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Development of gene therapy for refractory non-Hodgkin lymphoma using T-cells expressing a chimeric antigen receptor

Research Project

Project/Area Number 24390247
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Hematology
Research InstitutionJichi Medical University

Principal Investigator

OZAWA keiya  自治医科大学, 医学部, 客員教授 (30137707)

Co-Investigator(Kenkyū-buntansha) TSUKAHARA Tomonori  自治医科大学, 医学部, 講師 (10362120)
UCHIBORI Ryousuke  自治医科大学, 医学部, 助教 (20458285)
OHMINE Ken  自治医科大学, 医学部, 講師 (90316521)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords遺伝子治療 / 免疫療法 / 細胞療法 / キメラ抗原受容体 / Tリンパ球 / 造血器腫瘍 / 血液腫瘍学
Outline of Final Research Achievements

Gene therapy for refractory B-cell non-Hodgkin lymphoma using T-cells expressing a chimeric antigen receptor (CAR) was studied as follows: (1) To improve the anti-tumor activity, T-cells were transduced with CD19-targeted CAR and IL-21 genes. However, the therapeutic effect was not enhanced by IL-21 in tumor-bearing mice. (2) For the safety, we developed a switch promoter, which stimulates transgene expression in CAR T-cells upon interaction with target cells. We demonstrated that this system works through CAR-dependent signaling in CAR T-cells in vitro and in tumor-bearing mice. (3) We manufactured CD19-CAR T-cells from patient-derived PBMCs by a closed cell-processing system, and confirmed that these T-cells can kill B lymphoma cells in vitro. (4) A clinical protocol (CD19-CAR T-cell therapy for B-cell lymphoma) was approved by IRB and the Ministry of Health, Labour and Welfare. Enrollment started in December 2014.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (51 results)

All 2015 2014 2013 2012 Other

All Journal Article (29 results) (of which Peer Reviewed: 29 results,  Open Access: 8 results) Presentation (22 results) (of which Invited: 2 results)

  • [Journal Article] Corticospinal tract development and spinal cord innervation differ between cervical and lumbar targets2015

    • Author(s)
      Kamiyama T, Kameda H, Murabe N, Fukuda S, Yoshioka N, Mizukami H, Ozawa K, Sakurai M.
    • Journal Title

      J Neurosci.

      Volume: 35 Issue: 3 Pages: 1181

    • DOI

      10.1523/jneurosci.2842-13.2015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex.2015

    • Author(s)
      Watakabe A, Ohtsuka M, Kinoshita M, Takaji M, Isa K, Mizukami H, Ozawa K, Isa T, and Yamamori T.
    • Journal Title

      Neurosci. Res.

      Volume: 93 Pages: 144-157

    • DOI

      10.1016/j.neures.2014.09.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution of serum erythropoietin levels in Japanese patients with myelodysplastic syndromes.2015

    • Author(s)
      Suzuki T, Oh I, Ohmine K, Meguro A, Mori M, Fujiwara S, Yamamoto C, Nagai T, Ozawa K.
    • Journal Title

      Int J Hematol.

      Volume: 101 Issue: 1 Pages: 32-36

    • DOI

      10.1007/s12185-014-1699-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central retinal vein occlusion caused by hyperviscosity syndrome in a young patient with Sjögren's syndrome and MALT lymphoma.2015

    • Author(s)
      Yoshida A, Watanabe M, Ohmine K, Kawashima H.
    • Journal Title

      Int Ophthalmol.

      Volume: 35 Issue: 3 Pages: 429-32

    • DOI

      10.1007/s10792-015-0056-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies2015

    • Author(s)
      Tsukahara, T., Iwase, N., Kawakami, K., Iwasaki, M., Yamamoto, C., Ohmine, K., Uchibori, R., Teruya, T., Ido, H., Saga, Y., Urabe, M., Mizukami, H., Kume, A., Nakamura, M., Brentjens, R., and Ozawa, K.
    • Journal Title

      Gene Therapy

      Volume: 22 Issue: 2 Pages: 209-215

    • DOI

      10.1038/gt.2014.104

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term outcome of patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy: a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA collaborative study group.2015

    • Author(s)
      Hirokawa M, Sawada K, Fujishima N, Teramura M, Bessho M, Dan K, Tsurumi H, Nakao S, Urabe A, Fujisawa S, Yonemura Y, Kawano F, Oshimi K, Sugimoto K, Matsuda A, Karasawa M, Arai A, Komatsu N, Harigae H, Omine M, Ozawa K, Kurokawa M; PRCA Collaborative Study Group.
    • Journal Title

      Br J Haematol.

      Volume: in press Issue: 6 Pages: 879-886

    • DOI

      10.1111/bjh.13376

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance.2014

    • Author(s)
      Cui W, Mizukami H, Yanagisawa M, Aida T, Nomura M, Isomura Y, Takayanagi R, Ozawa K, Tanaka K, and Aizawa H.
    • Journal Title

      J. Neurosci.

      Volume: 34 Issue: 49 Pages: 16273-16285

    • DOI

      10.1523/jneurosci.1465-14.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material.2014

    • Author(s)
      Ayuso E, et al
    • Journal Title

      Hum. Gene Ther.

      Volume: 25 Issue: 11 Pages: 977-987

    • DOI

      10.1089/hum.2014.057

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leukemia cells directly phagocytose blood cells in AML-associated hemophagocytic lymphohistiocytosis: A case report and review of the literature.2014

    • Author(s)
      Hatano K, Nagai T, Matsuyama T, Sakaguchi , Fujiwara S.I, Oh I, Muroi K, and Ozawa K.
    • Journal Title

      Acta Haematol.

      Volume: 133 Issue: 1 Pages: 98-100

    • DOI

      10.1159/000360840

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The bone marrow hematopoietic microenvironment is impaired in iron-overloaded mice.2014

    • Author(s)
      Okabe H, Suzuki T, Uehara E, Ueda M, Nagai T, Ozawa K.
    • Journal Title

      Eur J Haematol.

      Volume: in Press Issue: 2 Pages: 118-128

    • DOI

      10.1111/ejh.12309

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of functional coagulation factor VIII from iPSCs using a lentiviral vector2014

    • Author(s)
      Kashiwakura Y, Ohmori T, Mimuro J, Madoiwa S, Inoue M, Hasegawa M, Ozawa K, and Sakata Y.
    • Journal Title

      Haemophilia

      Volume: 20 Issue: 1

    • DOI

      10.1111/hae.12311

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells2014

    • Author(s)
      Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey T, Suzuki M, Ichimura K, Ozawa K
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 1 Pages: 72-80

    • DOI

      10.1111/cas.12315

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals.2014

    • Author(s)
      Mimuro J, Mizukami H, Shima M, Matsushita T, Taki M, Muto S, Higasa S, Sakai M, Ohmori T, Madoiwa S, Ozawa K, and Sakata Y.
    • Journal Title

      J. Med. Virol.

      Volume: 86 Issue: 11 Pages: 1990-1997

    • DOI

      10.1002/jmv.23818

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of resistance to azacitidine in human leukemia cell lines.2014

    • Author(s)
      Sripayap P, Nagai T, Uesawa M, Kobayashi H, Tsukahara T, Ohmine K, Muroi K, Ozawa K.
    • Journal Title

      Exp Hematol.

      Volume: 42 Issue: 4 Pages: 294-306

    • DOI

      10.1016/j.exphem.2013.12.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer gene therapy using mesenchymal stem cells.2014

    • Author(s)
      Uchibori R, Tsukahara T, Ohmine K, Ozawa K.
    • Journal Title

      Int J Hematol.

      Volume: 99 Issue: 4 Pages: 377-82

    • DOI

      10.1007/s12185-014-1537-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrathecal administration of high-titer cytomegalovirus immunoglobulin for cytomegalovirus meningitis.2014

    • Author(s)
      Fujiwara S, Muroi K, Tatara R, Ohmine K, Matsuyama T, Mori M, Nagai T, Ozawa K.
    • Journal Title

      Case Rep Hematol.

      Volume: 2014 Pages: 1-3

    • DOI

      10.1155/2014/272458

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Intra-Medullar and Intra-Venous Infusions of Mesenchymal Stem Cells on Cell Engraftment by In-Vivo Cell Tracking and Osteoinductivity in Rabbit Long Bones: A Pilot Study.2014

    • Author(s)
      Ishihara A, Ohmine K, Weisbrode SE, Bertone AL.
    • Journal Title

      Orthop Muscular Syst.

      Volume: 3 Issue: 03 Pages: 1-5

    • DOI

      10.4172/2161-0533.1000172

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-21 is not necessary for anti-lymphoma effects of T cells expressing second-generation CD19-specific chimeric antigen receptors in a xenograft mouse model.2014

    • Author(s)
      Yamamoto C, Tsukahara T, Omine K, Teruya T, Ido H, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Journal Title

      Jichi Medical University Journal

      Volume: 36 Pages: 23-31

    • NAID

      120006408261

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of lymph node and lung metastases of endometrial cancer by muscle-mediated expression of soluble VEGF receptor-32013

    • Author(s)
      Takahashi K, Mizukami H, Saga Y, Takei Y, Urabe M, Kume A, Machida S, Fujiwara H, Suzuki M, Ozawa K
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 8 Pages: 1107-1111

    • DOI

      10.1111/cas.12184

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models2013

    • Author(s)
      Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, Mineno J, Takesako K, Riviere I, Sadelain M, Brentjens R, Ozawa K
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 438 Issue: 1 Pages: 84-89

    • DOI

      10.1016/j.bbrc.2013.07.030

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unrelated allogeneic bone marrow-derived mesenchymal stem cells for steroid-refractory acute graft-versus-host disease: a phase I/II study.2013

    • Author(s)
      Muroi K, Miyamura K, Ohashi K, Murata M, Eto T, Kobayashi N, Taniguchi S, Imamura M, Ando K, Kato S, Mori T, Teshima T, Mori M, Ozawa K.
    • Journal Title

      Int J Hematol.

      Volume: 98 Issue: 2 Pages: 206-213

    • DOI

      10.1007/s12185-013-1399-4

    • NAID

      10031194736

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of factor VII ameliorates bleeding diathesis of factor VIII-deficient mice with inhibitors.2013

    • Author(s)
      Yasumoto A, Madoiwa S, Kashiwakura Y, Ishiwata A, Ohmori T, Mizukami H. Ozawa K, Sakata Y, and Mimuro J.
    • Journal Title

      Thromb. Res.

      Volume: 131 Issue: 5 Pages: 444-449

    • DOI

      10.1016/j.thromres.2013.03.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minimizing the inhibitory effect of neutralizing antibody for efficient gene expression in the liver with adeno-associated virus 8 vectors.2013

    • Author(s)
      Mimuro J, Mizukami H, Hishikawa S, Ikemoto T, Ishiwata A, Sakata A, Ohmori T, Madoiwa S, Ono F, Ozawa K, and Sakata Y
    • Journal Title

      Mol Ther

      Volume: 21 Issue: 2 Pages: 318-323

    • DOI

      10.1038/mt.2012.258

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.2013

    • Author(s)
      Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K
    • Journal Title

      Cancer Research

      Volume: 73 Issue: 1 Pages: 364-372

    • DOI

      10.1158/0008-5472.can-12-0088

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of indoleamine-2,3-dioxygenase in cervical cancer cells suppresses tumor growth by promoting natural killer cell accumulation.2012

    • Author(s)
      Sato, N.
    • Journal Title

      Oncol Rep.

      Volume: 28 Issue: 5 Pages: 1574-1578

    • DOI

      10.3892/or.2012.1984

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-articular injection of mesenchymal stem cells expressing coagulation factorameliorates hemophilic arthropathy in factor VIII-deficient mice.2012

    • Author(s)
      Kashiwakura, Y
    • Journal Title

      J Thromb Haemost.

      Volume: 10(9) Issue: 9 Pages: 1802-1813

    • DOI

      10.1111/j.1538-7836.2012.04851.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cetuximab inhibits the growth of mucinous ovarian carcinoma tumor cells lacking KRAS gene mutations.2012

    • Author(s)
      Sato, N.
    • Journal Title

      Oncol Rep.

      Volume: 27 Pages: 1336-1340

    • DOI

      10.3892/or.2012.1626

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-10 expression induced by adeno-associated virus vector suppresses proteinuria in Zucker obese rats2012

    • Author(s)
      Ogura M, Urabe M, Akimoto T, Onishi A, Ito C, Ito T, Tsukahara T, Mizukami H, Kume A, Muto S, Kusano E, and Ozawa K.
    • Journal Title

      Gene Ther

      Volume: 19巻 Issue: 5 Pages: 476-82

    • DOI

      10.1038/gt.2011.183

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recovery of neurogenic amines in phenylketonuria mice after liver-targeted gene therapy2012

    • Author(s)
      Yagi, H., Sanechika, S., Ichinose, H., Sumi-Ichinose, C., Mizukami, H., Urabe, M., Ozawa, K., and Kume, A.
    • Journal Title

      Neuroreport

      Volume: 23 Issue: 1 Pages: 30-34

    • DOI

      10.1097/wnr.0b013e32834e3a87

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] CD19特異的キメラ抗原受容体発現Tリンパ球を用いた難治性B細胞性悪性リンパ腫に対する遺伝子治療2014

    • Author(s)
      大嶺 謙
    • Organizer
      IMSUT-CGCTキックオフ・シンポジウム2014
    • Place of Presentation
      東京
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Analysis of function and response specificity of a switch promoter driven by activation signals from a CD19-targeted chimeric antigen receptor.2014

    • Author(s)
      Uchibori R, Takeshi T, Tsukahara T, Ohmine K, Riviere I, Brentjens RJ, Sadelain M, Mineno J, Takesako K, Ozawa K.
    • Organizer
      The 5th Meeting of Asian Cellular Therapy Organization.
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tol2 transposon-based gene transfer of CD19-specific chimeric antigen receptors into human T-cells.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Teruya T, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R, Kawakami K and Ozawa K.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Activation signals from CAR permit NFAT-controlled inducible expression of transgenes in PBMCs.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] フィラデルフィア染色体陽性急性白血病に対するPSL併用Dasatinib療法の効果と安全性に関する報告2014

    • Author(s)
      翁 家国, 多々良 礼音, 藤原 慎一郎, 大嶺 謙, 鈴木 隆浩, 永井 正, 室井 一男, 小澤 敬也
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Activation signals from chimeric antigen receptors permit NFAT-controlled inducible expression of transgene in PBMCs.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Mineno J, Ozawa K.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Generation of T-cells expressing a CD19-specific CAR by the Tol2 transposon system.2014

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] キメラ抗原受容体からの抗原刺激特異的な遺伝子発現誘導系の開発.2014

    • Author(s)
      内堀 亮介, 二宮 空暢, 照屋 武志, 塚原 智典, 大嶺 謙, 峰野 純一, 竹迫 一任, 小澤 敬也.
    • Organizer
      第6回血液疾患免疫療法研究会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tol2 transposon-mediated gene transfer of CD19-CAR to primary human T-cells for the treatment of B-cell malignancies.2014

    • Author(s)
      Tsukahara T, Iwase N, Yamamoto C, Ohmine K, Uchibori R, Takeshi T, Urabe M, Mizukami H, Kume A, Nakamura M, Brentjens R J, Kawakami K, Ozawa K.
    • Organizer
      第20回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] The NFAT response elements in the IL-2 gene promoter permit visualization and quantification of activation status in CAR-expressing PBMCs.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第20回日本遺伝子治療学会
    • Place of Presentation
      東京
    • Year and Date
      2014-08-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] B細胞リンパ腫に合併した腫瘍随伴性天疱瘡と考えた1例2014

    • Author(s)
      坂口 優, 宮本 有希子, 佐藤 篤子, 藤田 有理香, 小宮根 真弓, 村田 哲, 大槻 マミ太郎, 佐藤 一也, 大嶺 謙, 小澤 敬也
    • Organizer
      第113回 日本皮膚科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of switch promoters that is activated to induce exogenous gene expression upon the recognition of CD19 by chimeric antigen receptors.2014

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      17th Annual Meeting of the American Society of Gene & Cell Therapy.
    • Place of Presentation
      Washington, D.C.
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞療法の現状と将来 キメラ抗原受容体発現Tリンパ球を用いたB細胞性腫瘍に対する遺伝子治療2014

    • Author(s)
      大嶺 謙
    • Organizer
      第62回日本輸血・細胞治療学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2014-05-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Validation of anti-tumor activity mediated by T-lymphocytes with chimeric antigen receptor targeting CD19 for B cellymphoma2012

    • Author(s)
      塚原智典
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2012-10-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bリンパ腫に対する抗CD19キメラ抗原受容体発現T細胞の抗腫瘍効果2012

    • Author(s)
      塚原智典
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of anti-tumor effects mediated by engineered Tlymphocytes expressing a CD19 specific CAR for B cell lymphoma2012

    • Author(s)
      Tsukahara, T.
    • Organizer
      The 15th Annual Meeeting of The American Society of Gene and Cell Therapy
    • Place of Presentation
      Pennsylvania Convention Center (USA)
    • Year and Date
      2012-05-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tumor targeting and anti-tumor activity mediated by T-lymphocytes with an anti-CD19 CAR in human B-cell lymphoma models.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-tumor activity of CD19-specific chimeric antigen receptor-modified T-cells for B cell lymphoma.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Ozawa K.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tumor targeting using T-lymphocytes with an anti-CD19 chimeric antigen receptor for B cell lymphoma.

    • Author(s)
      Tsukahara T, Ohmine K, Uchibori R, Ido H, Urabe M, Mizukami H, Kume A, Nakamura M, Riviere I, Sadelain M, Brentjens R, Ozawa K.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report
  • [Presentation] DEVELOPMENT OF SIN RETROVIRAL VECTORS EQUIPPED WITH SWITCH PROMOTERS DRIVEN BY ACTIVATION SIGNALS FROM THE CHIMERIC ANTIGEN RECEPTORS.

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第18回日本遺伝子治療学会
    • Place of Presentation
      岡山市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of switch promoters that would respond to activation signals from the chimeric antigen receptors.

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ido H, Teruya T, Ohmine K, Urabe M, Mizukami H, Kume A, Riviere I, Sadelain M, Brentjens RJ, Mineno J, Ozawa K.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of switch promoters driven by activation signals from the chimeric antigen receptors.

    • Author(s)
      Uchibori R, Ninomiya S, Tsukahara T, Ohmine K, Urabe M, Mizukami H, Kume A, Mineno J, Ozawa K.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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