| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
In the present study, we examined the mechanisms of Rac1-MR signaling in target organ injury in rodents. Podocyte-specific Rac1 activation mice as well as Rac1 KO mice spontaneously developed podocyte injury, albuminuria, and glomerulosclerosis. Rac1 activity was correlated with MR activity and organ protective response of MR antagonist. Myeloid-specific and cardiomyocyte-specific Rac1/MR KO mice were protected against renal and cardiac injury. Activation of Rac1/MR was demonstrated in obese diabetic KKAy mice, TAC-induced cardiac injury, AngII/salt-induced renal injury, and senescence-associated skin injury models.
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