| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Outline of Final Research Achievements |
Insulin-stimulated phosphorylation of Akt and eNOS were significantly impaired in the endothelium from endothelial cell specific IRS-1/IRS2 double deficient mice. In these mice, glucose uptake by skeletal muscle during exercise was significantly decreased, suggesting that endothelial IRSs were crucial roles in the regulation of glucose metabolism during exercise. Moreover, neointima formation and arteriosclerosis were significantly exacerbated in endothelial cell specific IRS-2 knockout mice, suggesting that IRS-2 was important for protection of atherosclerosis in the endothelium.
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