Analysis of pollen-driven endogenous IL-33 and basophils in allergic rhinitis manifestation
| Project/Area Number |
24390253
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Kazufumi 兵庫医科大学, 医学部, 講師 (20581549)
YASUDA Koubun 兵庫医科大学, 医学部, 講師 (50333539)
MATSUMOTO Makoto 兵庫医科大学, 医学部, 講師 (40380521)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | アレルギー性鼻炎 / IL-33 / 好塩基球 / 好酸球 / 花粉 / モデルマウス / モデルマス |
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| Outline of Final Research Achievements |
We established a novel mouse model of ragweed (RW) pollen-specific allergic rhinitis (AR) and examined the pathological role for endogenous IL-33 in the induction of early- and late-phase AR manifestation using IL-33-deficient mice. After nasal challenge with RW pollen, RW-immunized wild-type mice manifested early-phase (sneezing), and late-phase (eosinophilic/basophilic accumulation) responses. In contrast, IL-33-deficient and basophils-depleted mice failed to develop AR. We revealed that IL-33-stimulated mast cells and basophils contribute to sneezing and accumulation of eosinophils/basophils in the nasal mucosa by increasing histamine release and production of chemoattractants for eosinophils/basophils, respectively. Finally, compared with healthy controls, IL-33 mRNA expression in nasal epithelial cells from AR patients significantly increased during the pollen season. Thus, RW pollen-driven endogenous IL-33 and basophils are promising therapeutic target molecules to prevent AR.
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] Contribution of IL-33-activated type II innate lymphoid cells to pulonary eosinophilia in intestinal nematode-infected mice.2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-umikura S, Tsutsui H, Ishii KJ, Yoshimoto T, Akira S, Nakanishi K.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 109
Pages: 3451-56
Related Report
Peer Reviewed
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[Journal Article] A critical role of IL-33 1n experimental allergic rhinitis.2012
Author(s)
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Iraoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T.
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Journal Title
J Allergy Clin Immunol
Volume: 130
Pages: 184-94
Related Report
Peer Reviewed
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[Journal Article] Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes.2012
Author(s)
Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara K.
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Journal Title
Allergol Int
Volume: 61
Pages: 563-72
NAID
Related Report
Peer Reviewed
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[Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia intestinal nematode-infected mice.2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishi KJ, Yoshimoto T, Akira S, Nakanishi K
Organizer
第77回日本インターフェロン・サイトカイン学会学術集会
Place of Presentation
神戸
Related Report
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[Presentation] Chitin induces lung eosinophilia dependently on IL-33.2012
Author(s)
Muto T, Yasuda K, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi-Yumikura S, Tsutsui H, Ishi K, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
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[Presentation] Contibution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice.2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi-Yumikura S, Tsutsui H, Ishi K, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
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