Study on homeostatic regulation by glucocorticoid
| Project/Area Number |
24390236
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Noriaki 東京大学, 医科学研究所, 特任研究員 (30396890)
YOSHIKAWA Noritada 東京大学, 医科学研究所, 助教 (70396878)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | ホルモン / ステロイド / 転写因子 / 代謝 / 副腎皮質 / 遺伝子発現 / 副作用 / 内分泌学 / 内科学 / 遺伝子 / 内科 / 臨床 / 骨格筋 / 心筋 / 筋萎縮 / 脂肪組織 / 内分泌 / ストレス |
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| Outline of Final Research Achievements |
Skeletal muscle has a pleiotropic role in organismal energy metabolism by storing protein as an energy source, or by excreting endocrine hormones. Muscle proteolysis is tightly controlled by the hypothalamus-pituitary-adrenal signalling axis via a glucocorticoid-driven transcriptional programme. We unraveled the physiological significance of this catabolic process using skeletal muscle-specific glucocorticoid receptor (GR) knockout (GRmKO) mice. These mice have increased muscle mass but smaller adipose tissues.
Metabolically, GRmKO mice show a drastic shift of energy utilization and storage in muscle, liver and adipose tissues. The resulting depletion of plasma alanine serves as a cue to increase plasma levels of FGF21 and activates liver-fat communication, leading to the activation of lipolytic genes in adipose tissues. This skeletal muscle-liver-fat signalling axis may serve as a target for the
development of therapies against various metabolic diseases, including obesity.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] A case with elevated serum IgG4 complicated by pericardial involvement with patchy 18F-FDG uptake in PET/CT - atypical presentation of IgG4-related disease?2015
Author(s)
Matsumiya R, Hosono O, Yoshikawa N, Uehara M, Kobayashi H, Oda A, Matsubara E, Tanada S, Shintani Y, Nagayama K, Nakajima J, Tanaka H
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Journal Title
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A Muscle-liver-fat signaling axis is essential for central control of adaptive adipose remodeling2015
Author(s)
Shimizu N, Maruyama T, Yoshikawa N, Matsumiya R, Ma Y, Ito N, Tasaka Y, Kuribara-Souta A, Miyata K, Oike Y, Berger S, Schutz G, Takeda S & Tanaka H
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Journal Title
Nat Commun
Volume: -
Issue: 1
Pages: 6693-6693
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Quantitative analysis of skeletal muscle mass in patients with rheumatic diseases under glucocorticoid therapy - Comparison among bioelectrical impedance analysis, computed tomography, and magnetic resonance imaging2015
Author(s)
Osamu Hosono, Noritada Yoshikawa(equal first authors), Noriaki Shimizu, Shigeru Kiryu, Masaaki Uehara, Hiroshi Kobayashi, Ryo Matsumiya, Akiko Kuribara, Takako Maruyama and Hirotoshi Tanaka
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Journal Title
Mod Rheumatol
Volume: 25(2)
Issue: 2
Pages: 257-263
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] ステロイドと骨格筋代謝2014
Author(s)
田中廣壽
Organizer
第32回先進リウマチ医学研究会
Place of Presentation
慶應義塾大学信濃町キャンパス（東京都新宿区）
Year and Date
2014-06-03
Related Report
Invited
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