The role of endothelial IRS in the regulation of glucose uptake by muscle during exercise and arteriosclerosis
| Project/Area Number |
24390232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUBOTA Naoto 東京大学, 医学部附属病院, 准教授 (50396719)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | インスリン受容体基質 / 血管内皮細胞 / インスリン作用 / インスリン抵抗性 / 運動 / 動脈硬化症 |
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| Outline of Final Research Achievements |
Insulin-stimulated phosphorylation of Akt and eNOS were significantly impaired in the endothelium from endothelial cell specific IRS-1/IRS2 double deficient mice. In these mice, glucose uptake by skeletal muscle during exercise was significantly decreased, suggesting that endothelial IRSs were crucial roles in the regulation of glucose metabolism during exercise. Moreover, neointima formation and arteriosclerosis were significantly exacerbated in endothelial cell specific IRS-2 knockout mice, suggesting that IRS-2 was important for protection of atherosclerosis in the endothelium.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Effects of beraprost sodium, an oral prostacyclin analog, on insulin resistance in patients with type 2 diabetes.2015
Author(s)
Katsuyama H, Kubota N, Kubota T, Haraguchi M, Obata A, Takamoto I, Shigematsu K, Miyata T, Ueki K, Kadowaki T
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Journal Title
Diabetology International
Volume: 6
Pages: 39-45
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] TCF7L2 in mouse pancreatic beta cells plays a crucial role in glucose homeostasis by regulating beta cell mass2014
Author(s)
Takamoto I, Kubota N, Nakaya K, Kumagai K, Hashimoto S, Kubota T, Inoue M, Kajiwara E, Katsuyama H, Obata A, Sakurai Y, Iwamoto M, Kitamura T, Ueki K, Kadowaki T
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Journal Title
Diabetologia
Volume: 57
Pages: 542-553
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Vagal hyperactivity due to ventromedial hypothalamic (VMH) lesions increases adiponectin production and release2014
Author(s)
Suzuki Y, Shimizu H, Ishizuka N, Kubota N, Kubota T, Senoo A, Kageyama H, Osaka T, Hirako S, Kim HJ, Matsumoto A, Shioda S, Mori M, Kadowaki T, Inoue S.
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Journal Title
Diabetes
Volume: 63(5)
Pages: 1637-1648
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Evi1 Defines Leukemia-initiating Capacity and Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia2014
Author(s)
Sato T, Goyama S, Kataoka K, Nasu R, Tsuruta-Kishino T, Kagoya Y, Nukina A, Kumagai K, Kubota N, Nakagawa M, Arai S, Yoshimi A, Honda H, Kadowaki T, Kurokawa M.
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Journal Title
Oncogene
Volume: 33
Pages: 5028-5038
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Protection from non-alcoholic steatohepatitis and liver tumourigen esis in high fat-fed insulin receptor substrate-1-knockout mice de spite insulin resistance.2012
Author(s)
Nakamura A, Tajima K, Zolzaya K, Sato K, Inoue R, Yoneda M, Fujita K, Nozaki Y, Kubota KC, Haga H, Kubota N, Nagashima Y, Nakajima A, Maeda S, Kadowaki T, Terauchi Y
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Journal Title
Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance
Volume: 55(12)
Pages: 3382-3391
DOI
Related Report
Peer Reviewed
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[Presentation] The Effect of Dietary Glutamine Supplementation on Chemotherapy-Induced Oral Mucositis in Patients with Esophagogastric Cancer2014
Author(s)
Yoko Uehata, Kumi Takagi, Kaori Kitakubo, Rie Sekine, Katsuhiko Nara, Harumi Watanabe, Kazuyo Saino, Nobuko Motojima, Hiroharu Yamashita, Yasuyuki Seto, Kazuhiko Fukatsu, Naoto Kubota:
Organizer
96th ESPEN Congress
Place of Presentation
Geneva, Switzerland
Year and Date
2014-09-06 – 2014-09-09
Related Report
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[Presentation] DPP-4 Inhibitor Anagliptin Increases Capillary Recruitment and Glucose Uptake in Skeletal Muscle via Endothelial NO-dependent Pathway2014
Author(s)
Hiroyuki Sato, Naoto Kubota, Tesyuya Kubota, Iseki Takamoto, Kumpei Tokuyama, Keizo Nakaya, Shinji Hashimoto, Moritaka Goto, Takahito Jomori, Kohjiro Ueki, Takashi Kadowaki
Organizer
ADA 74th Scientific Sessions
Place of Presentation
San Francisco, California, USA
Year and Date
2014-06-13 – 2014-06-17
Related Report
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[Presentation] インスリン作用機構2014
Author(s)
窪田直人、門脇孝
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪
Year and Date
2014-05-22 – 2014-05-24
Related Report
Invited
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