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Molecular bases and their regulations of mRNA aberrations in neuromuscular transmission defects and other muscular diseases

Research Project

Project/Area Number 24390221
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurology
Research InstitutionNagoya University

Principal Investigator

OHNO Kinji  名古屋大学, 医学(系)研究科(研究院), 教授 (80397455)

Co-Investigator(Kenkyū-buntansha) MASUDA Akio  名古屋大学, 大学院医学系研究科, 准教授 (10343203)
ITO Mikako  名古屋大学, 大学院医学系研究科, 助教 (60444402)
OHKAWARA Bisei  名古屋大学, 高等研究院, 特任講師 (80589606)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords先天性筋無力症候群 / 神経筋接合部 / RSPO2 / LGR5 / LRP4 / Wnt / ColQ
Outline of Final Research Achievements

Laser capture microdissection of mouse spinal motor neurons revealed that Rspo2 is highly expressed in spinal motor neurons. Rspo2 induces acetylcholine receptor (AChR) clustering, which is ~80% as potent as agrin. We propose that Rspo2 is an essential AChR clustering-inducing molecule after agrin.
We identified that mutations in LRP4 cause congenital myasthenic syndrome. Mutations in the 3rd beta-propeller domain of LRP4 cause either a defect in neuromuscular signal transmission or a defect in osteogenesis in a position-specific manner.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (54 results)

All 2015 2014 2013 2012

All Journal Article (22 results) (of which Peer Reviewed: 22 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (23 results) (of which Invited: 7 results) Book (7 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits2015

    • Author(s)
      Azuma Y, Nakata T, Tanaka M, Shen XM, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K.
    • Journal Title

      Neuromuscul Disord

      Volume: 25(1) Issue: 1 Pages: 60-69

    • DOI

      10.1016/j.nmd.2014.09.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner2014

    • Author(s)
      Ohkawara B, Cabrera-Serrano M, Nakata T, Milone M, Asai N, Ito K, Ito M, Masuda A, Ito Y, Engel AG, Ohno K
    • Journal Title

      Hum Mol Genet.

      Volume: Apr 1;23(7) Issue: 7 Pages: 1856-68

    • DOI

      10.1093/hmg/ddt578

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LDB3 splicing abnormalities are specific to skeletal muscles of patients with myotonic dystrophy type 1 and alter its PKC binding affinity2014

    • Author(s)
      Yamashita Y, Matsuura T, Kurosaki T, Amakusa Y, Kinoshita M, Ibi T, Sahashi K, Ohno K.
    • Journal Title

      Neurobiol Disord

      Volume: 69 Pages: 200-205

    • DOI

      10.1016/j.nbd.2014.05.026

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Collagen Q is a key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis.2014

    • Author(s)
      Ohno K, Ito M, Kawakami Y, Ohtsuka K.
    • Journal Title

      J Mol Neurosci

      Volume: 53(3) Issue: 3 Pages: 359-361

    • DOI

      10.1007/s12031-013-0170-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform2014

    • Author(s)
      Nasrin F, Rahman MA, Masuda A, Ohe K, Takeda J, Ohno K.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 6841-6841

    • DOI

      10.1038/srep06841

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical and genetic analysis of the first known Asian family with myotonic dystrophy type 22014

    • Author(s)
      Nakayama T, Nakamura H, Oya Y, Kimura T, Imahuku I, Ohno K, Nishino I, Abe K, Matsuura T.
    • Journal Title

      J Hum Genet

      Volume: 59 Issue: 3 Pages: 129-133

    • DOI

      10.1038/jhg.2013.133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Kir3.4 mutation causes Andersen–Tawil syndrome by an inhibitory effect on Kir2.1.2014

    • Author(s)
      Kokunai Y, Nakata T, Furuta M, Sakata S, Kimura H, Aiba T, Yoshinaga M, Osaki Y, Nakamori M, Itoh H, Sato T, Kubota T, Kadota K, Shindo K, Mochizuki H, Shimizu W, Horie M, Okamura Y, Ohno K, Takahashi MP
    • Journal Title

      Neurology

      Volume: 82 Issue: 12 Pages: 1058-64

    • DOI

      10.1212/wnl.0000000000000239

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.2013

    • Author(s)
      Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
    • Journal Title

      BMC Genomics.

      Volume: 14(1): Issue: 1 Pages: 248-248

    • DOI

      10.1186/1471-2164-14-248

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutations in the C-Terminal Domain of ColQ in Endplate Acetylcholinesterase Deficiency Compromise ColQ-MuSK Interaction.2013

    • Author(s)
      Nakata T, Ito M, Azuma Y, Otsuka K, Noguchi Y, Komaki H, Okumura A, Shiraishi K, Masuda A, Natsume J, Kojima S, Ohno K.
    • Journal Title

      Human Mutation

      Volume: in press Issue: 7 Pages: 997-1004

    • DOI

      10.1002/humu.22325

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gfpt1-myasthenia: Clinical, structural, and electrophysiologic heterogeneity2013

    • Author(s)
      Selcen D, Shen XM, Milone M, Brengman J, Ohno K, Deymeer F, Finkel R, Rowin J, Engel AG.
    • Journal Title

      Neurology

      Volume: 81 Issue: 4 Pages: 378-378

    • DOI

      10.1212/wnl.0b013e31829c5e9c

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA.2013

    • Author(s)
      Rahman, M. A., Masuda, A., Ohe, K., Ito, M. , Hutchinson, D. O., Mayeda, A., Engel, A. G. and Ohno, K.
    • Journal Title

      Sci. Rep.

      Volume: 3 Issue: 1 Pages: 2931-2931

    • DOI

      10.1038/srep02931

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice2013

    • Author(s)
      Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K
    • Journal Title

      J Bone Miner Metab

      Volume: 31 Pages: 26-33

    • DOI

      10.1007/s00774-012-0380-2

    • NAID

      10031168834

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S100A10 is required for the organization of actin stress fibers and promotion of cell spreading.2013

    • Author(s)
      Shurovi Sayeed
    • Journal Title

      Molecular and cellular biochemistry

      Volume: 374 Issue: 1-2 Pages: 105-11

    • DOI

      10.1007/s11010-012-1509-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells2013

    • Author(s)
      Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M
    • Journal Title

      Med Gas Res

      Volume: 3 Issue: 1 Pages: 6-6

    • DOI

      10.1186/2045-9912-3-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CUGBP1 and MBNL1 preferentially bind to 3’ UTRs and facilitate mRNA decay2012

    • Author(s)
      Masuda A, Andersen HS, Doktor TK, Okamoto T, Ito M, Andresen BS, Ohno K
    • Journal Title

      Sci Rep

      Volume: 2 Issue: 1 Pages: 209-209

    • DOI

      10.1038/srep00209

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mutation in SCN4A causes severe myotonia and school-age-onset paralytic episodes2012

    • Author(s)
      Yoshinaga Y. Sakoda S-I, Good JM, Takahashi MP, Kubota T, Arikawa-Hirasawa E, Nakata T, Ohno K, Kitamura T, Kobayashi K, Ohtsuka Y
    • Journal Title

      J Neurol Sci

      Volume: 315(1-2) Issue: 1-2 Pages: 15-9

    • DOI

      10.1016/j.jns.2011.12.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myotonic dystrophy type 2 (DM2) is rare in the Japanese population2012

    • Author(s)
      Matsuura T, Minami N, Arahata H, Ohno K, Abe K, Hayashi YK, Nishino I
    • Journal Title

      J Hum Genet

      Volume: (印刷中) Issue: 3 Pages: 219-220

    • DOI

      10.1038/jhg.2011.152

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction2012

    • Author(s)
      Ito M, Suzuki Y, Okada T, Fukudome T, Yoshimura T, Masuda A, Takeda S, Krejci E, Ohno K
    • Journal Title

      Mol Ther

      Volume: (印刷中) Issue: 7 Pages: 1384-1392

    • DOI

      10.1038/mt.2012.34

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats2012

    • Author(s)
      Ito M, Hirayama M, Yamai K, Goto S, Ito M, Ichihara M, Ohno K
    • Journal Title

      Med Gas Res

      Volume: 2 Issue: 1 Pages: 15-15

    • DOI

      10.1186/2045-9912-2-15

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The unstable CCTG repeat responsible for myotonic dystrophy type 2 originates from an AluSx element insertion into an early primate genome2012

    • Author(s)
      Kurosaki, T., Ueda, S., Ishida, T., Abe, K., Ohno, K. and Matsuura, T
    • Journal Title

      PLos One

      Volume: 7 Issue: 6 Pages: e38379-e38379

    • DOI

      10.1371/journal.pone.0038379

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four parameters increase the sensitivity and specificity of the exon array analysis and disclose twenty-five novel aberrantly spliced exons in myotonic dystrophy.2012

    • Author(s)
      Yamashita Y, Matsuura T, Shinmi J, Amakusa Y, Masuda A, Ito M, Kinoshita M, Furuya H, Abe K, Ibi T, Sahashi K, Ohno K.
    • Journal Title

      Journal of Human Genetics

      Volume: 57 Issue: 6 Pages: 368-374

    • DOI

      10.1038/jhg.2012.37

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.2012

    • Author(s)
      Ishigaki S, Masuda A, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K
    • Journal Title

      Sci Rep

      Volume: 2 Issue: 1 Pages: 529-529

    • DOI

      10.1038/srep00529

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Alternative splicing of human MUSK exon 10 is physiologically regulated by multiple splicing regulatory cis-elements and cognate trans-factors2014

    • Author(s)
      Rahman MA, Masuda A, Takeda J, Ohno K
    • Organizer
      RNA Biology meeting, Cold Spring Harbor Asia Conference
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2014-11-10 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] IntSplice: A tool to predict aberrant splicing of an SNV at intronic positions -50 to -32014

    • Author(s)
      Ohno K, Shibata A, Okuno T, Rahman MA, Azuma Y, Masuda A
    • Organizer
      64th Annual Meeting of the American Society of Human Genetics
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2014-10-18 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Maintenance of the neuromuscular junction and its aberrations in hereditary and autoimmune disorders2014

    • Author(s)
      Ohno K
    • Organizer
      Guarda-Symposium 2014 on the Molecular and Cell Biology of the Neuromuscular System
    • Place of Presentation
      Guarda, Switzerland
    • Year and Date
      2014-09-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Collagen Q is a key player for developing rational therapy for congenital myasthenia and for causing anti-MuSK myasthenia gravis2013

    • Author(s)
      Ohno K, Ito M, Kawakami Y, Ohtsuka K, Krejci E.
    • Organizer
      XIV International Symposium on Cholinergic Mechanisms (Platform)
    • Place of Presentation
      Hangzhou, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mutations in the third β-propeller domain of LRP4 in congenital myasthenia compromise agrin-mediated MuSK signaling in a position-specific manner2013

    • Author(s)
      Ohkawara B, Cabrera M, Nakata T, Milone M, Ito Y, Engel AG, Ohno K
    • Organizer
      36th Annual Meeting of the Japan Neuroscience Society (Poster)
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] R-spondin2 is crucial for neuromuscular junction formation2013

    • Author(s)
      Nakashima H, Ohkawara B, Imagama S, Ito Z, Ishiguro N, Ohno K
    • Organizer
      43rd Annual Meeting, Society for Neuroscience (Poster)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mutations in LRP4 in congenital myasthenia reveal position-specific regulations of agrin and Wnt signaling of LPR42013

    • Author(s)
      Ohkawara B, Cabrera M, Nakata T, Shen X, Ito Y, Engel AG, Ohno K
    • Organizer
      43rd Annual Meeting, Society for Neuroscience (Poster)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Alternative RNA splicing regulating the molecular architecture of NMJ2013

    • Author(s)
      Nasrin F, Rahman MA, Ohe K, Masuda A, Ohno K
    • Organizer
      5th NAGOYA Global Retreat (Poster)
    • Place of Presentation
      あいち健康プラザ(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] RNA diseases caused by defects in cis-acting elements and trans-acting factors2013

    • Author(s)
      Ohno K
    • Organizer
      "Danish-Japanese joint seminar on aberrant RNA splicing in neuromuscular disease", Department of Biochemistry and Molecular Biology, University of Southern Denmark (SDU)
    • Place of Presentation
      Odense, Denmark
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Investigation of 11 Patients with GFPT1-Myasthenia Reveals Clinical, Structural, and Electrophysiologic Heterogeneity2013

    • Author(s)
      Selcen D, Shen X-M, Milone M, Brengman J, Ohno K, McQuillen M, Deymeer F, Finkel R, Rowin J, Engel AG
    • Organizer
      65th American Academy of Neurology (Platform)
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular mechanism of the inhibitory effect of hydrogen on inflammation2013

    • Author(s)
      Ito M, Itoh T, Ohno K, Nozawa Y
    • Organizer
      90th Annual Meeting of the Physiological Society of Japan (Platform)
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis2012

    • Author(s)
      Ohno K
    • Organizer
      11th International Meeting on Cholinesterases
    • Place of Presentation
      Kazan, Russia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] EMG findings at non-myotonia and myotonia states in patients with Na channelopathies2012

    • Author(s)
      Kinoshita M, Kokunai Y, Kubota T, Takahashi M, Sasaki R, Ohno K, Hirose K
    • Organizer
      The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center (Poster)
    • Place of Presentation
      京都市芝蘭会館(京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] In myotonic dystrophy type 1 Peroxiredoxin-2 of RBC membrane protein was reduced, compared with a normal subject2012

    • Author(s)
      Kinoshita M, Morita S, Ohno K, Hirose K
    • Organizer
      The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center (Poster)
    • Place of Presentation
      京都市芝蘭会館(京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Global analysis of RNA-binding sites of CUGBP1 and MBNL1 reveal their preferential binding to 3’ UTRs to regulate mRNA stability2012

    • Author(s)
      Masuda A, Andersen HS, Doktor TK, Okamoto T, Ito I, Andresen BS, Ohno K
    • Organizer
      The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center (Poster)
    • Place of Presentation
      京都市芝蘭会館(京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional characterization of GFPT1 during myogenesis and NMJ formation2012

    • Author(s)
      Ohkawara B, Fuse Y, Nakashima H, Ohno K
    • Organizer
      The 11th Annual Scientific Meeting of the Asian and Oceanian Myology Center (Poster)
    • Place of Presentation
      京都市芝蘭会館(京都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Congenital defects of neuromuscular signal transduction2012

    • Author(s)
      Ohno K
    • Organizer
      3rd Berlin Summer School for Myology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular bases and therapeutic intervention of neuromuscular transmission defects2012

    • Author(s)
      Ohno K
    • Organizer
      Ninth French-Japanese Workshop on Muscular Dystrophies
    • Place of Presentation
      JA共済ビル カンファレンス・ホール(東京都千代田区)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Global mapping and global expression profiling of RNA-binding proteins that are associated with neurological and neuromuscular diseases2012

    • Author(s)
      Ohno K
    • Organizer
      35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Mutation in congenital myasthenic syndrome reveals opposite splicing regulatory effects of hnRNPs L and LL2012

    • Author(s)
      Rahman MA, Ohe K, Masuda A, Ito M, Hutchinson DO, Engel AG, Ohno K
    • Organizer
      35th Annual Meeting of the Japan Neuroscience Society (Poster)
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Global mapping of FUS-binding sites and global profiling of FUS-mediated RNA metabolisms in the mouse brain2012

    • Author(s)
      Masuda A, Ishigaki S, Fujioka Y, Iguchi Y, Katsuno M, Shibata A, Urano F, Sobue G, Ohno K
    • Organizer
      62nd Annual Meeting of the American Society of Human Genetics (Poster)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] A comprehensive and efficient algorithm to predict splicing consequences of intronic nucleotide substitutions in the human genome2012

    • Author(s)
      Shibata A, Masuda A, Ohno K
    • Organizer
      62nd Annual Meeting of the American Society of Human Genetics (Poster)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular hydrogen alters signaling pathways and gene expression profiles in multiple mouse organs2012

    • Author(s)
      Sobue S, Yamai K, Ito M, Ohno K, Ito M, Ohkuwa T, Ichihara M
    • Organizer
      52nd Annual Meeting of the American Society for Cell Biology (Poster)
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Annual Research Report
  • [Book] Molecular Genetics of Congenital Myasthenic Syndromes. in eLS. DOI: 10.1002/9780470015902.a0024314)2014

    • Author(s)
      Ohno K, Ohkawara B, Ito M, Engel AG.
    • Publisher
      John Wiley & Sons, Inc., Hoboken, Chichester
    • DOI

      10.1002/9780470015902.a0024314

    • Related Report
      2014 Annual Research Report
  • [Book] "Collagen Q is a key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis" in J Mol Neurosci2014

    • Author(s)
      Ohno K, Ito M, Kawakami Y.
    • Publisher
      Springer, New York
    • Related Report
      2013 Annual Research Report
  • [Book] "Molecular Genetics of Congenital Myasthenic Syndromes" in eLS2014

    • Author(s)
      Ohno K, Ohkawara B, Ito M, Engel AG.
    • Publisher
      John Wiley & Sons, Inc., Hoboken
    • Related Report
      2013 Annual Research Report
  • [Book] "Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis" in Chem Biol Interact 203(1)2013

    • Author(s)
      Ohno K, Ito M, Kawakami Y, Krejci E, Engel AG.
    • Total Pages
      376
    • Publisher
      Elsevier, Amsterdam
    • Related Report
      2013 Annual Research Report
  • [Book] Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis. Chem Biol Interact 203(1)2013

    • Author(s)
      Ohno K, Ito M, Kawakami Y, Krejci E, Engel AG.
    • Total Pages
      376
    • Publisher
      Elsevier, Amsterdam
    • Related Report
      2012 Annual Research Report
  • [Book] Chapter 2: Intronic and exonic nucleotide variations that affect RNA splicing in humans. Genomics I - Humans, Animals and Plants.2013

    • Author(s)
      Ohe K, Masuda A, Ohno K.
    • Total Pages
      344
    • Publisher
      iConcept Press, Hong Kong
    • Related Report
      2012 Annual Research Report
  • [Book] Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases. Oxid Med Cell Longev vol.2012. Article ID:3531522012

    • Author(s)
      Ohno K, Ito M, Ichihara M, and Ito M.
    • Publisher
      Hindawi Publishing Corporation, Cairo
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨格筋増量剤及びその用途2014

    • Inventor(s)
      大野欽司、石黒直樹、飛田哲朗、松下雅樹
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-176248
    • Filing Date
      2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 「骨系統疾患治療薬及びその用途」2013

    • Inventor(s)
      大野欽司、石黒直樹、鬼頭浩史、松下雅樹
    • Industrial Property Rights Holder
      国立大学法人名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-047426
    • Filing Date
      2013-03-10
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2023-03-16  

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