Study for tissue specific change of lipid quality and metabolism by fatty acid elongase Elovl6
Project/Area Number |
24390230
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TAKASHI Matsuzaka 筑波大学, 医学医療系, 准教授 (70400679)
YOSHIMI Nakagawa 筑波大学, 医学医療系, 准教授 (80361351)
NAOYA Yahagi 筑波大学, 医学医療系, 准教授 (60420246)
石井 清朗 筑波大学, 医学医療系, 助教 (80419150)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | 脂肪酸 / インスリン感受性 / 精神神経疾患 / インスリン抵抗性 / インスリン分泌 / 炎症 / 糖尿病 / 肝臓 / 膵β細胞 / 脳 |
Outline of Final Research Achievements |
Elovl6 is a microsomal enzyme involved in the elongation of saturated and monounsaturated FAs with 12, 14, and 16 carbons. In this research, we generated liver-specific Elovl6 deficient mice (LKO) and brain-specific Elovl6 deficient mice (BKO), and aimed to elucidate the role of Elovl6 in the liver and brain. High carbohydrate diet-feeding in LKO mice caused lower blood glucose and higher insulin sensitivity than those of flox mice. BKO mice showed increased brain weight, decreased neural precursors, decreased spine density, and memory impairment. These results suggest that undarstanding of tissue or cell specific role of Elovl6 may provide a novel therapeutic approach for treating lifestyle-related disease and mental and neurological disorders based on control of fatty acid composition.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.2014
Author(s)
Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimoto K, Tamiya T, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y.
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Journal Title
Diabetes.
Volume: 64(3)
Issue: 3
Pages: 775-84
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes2014
Author(s)
Yoshimi Nakagawa,* Aoi Satoh,* Sachiko Yabe,* Mika Furusawa, Naoko Tokushige, Hitomi Tezuka, Motoki Mikami, Wakiko Iwata, Akiko Shingyouchi, Takashi Matsuzaka, Shiori Kiwata, Yuri Fujimoto, Yasushi Kawakami, Osamu Urayama, Nobuhiro Yamada, and Hitoshi Shimano et. al
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Journal Title
Endocrinology
Volume: 155(12)
Issue: 12
Pages: 4706-4719
DOI
Related Report
Peer Reviewed
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[Journal Article] Utility of the triglyceride level for predicting incident diabetes mellitus according to the fasting status and body mass index category: the Ibaraki Prefectural Health Study.2014
Author(s)
Fujihara K, Sugawara A, Heianza Y, Sairenchi T, Irie F, Iso H, Doi M, Shimano H, Watanabe H, Sone H, Ota H.
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Journal Title
J Atheroscler Thromb.
Volume: 21(11)
Pages: 1152-69
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Ablation of Elovl6 protects pancreatic islets from high-fat diet-induced impairment of insulin secretion.2014
Author(s)
Tang N, Matsuzaka T, Suzuki M, Nakano Y, Zao H, Yokoo T, Suzuki-Kemuriyama N, Kuba M, Okajima Y, Takeuchi Y, Kobayashi K, Iwasaki H, Yatoh S, Takahashi A, Suzuki H, Sone H, Shimada M, Nakagawa Y, Yahagi N, Yamada N, Shimano H.
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Journal Title
Biochem Biophys Res Commun.
Volume: 450(1)
Issue: 1
Pages: 318-23
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] MafB promotes atherosclerosis by inhibiting foam-cell apoptosis2014
Author(s)
Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M, Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M, Shimano H, Miyazaki T, Tontonz P, Takahashi S
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Journal Title
Nat Commun
Volume: 5
Issue: 1
Pages: 3147-3147
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice.2014
Author(s)
Han SI, Komatsu Y, Murayama A, Steffensen KR, Nakagawa Y, Nakajima Y, Suzuki M, Oie S, Parini P, Vedin LL, Kishimoto H, Shimano H, Gustafsson JÅ, Yanagisawa J.
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Journal Title
Hepatology
Volume: 59(5)
Issue: 5
Pages: 1791-1802
DOI
Related Report
Peer Reviewed
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[Journal Article] MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.2013
Author(s)
Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
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Journal Title
Nat Commun.
Volume: 4:2883
Issue: 1
Pages: 2883-2883
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP1c Tg mice fed high-fat and high-fructose diet2013
Author(s)
Wada T, Miyashita Y, Sasaki M, Aruga Y, Nakamura Y, Ishii Y, Sasahara M, Kanasaki K, Kitada M, Koya D, Shimano H, Tsuneki H, Sasaoka
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 305
Issue: 11
Pages: E1415-E1425
DOI
Related Report
Peer Reviewed
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[Journal Article] Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization.2013
Author(s)
Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H
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Journal Title
Nat Commun.
Volume: 4
Issue: 1
Pages: 2316-2316
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.2012
Author(s)
Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H
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Journal Title
Biochem Biophys Res Commun
Volume: 420
Issue: 4
Pages: 931-6
DOI
Related Report
Peer Reviewed
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[Presentation] Deletion of Elovl6 protects against the failure of pancreatic beta-cell mass and function in db/db mice.2012
Author(s)
Yuta Nakano, Takashi Matsuzaka, Nie Tang, Marii Suzuki, Noriko Suzuki-Kemuriyama, Motoko Kuba, Keita Shoshi, Tomotaka Yokoo, Yoshimi Nakagawa, Kiyoaki Ishii, Masako Shimada, Hitoshi Iwasaki, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Naoya Yahagi, Hiroaki Suzuki, Nobuhiro Yamada, Hitoshi Shimano.
Organizer
第35回日本分子生物学会年会
Place of Presentation
マリンメッセ福岡
Year and Date
2012-12-11
Related Report
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[Presentation] Elov16 promotes nonalcoholic steatohepatitis in mice and humane.2012
Author(s)
Takashi Matauzaka, Tang Nie, Noriko Suzuki-Kemuriyama, Motoko Kuba, Yoshimi Nakagawa, Kiyoaki Ishii, Masako Shimada, Kazuto Kobayashi, Shigeru Yatoh, Akimitsu Takahashi, Hirohito Sone, Naoya Yahagi, Hiroaki Suzuki, Makoto Nakamuta, Nobuhiro Yamada, Hitoshi Shimano.
Organizer
9th IDF-WPR Congress and 4th AASD Scientific Meeting
Place of Presentation
国立京都国際会館
Year and Date
2012-11-26
Related Report
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