘉
  • Organizer: 第16回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2012-11-23
• [Presentation] 腹膜透析におけるカルボニルストレスによる腹膜障害機序の解明 (2012)
  • Author(s): 大場郁子、森建文、佐藤恵美子、中道淑美、赤尾研人、宮田敏男、伊藤貞嘉
  • Organizer: 第18回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 徳島
  • Year and Date: 2012-09-22
• [Presentation] 急性腎障害におけるミトコンドリア内活性酸素種の役割 (2012)
  • Author(s): 赤尾研人、森建文、芦骰、米城淑美、清元秀泰、伊藤肖嘉
  • Organizer: 第16回腎間質障害研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-08
• [Presentation] 急性腎障害におけるミトコンドリア内活性酸素種の役割 (2012)
  • Author(s): 赤尾研人、森建文、芦毅、米城淑美、清元秀泰、伊藤貞嘉
  • Organizer: 第四回腎疾患と高血圧研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-07
• [Presentation] 若年者におけるレニン・アンジオテンシン系と酸化ストレスおよび炎症マーカーの関連才 (2012)
  • Author(s): 森建文、佐藤恵美子、藤原睦子、米城淑美、大場郁子、伊藤貞嘉
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-23
• [Presentation] 慢性腎不全ラットの加齢に伴う心臀連関障害に対する水素(H2)含有電解水の長期飲用による抑制効果 (2012)
  • Author(s): 朱万君、樺山繁、森建文、中山昌明、伊藤貞嘉
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-23
• [Presentation] 腎髄質循環におけるミトコンドリアストレス (2012)
  • Author(s): 森建文
  • Organizer: 第55回日本腎臓学会学術総会(シンポジウム)
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-02
• [Presentation] ミトコンドリアROSによる腎髄質機能への関与 (2012)
  • Author(s): 赤尾研人、芦毅、森建文、米城淑美、清元秀泰、伊藤貞嘉
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-02
• [Presentation] メチルグリオキサールによる腹膜障害に対するGLO-1の役割 (2012)
  • Author(s): 大場郁子、森建文、佐藤恵美子、米城淑美、赤尾研人、宮田敏男、伊藤貞嘉
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-01
• [Presentation] 腎疾患における糖化ストレス (2012)
  • Author(s): 森 建文
  • Organizer: 第2回糖化ストレス研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] 若年肥満者の高血圧と尿中バイオマーカーの関連 (2012)
  • Author(s): 佐藤恵美子、森建文、米城淑美、大場郁子、伊藤貞嘉
  • Organizer: 第1回臨床高血圧フォーラム
  • Place of Presentation: 大阪
  • Year and Date: 2012-05-12
• [Presentation] Role of glyoxalase system on methylglyoxal induced peritoneal thickeness in glyoxalase transgenic rats. (2012)
  • Author(s): I. Ooba, T. Mori, E. Sato, Y. Yoneki, K. Akao, M. Ishikawa, K. Kisu, H. Ito, M. Saito, T. Nakamichi, H. Kiyomoto, M. Miyazaki, T. Miyata, H. Sato and S. Ito.
  • Organizer: Experimental Biology 2012
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2012-04-22
• [Presentation] 腎ミトコンドリア内酸化ストレスの抑制が腎循環に及ぼす影響の検討 (2012)
  • Author(s): 米城淑美、森建文、赤尾研人、芦毅、伊藤貞嘉
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-04-21
• [Presentation] Carbonyl Stress Mediated Peritoneal Thickness is Reduced in Glyoxalase Transgenic Rats. (2012)
  • Author(s): Ikuko Oba, Takefumi Mori, Emiko Sato, Yoshimi Yoneki, Mai Saito, Hideyasu Kiyomoto, Mariko Miyazaki, Toshio Miyata, Hiroshi Sato, Sadayoshi Ito.
  • Organizer: 14th Congress of the International Society for Peritoneal Dialysis
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Overexpression of glyoxalase 1 attenuates methylglyoxal-induced peritoneal injury with suppression of epithelial mesenchymal transition pathway and neovascularization in Wistar rats
  • Author(s): Ikuko Oba, Takefumi Mori, Yusuke Ohsaki, Emiko Sato, Yoshimi Yoneki, Toshio Miyata, Sadayoshi Ito
  • Organizer: Experimental Biology
  • Place of Presentation: Boston, USA
• [Presentation] Chronic Kidney Disease and Uric Acid
  • Author(s): Sadayoshi Ito
  • Organizer: ISARSH 2013
  • Place of Presentation: 仙台
  • Invited
• [Presentation] Should patients with CKD be salt restｒicted?
  • Author(s): Sadayoshi Ito
  • Organizer: WCN2013
  • Place of Presentation: HongKong, China
  • Invited
• [Presentation] Cardio-renal connection
  • Author(s): Sadayoshi Ito
  • Organizer: APCCN2013
  • Place of Presentation: 東京
  • Invited
• [Presentation] Cardiorenal Syndrome and Medullary Circulation
  • Author(s): Sadayoshi Ito
  • Organizer: FASEB2013
  • Place of Presentation: Saxtons River, USA
  • Invited
• [Presentation] Strain vessel: a link between microalbuminuria and cardiovascular disease and salt sensitive hypertension
  • Author(s): Sadayoshi Ito
  • Organizer: The 20th Budapest Nephrology School
  • Place of Presentation: Budapest, Hungary
  • Invited
• [Presentation] Methylglyoxal: a new target in CKD
  • Author(s): Sadayoshi Ito
  • Organizer: The 20th Budapest Nephrology School
  • Place of Presentation: Budapest, Hungary
  • Invited
• [Presentation] Overexpression of glyoxalase 1 attenuates methylglyoxal-induced epithelial mesenchymal transition and peritoneal fibrosis in Wistar rats
  • Author(s): Ikuko Oba, Takefumi Mori, Yusuke Ohsaki, Emiko Sato, Yoshimi Nakamichi, Kenji Koizumi, Masahide Furusho, Toshio Miyata, Sadayoshi Ito
  • Organizer: European Society of Peritoneal Dialysis
  • Place of Presentation: Maastricht, Nederland
• [Presentation] V2 receptor antagonist tolvaptan ameliorates left ventricular mass index (LVMI) and urinary output without reduction in residual renal function in patients on peritoneal dialysis (PD)
  • Author(s): Kenji Koizumi, Takefumi Mori, Ikuko Oba, Sadayoshi Ito
  • Organizer: American Society of Nephrology
  • Place of Presentation: Atlanta, USA
• [Presentation] 進化と腎臓
  • Author(s): 伊藤貞嘉
  • Organizer: 第30回日本臨床内科医会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] コモンディジーズへの挑戦～復興・未来・希望～
  • Author(s): 伊藤貞嘉
  • Organizer: 第86回日本内分泌学会
  • Place of Presentation: 仙台
  • Invited
• [Presentation] 糖尿病腎症を合併した高血圧におけるアルドステロンブロックの臨床的意義
  • Author(s): 伊藤貞嘉
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 糖尿病患者の血圧管理におけるＲＡＳ阻害の意義
  • Author(s): 伊藤貞嘉
  • Organizer: 第56回日本糖尿病学会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] V2受容体拮抗薬による腹膜透析患者の体液管理と残腎機能維持
  • Author(s): 森 建文、大場郁子、小泉賢治、丹野瑞穂、島貫美和子、千田真貴子、大崎雄介、伊藤貞嘉
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] 腹膜透析排液における（プロ）レニン受容体の検討
  • Author(s): 大場郁子、森 建文、大崎雄介、鳴海 かほり、佐藤 恵美子、小泉賢治、丹野瑞穂、島貫美和子、千田真貴子、堀内 孝、伊藤貞嘉
  • Organizer: 第58回日本透析医学会
  • Place of Presentation: 福岡
• [Presentation] 末期腎不全患者における残腎機能に対するV2受容体拮抗薬の役割
  • Author(s): 森 建文、大場郁子、小泉賢治、丹野瑞穂、児玉真由美、千田真貴子、大崎雄介、伊藤貞嘉
  • Organizer: 第13回日本抗加齢医学会総会
  • Place of Presentation: 横浜
• [Presentation] CKD患者における血圧管理
  • Author(s): 伊藤貞嘉
  • Organizer: 第45回日本動脈硬化学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 当科における腹膜透析患者の血清アルブミン値に影響を及ぼす因子
  • Author(s): 丹野瑞穂、森 建文、古庄正英、千田真貴子、小泉賢治、大場郁子、児玉真由美、新沼美喜、伊藤貞嘉
  • Organizer: 第19回日本腹膜透析医学会
  • Place of Presentation: 大阪
• [Presentation] 糖尿病合併腹膜透析患者の持続血糖測定システムを用いた血糖変動調査の症例報告
  • Author(s): 千田真貴子、 森 建文、 大場郁子、 丹野瑞穂、 小泉賢治、古庄正英、 児玉真由美、 新沼美喜、伊藤貞嘉
  • Organizer: 第19回日本腹膜透析医学会
  • Place of Presentation: 大阪
• [Presentation] 体液調節における腎髄質機能の役割
  • Author(s): 伊藤貞嘉
  • Organizer: 第43回日本腎臓学会東部学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 腎と代謝
  • Author(s): 伊藤貞嘉
  • Organizer: 第43回日本腎臓学会西部学術大会
  • Place of Presentation: 松山
  • Invited
• [Presentation] ＣＫＤ合併高血圧の治療：Treatment of hypertensive CKD patients
  • Author(s): 伊藤貞嘉
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Glyoxalase1過剰発現による腹膜保護機序の解明
  • Author(s): 大場 郁子、森 建文、大崎雄介、佐藤恵美子、宮田敏男、伊藤貞嘉
  • Organizer: 日本メイラード学会
  • Place of Presentation: 大阪
• [Presentation] 腎臓と代謝
  • Author(s): 伊藤貞嘉
  • Organizer: 第4回日本腎臓リハビリテーション学会
  • Place of Presentation: 福岡
  • Invited