| Project/Area Number |
24390225
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAIGOH Kazumasa 近畿大学, 医学部, 講師 (50319688)
HIRANO Makito 近畿大学, 医学部・附属病院, 准教授 (50347548)
MIYAMOTO Katsuichi 近畿大学, 医学部, 准教授 (50388526)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUBATA Takeshi 東京医科歯科大学, 大学院・疾患生命科学研究部, 教授 (80197756)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 糖鎖 / 自己免疫 / 神経疾患 / 糖脂質 / ガングリオシド / 硫酸化糖脂質 / 脱髄 / ギラン・バレー症候群 / シアル酸 / ミエリン / 自己抗体 |
|---|
| Outline of Final Research Achievements |
Gene analysis of the molecules regulating immunological reactions to glycoconjugates were investigated in neuroimmunological diseases with anti-glycolipid antibodies. Mutations were detected in such molecules specifically in some cases of Guillain-Barre syndrome (GBS). Patients with CIDP having antibodies to LM1-associated antigens rarely had cranial neuropathies and frequently had ataxia. GBS cases with antibodies to Gal-C, a myelin antigen, more frequently were classified as demyelinating type. In IgM paraproteinemic neuropathies, specificities of IgM M-proteins were associated with the clinical features.
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