Mechanism for Adiponectin tissue defense and pathophysiological significance of Favine
| Project/Area Number |
24390238
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
SHIMOMURA Iichiro 大阪大学, 医学(系)研究科(研究院), 教授 (60346145)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKI Michio 大阪大学, 大学院医学系研究科, 講師 (00403056)
FUKUHARA Atsunori 大阪大学, 大学院医学系研究科, 助教 (00437328)
NISHIZAWA Hitoshi 大阪大学, 大学院医学系研究科, 助教 (20379259)
MAEDA Norikazu 大阪大学, 大学院医学系研究科, 助教 (30506308)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | アディポネクチン / Favine / T-カドヘリン / 血管内皮細胞 / 糖尿病 / Ｔ－カドヘリン |
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| Outline of Final Research Achievements |
Adiponectin (Adp) protein was detected in murine aorta, heart, and skeletal muscle. In the atherosclerotic lesion, Adp was detected in endothelial cells, synthetic smooth muscle cells and monocytes attaching to endothelial cells. Tissue accumulation of Adp was reduced in T-cadherin knockout mice while plasma Adp level significantly increased compared to control. Accumulation and function of Adp exerted through T-cadherin. ELISA system to measure C1q- Adp complex was established, and circulating levels of complex were associated with body mass index, visceral and subcutaneous fat area, and atherosclerosis. Adp possessed an anti-fibrotic effect of heart partly through the suppression of beta-catenin pathway. We generated Favine (Fav) knockout mice. Adipose tissue and body weight were significantly less in Fav-KO mice than control. It was revealed that Fav has both adipogenic and lipogenic effects on adipocytes.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice.2015
Author(s)
Matsuda K, Fujishima Y, Maeda N, Mori T, Hirata A, Sekimoto R, Tsushima Y, Masuda S, Yamaoka M, Inoue K, Nishizawa H, Kita S, Ranscht B, Funahashi T, Shimomura I.
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Journal Title
Endocrinology.
Volume: 156
Issue: 3
Pages: 934-946
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effect of adiponectin on cardiac beta-catenin signaling pathway under angiotensin II infusion.2014
Author(s)
Fujishima Y, Maeda N, Matsuda K, Komura N, Hirata A, Mori T, Sekimoto R, Tsushima Y, Nishizawa H, Funahashi T, Shimomura I.
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Journal Title
Biochem Biophys Res Commun.
Volume: 444
Issue: 2
Pages: 224-229
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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