Identification and characterization of a membrane protein TRAP involved in Fanconi syndrome like symptoms.

• Project/Area Number: 24390217
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: Kanai Yoshikatsu 大阪大学, 医学(系)研究科(研究院), 教授 (60204533)
• Co-Investigator(Kenkyū-buntansha): 大垣 隆一 大阪大学, 医学(系)研究科(研究院), 助教 (20467525) ; 永森 收志 大阪大学, 医学(系)研究科(研究院), 准教授 (90467572) ; 奥田 傑 大阪大学, 医学(系)研究科(研究院), 助教 (50511846)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 腎臓学 / 腎生理学 / トランスポーター / 腎生理

Outline of Final Research Achievements

We identified a novel membrane protein TRAP, which was specifically localized at luminal membrane of renal proximal tubules. It's KO mice showed Fanconi syndrome-like symptoms such as glucosuria, aminoaciduria and uricosuria. TRAP was co-expressed with various renal transporters. Proteomics analysis showed that TRAP interacts directly with those transporters to regulate their localization at luminal membrane of renal proximal tubules. TRAP KO mice did not maintaine normal distribution of transporters at luminal membrane. These data suggest that TRAP can regulate multiple transporters of renal proximal tubules by affecting their localization at luminal membrane.
Our results indicate that TRAP can be a new candidate gene responsible for Fanconi syndrome. They, furthermore, suggest a novel mechanism to integrate multiple transporters in solute transport.

Research Products

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  • Organizer: The final HD physiology Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2015-03-06
• [Presentation] 膜輸送複合体transportsome における輸送機能共役の解析 ―再構成プロテオリポソームによる実証 (2015)
  • Author(s): 永森收志、大垣隆一、金井好克
  • Organizer: 第2回生体界面研究会
  • Place of Presentation: 大阪
  • Year and Date: 2015-02-20
• [Presentation] トランスポーターの生体恒常性維持における役割と疾患治療標的としての意義 (2015)
  • Author(s): 金井好克
  • Organizer: 第44回日本心脈管作動物質学会
  • Place of Presentation: 高松
  • Year and Date: 2015-02-06
  • Invited
• [Presentation] Expression Profiles of Amino Acid Transporters in Cancer Cell Lines by Comprehensive Quantitative Proteomics (2015)
  • Author(s): Noriyoshi Isozumi、Pattama Wiriyaserkul、Pornparn Kongpracha、Shushi Nagamori、Yoshikatsu Kanai
  • Organizer: 新学術領域研究「多階層生体機能学」最終成果報告会・終了記念シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2015-02-05
• [Presentation] トランスポーターの分子実体の解明と分子標的創薬への応用 (2015)
  • Author(s): 金井好克
  • Organizer: バイオインフォマティクス・ジャパン 第６回新たな創薬パラダイムの創出
  • Place of Presentation: 東京
  • Year and Date: 2015-01-09
  • Invited
• [Presentation] トランスポーターの網羅的プロテオミクスによるアミノ酸輸送系のプロファイリングと変動解析 (2014)
  • Author(s): 永森收志
  • Organizer: 第19回アミノ酸セミナー
  • Place of Presentation: 東京
  • Year and Date: 2014-12-05
• [Presentation] アミノ酸トランスポーターの機能と病態 (2014)
  • Author(s): 金井好克
  • Organizer: 日本甲状腺学会基礎甲状腺学シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-14
  • Invited
• [Presentation] Transportsomes; the physical and/or functional complexes of transporters (2014)
  • Author(s): Nagamori S
  • Organizer: The 2nd International Symposium on Epithelial Barrier and Transport
  • Place of Presentation: 滋賀
  • Year and Date: 2014-11-01
• [Presentation] 栄養素トランスポーター：病態形成における役割と分子標的創薬への応用 (2014)
  • Author(s): 金井好克
  • Organizer: 第11回 Metabolic Syndrome Forum in Tokyo
  • Place of Presentation: 東京
  • Year and Date: 2014-10-30
  • Invited
• [Presentation] 腎近位尿細管におけるアミノ酸輸送複合体の解析 (2014)
  • Author(s): 永森收志
  • Organizer: 2014年度生理研研究会「粘膜免疫学と膜輸送生理学の融合」
  • Place of Presentation: 岡崎
  • Year and Date: 2014-10-27
• [Presentation] Inhibition of cancer-type amino acid transporter LAT1 affects multiple cellular events in pancreatic cancer cells (2014)
  • Author(s): Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: The 87th Meeting of Japanese Pharmacological Society Kinki Branch
  • Place of Presentation: 和歌山
  • Year and Date: 2014-10-24
• [Presentation] 網羅的定量プロテオミクス解析によるがん細胞株のトランスポーター発現プロファイル (2014)
  • Author(s): Noriyoshi Isozumi、Pattama Wiriyaserkul、Pornparn Kongpracha、Shushi Nagamori、Yoshikatsu Kanai
  • Organizer: 第87回 日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-10-17
• [Presentation] Elucidation of cancer-specificity and renal background in 18F-FAMT (3-fluoro-L-alpha-methyl-tyrosine) PET (2014)
  • Author(s): 魏 玲
  • Organizer: 新学術領域研究「多階層生体機能学」若手ワークショップ2014
  • Place of Presentation: 静岡
  • Year and Date: 2014-09-22
• [Presentation] From transporter to transportsome: Protein-protein interactions assemble membrane transport functions (2014)
  • Author(s): Kanai Y
  • Organizer: 6th Special Conference of ISN: Dynamic Change of Nanostructure in the Brain in Health and Disease
  • Place of Presentation: 東京
  • Year and Date: 2014-09-22
  • Invited
• [Presentation] トランスポーター研究のススメ： 古典的生化学とオミクスの融合 (2014)
  • Author(s): 永森收志
  • Organizer: 新潟大学 大学院特別講義第 7 回 分子生理セミナー
  • Place of Presentation: 新潟
  • Year and Date: 2014-09-17
  • Invited
• [Presentation] Functions and roles of amino acid transporters. (2014)
  • Author(s): Nagamori S
  • Organizer: The 2nd Awaji International Workshop on “Electron Spin Science & Technology
  • Place of Presentation: 淡路島
  • Year and Date: 2014-09-03
• [Presentation] 栄養とトランスポーター：アミノ酸の場合 (2014)
  • Author(s): 永森收志
  • Organizer: 第３４９回大阪大学臨床栄養研究会
  • Place of Presentation: 大阪
  • Year and Date: 2014-07-28
  • Invited
• [Presentation] 栄養素トランスポーター：その病態形成における役割 (2014)
  • Author(s): 金井好克
  • Organizer: 第９回神戸生活習慣病研究会
  • Place of Presentation: 神戸
  • Year and Date: 2014-07-26
  • Invited
• [Presentation] Amino acid transporters: novel molecular targets for cancer diagnosis and therapeutics (2014)
  • Author(s): Kanai Y
  • Organizer: 17th World Congress of Basic and Clinical Pharmacology
  • Place of Presentation: Cape town, South Africa
  • Year and Date: 2014-07-14
  • Invited
• [Presentation] A new cystine transporter in S3 segment of the renal proximal tubule is an “unknown-partner” of Slc3a1 (rBAT) (2014)
  • Author(s): Nagamori S
  • Organizer: Gordon Research Conference Membrane Transport Proteins
  • Place of Presentation: West Dover, VT, United States
  • Year and Date: 2014-07-13 – 2014-07-18
• [Presentation] 生体膜表面で輸送体の機能共役を実現するトランスポートソーム (2014)
  • Author(s): 金井好克
  • Organizer: 第１回生体界面研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-06-13
• [Presentation] Study of a cellular signaling network stimulated with leucine transported by a cancer-type amino acid transporter LAT1. (2014)
  • Author(s): Pornparn Kongprach, Pattama Wiriyasermkul, Noriyoshi Isozumi, Printip Wongthai, Suguru Okuda, Kenjiro Tadagaki, Ryuichi Ohgaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: The 61th Japanese Biochemical Society Kinki Branch
  • Place of Presentation: 京都
  • Year and Date: 2014-05-17
• [Presentation] Transporters in pharmacology and molecular target drug discovery (2014)
  • Author(s): Kanai Y
  • Organizer: 5th Asia Pacific ISSX Meeting 201
  • Place of Presentation: 天津・中国
  • Year and Date: 2014-05-11
  • Invited
• [Presentation] Transport of 3-fluoro-L-alpha-methyltyrosine (FAMT) by amino acid transports and organic ion transporters explains cancer-specificity and renal background in 18F-FAMT PET (2014)
  • Author(s): Ling Wei, 富永 英之, Pattama Wiriyasermkul, 大垣 隆一, 萩原 浩平, 永森 收志, 金井 好克
  • Organizer: th Asia Pacific ISSX Meeting 2014
  • Place of Presentation: 天津・中国
  • Year and Date: 2014-05-10
• [Presentation] 比較定量オミクスを用いた新規ケトン体トランスポーターの生体における機能の解析 (2013)
  • Author(s): 永森牧志、平田拓、何新、Pattama Wiriyasermkul、中込咲綾、石川貴正、曽我朋義、金井好克
  • Organizer: 日本農芸化学会2013年度大会
  • Place of Presentation: 仙台市
  • Year and Date: 2013-03-26
• [Presentation] Kinetic analysis of 3F-L-a-methyltyrosine (FAMT) transport by L-type amino acid transporter 1 (2013)
  • Author(s): Ling Wei, Hideyuki Tominaka, Pattama Wiriyasermkul, Yumiko Nishinaka, Ryuichi Ohgaki, Kenjiro Tadagaki, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡市
  • Year and Date: 2013-03-23
• [Presentation] Boronophenylalanine;a rational carrier for 10B for BNCT, is transportsd by both LAT1 and LAT2. (2013)
  • Author(s): Printip Wongthai, Pattama Wiriyasermkul, Yumiko Nishinaka, Ryuichi Ohgaki, Ker!jiro Tadagaki, Shushi Nagamori, Yoshikatsu Kanai.
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡市
  • Year and Date: 2013-03-23
• [Presentation] Cellular responses to LAT1-mediated leucine uptake are revealed by using an LAT1 inhibitor and comprehensive phosphoproteomics (2013)
  • Author(s): Shushi Nagamori, Pattama Wiriyasermkul, Satoshi Serada, Masaki Matsumoto, Keiichi I Nakayama, Tetsuji Naka, Yoshikatsu Kanai
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡市
  • Year and Date: 2013-03-23
• [Presentation] A C-terminus mutation of b0+AT/SLC7A9 amino acid transporter f1' equent in Japanese cystinuria patients binds substrates but diminishes the transport activity. (2013)
  • Author(s): Y asuharu Kawamoto, Shushi Nagamori, Saya Nakagomi, Pattama Wiriyasermkul, Yoshikatsu Kanai
  • Organizer: Nagoya Symposium; Frontiers in Structural Physiology
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2013-01-22
• [Presentation] アミノ酸トランスポーターと細胞内アミノ酸シグナリング (2013)
  • Author(s): 永森 收志
  • Organizer: 生理学研究所研究会「細胞センサーの分子機構・相互関連・ネットワーク研究会」
  • Place of Presentation: 岡崎
  • Invited
• [Presentation] Age-dependent maintenance of transportsome in C. elegans (2013)
  • Author(s): ○Kohei Hagiwara, Shushi Nagamori, Yasuhiro M. Umemura, Ryuichi Ohgaki, Yoshikatsu Kanai
  • Organizer: First Awaji International Workshop on “Electron Spin Science & Technology: Biological and Materials Science Oriented Applications”
  • Place of Presentation: Awaji
• [Presentation] Substrate recognition by L-type amino acid transporter 1 (LAT1) and the important moieties of LAT1 substrates to regulate cell growth (2013)
  • Author(s): ○Pattama Wiriyasermkul, Shushi Nagamori, Naoto Kojima, Yoshikatsu Kanai
  • Organizer: Gordon Research Conferences 2013: Mechanisms of membrane transport
  • Place of Presentation: South Hadley, MA, USA
• [Presentation] A novel cystine transporter in S3 segment of the renal proximal tubule is an “unknown-partner” of Slc3a1 (rBAT) (2013)
  • Author(s): ○Shushi Nagamori, Pattama Wiriyasermkul, Meritxell Espino Guarch, Kazuhisa Okuyama, Saya Nakagomi, Kenijiro Tadagaki, Kazuaki Takafuji, Ryuichi Ohgaki, Manuel Palacin, Yoshikatsu Kanai
  • Organizer: 2nd HDP international symposium on Multi-Level Systems Biology
  • Place of Presentation: Tokyo, Japan
• [Presentation] 日本人型シスチン尿症を発症させるアミノ酸トランスポーター変異体の機能解析 (2013)
  • Author(s): ○永森 收志、河本 泰治、Pattama Wiriyasermkul、金井 好克
  • Organizer: 生理学研究所研究会「上皮膜輸送の多層的コントロールによる生体の恒常性維持機構」
  • Place of Presentation: 岡崎
• [Presentation] Midgestational lethality in mice lacking LAT1, large neutral amino acid transporter 1, is associated with abnormal blood vessel formation and defective placental development (2013)
  • Author(s): ○大垣 隆一、李 悦、原 沙織、中込 紗綾、永森 收志、金井 好克
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] アミノ酸輸送体LAT1によって取り込まれたロイシンに対する細胞応答のリン酸プロテオミクスによる解析 (2013)
  • Author(s): ○永森收志、Pattama Wiriyasermkul、世良田聡、仲哲治、金井好克
  • Organizer: 日本アミノ酸学会第７回学術大会
  • Place of Presentation: 熊本
• [Presentation] Involvement of amino acid transporter in vascular endothelial cell tube formation (2013)
  • Author(s): ○Saori Hara, Ryuichi Ohgaki, Printip Wongthai, Saya Nakagomi, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 生理学研究所研究会「細胞センサーの分子機構・相互関連・ネットワーク研究会」
  • Place of Presentation: 岡崎
• [Presentation] Cellular responses to LAT1-mediated leucine uptake revealed by comprehensive phosphoproteomics. (2012)
  • Author(s): Pattama Wiriyasermkul, Shushi Nagamori, Satoshi Serada, Masaki Matsumoto, Keiichi I Nakayama, Tetsuji Naka, Yoshikatsu Kanai
  • Organizer: 2012 American Society of Cell Biology (ASCB)Annual Meeting.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2012-12-17
• [Presentation] A C-terminus mutation of SLC7A9 amino acid transporter fiequent in Japanese cystinuria patients retains substrate binding but diminishes the transport activity. (2012)
  • Author(s): Y. Kawamoto, S. Nagamori, P. Wiriyasermkul, Y. Kanai
  • Organizer: 2012 American Society of Cell Biology (ASCB)Annual Meeting.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2012-12-17
• [Presentation] Substrate recognition of L-type amino acid transporter l provide the understanding of amino acid-mediated cancer cell growth regulation (2012)
  • Author(s): Pattama Wiriyasermkul, Shushi Nagamori, Naoto Kojima, Yoshikatsu Kanai.
  • Organizer: Nagoya Symposium; Frontiers in Structural Physiology
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2012-12-17
• [Presentation] 質量分析計と再構成プロテオリボソームを用いた新規トランスポーター複合体の解析-腎尿細管に残された第二のシスチントランスポーターの分子同定 (2012)
  • Author(s): 永森收志、奥山裕久、PattamaWiriyasermkul、中込咲綾、西中由美子、高藤和輝、大垣隆一、金井好克
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡市
  • Year and Date: 2012-12-15
• [Presentation] 悪性腫瘍のアミノ酸トランスポーター (2012)
  • Author(s): 金井好克
  • Organizer: 第85回日本生化学会大会シンポジウム「分子標的トランスポーター」
  • Place of Presentation: 福岡市
  • Year and Date: 2012-12-15
• [Presentation] アミノ酸トランスポーターLATI阻害によるがん細胞増殖抑制 (2012)
  • Author(s): 西中由美子、永森牧志、Printip Wongthai、遠藤 仁、金井好克
  • Organizer: 第85回日本生化学会大会シンポジウム「分子標的トランスポーター」
  • Place of Presentation: 福岡市
  • Year and Date: 2012-12-15
• [Presentation] 腎近位尿細管の第二のシスチントランスポーターの分子同定と機能解析 (2012)
  • Author(s): 永森收志、奥山裕久、PattamaWiriyasermkul、中込咲綾、西中由美子、高藤和輝、大垣隆一、金井好克
  • Organizer: 2012年度生理研研究会『粘膜防御における上皮膜輸送の役割とその破綻による疾病発症メカニズム』
  • Place of Presentation: 岡崎市
  • Year and Date: 2012-12-01
• [Presentation] Metabolomics and proteomics in transporter research (トランスポーター研究におけるメタボロームとプロテオーム解析) (2012)
  • Author(s): 金井好克
  • Organizer: 日本薬物動態学会第27回年会シンポジウム「トランスポーターの生理機能:統合的理解に向けて」
  • Place of Presentation: 東京
  • Year and Date: 2012-11-20
• [Presentation] Comprehensive phosphoproteomics analysis of cellular responses indueed by LAT1-mediated leucine uptake. (2012)
  • Author(s): Pattama Wiriyasermkul, 永森牧志,世良田聡,仲哲治,金井好克
  • Organizer: 第122回日本薬理学会近畿部会
  • Place of Presentation: 豊中市
  • Year and Date: 2012-11-16
• [Presentation] Na+依存性グルコーストランスポーター:基礎研究から次世代抗糖尿病薬開発まで. (2012)
  • Author(s): 金井好克
  • Organizer: 第102回東京腎生理集談会「腎臓のイオントランスポートUpdate」
  • Place of Presentation: 東京
  • Year and Date: 2012-11-10
• [Presentation] Comprehensive variability analysis of nutrients absorption mechanism in small intestine by quantitative proteomics. (2012)
  • Author(s): Takashi Nishiyama , Shushi Nagamori , Kazuaki Takafuji , Yoshikatsu Kanai
  • Organizer: 第19回国際質量分析会議
  • Place of Presentation: 京都市
  • Year and Date: 2012-09-19
• [Presentation] "Transportsome", the multi-molecular assemblies for transport-transportand transport-metabol ism couplings. (2012)
  • Author(s): Yoshikatsu Kanai
  • Organizer: International Symposium on Epithelial Barrier and Transport 2012.
  • Place of Presentation: Kusatsu/Shiga, Japan
  • Year and Date: 2012-09-15
• [Presentation] 腎尿細管に残された第二のシスチントランスポーターの分子同定 (2012)
  • Author(s): 大垣隆一,奥山裕久, Pattama Wiriyasermkul,中込咲綾,西中由美子,高藤和輝,永森牧志,金井好克.
  • Organizer: 第3回分子腎臓フォーラム
  • Place of Presentation: 東京
  • Year and Date: 2012-09-01
• [Presentation] 定量プロテオミクスを用いた小腸トランスポーターの網羅的変動解析 (2012)
  • Author(s): 西山俊、永森收志、高藤和輝、金井好克.
  • Organizer: 日本プロテオーム学会2012年大会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-26
• [Presentation] 小腸上皮トランスポーター発現の網羅的変動解析 (2012)
  • Author(s): 西山俊、永森收志、高藤和輝、金井好克
  • Organizer: 第121回日本薬理学会近畿部会
  • Place of Presentation: 徳島市
  • Year and Date: 2012-06-29
• [Presentation] ショ糖と人工甘味料による小腸上皮トランスポーター発現の網羅的変動解析 (2012)
  • Author(s): 西山俊、永森牧志、高藤和輝、金井好克
  • Organizer: 第7回トランスポーター研究会
  • Place of Presentation: 京都市
  • Year and Date: 2012-06-09
• [Presentation] 日本人型シスチン尿症を発症させるアミノ酸トランスポーター変異体の機能解析 (2012)
  • Author(s): 河本泰治,永森牧志, Pattama Wiriyasermkul,金井好克
  • Organizer: 日本生化学会近畿部会
  • Place of Presentation: 宇治市
  • Year and Date: 2012-05-19
• [Presentation] Functional coupling between a Na+-dependent anion transporter SMCT2 and a urate-anion exchanger URAT1 through a scaffold protein PDZK (2012)
  • Author(s): Shushi Nagamori, Yasuhiro Umemura, Pattama Wiriyasermkul, Saya Nakagomi, Yumiko Nishinaka, Kazuaki Takafuji, Ryuichi Ohgaki, Yoshikatsu Kanai.
  • Organizer: Gordon Research Conferences, Membrane Transport Proteins.
  • Place of Presentation: Les Diablerets, Switzerland
• [Presentation] アミノ酸トランスポーターLATIを介したロイシンの取り込みとmTOR系活性化の網羅的解析 (2012)
  • Author(s): 永 森 收 志 、 Pattama Wiriyasermkul、世良田聡、仲哲治,金井好克
  • Organizer: 日本アミノ酸学会第6回学術大会
  • Place of Presentation: 松戸市
• [Presentation] Functional coupling of transporters in a complex
  • Author(s): Shushi Nagamori
  • Organizer: First Awaji International Workshop on “Electron Spin Science & Technology: Biological and Materials Science Oriented Applications”
  • Place of Presentation: Awaji, Japan
  • Invited
• [Presentation] "Transportsome”, the multi-molecular assemblies for transport-transport and transport-metabolism couplings
  • Author(s): Yoshikatsu Kanai, Shushi Nagamori
  • Organizer: 2nd HDP international symposium on Multi-Level Systems Biology
  • Place of Presentation: Tokyo, Japan
  • Invited
• [Presentation] アミノ酸トランスポーターを利用した癌へのドラッグデリバリー
  • Author(s): 金井 好克
  • Organizer: 第29回日本DDS学会学術集会
  • Place of Presentation: 京都
  • Invited
• [Presentation] The role of heterodimeric transporters in cancer cell growth
  • Author(s): Yoshikatsu Kanai
  • Organizer: Symposium:“The role of membrane transport in tumor cell growth and metabolism” organized by Stefan Broer and Yoshikatsu Kanai XXXVII International Congress of Physiological Sciences (IUPS 2013)
  • Place of Presentation: Birmingham, UK
  • Invited
• [Presentation] がん細胞のアミノ酸トランスポーター
  • Author(s): 永森收志、金井好克
  • Organizer: 第31回日本ヒト細胞学会学術集会
  • Place of Presentation: 所沢
  • Invited
• [Presentation] Amino acid transporters in cancers for effective and selective delivery of cancer-targeting agents
  • Author(s): Yoshikatsu Kanai
  • Organizer: BioMedical Transporters 2013
  • Place of Presentation: St. Moritz, Switzerland
  • Invited
• [Presentation] がんの診断・治療の分子標的としてのアミノ酸トランスポーター
  • Author(s): 金井 好克
  • Organizer: 金沢大学『Transcriptotherapeuticsの創出と医療への展開』セミナー
  • Place of Presentation: 金沢
  • Invited
• [Presentation] アミノ酸トランスポーターと疾患
  • Author(s): 金井 好克
  • Organizer: 第86回日本生化学会大会 シンポジウム「トランスポーターと疾患の最前線」
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Metabolomics and proteomics analyses of knockout mice reveal real physiological substrates of an organic anion transporter
  • Author(s): Shushi Nagamori, Xi He, Taku Hirata, Pattama Wiriyasermkul, Saya Nakagomi, Takamasa Ishikawa, Tomoyoshi Soga, Yoshikatsu Kanai
  • Organizer: 第86回日本生化学会大会 International Session “The way to study my membrane transport protein(s); how to listen to their whispers.”
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 膜輸送複合体におけるトランスポーターの機能共役
  • Author(s): 永森收志
  • Organizer: 第4回難治疾患共同研究拠点シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] トランスポーターの機能と病態
  • Author(s): 金井 好克
  • Organizer: 第23回国際痒みシンポジウム
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 新たな作用機序の糖尿病治療薬としてのSGLT2阻害薬
  • Author(s): 金井 好克
  • Organizer: 第34回日本臨床薬理学会学術総会 シンポジウム「循環器・代謝性疾患の新規治療薬：基礎から臨床へ」（日本薬理学会・日本臨床薬理学会共催シンポジウム）
  • Place of Presentation: 東京
  • Invited
• [Presentation] 特別講演「トランスポーターシステムの分子的描像と疾患治療への可能性を求めて」
  • Author(s): 金井 好克
  • Organizer: Advans研究会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 糖尿病の新たな治療標的SGLT2 糖再吸収における役割とその阻害薬の基礎
  • Author(s): 金井 好克
  • Organizer: 第23回糖尿病性腎症セミナー
  • Place of Presentation: 岡山
  • Invited
• [Presentation] アミノ酸トランスポーターを標的とした抗腫瘍薬の創製
  • Author(s): 金井 好克
  • Organizer: 第98回岡山県医用工学研究会シンポジウム
  • Place of Presentation: 岡山
  • Invited
• [Presentation] 血糖調節と2型糖尿病における腎臓の役割：トランスポーターの治療的意義
  • Author(s): 金井 好克
  • Organizer: 第28回日本糖尿病・肥満動物学会 シンポジウム「糖尿病・肥満モデル動物を用いた治療薬の開発研究」
  • Place of Presentation: 宮崎
  • Invited
• [Presentation] 芳香族アミン誘導体の抗腫瘍効果の確立と非臨床POCの取得
  • Author(s): 金井 好克
  • Organizer: 文部科学省橋渡し研究加速ネットワークプログラム平成25年度成果報告会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 輸送体間相互作用と発現変動の網羅的解析
  • Author(s): 永森收志
  • Organizer: 新学術領域研究「統合的多階層生体機能学領域の確立とその応用」第八回（平成25年度第二回）領域全体会議・研究報告会
  • Place of Presentation: 京都
  • Invited
• [Presentation] アミノ酸トランスポーターを標的とした悪性腫瘍のPET診断と治療薬の開発
  • Author(s): 金井 好克
  • Organizer: 第87回日本薬理学会年会 シンポジウム「アカデミアにおける創薬とトランスレーショナルリサーチの展望」
  • Place of Presentation: 仙台
  • Invited
• [Presentation] がん細胞のアミノ酸取り込みを標的とした新しい作用機序の抗がん薬～難治性がんの新薬～
  • Author(s): 金井 好克
  • Organizer: 大阪大学未来戦略機構シンポジウム アカデミア基盤研究から未来創薬へ
  • Place of Presentation: 東京
  • Invited
• [Presentation] 網羅的定量オミクスによるトランスポーター研究の新しい展開Comprehensive and quantitative "omics" bring up new world of transporter research
  • Author(s): 永森收志、金井好克
  • Organizer: 2014年度日本農芸化学会 シンポジウム「トランスポーターを通して見る生命現象」
  • Place of Presentation: 東京
  • Invited
• [Presentation] 線虫腸管細胞におけるアミノ酸トランスポーターAAT-6の頂端膜局在に寄与するトランスポートソーム
  • Author(s): 村田 大輔、○大垣 隆一、萩原 浩平、Kanokporn Phetdee、永森 收志、平田 拓、野村 和子、野村 一也、三谷 昌平、金井 好克
  • Organizer: 第8回トランスポーター研究会年会
  • Place of Presentation: 熊本
• [Presentation] 3-Fluoro-L-α-methyltyrosine (FAMT), a positron emission tomography probe for cancer diagnosis, is a selective substrate of cancer-specific amino acid transporter L-type amino acid transporter 1 (LAT1)
  • Author(s): ○Ling Wei、富永 英之、Pattama Wiriyasermkul、大垣 隆一、忠垣 憲次郎、永森 收志、金井 好克
  • Organizer: 第123回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
• [Presentation] 疾患起因性変異ノックインマウスを用いた日本人型シスチン尿症変異の特性解析
  • Author(s): ○河本 泰治、永森 收志、中込 咲綾、Pattama Wiriyasermkul、金井 好克
  • Organizer: 第三回全国合同リトリート
  • Place of Presentation: 大阪
• [Presentation] 疾患起因性変異ノックインマウスを用いた日本人型シスチン尿症変異の特性解析
  • Author(s): ○河本 泰治、永森 收志、Pattama Wiriyasermkul、中込 咲綾、金井 好克
  • Organizer: 第四回分子腎臓フォーラム
  • Place of Presentation: 京都
• [Presentation] Expression and functional profiles of amino acid transporters in cancer cell lines
  • Author(s): ○Pattama Wiriyasermkul, Shushi Nagamori, Noriyoshi Isozumi, Ryuichi Ohgaki, Hideyuki Tominaga and Yoshikatsu Kanai
  • Organizer: 第86回日本生化学会
  • Place of Presentation: 横浜
• [Presentation] モデル生物が明らかにするトランスポートソームの構成と生理機能
  • Author(s): 村田 大輔
  • Organizer: 新学術領域研究「統合的多階層生体機能学領域の確立とその応用」若手ワークショップ2013
  • Place of Presentation: 豊橋
• [Presentation] アミノ酸トランスポーターLAT1阻害による血管内皮細胞 チューブ形成への影響についての検討
  • Author(s): ○原 早織、大垣 隆一、Printip Wongthai、中込 咲綾、永森 收志、金井 好克
  • Organizer: 第124回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] Transport of 4-borono-L-phenylalanine, a 10B carrier of boron neutron capture therapy, by system L amino acid transporters
  • Author(s): ○Printip Wongthai, Kohei Hagiwara, Yurika Miyoshi, Pattama Wiriyasermkul, Ryuichi Ohgaki, Kenjiro Tadagaki, Kenji Hamase, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第124回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] 線虫アミノ酸トランスポーターAAT-6の輸送機能および細胞内局在の解析
  • Author(s): ○村田 大輔、大垣 隆一、萩原 浩平、Kanokporn Phetdee、永森 收志、魏 玲、平田 拓、野村 一也、三谷 昌平、金井 好克
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Functional coupling of a urate-anion exchanger URAT1 and Na+-dependent anion transporter SMCT2 on a PDZK1 scaffold; Proposal of “Transportsome” for urate-transport
  • Author(s): ○Shushi Nagamori, Yasuhiro Umemura, Pattama Wiriyasermkul, Yumiko Nishinaka, Noriyoshi Isozumi, Yoshikatsu Kanai
  • Organizer: The 58th Annual Meeting of the Biophysical Society
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Mechanisms of tumor cell uptake of 4-borono-phenylalanine, a 10B carrier of boron neutron capture therapy, mediated by system L amino acid transporters
  • Author(s): ○Printip Wongthai, Kohei Hagiwara, Yurika Miyoshi, Pattama Wiriyasermkul, Pornparn Kongpracha, Isozumi Noriyoshi, Ryuichi Ohgaki, Kenjiro Tadagaki, Kenji Hamase, Shushi Nagamori, Yoshikatsu Kanai
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] Evaluation of amino acid transporter LAT1 as a molecular target of anti-tumor therapy by means of the combination of comprehensive proteomics and transport assay. 網羅的プロテオミクスと輸送解析によるアミノ酸トランスポーター LAT1の抗腫瘍薬分子標的としての意義の検討
  • Author(s): ○永森 收志、Pattama Wiriyasermkul、五十棲 規嘉、Pornparn Kongpracha、大垣 隆一、金井 好克
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台
• [Presentation] トランスポーターの網羅的比較定量プロテオミクス技術の確立とショ糖摂取による小腸上皮トランスポーター発現変動解析への適用
  • Author(s): 西山 俊、○奥田 傑、高藤 和輝、ウォンタイ プリンティップ、五十棲 規嘉、永森 收志、金井 好克
  • Organizer: 日本農芸化学会2014年度大会
  • Place of Presentation: 東京
• [Book] トランスポートソーム:その生理的意義と疾患 (2013)
  • Author(s): 金井 好克
  • Total Pages: 8
  • Publisher: 中外医学社