| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Our objectives were to identify candidate circulating factor(s) of idiopathic nephrotic syndrome, and to elucidate the mechanism of impaired glomerular barrier function by nephrotic circulating factor(s). We found that soluble urokinase plasminogen receptor (suPAR) is not the primary factor of focal segmental glomerulosclerosis, and searched for novel candidate circulating factors of idiopathic nephrotic syndrome. We also identified the molecular mechanism of slit diaphragm maintenance crucial for prevention of proteinuria, and the molecular changes in podocytes in patients with various types of nephrotic syndrome. The present study revealed novel pathogenic mechanisms crucial for development of therapeutic targets of nephrotic syndrome.
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