Lymphomagenesis pathway consisting of various cooperative genes and their relevance as molecular target therapy
| Project/Area Number |
24390249
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kurume University (2014)
Aichi Cancer Center Research Institute (2012-2013) |
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Principal Investigator |
SETO Masao 久留米大学, 医学部, 客員教授 (80154665)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | リンパ腫 / 染色体転座 / 転座関連遺伝子 / シグナルトランスダクション / MYC、BCL2 、CCND1 / 腫瘍化機構 / リンパ腫モデル / 分子標的 / 悪性リンパ腫 / ゲノム異常 |
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| Outline of Final Research Achievements |
Various genetic alterations have been reported in lymphoid malignancies. Frequencies of such alterations in each disease entity are low except for translocation-juncture genes. It is not an easy task to provide evidences that such genes are directly involved in lymphomagenesis. Transgenic and know-out mouse technology is limited in analyzing several genes within a relatively short period of time. In this research project, we have established the cell culture system, using feeder cells and cytokines, which can analyze several genes by retroviral vector transduction. Indeed, we could transform normal mouse B-cells to lethally malignant lymphoma by three translocation juncture genes, MYC, BCL2 and CCND1. This system could be extended to examine oncogenic ability for several other genes reported by genomic or exome sequencing. This system will further provide a good system to screen molecular targets.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Gene expression profiling of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly reveals alterations of characteristic oncogenetic pathways.2014
Author(s)
Kato H, Karube K, Yamamoto K, Takizawa J, Tsuzuki S, Yatabe Y, Kanda T, Katayama M, Ozawa Y, Ishitsuka K, Okamoto M, Kinoshita T, Ohshima K, Nakamura S, Morishima Y, Seto M.
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Journal Title
Cancer Sci.
Volume: 105
Issue: 5
Pages: 537-544
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.2014
Author(s)
Suguro M, Yoshida N, Umino A, Kato H, Tagawa H, Nakagawa M, Fukuhara N, Karnan S, Takeuchi I, Hocking TD, Arita K, Karube K, Tsuzuki S, Nakamura S, Kinoshita T, Seto M.
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Journal Title
Cancer Sci.
Volume: 105
Issue: 7
Pages: 897-904
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Molecular Characterization of Chronic-type Adult T-cell Leukemia/Lymphoma2014
Author(s)
Yoshida N, Karube K, Utsunimiya A, Tsukasaki K, Imaizumi Y, Taira N, Uike N, Umino A, Arita K, Suguro M, Tsuzuki S, Kinoshita T, Ohshima K, Seto M.
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Journal Title
Cancer Research
Volume: 74
Issue: 21
Pages: 6129-6138
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gene expression profiling of Epstein-Barr virus positive diffuse large B-cell lymphoma of the elderly reveals alterations of characteristic oncogenetic pathways.2014
Author(s)
Kato H, Karube K, Yamamoto K, Takizawa J, Tsuzuki S, Yatabe Y, Kanda T, Katayama M, Ozawa Y, Ishitsuka K, Okamoto M, Kinoshita T, Ohshima K, Nakamura S, Morishima Y, Seto M.
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Journal Title
Cancer Sci.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Behavior of bone marrow-derived cells following in vivo transplantation: differentiation into stromal cells with roles in organ maintenance.2013
Author(s)
Taguchi O, Tsujimura K, Kontani K, Harada Y, Nomura S, Ikeda H, Morita A, Sugiura H, Hayashi N, Yatabe Y, Seto M, Tatematsu M, Takahashi T, Fukushima A.
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Journal Title
Am J Pathol
Volume: 182(4)
Issue: 4
Pages: 1255-1262
DOI
Related Report
Peer Reviewed
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[Journal Article] Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status.2012
Author(s)
Karube K, Tsuzuki S, Yoshida N, Arita K, Liu F, Kondo E, Ko YH, Ohshima K, Nakamura S, Kinoshita T, Seto M.
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Journal Title
Exp. Hematol.
Volume: 40
Issue: 12
Pages: 1005-1015
DOI
Related Report
Peer Reviewed
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