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Comprehensive gene analysis of acute encephalopathy to elucidate its variability and commonality

Research Project

Project/Area Number 24390258
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokyo

Principal Investigator

MIZUGUCHI Masashi  東京大学, 医学(系)研究科(研究院), 教授 (20209753)

Co-Investigator(Kenkyū-buntansha) TAKANASHI Jun-ichi  東京女子医科大学, 八千代医療センター, 教授 (00302555)
SAITOH Makiko  東京大学, 大学院医学系研究科, 助教 (20225733)
Co-Investigator(Renkei-kenkyūsha) HIROSE Shin-ichi  福岡大学, 医学部, 教授 (60248515)
YAMANOUCHI Hideo  埼玉医科大学, 医学部, 教授 (10250226)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords急性脳症 / 遺伝子多型 / 遺伝子変異 / 自然免疫 / 神経興奮 / 急性壊死性脳症 / けいれん重積型(二相性)急性脳症 / 難治頻回部分発作重積型急性脳炎 / HHE症候群 / 遺伝子解析 / サイトカイン / イオンチャネル / けいれん重積型急性脳症 / HLA / 難治頻回部分発作重積型脳炎 / アデノシン
Outline of Final Research Achievements

Acute encephalopathy is classified into multiple syndromes, such as acute necrotizing encephalopathy (ANE), acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) and acute encephalitis with refractory, repetitive partial seizures (AERRPS). To elucidate the molecular background of their variability and commonality, we conducted a comprehensive gene analysis and functional analysis. Risk gene variants specific to individual syndromes included HLA genotypes, IL6 and IL10 polymorphisms for ANE, ADORA2A and IL1B polymorphisms for AESD, and SCN2A polymorphism for AERRPS. Risk variants relevant to multiple syndromes included CPT2 and IL1RN polymorphisms and missense SCN1A mutations. Most factors were involved in either innate immunity or neuronal excitation.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (66 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 17 results,  Acknowledgement Compliant: 2 results) Presentation (31 results) (of which Invited: 5 results) Book (7 results) Remarks (3 results)

  • [Journal Article] An unusual autopsy case of cytokinestorm-derived influenza-associated encephalopathy without typical histopathological findings: Autopsy case report.2015

    • Author(s)
      Nara A, Nagai H, Yamaguchi R, Yoshida K, Iwase H, Mizuguchi M.
    • Journal Title

      American Journal of Forensic medicine and Pathology.

      Volume: 36 Issue: 1 Pages: 3-5

    • DOI

      10.1097/paf.0000000000000129

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A severity score for acute necrotizing encephalopathy.2015

    • Author(s)
      Yamamoto H, Okumura A, Natsume J, Kojima S, Mizuguchi M.
    • Journal Title

      Brain and Development

      Volume: 37 Issue: 3 Pages: 322-327

    • DOI

      10.1016/j.braindev.2014.05.007

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and genetic features of acute encephalopathy in children taking theophylline.2015

    • Author(s)
      Saitoh M, Shinohara M, Ishii A, Ihara Y, Hirose S, Shiomi M, Kawawaki H, Kubota M, Yamagata T, Miyamoto A, Yamanaka G, Amemiya K, Kikuchi K, Kamei A, Akasaka M, Anzai Y, Mizuguchi M.
    • Journal Title

      Brain Dev

      Volume: 37 Issue: 5 Pages: 463-70

    • DOI

      10.1016/j.braindev.2014.07.010

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination.2015

    • Author(s)
      Takanashi J, Shiihara T, Hasegawa T, Takayanagi M, Hara M, Okumura A, Mizuguchi M.
    • Journal Title

      J Neurol Sci

      Volume: 349(1-2) Issue: 1-2 Pages: 226-228

    • DOI

      10.1016/j.jns.2014.12.019

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acute encephalopathy with callosal, subcortical and thalamic lesions.2015

    • Author(s)
      Nakano Y, Monden Y, Mizuguchi M, Nagashima M, Koike Y, Gunji Y, Takahashi N, Sugie H, Momoi, M.Y.
    • Journal Title

      Neurology Asia

      Volume: 20 Pages: 85-89

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児のウイルス感染症と意識障害.2015

    • Author(s)
      水口雅.
    • Journal Title

      小児科

      Volume: 56 Pages: 161-167

    • NAID

      40020363064

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 回復期に眼球上転・口部ジスキネジアが遷延したインフルエンザ脳症の1例2014

    • Author(s)
      森川美佳, 三牧正和, 高橋長久, 内野俊平, 水野葉子, 岩崎博之, 水口雅, 五十嵐隆.
    • Journal Title

      小児科臨床

      Volume: 67 Pages: 995-1000

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腸管出血性大腸菌O111集団感染における危機対応2014

    • Author(s)
      種市尋宙,六車崇,太田邦雄,小西道雄,住田亮,奥村彰久,高梨潤一,水口雅,宮脇利男
    • Journal Title

      日本小児科学会雑誌

      Volume: 118 Pages: 1103-1108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] インフルエンザ脳症および関連した神経精神症状2014

    • Author(s)
      水口雅
    • Journal Title

      小児科臨床

      Volume: 67 Pages: 1463-1470

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Clinical and radiologic features of encephalopathy during 2011 E coli O111 outbreak in Japan.2014

    • Author(s)
      Takanashi JI, Taneichi H, Misaki T, Yahata Y, Okumura A, Ishida YI, Miyawaki T, Okabe N, Sata T, Mizuguchi M.
    • Journal Title

      Neurology

      Volume: 82 Issue: 7 Pages: 564-572

    • DOI

      10.1212/wnl.0000000000000120

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of recurrent acute encephalopathy with febrile convulsive status epilepticus with carnitine palmitoyltransferase II variation.2013

    • Author(s)
      Sakai E, Yamanaka G, Kawashima H, Morishima Y, Ishida Y, Oana S, Miyajima T, Shinohara M, Saitoh M, Mizuguchi M.
    • Journal Title

      Neuropediatrics

      Volume: 44 Issue: 04 Pages: 218-221

    • DOI

      10.1055/s-0032-1333439

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus2013

    • Author(s)
      Shinohara M, Saitoh M, Nishizawa D, Ikeda K, Hirose S, Takanashi J, Takita J, Kikuchi K, et al
    • Journal Title

      Neurology

      Volume: 80 Issue: 17 Pages: 1571-1576

    • DOI

      10.1212/wnl.0b013e31828f18d8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性脳症―発症の遺伝的背景―2013

    • Author(s)
      水口雅
    • Journal Title

      Neuroinfection

      Volume: 18 Pages: 54-59

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Influenza encephalopathy and related neuropsychiatric syndromes.2013

    • Author(s)
      Mizuguchi M.
    • Journal Title

      Influenza and Other Respiratory Viruses

      Volume: 7 Issue: s3 Pages: 67-71

    • DOI

      10.1111/irv.12177

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal herpes encephalitis caused by a virologically confirmed acyclovir resistant herpes simplex virus type 12013

    • Author(s)
      Kakiuchi S, Nonoyama S, Wakamatsu H, Kogawa K, Wang L, Kinoshita-Yamaguchi H, Takayama-Ito M, Lim CK, Inoue N, Mizuguchi M, Igarashi T, Saijo M
    • Journal Title

      J. Clin. Microbiol

      Volume: 51 Issue: 1 Pages: 356-9

    • DOI

      10.1128/jcm.02247-12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of recurrent acute encephalopathy with febrile convulsive status epilepticus with carnitine palmitoyltransferase II variation.2013

    • Author(s)
      Sakai E, et al.
    • Journal Title

      Neuropediatrics.

      Volume: (in press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunomodulatory therapy in recurrent acute necrotizing encephalopathy ANEl : Is it useflil?2012

    • Author(s)
      Bergamino L, et al.
    • Journal Title

      Brain and Developmen

      Volume: 34 Pages: 384-391

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy with. a novel point mutation in the SCN2A gene.2012

    • Author(s)
      Kobayashi K, et al.
    • Journal Title

      Epilepsy Research

      Volume: 102 Pages: 109-112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児のADEM, MS, NMO.2012

    • Author(s)
      水口雅
    • Journal Title

      神経内科

      Volume: 76 Pages: 559-563

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 急性脳症の診断と治療.2012

    • Author(s)
      水口雅
    • Journal Title

      小児内科

      Volume: 44 Pages: 1486-1489

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 序 : けいれん重積型(二相性)急性脳症のオーバービュー2012

    • Author(s)
      水口雅
    • Journal Title

      小児科臨床

      Volume: 65 Pages: 1941-1945

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 熱性けいれんと髄膜炎・脳炎・脳症2012

    • Author(s)
      水口雅
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 84 Pages: 927-930

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 序-急性脳炎・脳症研究の最近の進歩.2012

    • Author(s)
      水口雅
    • Journal Title

      小児内科

      Volume: 45 Pages: 172-175

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes2011

    • Author(s)
      Hoshino A, Saitoh M, Oka A, Okumura A, Kubota M, Saito Y, Takanashi J, Hirose S, Yamagata T, Yamanouchi H, Mizuguchi M
    • Journal Title

      Brain Dev

      Volume: 34 Issue: 5 Pages: 337-343

    • DOI

      10.1016/j.braindev.2011.07.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AD0RA2A polymorphism prediSposes children to encephalopathy with febrile status epilepticus.

    • Author(s)
      Shinohara M, et al.
    • Journal Title

      Neurology

      Volume: 80 Pages: 1571-1576

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] CPT2の熱感受性多型を認めた覚醒障害を主体とする急性脳症の1例2015

    • Author(s)
      安西真衣, 熊谷淳之, 竹中暁, 葛西真理子, 渡邉優, 寺嶋宙, 久保田雅也, 斎藤真木子, 水口雅
    • Organizer
      第62回日本小児神経学会関東地方会
    • Place of Presentation
      国立精神・神経医療研究センター(東京都)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] インフルエンザ罹患後に周期的な過眠を生じ、Klein-Levin症候群と診断した12歳女児2014

    • Author(s)
      山口有沙, 下田木の実, 佐久間啓, 太田さやか, 水野葉子, 高橋長久, 岩崎博之, 三牧正和, 岡明, 水口雅
    • Organizer
      第61回日本小児神経学会関東地方会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 小児のウイルス感染症と意識障害2014

    • Author(s)
      水口雅
    • Organizer
      第55回日本臨床ウイルス学会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] けいれん重積型急性脳症におけるナトリウムチャネルSCN1AおよびSCN2A変異解析2014

    • Author(s)
      齋藤真木子, 石井敦士, 井原由紀子, 星野愛, 寺嶋宙, 久保田雅也, 山中岳, 河島尚志, 菊池健二郎, 雨宮馨,亀井淳,廣瀬伸一,水口雅
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 重度後遺症を伴ったけいれん重積型急性脳症5例の脳症関連遺伝子の解析2014

    • Author(s)
      山中岳, 竹下美佳, 小穴信吾, 石田悠, 森地振一郎, 宮島佑, 齋藤真木子, 水口雅, 廣瀬伸一, 河島尚志
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 急性壊死性脳症における遺伝的素因―HLAタイピング及びサイトカイン遺伝子多型解析―第2報2014

    • Author(s)
      星野愛, 齋藤真木子, 久保田雅也, 高梨潤一, 豊島光雄, 宮本晶恵, 奥村彰久, 水口雅
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] テオフィリン関連急性脳症における複数の遺伝的素因2014

    • Author(s)
      齋藤真木子, 塩見正司, 山形崇倫, 亀井淳, 赤坂真奈美, 廣瀬伸一, 水口雅
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Genetic backgrounds in Japanese patients with acute necrotiaing encephalopathy.―HLA typing and cytokine gene polymorphisms.2014

    • Author(s)
      Hoshino A, Saitoh M, Kubota M, Takanashi J, Toyoshima M, Miyzmoto A, Okumura A, Mizuguchi M.
    • Organizer
      7th IGAKUKEN International Symposium on Fever, Inflammation, and Epilepsy
    • Place of Presentation
      東京都医学総合研究所(東京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gene polymorphisms and mutations predispose children to encephalopathy with febrile status epilepticus.2014

    • Author(s)
      Saitoh M, Mizuguchi M.
    • Organizer
      7th IGAKUKEN International Symposium on Fever, Inflammation, and Epilepsy
    • Place of Presentation
      東京都医学総合研究所(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 腸管出血性大腸菌(EHEC)O111関連急性脳症の頭部画像所見の検討.2013

    • Author(s)
      高梨潤一, 水口雅, 奥村彰久, 種市尋宙, 田中朋美
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] けいれん重積型急性脳症の遺伝的素因.2013

    • Author(s)
      齋藤真木子, 篠原麻由, 高梨潤一, 菊池健二郎, 久保田雅也, 山中岳, 水口雅
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 病原体及び症候群分類に基づいた急性脳症の全国実態調査.2013

    • Author(s)
      星野愛, 齋藤真木子, 水口雅
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      広島国際会議場(広島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 二相性けいれんと遅発性拡散低下を呈する急性脳症(AESD)の予後予測に関する検討.2013

    • Author(s)
      多田弘子, 高梨潤一, 山形崇倫, 奥野英夫, 久保田雅也, 河野剛, 椎原隆, 浜野晋一郎, 廣瀬伸一, 水口雅
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      iichiko総合文化センター(大分県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] けいれん重積型急性脳症と熱性けいれんの遺伝的素因の比較―サイトカイン遺伝子多型解析―.2013

    • Author(s)
      齋藤真木子, 星野愛, 久保田雅也, 菊池健二郎, 山中岳, 廣瀬伸一, 水口雅
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      iichiko総合文化センター(大分県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RSウイルス関連脳症の2例:発症機序についての考察.2013

    • Author(s)
      座波清誉, 松本浩, 中村康子, 齋藤真木子, 水口雅
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      iichiko総合文化センター(大分県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急性脳症の包括的遺伝子解析.2013

    • Author(s)
      水口雅
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      iichiko総合文化センター(大分県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] RANBP2, CPT-II遺伝子変異を認めなかった急性脳症の兄弟例.2013

    • Author(s)
      西村尚子, 樋口嘉久, 井口牧子, 木村暢佑, 野崎章仁, 熊田知浩, 藤井達哉, 星野愛, 齋藤真木子,水口雅
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      iichiko総合文化センター(大分県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genetics of early onset epilepsy with encephalopathy.2013

    • Author(s)
      Mizuguchi, M.
    • Organizer
      12th Asian and Oceanian Congress of Child Neurology
    • Place of Presentation
      King Faisal Conference Hall, Riyadh(サウジアラビア)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] インフルエンザと急性脳症.2013

    • Author(s)
      水口雅
    • Organizer
      第283回新潟市小児科医会集談会
    • Place of Presentation
      万代シルバーホテル(新潟県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Influenza encephalopathy and related neuropsychiatric syndromes.2012

    • Author(s)
      Mizuguchi, M.
    • Organizer
      2nd ISIRV- Antiviral Group Conference
    • Place of Presentation
      Melia Hanoi Hotel, HaNoi(ベトナム)(招待講演)
    • Year and Date
      2012-10-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性脳症 : 発症の遺伝的背景2012

    • Author(s)
      水口雅
    • Organizer
      第17回日本神経感染症学会総会学術集会
    • Place of Presentation
      ホテルルビノ京都堀川(京都府)(招待講演)
    • Year and Date
      2012-10-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Acute encephalopathy : devastating complications of influenza and other viral infections.2012

    • Author(s)
      Mizuguchi, M.
    • Organizer
      12^<th> International Child Neurology Congress and 11^<th> Asia and Oceanian Congress of Child Neurology
    • Place of Presentation
      Brisbane Convention & Exhibition Centre, Brisbane, (オーストラリア)(招待講演)
    • Year and Date
      2012-05-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] A recurrent case of acute encephalopathy with biphasic seizures and late reduced diffusion after acute necrotizing encephalopathy2012

    • Author(s)
      Yonee C, Toyoshima M, Maruyama S, Maegaki Y, Saito M, Mizuguchi M.
    • Organizer
      12th International Child Neurology Congress and 11th Asia and Oceanian Congress of Child Neurology
    • Place of Presentation
      Brisbane Convention & Exhibition Centre, Brisbane, (オーストラリア)
    • Year and Date
      2012-05-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 先天性副腎皮質過形成に合併する小児急性脳症の臨床的検討.2012

    • Author(s)
      阿部裕一, 酒井哲郎, 水口雅, 山内秀雄.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] テオフィリン関連急性脳症における遺伝的素因.2012

    • Author(s)
      篠原麻由, 斎藤真木子, 山中岳, 雨宮馨, 久保田雅也, 山形崇倫, 菊池健二郎, 川脇寿, 亀井淳, 赤坂真奈美, 安西有紀, 塩見正司, 水口雅, 山内秀雄.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] 深部灰白質の両側対称性病変を伴う腸管出血性大腸菌(EHEC)脳症.2012

    • Author(s)
      中川裕康,八木信一,水口雅.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] Acute encephalopathy with biphasic seizures and late reduced diffusion [AESD]における早期診断に関する後方視的検討.2012

    • Author(s)
      多田弘子, 高梨潤一, 山形崇倫, 奥野英夫, 久保田雅也, 河野剛, 椎原隆, 浜野晋一郎, 廣瀬伸一, 水口雅.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-05-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性壊死性脳症における遺伝的素因2012

    • Author(s)
      星野愛, 斎藤真木子, 篠原麻由, 長嶋雅子, 吉田健司, 加藤竹雄, 豊島光雄, 李守永, 水口雅
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-05-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性脳症におけるSCN1A遺伝子解2012

    • Author(s)
      斎藤真木子, 篠原麻由, 星野英紀, 久保田雅也, 雨宮馨, 高梨潤一, 黄壽梛, 廣瀬伸一, 水口雅.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-05-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性壊死性脳症の重症度予測スコア.2012

    • Author(s)
      山本啓之, 奥村彰久, 夏目淳, 水口雅
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-04-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 急性腎不全と後頭葉可逆性白質脳症(PRES)を合併したサルモネラ脳症の1例2012

    • Author(s)
      大内啓嗣, 三浦健一郎, 内野俊平, 岩崎博之, 竹内正人, 磯島豪, 張田豊, 水口雅, 五十嵐隆, 武藤浩司
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-04-22
    • Related Report
      2012 Annual Research Report
  • [Book] 発達障害 基礎と臨床2014

    • Author(s)
      水口雅
    • Publisher
      日本文化科学社
    • Related Report
      2014 Annual Research Report
  • [Book] 溶血性尿毒症症候群の診断・治療ガイドライン2014

    • Author(s)
      水口雅
    • Publisher
      東京医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 別冊日本臨牀, 新領域別症候群シリーズ, No. 30, 神経症候群(第2版)―その他の神経疾患を含めて―V2014

    • Author(s)
      水口雅
    • Publisher
      日本臨牀社
    • Related Report
      2014 Annual Research Report
  • [Book] 新領域別症候群シリーズ, No. 25, 感染症症候群(第2版)―症候群から感染性単一疾患までを含めて―2013

    • Author(s)
      水口雅
    • Total Pages
      760
    • Publisher
      日本臨牀社
    • Related Report
      2013 Annual Research Report
  • [Book] 新領域別症候群シリーズ, No. 26, 神経症候群(第2版)―その他の神経疾患を含めて―2013

    • Author(s)
      水口雅
    • Total Pages
      924
    • Publisher
      日本臨牀社
    • Related Report
      2013 Annual Research Report
  • [Book] 疾患・症状別今日の治療と看護,第3版2013

    • Author(s)
      水口雅
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Book] エキスパートに学ぶけいれん重積・意識障害-小児の救急、当直ですぐに役立つ症例とQ&A-.2012

    • Author(s)
      水口雅(編)
    • Total Pages
      958
    • Publisher
      総合医学社
    • Related Report
      2012 Annual Research Report
  • [Remarks] 東京大学発達医科学HP

    • URL

      http://www.development.m.u-tokyo.ac.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 東京大学発達医科学教室HP

    • URL

      http://www.development.m.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.development.m.u-tokyo.ac.jp/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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