| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
We have characterized the physiological function of novel isoforms of PGC1α mainly by the investigation of metabolic phenotypes of mice that specifically lack the genes for these isoforms. These novel isoforms, PGC1αb and PGC1αc, are greatly induced in skeletal muscle in response to exercise and increased energy expenditure through stimulating fatty acid metabolism and mitochondrial proton leakage. These isoforms also play an important role for the maintenance of exercise capacity. Novel isoforms that transcribed from the same exon as PGC1αb and PGC1αc were transcribed were identified, and termed PGC1α2, 3, and 4. PGC1α2, 3, and 4 however do not possess such metabolic function in skeletal muscle.
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