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Elucidation of the pathogenesis of kidney disease via epigenetic responses against hypoxia

Research Project

Project/Area Number 24390213
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

NANGAKU Masaomi  東京大学, 医学部附属病院, 教授 (90311620)

Co-Investigator(Kenkyū-buntansha) INAGI Reiko  東京大学, 医学部附属病院, 特任准教授 (50232509)
WADA Takehiko  東京大学, 医学部附属病院, 講師 (90447409)
TANAKA Tetsuhiro  東京大学, 医学部附属病院, 病院講師 (90508079)
OHSE Takamoto  東京大学, 医学部附属病院, その他 (10568447)
Co-Investigator(Renkei-kenkyūsha) KODAMA Tatsuhiko  東京大学, 先端科学技術センター, 教授 (90170266)
ABURATANI Hiroyuki  東京大学, 先端科学技術センター, 教授 (10202657)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywords低酸素 / HIF / エピジェネティックス / エピゲノム / ヒストン修飾 / 慢性腎臓病 / 腎細胞癌 / エピジェネティクス
Outline of Final Research Achievements

To elucidate a pathogenic role of epigenetic changes in the kidney in vivo, we tried to optimize experimental conditions to perform ChIP-seq of organs. We attempted to perform PAT-ChIP utilizing laser capture microdissection. However, we could not obtain RNA with the quality high enough for ChIP analysis. We finally decided to perform ChIP of the whole kidney with expectation that the results should reflect change of the tubules, which comprise most of the kidney. We employed a kidney fibrosis model that develops long after transient acute kidney injury by ischemia/reperfusion. We found that fibrotic conditions alter by treatment of compounds that regulate histone modifications.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (57 results)

All 2015 2014 2013 2012 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Acknowledgement Compliant: 5 results,  Open Access: 2 results) Presentation (39 results) (of which Invited: 10 results)

  • [Journal Article] Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein δ..2015

    • Author(s)
      Yamaguchi J, Tanaka T, Eto N, Nangaku M.
    • Journal Title

      Kidney Int

      Volume: x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] SIRT1 maintains actin cytoskeleton by deacetylation of cortactin in injured podocytes.2015

    • Author(s)
      Motonishi S, Nangaku M, Wada T, Ishimoto Y, Ohse T, Matsusaka T, Kubota N, Shimizu A, Kadowaki T, Tobe K, Inagi R.
    • Journal Title

      J Am Soc Nephrol

      Volume: x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation.2014

    • Author(s)
      Jo-Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T, Shirakawa J, Nagai R, Miyata T, Nagano T, Hirata Y, Inagi R, Nangaku M.
    • Journal Title

      Aging Cell

      Volume: Epub ahead of print Issue: 3 Pages: 519-28

    • DOI

      10.1111/acel.12204

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements.2014

    • Author(s)
      Inoue T, Kohro T, Tanaka T, Kanki Y, Li G, Poh HM, Mimura I, Kobayashi M, Taguchi A, Maejima T, Suehiro JI, Sugiyama A, Kaneki K, Aruga H, Dong S, Stevens JF, Yamamoto S, Tsutsumi S, Fujita T, Ruan X, Aburatani H, Nangaku M, Ruan Y, Kodama T, Wada Y.
    • Journal Title

      Genome Biology

      Volume: 15 Issue: 4

    • DOI

      10.1186/gb-2014-15-4-r63

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia as a key player in the AKI-to-CKD transition.2014

    • Author(s)
      Tanaka S, Tanaka T, Nangaku M.
    • Journal Title

      Am J Phyisol Renal Physiol

      Volume: 307 Issue: 11 Pages: F1187-F1195

    • DOI

      10.1152/ajprenal.00425.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hypoxia and fibrosis in chronic kidney disease: crossing at pericytes.2014

    • Author(s)
      Kawakami T, Mimura I, Shoji K, Tanaka T, Nangaku M.
    • Journal Title

      Kidney Int

      Volume: Suppl 4 Pages: 107-112

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role of hypoxia in progressive chronic kidney disease and implications for therapy.2014

    • Author(s)
      Shoji K, Tanaka T, Nangaku M.
    • Journal Title

      Curr Opin Nephrol Hypertens

      Volume: 23 Issue: 2 Pages: 161-8

    • DOI

      10.1097/01.mnh.0000441049.98664.6c

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Revolution of nephrology research by deep sequencing : ChIP-seq and RNA-seq.2014

    • Author(s)
      Mimura I, Kanki Y, Kodama T, Nangaku M.
    • Journal Title

      Kidney International

      Volume: 85 Issue: 1 Pages: 31-38

    • DOI

      10.1038/ki.2013.321

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indoxyl sulfate signals for rapid mRNA stabilization of Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) and suppresses the expression of hypoxia-inducible genes in experimental CKD and uremia2013

    • Author(s)
      Tanaka T, Yamaguchi J, Higashijima Y, Nangaku M
    • Journal Title

      FASEB J

      Volume: 27 Issue: 10 Pages: 4059-4075

    • DOI

      10.1096/fj.13-231837

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates eytokinesis, and its expression correlates with the prognosis of renal cell earcinoma.2013

    • Author(s)
      Shoji K, Mimura I, Murayama T, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M.
    • Journal Title

      American Journal of Pathology

      Volume: 182 Issue: 6 Pages: 2191-2203

    • DOI

      10.1016/j.ajpath.2013.02.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum stress signal impairs erythropoietin production:a role for ATF4.2013

    • Author(s)
      Chiang CK, Nangaku M, Tanaka T, IwawakiT, Inagi R.
    • Journal Title

      Am J Physiol Cell Physiol.

      Volume: 304(4) Issue: 4 Pages: C342-C353

    • DOI

      10.1152/ajpcell.00153.2012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic strategy with hypoxia-inducible factors via reversible epigenetic regulation mechanisms in progressive tubulointerstitial fibrosis.2013

    • Author(s)
      Mimura I, Tanaka T, Nangaku M.
    • Journal Title

      Seminars in Nephrology

      Volume: 33 Issue: 4 Pages: 375-382

    • DOI

      10.1016/j.semnephrol.2013.05.009

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenesis and hypoxia.2013

    • Author(s)
      Tanaka T, Nangaku M
    • Journal Title

      Nature Rev Nephrol

      Volume: 9 Issue: 4 Pages: 211-22

    • DOI

      10.1038/nrneph.2013.35

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HIF regulation in kidney disease.2013

    • Author(s)
      Nangaku M, Rosenberger C, Heyman SN, Eckardt KU
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 40 Issue: 2 Pages: 148-57

    • DOI

      10.1111/1440-1681.12005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel roles of complement in renal diseases and their therapeutic consequences.2013

    • Author(s)
      Wada T, Nangaku M.
    • Journal Title

      Kidney Int

      Volume: 84 Issue: 3 Pages: 441-50

    • DOI

      10.1038/ki.2013.134

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sperm-associated antigen 4, a novel hypoxia-inducible factor l target, regulates cytokinesis and its expression correlates with the prognosis of renal cell carcinoma.2013

    • Author(s)
      Shoji K, et al.
    • Journal Title

      Am J Pathol

      Volume: (in press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host2012

    • Author(s)
      Tanaka T
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 42 Pages: 34866-34882

    • DOI

      10.1074/jbc.m112.374587

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible factor 1 and KDM3A.2012

    • Author(s)
      Mimura I
    • Journal Title

      Mol Cell Biol.

      Volume: Aug;32(15) Issue: 15 Pages: 3018-3032

    • DOI

      10.1128/mcb.06643-11

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hypoxia and Renal Disease.2015

    • Author(s)
      Masaomi Nangaku
    • Organizer
      8th World Congress of Nephrology
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2015-03-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Diabetic nephropathy and metabolic memory: role of epigenetics.2014

    • Author(s)
      Masaomi Nangaku
    • Organizer
      45th Indian Society of Nephrology Conference.
    • Place of Presentation
      Kolkata, India
    • Year and Date
      2014-12-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Hypoxic HIF, Fibrosis, and CKD.2014

    • Author(s)
      Masaomi Nangaku
    • Organizer
      The 47th Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Long-Chain Saturated Fatty Acid-Induced Endoplasmic Reticulum Stress Suppresses Erythropoietin Production in Kidney.2014

    • Author(s)
      Thitinun Anusornvongchai, Chih-Kang Chiang, Yu Ishimoto, Norio Suzuki, Masayuki Yamamoto, Masaomi Nangaku, Reiko Inagi.
    • Organizer
      The 47th Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] SIRT1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Podocytes.2014

    • Author(s)
      Shuta Motonishi, Masaomi Nangaku, Takehiko Wada, Yu Ishimoto, Taiji Matsusaka, Akira Shimizu, Reiko Inagi.
    • Organizer
      The 47th Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways.2014

    • Author(s)
      Hideki Kato, Taiji Matsusaka, Masaomi Nangaku.
    • Organizer
      The 47th Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Epigenetic Induction of Kidney Lineages in Human Kidney Derived iPS Cells.2014

    • Author(s)
      Osamu Takase, Masaomi Nangaku, Keiichi Hishikawa.
    • Organizer
      The 47th Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] SIRT1 MAINTAINS ACTIN CYTOSKELETON BY DEACETYLATION OF CORTACTIN IN PODOCYTES2014

    • Author(s)
      Reiko Inagi, Shuta Motonishi, Masaomi Nangaku
    • Organizer
      The 51st European Renal Association/European Dialysis and Transplantation Association
    • Place of Presentation
      Amsterdam, the Netherlands
    • Year and Date
      2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] A NON-TRANSCRIPTIONAL ROLE OF HYPOXIA-INDUCIBLE FACTOR (HIF)-1 IN DEFENSE AGAINST DNA DOUBLE STRAND INJURY.2014

    • Author(s)
      Tetsuhiro Tanaka, Yoshiki Higashijima, Shinji Tanaka, Junna Yamaguchi, Masaomi Nangaku
    • Organizer
      The 51st European Renal Association/European Dialysis and Transplantation Association
    • Place of Presentation
      Amsterdam, the Netherlands
    • Year and Date
      2014-06-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Histone modifications in kidney disease2014

    • Author(s)
      Masaomi Nangaku
    • Organizer
      International Society of Nephrology, NEXUS-drug discovery
    • Place of Presentation
      Belgamo, Italy
    • Year and Date
      2014-04-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病と癌における低酸素とHIFの役割の解明.2012

    • Author(s)
      南学正臣
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡 Japan(招待講演)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Uremia and hypoxic organ damage: a long-term consequence.2012

    • Author(s)
      Nangaku M
    • Organizer
      30th International Society of Blood Purification.
    • Place of Presentation
      パシフィコ横浜 Japan(招待講演)
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Epigenetic modulation of renal ischemic response.2012

    • Author(s)
      Nangaku M
    • Organizer
      ISN Forefront Systems Biology and the Kidney.
    • Place of Presentation
      Michigan, USA(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ChIP-seq revealed dynamic change of the chromatin conformation of GL UT3 in response to hypoxia via epigenetic modification.2012

    • Author(s)
      Mimura I, et al.
    • Organizer
      ISN Forefront Systems Biology and the Kidney.
    • Place of Presentation
      Michigan, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Activation of a HIF1 alpha-PPAR delta axis underlies the induction of ANGPTL4, a mediator of nephrotic syndrome, under hypoxia.2012

    • Author(s)
      Inoue T, et al.
    • Organizer
      ISN Forefront Systems Biology and the Kidney.
    • Place of Presentation
      Michigan, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] miR-205 modulates cellular senescence state caused by oxidative and endoplasmic reticulum (ER) stresses in renal tubular cells.2012

    • Author(s)
      Muratsu S, et al.
    • Organizer
      Keystone Symposium: Aging and diseases of aging.
    • Place of Presentation
      シェラトン都ホテル、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synchronous recruitment of two transcription complexes exist under synergistic induction of ANGPTL4 by two different stimuli.2012

    • Author(s)
      Inoue T, et al.
    • Organizer
      Keystone Symposium: Aging and diseases of aging.
    • Place of Presentation
      シェラトン都ホテル、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glyoxalase I ameliorates age-related endothelial dysfunction.2012

    • Author(s)
      Jo A, et al.
    • Organizer
      Keystone Symposium: Aging and diseases of aging.
    • Place of Presentation
      シェラトン都ホテル、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] GLUT3 expression is enhanced by chromatin conformational change in response to hypoxia via cooperative interaction of HIF1 and KDM3A.2012

    • Author(s)
      Mimura I, et al.
    • Organizer
      Keystone Symposium: Aging and diseases of aging.
    • Place of Presentation
      シェラトン都ホテル、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Downregulation of miR-205 Modulates Cell Susceptibility to Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells.2012

    • Author(s)
      Muratsu S, et al.
    • Organizer
      The 45^<th> Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Anthracycline Inhibits Recruitment of Hypoxia-Inducible Transcription Factors, Blunts the Induction of Lysyl Oxidase and Suppresses Migration of Renal Cell Carcinoma.2012

    • Author(s)
      Tanaka T, et al.
    • Organizer
      The 45^<th> Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification and Characterization of a Novel HIF-1 Target that Regulates Cytokinesis as a Defensive Mechanism against Polyploidy.2012

    • Author(s)
      Shoji K, et al.
    • Organizer
      The 45^<th> Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dynamic Change of the Chromatin Conformation in Response to Hypoxia Enhances the Expression of GLUT3 (SLC2A3) by Cooperative Interaction of HIF1 and KDM3A.2012

    • Author(s)
      Mimura l, et al.
    • Organizer
      The 45^<th> Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] ANGPTL4, a Mediator of Nep!irotic Syndrome, Is Induced through a HIF1 alpha-PPAR beta/delta Axis under Hypoxia.2012

    • Author(s)
      Inoue T, et al.
    • Organizer
      The 45^<th> Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Downregulation of miR-205 Modulates Cell Susceptibility t0 Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells.2012

    • Author(s)
      Muratsu S, et al.
    • Organizer
      The 45^<th> Annual Meeting of the American Society of Nephrology.
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Breathless: Dynamic Changes in Chromatin Conformation in Renal Hypoxia.

    • Author(s)
      Nangaku M
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Indoxyl Sulfate Signals for Rapid mRNA Stabilization of Cbp/p300-Interacting Transactivator with Glu/Asp-Rich Carboxy-Terminal Domain 2 (CITED2) and Suppresses the Expression of Hypoxia-Inducible Genes in Experimental CKD and Uremia.

    • Author(s)
      Tetsuhiro Tanaka, Junna Yamaguchi, Yoshiki Higashijima, Masaomi Nangaku.
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Glyoxalase I Prevents Age-Related Endothelial Dysfunction through Modulation of eNOS Phosphorylation.

    • Author(s)
      Airi Jo, Takamoto Ohse, Hiroaki Nishimatsu, Masao Takahashi, Satoshi Unuma, Takehiko Wada, Yoichiro Ikeda, Toshio Miyata, Yasunobu Hirata, Reiko Inagi, Masaomi Nangaku.
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Optimal Hemoglobin Target Might Be Different between Elderly Hemodialysis Patients and Non-Elderly Patients.

    • Author(s)
      Norio Hanafusa, Takanobu Nomura, Takeshi Hasegawa, Masaomi Nangaku.
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] SIRT1 Maintains Podocyte Homeostasis via Regulation of Actin Fiber Formation.

    • Author(s)
      Shuta Motonishi, Reiko Inagi, Takehiko Wada, Takamoto Ohse, Akira Shimizu, Masaomi Nangaku.
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] An Antifibrotic Role of Hypoxia-Inducible Factor 3 in Renal Tubular Cells.

    • Author(s)
      Tetsuhiro Tanaka, Kumi Shoji, Junna Yamaguchi, Masaomi Nangaku.
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Mechanism of ANGPTL4 Induction, a Mediator of Nephrotic Syndrome, through Its Chromatin Conformational Change.

    • Author(s)
      Tsuyoshi Inoue, Imari Mimura, Takahide Kohro, Toshiya Tanaka, Hiroyuki Aburatani, Tatsuhiko Kodama, Youichiro Wada, Masaomi Nangaku
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Galacto-Oligosaccharides Modified Gut Microbiota and Attenuated Renal Injury.

    • Author(s)
      Satoshi Unuma, Takamoto Ohse, Airi Jo, Akira Shigehisa, Koji Kawakami, Takahiro Matsuki, Osamu Chonan, Masaomi Nangaku.
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Induction of CCAAT/Enhancer-Binding Protein Delta (CEBPD) Links Inflammation and Hypoxia to Injury by Regulating Hypoxia-Inducible Factor 1 (HIF-1).

    • Author(s)
      Junna Yamaguchi, Tetsuhiro Tanaka, Nobuaki Eto, Masaomi Nangaku.
    • Organizer
      The 46th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Toward the podocyte protection therapy.

    • Author(s)
      Nangaku M.
    • Organizer
      7th World Congress of Nephrology
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Hypoxia as a converging pathway in renal fibrosis.

    • Author(s)
      Nangaku M.
    • Organizer
      Satellite Symposium on renal fibrosis of 7th World Congress of Nephrology
    • Place of Presentation
      Guangzhou, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] combat with kidney disease: current and future

    • Author(s)
      Nangaku M.
    • Organizer
      50th Anniversary of Dialysis in Taiwan
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Hypoxia and fibrosis of the kidney

    • Author(s)
      Nangaku M.
    • Organizer
      International Symposium "Frontiers in Renal Disease Research”
    • Place of Presentation
      Daejeon, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of Uremic Toxins in ESA Resistance in Dialysis Patients

    • Author(s)
      Nangaku M.
    • Organizer
      8th International Congress on Uremia Research and Toxicity
    • Place of Presentation
      Okinawa, Japan
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2012-04-24   Modified: 2019-07-29  

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