Elucidation of the pathogenic mechanism of glomerulosclerosis by circulating factors
| Project/Area Number |
24390259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HARITA Yutaka 東京大学, 医学部附属病院, 講師 (10451866)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Kenichiro 東京大学, 医学部附属病院, 助教 (70408483)
IGARASHI Takashi 独立行政法人国立成育医療センター, 総長室, 総長 (70151256)
HATTORI Seisuke 北里大学, 薬学部, 教授 (50143508)
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| Co-Investigator(Renkei-kenkyūsha) |
HATTORI Motoshi 東京女子医科大学, 医学部, 教授 (50192274)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | ネフローゼ症候群 / 巣状糸球体硬化症 / 糸球体上皮細胞 / 腎臓 / suPAR |
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| Outline of Final Research Achievements |
Our objectives were to identify candidate circulating factor(s) of idiopathic nephrotic syndrome, and to elucidate the mechanism of impaired glomerular barrier function by nephrotic circulating factor(s). We found that soluble urokinase plasminogen receptor (suPAR) is not the primary factor of focal segmental glomerulosclerosis, and searched for novel candidate circulating factors of idiopathic nephrotic syndrome. We also identified the molecular mechanism of slit diaphragm maintenance crucial for prevention of proteinuria, and the molecular changes in podocytes in patients with various types of nephrotic syndrome. The present study revealed novel pathogenic mechanisms crucial for development of therapeutic targets of nephrotic syndrome.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.2015
Author(s)
Sato T, Akasu H, Shimono W, Matsu C, Fujiwara Y, Shibagaki Y, Heard JJ, Tamanoi F, Hattori S.
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Journal Title
J Biol Chem.
Volume: 290
Issue: 2
Pages: 1096-1105
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decreased glomerular filtration as the primary factor of elevated circulating suPAR levels in focal segmental glomerulosclerosis.2014
Author(s)
Harita Y, Ishizuka K, Tanego A, Sugawara N, Chikamoto H, Akioka Y, Tsurumi H, Miura K, Gotoh Y, Tsujita M, Yamamoto T, Horike K, Takeda A, Oka A, Igarashi T, Hattori M.
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Journal Title
Pediatr Nephrol.
Volume: 29
Issue: 9
Pages: 1553-1560
DOI
Related Report
Peer Reviewed
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[Journal Article] LMX1B Mutation with Residual Transcriptional Activity as a Cause of Isolated Glomerulopathy.2014
Author(s)
Isojima T, Harita Y, Furuyama M, Sugawara N, Ishizuka K, Horita S, Kajiho Y, Miura K, Igarashi T, Hattori M, Kitanaka S
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Journal Title
Nephrol Dial Transplant
Volume: 29
Issue: 1
Pages: 81-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Aralin, a type II ribosome-inactivating protein from Aralia elata, exhibits selective anticancer activity through the processed form of a 110-kDa high-density lipoprotein-binding protein: a promising anticancer drug.2014
Author(s)
Otsuka H, Gotoh Y, Komeno T, Ono T, Kawasaki Y, Iida N, Shibagaki Y, Hattori S, Tomatsu M, Akiyama H, Tashiro F.
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Journal Title
Biochem Biophys Res Commun.
Volume: 453
Issue: 1
Pages: 117-123
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel CD3-specific antibody induces immunosuppression via impaired phosphorylation of LAT and PLCγ1 following T-cell stimulation2014
Author(s)
Shiheido H, Aoyama T, Takahashi H, Hanaoka K, Abe T, Nishida E, Chen C, Koga O, Hikida M, Shibagaki Y, Morita A, Nikawa T, Hattori S, Watanabe T, Shimizu J.
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Journal Title
Eur J Immunol
Volume: in press
Issue: 6
Pages: 1770-1780
DOI
Related Report
Peer Reviewed
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[Journal Article] Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis.2013
Author(s)
Miura K, Kurihara H, Horita S, Chikamoto H, Hattori M, Harita Y, Tsurumi H, Kajiho Y, Sawada Y, Sasaki S, Igarashi T, Kunishima S, Sekine T.
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Journal Title
Nephrol Dial Transplant.
Volume: 28
Issue: 12
Pages: 2993-3003
DOI
Related Report
Peer Reviewed
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[Presentation] 蛋白尿の成因2014
Author(s)
張田豊
Organizer
日本腎臓学会学術集会
Place of Presentation
横浜
Year and Date
2014-07-04 – 2014-07-06
Related Report
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[Presentation] Nail-patella-like renal diseaseが疑われる、急速に末期腎不全へ進行した巣状分節性糸球体硬化症の姉弟例2014
Author(s)
菅原 典子, 張田 豊, 磯島 豪, 徐 東博, 浅野 達雄, 西山 慶, 宮井 貴之, 神田 祥一郎, 石塚 喜世伸, 末廣 真美子, 久野 正貴, 近本 裕子, 秋岡 祐子, 北中 幸子, 服部 元史
Organizer
日本小児腎臓病学会
Place of Presentation
秋田
Year and Date
2014-06-05 – 2014-06-07
Related Report
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[Presentation] 後天性ネフローゼ症候群再発時におけるスリット膜構成分子の細胞内局在変化の検討2014
Author(s)
石塚 喜世伸, 張田 豊, 梶保 祐子, 鶴見 晴子, 浅野 達雄, 西山 慶, 菅原 典子, 久野 正貴, 近本 裕子, 秋岡 祐子, 山口 裕, 服部 元史
Organizer
日本小児腎臓病学会
Place of Presentation
秋田
Year and Date
2014-06-05 – 2014-06-07
Related Report
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[Presentation] High Serum Soluble Urokinase Receptor (suPAR) Is NOT the Cause of Post-Transplant Recurrence of Focal Segmental Glomerulosclerosis2014
Author(s)
Yutaka Harita, Kiyonobu Ishizuka, Atsushi Tanego, Noriko Sugawara, Hiroko Chikamoto,Yuko Akioka, Haruko Tsurumi, Kenichiro Miura, Yoshimitsu Goto, Makoto Tsujita, Takayuki Yamamoto, Keiji Horike, Asami Takeda, Akira Oka, Takashi Igarashi, Motoshi Hattori M.D.
Organizer
Pediatric Academic Societies/Asian Pediatric Research Society
Place of Presentation
バンクーバー
Year and Date
2014-04-25 – 2014-04-28
Related Report
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[Presentation] High serum soluble urokinase receptor (suPAR) is not the leading cause of FSGS -Circulating suPAR during posttransplant recurrence of FSGS-2013
Author(s)
HaritaY, Ishizuka K, Tangeo A, Sugawara N, Chikamoto H, Akioka Y, Tsurumi H, Miura K, Goto Y, Tsujita M, Yamamoto T, Horike K, Takeda A, Oka A, Igarashi T, Hattori M
Organizer
International Congress of Pediatrics
Place of Presentation
Melbourne, Austraria
Related Report
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[Presentation] Sequential events in posttransplant graft associated with recurrence of focal segmental glomerulosclerosis2013
Author(s)
Ishizuka K, Harita Y, Kajiho Y, Tsurumi H, Tatsuo A, Nishiyama K, Sugawara N, Chikamoto H, Akioka Y, Yamaguchi Y and Hattori M
Organizer
ERA-EDTA 50th congress
Place of Presentation
Istanbul, Turkey
Related Report
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[Presentation] 尿電解質の使い方2012
Author(s)
三浦健一郎
Organizer
第47回日本小児腎臓病学会
Place of Presentation
都市センターホテル(東京)
Year and Date
2012-06-29
Related Report
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[Presentation] 蛋白尿の発症機序2012
Author(s)
張田豊
Organizer
第115回 小児科学会学術講演会
Place of Presentation
都市センターホテル(東京)
Year and Date
2012-04-12
Related Report
