Molecular analyses and the development of targeting therapy of pediatric acute myeloid leukemia using next generation sequencer

• Project/Area Number: 24390268
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Gunma Institute of Public Health and Environmental Sciences
• Principal Investigator: HAYASHI YASUHIDE 群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
• Co-Investigator(Kenkyū-buntansha): ICHIKAWA Hitoshi 独立行政法人国立がん研究センター, その他部局等, その他 (30201924) ; OHKI Kentaro 群馬県衛生環境研究所, 研究企画係, 研究員 (50400966) ; PARK Myoung-ja 群馬県衛生環境研究所, 研究企画係, 研究員 (50450375) ; SOTOMATSU Manabu 群馬県衛生環境研究所, 研究企画係, 研究員 (70251113)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Seishi 国立大学法人京都大学大学院医学研究科, 腫瘍生物学, 教授 (50292900)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 次世代シーケンサー / コヒーシン / 急性骨髄性白血病 / 遺伝子 / ゲノム / マイクロアレイ / 癌 / 臨床

Outline of Final Research Achievements

Whole-exome resequencing of 19 cases with acute myeloid leukemia (AML) was analyzed with a mean coverage of approximately x100. A total of 80 somatic mutations or 4.2 mutations per sample was identified. The mean number of somatic mutations in pediatric AML might be fewer than in adult AML. Many mutations identified in this study involved previously reported targets in AML. On the other hand, several genes including BCOR, BCORL1, ASXL2, MLL2,3, SMC3 and RAD21 were newly identified. Furthermore, we examined mutations of these genes in pediatric 192 AML patients by gene targeting. In total, 32 mutations were identified in 31 of these specimens. The mutually exclusive pattern of the mutations in these BCOR, BCORL1 and cohesin components genes was confirmed in this study, suggesting a common impact of these mutations on the pathogenesis of pediatric AML. Our results indicated that a subset of pediatric AML represents a discrete entity different from the adult AML.

Research Products

• [Journal Article] Gene alterations involving the CRLF2-JAK pathway and recurrent gene deletions in Down syndrome-associated acute lymphoblastic leukemia in Japan. (2014)
  • Author(s): Hanada I, Terui K, Ikeda F, Toki T, Kanezaki R, Sato T, Kamio T, Kudo K, Sasaki S, Takahashi Y, Hayashi Y, Inukai T, Kojima S, Koike K, Kosaka Y, Kobayashi M, Imaizumi M, Mitsui T, Hori H, Hara J, Horibe K, Nagai J, Goto H, Ito E.
  • Journal Title: Genes Chromosomes Cancer Volume: 53 Issue: 11 Pages: 902-910
  • DOI: 10.1002/gcc.22201
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of gained chromosomes in high-hyperdiploid childhood acute lymphoblastic leukaemia (2014)
  • Author(s): Kato M, Imamura T, Manabe A, Hashii Y, Koh K, Sato A, Takahashi H, Hori H, Taki T, Inoue M, Hayashi Y, Horibe K, Tsuchida M, Kojima S, Oda M, Ohara A .
  • Journal Title: Br J Haematol Volume: 166 Issue: 2 Pages: 295-298
  • DOI: 10.1111/bjh.12836
  • Peer Reviewed
• [Journal Article] Acute myeloid leukaemia with myelodysplastic features in children (2014)
  • Author(s): Kinoshita A, Miyachi H, Matsushita H, Yabe M, Taki T, Watanabe T, Saito AM, Tomizawa D, Taga T, Takahashi H, Matsuo H, Kodama K, Ohki K, Hayashi Y, Tawa A, Horibe K, Adachi S.
  • Journal Title: Br J Haematol Volume: 167 Issue: 1 Pages: 80-86
  • DOI: 10.1111/bjh.12993
  • Peer Reviewed
• [Journal Article] EVI1 overexpression is a poor prognostic factor in pediatric patients with mixed lineage leukemia-AF9 rearranged acute myeloid leukemia. (2014)
  • Author(s): Matsuo H, Kajihara M, Tomizawa D, Watanabe T, Saito AM, Fujimoto J, Horibe K, Kodama K, Tokumasu M, Itoh H, Nakayama H, Kinoshita A, Taga T, Tawa A, Taki T, Shiba N, Ohki K, Hayashi Y, Yamashita Y, Shimada A, Tanaka S, Adachi S.
  • Journal Title: Haematologica Volume: 99 Issue: 11 Pages: 225-227
  • DOI: 10.3324/haematol.2014.107128
  • Peer Reviewed / Open Access
• [Journal Article] Outcome of children with relapsed acute myeloid leukemia following initial therapy under the AML99 protocol (2014)
  • Author(s): Nakayama H, Tabuchi K, Tawa A, Tsukimoto I, Tsuchida M, Morimoto A, Yabe H, Horibe K, Hanada R, Imaizumi M, Hayashi Y, Hamamoto K, Kobayashi R, Kudo K, Shimada A, Miyamura T, Moritake H, Tomizawa D, Taga T, Adachi S.
  • Journal Title: Int J Hematol Volume: 100(2) Issue: 2 Pages: 171-9
  • DOI: 10.1007/s12185-014-1616-9
  • Peer Reviewed / Open Access
• [Journal Article] Mutations of the GATA2 and CEBPA genes in paediatric acute myeloid leukaemia. (2014)
  • Author(s): Shiba N, Funato M, Ohki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
  • Journal Title: Brit J Haematol Volume: 印刷中 Issue: 1 Pages: 142-159
  • DOI: 10.1111/bjh.12559
  • Peer Reviewed
• [Journal Article] Recurrent CDC25C mutations drive malignant transformation in FPD/AML (2014)
  • Author(s): Yoshimi A, Toya T, Kawazu M, Ueno T, Tsukamoto A, Iizuka H, Nakagawa M, Nannya Y, Arai S, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Ichikawa M, Mano H, Kurokawa M
  • Journal Title: Nature communications Volume: 5 Issue: 1 Pages: 4770-4770
  • DOI: 10.1038/ncomms5770
  • Peer Reviewed / Open Access
• [Journal Article] Liver disease is frequently observed in Down syndrome patients with transient abnormal myelopoiesis. (2014)
  • Author(s): Park MJ, Sotomatsu M, Ohki K, Arai K, Maruyama K, Kobayashi T, Nishi A, Sameshima K, Takagi T, Hayashi Y.
  • Journal Title: Int J Hematol Volume: 99 Issue: 2 Pages: 154-161
  • DOI: 10.1007/s12185-013-1487-5
  • Peer Reviewed
• [Journal Article] Cytomegalovirus retinitis during maintenance therapy for T-cell acutelymphoblastic leukemia. (2014)
  • Author(s): Wakai K, et al.
  • Journal Title: J Pediatr Hematol Oncol Volume: 35 Pages: 162-163
  • Peer Reviewed
• [Journal Article] SETBP1 mutations in juvenile myelomonocytic leukaemia and myelodysplastic syndrome but not in paediatric acute myeloid leukaemia (2013)
  • Author(s): Shiba N, Ohki K, Park MJ, Sotomatsu M, Kudo K, Ito E, Sako M, Arakawa H, Hayashi Y
  • Journal Title: Br J Haematol Volume: Epub ahead of print Issue: 1 Pages: 156-159
  • DOI: 10.1111/bjh.12595
  • Peer Reviewed
• [Journal Article] The landscape of somatic mutations in Down syndrome-related myeloid disorders. (2013)
  • Author(s): Yoshida K
  • Journal Title: Nature Genet. Volume: 45 Issue: 11 Pages: 1293-1200
  • DOI: 10.1038/ng.2759
  • Peer Reviewed
• [Journal Article] WT1 mutation in pediatric patients with acute myeloid leukemia: A study of the Japanese Childhood AML Cooperative Study Group (2013)
  • Author(s): Sano H, Shimada A, Tabuchi K, Taki T, Murata C, Park M, Sotomatsu Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
  • Journal Title: Int J Hematol Volume: 98 Issue: 4 Pages: 437-445
  • DOI: 10.1007/s12185-013-1409-6
  • Peer Reviewed
• [Journal Article] Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array (2013)
  • Author(s): Nishimura R, Takita J, Sato-Otsubo A, Kato M, Koh K, Hanada R, Tanaka Y, Kato K, Maeda D, Fukuyama M, Sanada M, Hayashi Y, Ogawa S
  • Journal Title: Cancer Sci Volume: 104 Issue: 7 Pages: 856-864
  • DOI: 10.1111/cas.12173
  • NAID: 120007089073
  • Peer Reviewed
• [Journal Article] NUP98-NSD1 related gene expression signature is strongly associated with a poor prognosis in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group Cooperative Study Group (2013)
  • Author(s): Shiba N, Ichikawa H, Taki T, Park M, Jo A, Mitani S, Shimada A, Sotomatsu M, Arakawa H, Tabuchi K, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y
  • Journal Title: Genes Chromosomes Cancer Volume: 52 Issue: 7 Pages: 683-693
  • DOI: 10.1002/gcc.22064
  • Peer Reviewed
• [Journal Article] An empirical Bayesian framework for somatic mutation detection from cancer genome sequencing data (2013)
  • Author(s): Yuichi Shiraishi
  • Journal Title: Nucleic Acid Research Volume: 41 Issue: 7 Pages: e89-e89
  • DOI: 10.1093/nar/gkt126
  • Peer Reviewed
• [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome (2013)
  • Author(s): Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
  • Journal Title: Blood Volume: 121(16) Issue: 16 Pages: 3181-3184
  • DOI: 10.1182/blood-2012-01-405746
  • Peer Reviewed
• [Journal Article] An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia (2012)
  • Author(s): Gruber TA, Larson Gedman A, Zhang J, Koss CS, Marada S, Ta HQ, Chen SC, Su X, Ogden SK, Dang J, Wu G, Gupta V, Andersson AK, Pounds S, Shi L, Easton J, Barbato MI, Mulder HL, Manne J, Wang J, Rusch M, Ranade S, Ganti R, Parker M, Ma J, Radtke I, Ding L, Cazzaniga G, Biondi A, Kornblau SM, Ravandi F, Kantarjian H, Nimer SD, Dohner K, Dohner H, Ley TJ, Ballerini P, Shurtleff S, Tomizawa D, Adachi S, Hayashi Y, Tawa A, Shih LY, Liang DC, Rubnitz JE, Pui CH, Mardis ER, Wilson RK, Downing JR.
  • Journal Title: Cancer Cell Volume: 22 Issue: 5 Pages: 683-697
  • DOI: 10.1016/j.ccr.2012.10.007
  • Peer Reviewed
• [Journal Article] High WT1 mRNA expression after induction chemotherapy andFLT3-ITD have prognostic impact in pediatric acute myeloid leukemia : astudy of the Japanese Childhood AML Cooperative Study Group. (2012)
  • Author(s): Shimada A, et al.
  • Journal Title: Int J Hematol Volume: 96 Pages: 469-476
  • Peer Reviewed
• [Journal Article] Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia (2012)
  • Author(s): Doisaki S, Muramatsu H, Shimada A, Takahashi Y, Mori-Ezaki M, Sato M, Kawaguchi H, Kinoshita A, Sotomatsu M, Hayashi Y, Furukawa-Hibi Y, Yamada K, Hoshino H, Kiyoi H, Yoshida N, Sakaguchi H, Narita A, Wang X, Ismael O, Xu Y, Nishio N, Tanaka M, Hama A, Koike K, Kojima S
  • Journal Title: Blood Volume: 120 Issue: 7 Pages: 1485-1488
  • DOI: 10.1182/blood-2012-02-406090
  • Peer Reviewed
• [Journal Article] Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22) (2012)
  • Author(s): Kawashima N, Shimada A, Taketani T, Hayashi Y, Yoshida N, Matsumoto K, Takahashi Y, Kojima S, Kato K
  • Journal Title: Int J Hematol Volume: 95 Issue: 5 Pages: 577-580
  • DOI: 10.1007/s12185-012-1044-7
  • NAID: 10030633418
  • Peer Reviewed
• [Journal Article] RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse : a study of the Japanese Childhood AML Cooperative Study Group (2012)
  • Author(s): Sano H, Shimada A, Taki T, Murata C, Park MJ, Sotomatsu M, Tabuchi K, Tawa A, Kobayashi R, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y.
  • Journal Title: Int J Hematol Volume: 95 Issue: 5 Pages: 509-515
  • DOI: 10.1007/s12185-012-1033-x
  • NAID: 10030633077
  • Peer Reviewed
• [Journal Article] Novel splicing-factor mutations in juvenile myelomonocytic leukemia (2012)
  • Author(s): 滝田順子、吉田健一
  • Journal Title: Leukemia Volume: 26 Issue: 8 Pages: 1879-1881
  • DOI: 10.1038/leu.2012.45
  • Peer Reviewed
• [Journal Article] Identification of TRIB1 R107L gain-of-function mutation in human acute megakaryocytic leukemia (2012)
  • Author(s): Yokoyama T, Toki T, Aoki Y, Kanezaki R, Park MJ, Kanno Y, Takahara T, Yamazaki Y, Ito E, Hayashi Y, Nakamura T.
  • Journal Title: Blood Volume: 119 Issue: 11 Pages: 2608-2611
  • DOI: 10.1182/blood-2010-12-324806
  • Peer Reviewed
• [Journal Article] Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma (2012)
  • Author(s): Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S.
  • Journal Title: Oncogene Volume: 31 Issue: 44 Pages: 4667
  • DOI: 10.1038/onc.2011.616
  • URL: https://pure.teikyo.jp/en/publications/1f5ea500-7cb6-45d4-9bfd-f59081d4cbe0
  • Peer Reviewed
• [Journal Article] CBL mutation in chronic myelomonocytic leukemia secondary to familial platelet disorder with propensity to develop acute myeloid leukemia (2012)
  • Author(s): Shiba N, Hasegawa D, Park MJ, Murata C, Matsubara A, Ogawa C, Manabe A, Arakawa H, Ogawa S, Hayashi Y.
  • Journal Title: Blood Volume: 119 Issue: 11 Pages: 2612-2614
  • DOI: 10.1182/blood-2011-02-333435
  • Peer Reviewed
• [Journal Article] Clinical significance of early T-cell precursor acute lymphoblastic leukaemia : Results of the Tokyo Children's Cancer Study Group Study L99-15 (2012)
  • Author(s): Inukai T, Kiyokawa N, Campana D, Coustan-Smith E, Kikuchi A, Kobayashi M, Takahashi H, Koh K, Manabe A, Kumagai M, Ikuta K, Hayashi Y, Tsuchida M, Sugita K, Ohara A.
  • Journal Title: Brit J Haematol Volume: 156 Issue: 3 Pages: 358-365
  • DOI: 10.1111/j.1365-2141.2011.08955.x
  • Peer Reviewed
• [Journal Article] DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia (2012)
  • Author(s): Shiba N, Taki T, Park MJ, Shimada A, Sotomatsu M, Adachi S, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Arakawa H, Hayashi Y.
  • Journal Title: Br J Haematol Volume: 156 Issue: 3 Pages: 413-414
  • DOI: 10.1111/j.1365-2141.2011.08879.x
  • Peer Reviewed
• [Journal Article] CBL mutations in infant acute lymphoblastic leukaemia (2012)
  • Author(s): 6. Shiba N, Park MJ, Taki T, Takita J, Hiwatari M, Kanazawa T, Sotomatsu M, Ishii E, Arakawa H, Ogawa S, Hayashi Y
  • Journal Title: Br J Haematol Volume: 156 Issue: 5 Pages: 672
  • DOI: 10.1111/j.1365-2141.2011.08900.x
  • URL: https://localhost/en/publications/b66f6b30-220d-4440-9f6c-933d7840fece
  • Peer Reviewed
• [Presentation] Whole Exome and Transcriptome Analyses in Pediatric T-Cell Acute Lymphoblastic Leukemia. (2014)
  • Author(s): Seki M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Kato M, Hanada R, Miyano S, Hayashi Y, Ogawa S, Takita J.
  • Organizer: 56th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2014-12-08
• [Presentation] The Prognostic Impact of High MEL1 Gene Expression in Pediatric Acute Myeloid Leukemia. (2014)
  • Author(s): Shiba N, Ohki K, Hara Y, Yamato G, Park M, Ichikawa H, Kobayashi T, Tomizawa D, Sotomatsu M, Arakawa H, Horibe K, Taga T, Adachi S, Tawa A, Hayashi Y.
  • Organizer: 56th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2014-12-06
• [Presentation] Poor Prognosis Associated with FAB Subtypes M4 and M5 in Japanese Pediatric Acute Myeloid Leukemia Patients with FLT3-ITD. (2014)
  • Author(s): Hara Y, Shiba N, Ohki K, Park M, Shimada A, Tomizawa D, Moriya Saito M, Fujimoto J, Taki T, Kinoshita A, Taga T, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y.
  • Organizer: 56th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2014-12-06
• [Presentation] Clinical Features of Patients with ASXL1 and ASXL2 Mutations in Pediatric Acute Myeloid Leukemia. 56th ASH Annual Meeting and Exposition (2014)
  • Author(s): Yamato G, Shiba N, Yoshida K, Ohki K, Park M, Hara Y, Tomizawa D, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Ogawa S, Hayashi Y.
  • Organizer: 56th ASH Annual Meeting and Exposition
  • Place of Presentation: San Francisco, U.S.A.
  • Year and Date: 2014-12-06
• [Presentation] 小児AMLにおけるIKZF1欠失の頻度と予後解析 JPLSG AML-05(Frequency and prognosis of IKZF1 deletions in pediatric acute myeloid leukemia (2014)
  • Author(s): 大木 健太郎, 朴 明子, 原 勇介, 柴 徳生, 外松 学, 富澤 大輔, 多賀 崇, 齋藤 明子, 藤本 純一郎, 多和 昭雄, 堀部 敬三, 足立 壮一, 林 泰秀.
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-29
• [Presentation] 小児急性骨髄性白血病における寛解導入療法後非寛解例の遺伝子解析による予後不良因子の同定(Poor prognostic factors identified by molecular analysis of pediatric acute myeloid leukemia patients with non-complete remission after induction therapy). (2014)
  • Author(s): 原 勇介, 大木 健太郎, 柴 徳生, 朴 明子, 富澤 大輔, 多賀 崇, 荒川 浩一, 足立 壮一, 多和 昭雄, 林 泰秀.
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-29
• [Presentation] 小児急性骨髄性白血病におけるASXL1、ASXL2遺伝子変異と臨床像(Clinical features of Patients with ASXL1 and ASXL2 mutations in pediatric acute myeloid leukemia). (2014)
  • Author(s): 大和 玄季, 柴 徳生, 吉田 健一, 大木 健太郎, 朴 明子, 原 勇介, 外松 学, 多賀 崇, 富澤 大輔, 足立 壮一, 多和 昭雄, 堀部 敬三, 荒川 浩一, 小川 誠司, 林 泰秀.
  • Organizer: 第56回日本小児血液・がん学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2014-11-29
• [Presentation] The prognostic impact of high EV1-related genes expression in pediatric acute myeloid leukemia. (2014)
  • Author(s): Shiba N, Hara Y, Ohki K, Yamato G, Park M, Kobayashi T, Ichikawa H, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Arakawa H, Horibe H, Adachi S, Tawa A, Hayashi Y.
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-02
• [Presentation] CSF3R and CALR mutations and cytogenetic findings in pediatric myeloid malignancies. (2014)
  • Author(s): Sano H, Ohki K, Park M, Shiba N, Hara Y, Sotomatsu M, Tomizawa D, Taga T, Kiyokawa N, Tawa A, Horibe K, Adachi A, Hayashi Y.
  • Organizer: 第76回日本血液学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-11-01
• [Presentation] 小児急性骨髄性白血病における分子生物学的背景を用いた新たな治療層別化への試み. (2014)
  • Author(s): 柴 徳生, 吉田 健一, 大木 健太郎, 金澤 崇, 足立 壮一, 多和 昭雄, 伊藤 悦朗, 荒川 浩一, 小川 誠司, 林 泰秀, JPLSG AML委員会
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-04-13
• [Presentation] 小児急性骨髄性白血病におけるGATA2変異の解析. (2014)
  • Author(s): 原 勇介, 柴 徳生, 大木 健太郎, 朴 明子, 足立 壮一, 多賀 崇, 荒川 浩一, 多和 昭雄, 堀部 敬三, 林 泰秀.
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-04-12
• [Presentation] Recurrent CDC25C mutations drive malignant transformation in FPD/AML. (2014)
  • Author(s): Yoshimi A, Toya T, Kawazu M, Ueno T, Tsukamoto A, Iizuka1 H, Nakagawa M, Nannya Y, Arai S, Ichikawa M, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Mano H, Kurokawa M.
  • Organizer: AACR Annual Meeting 2014
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] Whole-Exome Resequencing Identifies Somatic Mutations Of BCOR and BCORL1 Transcriptional Corepressor Genes and Major Cohesin Complex Component Genes In Pediatric Acute Myeloid Leukemia. (2013)
  • Author(s): Shiba N, Ohki K, Nagata Y, Kon A, Okuno Y,Shiraishi Y, Kato M, Park MJ, Ohki K, Takita J, Kanazawa T, Kudo K, Ito E, Sanada M, Tomizawa D, Tawa A, Adachi S, Miyano S, Ogawa S, Hayashi Y.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] Low Frequency and Poor Prognosis Of MLL-Partial Tandem Duplications In Pediatric Acute Myeloid Leukemia Using MLPA Method: The Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05 Trial. (2013)
  • Author(s): Ohki K, Park MJ, Sano H, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, Hayashi Y.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] Whole Exome Sequencing Reveals Clonal Evolution Pattern and Driver Mutations Of Relapsed Pediatric AML. (2013)
  • Author(s): Yoshida K, Shiba N, Shiraishi Y, Shimada A, Terui K, Kato M, Okuno Y, Nagata Y, Kon A, Yoshizato T, Matsunawa, M, Chiba K, Tanaka H, Sanada M, Miyano S, Ito E, Hayashi Y, Ogawa S.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] Poor Prognosis With Different Induction Rate Was Observed In Children With Acute Myeloid Leukemia and FLT3-ITD According To The ITD/WT Allelic Ratio: A Result From The Japanese Pediatric Leukemia/Lymphoma Study Group. (2013)
  • Author(s): Shimada A, Yamashita Y, Tomizawa D, Tawa A, Watanabe T, Yokozawa T, Kudo K, Taga T, Iwamoto S, Terui K, Moritake H, Kinoshita A, Takahashi H, Nakayama H, Koh K, Goto H, Kosaka Y, Moriya Saito A, Fujimoto J, Horibe K, Oki K, Hayashi Y, SAdachi S.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] Comprehensive Fusion Gene Analysis Of Pediatric Non-Down Syndrome Acute Megakaryoblasitc Leukemia. (2013)
  • Author(s): Hara Y, Shiba n, Ohki K, Park MJ, Tomizawa D, Taga T, Saito A, Fujimoto J, Arakawa H, Tawa A, Horibe K, Adachi S, Hayashi Y.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] Genetic Landscapes Of Childhood T-Cell Acute Lymphoblastic Leukemia. (2013)
  • Author(s): Seki M, Yoshida K, Sato Y, Shiraishi Y, Chiba K, TanakaH, Kato M, Hiwatari M, Koh K, Hanada R, Sanada M, Miyano S, Oka A, Hayashi Y, Ogawa S, Takita J.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] The Genetic Landscape Of FPD/AML Revealed CDC25C Mutation As a Driver That Promotes Malignant Transformation. (2013)
  • Author(s): Yoshimi A, Toya T, Nakagawa M, Kawazu M, Nannya Y, Ichikawa M, Arai S, Harada H, Usuki K, Hayashi Y, Ito E, Kirito K, Nakajima H, Mano H, Kurokawa M.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] CSF3R Gene Mutations In Myeloid Malignancy Of Childhood. (2013)
  • Author(s): Sano H, Ohki K, Park MJ, Hara Y, Shiba N, Tomizawa D, Taga T, Moriya Saito A, Fujimoto J, Tawa A, Horibe K, Adachi S, Hayashi Y.
  • Organizer: 55rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans
• [Presentation] Whole exome sequencing reveals spectrum of gene mutations in pediatric AML. (2012)
  • Author(s): Shiba N, et al.
  • Organizer: 54rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: Atlanta
  • Year and Date: 2012-12-09
• [Presentation] GATA2 mutations in pediatric acute myeloid leukemia: a study of the Japanese Childhood AML Cooperative Study Group. (2012)
  • Author(s): Shiba N, et al.
  • Organizer: 54rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: Atlanta
  • Year and Date: 2012-12-09
• [Presentation] NUP98-NSD1 related gene expression signature is strongly associated with a poor prognosis in pediatric acute myeloid leukemia., (2012)
  • Author(s): Shiba N, et al.
  • Organizer: 54rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: Atlanta
  • Year and Date: 2012-12-08
• [Presentation] TAM芽球におけるCD117発現と末梢血中芽球割合の相関. (2012)
  • Author(s): 出口隆生, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-02
• [Presentation] ダウン症候群に合併した一過性骨髄異常増殖症に対する少量シタラビン療法による腫瘍崩壊症候群. (2012)
  • Author(s): 村松秀城, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-02
• [Presentation] 小児骨髄増殖疾患におけるJAK2V617F遺伝子変異. (2012)
  • Author(s): 嶋田明, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-02
• [Presentation] CD66c陽性小児急性リンパ芽球性白血病の特徴. (2012)
  • Author(s): 富田理, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-02
• [Presentation] 小児リンパ腫における遺伝子異常の解析. (2012)
  • Author(s): 大木健太郎, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-02
• [Presentation] 次世代シーケンサとSNPアレイを用いた横紋筋肉腫3例における初発/再発・転移巣の比較. (2012)
  • Author(s): 西村力, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-02
• [Presentation] 全エクソーム解析による小児急性骨髄性白血病の新規発症原因遺伝子変異の同定 (2012)
  • Author(s): 柴徳生, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-01
• [Presentation] 小児急性骨髄性白血病におけるGATA2遺伝子変異同定. (2012)
  • Author(s): 柴徳生, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-01
• [Presentation] 小児B前駆細胞型急性リンパ性白血病におけるclonal evolutionの解析. (2012)
  • Author(s): 大木健太郎, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] 進行期T細胞性リンパ芽球性リンパ腫の染色体異常解析―JPLSGからの報告. (2012)
  • Author(s): 関水匡大, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] 先端的ゲノム解析技術を用いた胸膜肺芽腫における発症分子機構の解明. (2012)
  • Author(s): 関正史, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会.
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] MLPA法を用いたT-ALL遺伝子異常についての解析. (2012)
  • Author(s): 朴明子, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] t(l 7; 19)(q22;p 13.3)を含む染色体異常を呈したT細胞性急性リンパ性白血病の1例. (2012)
  • Author(s): 西眞範, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] 神経芽腫におけるエピジェネティツク関連遺伝子の網羅的ゲノム解析 (2012)
  • Author(s): 星野諭子, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] 神経芽腫における網羅的メチル化解析 (2012)
  • Author(s): 関正史, 他
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] Characteristics and prognostic impacts of structural chromosomal abnormalities in childhood ALL. (2012)
  • Author(s): Takahashi H, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-21
• [Presentation] NUP98-NSD1 related gene expression signature is associated with a poor prognosis in pediatric AML. (2012)
  • Author(s): Shiba N, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-21
• [Presentation] JAK2 V6 1 7F mutation in pediatric myeloproliferative neoplasm. (2012)
  • Author(s): ShimadaA, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-20
• [Presentation] Clonal architecture and evolution of pediatric AML. (2012)
  • Author(s): Okuno Y, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-20
• [Presentation] Whole exome resequencing reveals novel gene mutations in pediatric AML. (2012)
  • Author(s): Shiba N, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-20
• [Presentation] Fusion gene-specific signature of microRNR expression in childhood ALL (2012)
  • Author(s): Kiyokawa N, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-19
• [Presentation] Gene expression profile related to prognosis of childhood ALL without fusion genes. (2012)
  • Author(s): Iijima K, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-19
• [Presentation] IL-7R gene mutations in childhood T-cell acute lymphoblastic leukemia. (2012)
  • Author(s): Park MJ, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-19
• [Presentation] Analysisi of CRLF2 and IKZF1, JAK, IL7R genes in pediatric B-precursor ALL treated on TCCSG protocol. (2012)
  • Author(s): Oki K, et al.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-19
• [Presentation] 全エクソーム解析による小児急性骨髄性白血病の新規発症原因遺伝子, (2012)
  • Author(s): 柴徳生, 他
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] 次世代シーケンサーによる再発肺芽腫のエクソーム解析. (2012)
  • Author(s): 関正史, 他
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] SNPアレイをエクソーム解析を用いた横紋筋肉腫の初発・再発/転移巣のクローン比較 (2012)
  • Author(s): 西村力, 他
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] 次世代シークェンサーを用いたユーイング肉腫発生の分子生物学的検討 (2012)
  • Author(s): 樋渡光輝, 他
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] BLNK欠損preB-ALLとB細胞分化におけるC/Ebpbの働き. (2012)
  • Author(s): 倉田盛人, 他
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-20
• [Presentation] 神経芽腫におけるエピジェネティック関連遺伝子の網羅的ゲノム解柧 (2012)
  • Author(s): 星野諭子, 他
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-20
• [Presentation] 2遺伝子の発現に基づく高リスク小児急性骨髄性白血病の同定. (2012)
  • Author(s): 三谷幸代, 他
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] TAMに合併する肝機能障害について. (2012)
  • Author(s): 朴明子, 他
  • Organizer: 第48回日本周産期・新生児医学会学術集会
  • Place of Presentation: さいたま
  • Year and Date: 2012-07-08
• [Presentation] 第2再発時に初めてMLL-AF4陽性となったB前駆型急性リンパ性白血病1例におけるクローン構造の検討. (2012)
  • Author(s): 大木健太郎, 他
  • Organizer: 第8回北関東小児がんセミナー
  • Place of Presentation: 高崎
  • Year and Date: 2012-05-19
• [Presentation] 先端的ゲノムスキャニングを用いた難治性小児固形腫瘍における標的分子の探索. (2012)
  • Author(s): 滝田順子, 他
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-21
• [Presentation] 次世代シークエンサーを用いた神経芽腫のエクソーム解析. (2012)
  • Author(s): 西村力, 他.
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-21
• [Presentation] 次世代シークエンサーを用いたEwing肉腫のエクソーム解析. (2012)
  • Author(s): 大久保純, 他
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-21
• [Presentation] 発現アレイを用いた小児急性骨髄性白血病における、NUP98-NSD1融合遺伝子の解析. (2012)
  • Author(s): 柴徳生, 他
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-21
• [Presentation] TCCSGの小児B前駆細胞型急性リンパ性白血病におけるCRLF2とIKZF1、 JAK遺伝子解析. (2012)
  • Author(s): 大木健太郎, 他
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-21
• [Presentation] 小児急性骨髄性白血病におけるGATA2遺伝子変異の解析.
  • Author(s): 柴 徳生, 朴 明子, 舩戸道徳, 小林正夫, 木下明俊, 足立壮一, 荒川浩一, 多和昭雄, 月本一郎, 林 泰秀.
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
• [Presentation] NUP98-NSD1融合遺伝子陽性例は小児急性骨髄性白血病において予後不良である
  • Author(s): 原 勇介, 柴 徳生, 嶋田 明, 工藤寿子, 富澤大輔, 多賀 崇, 多和昭雄, 荒川浩一, 足立壮一, 林 泰秀.
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
• [Presentation] 小児B型前駆細胞型ALLにおけるCRLF2高発現例の特徴：TCCSG-ALL研究
  • Author(s): 大木健太郎, 朴 明子, 柴 徳生, 清河信敬, 康 勝好, 花田良二, 真部 淳, 菊地 陽, 小原 明, 林 泰秀
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
• [Presentation] 染色体異常を伴ったダウン症合併TAMとAMKLの遺伝子解析
  • Author(s): 6. 朴 明子, 大木健太郎, 新井 心, 外松 学, 林 泰秀
  • Organizer: 第116回日本小児科学会学術集会
  • Place of Presentation: 広島
• [Presentation] NUP98-MSD1 gene fusion is a strong poor prognostic factor in pediatric AML.
  • Author(s): Hara Y, Shiba N, Shimada A, Kudo K, Tomizawa D, Taga T, Horibe K, Adachi S, Arakawa H, Tawa A, Hayashi Y.
  • Organizer: 45th Congress of the International Society of Pediatric Oncology.
  • Place of Presentation: 香港
• [Presentation] RNAシークエンシングによる小児AMLの融合遺伝子探索.
  • Author(s): 三谷幸代, 坂本裕美, 柴 徳生, 林 泰秀, 吉田輝彦, 市川 仁.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 小児non-Down急性巨核芽球性白血病における遺伝子解析
  • Author(s): 原 勇介, 柴 徳生, 大木健太郎, 朴 明子, 富澤大輔, 多賀 崇, 足立壮一, 荒川浩一, 多和昭雄, 堀部敬三, 林 泰秀.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] JPLSG AML05臨床試験登録症例においてMLPA法によるMLL-PTDの頻度はこれまでの報告より少なく予後不良である
  • Author(s): 大木健太郎, 柴 徳生, 朴 明子, 富澤大輔, 多賀 崇, 堀部敬三, 多和昭雄, 足立壮一, 林 泰秀.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] A diversity of cases in AML with promyelocytic differentiation; A report from JPLSG.
  • Author(s): Takahashi H, Matsushita H, Kinoshita A, Taki T, Taki T, Deguchi T, Kiyokawa N, Hashii Y, Hayashi Y, Tomizawa D, Taga T, Tawa A, Adachi S, Tabe M, Miyachi H.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] Prognostic impact of KIT mutatkon in t(8;21) childhood AML: The JPLSG AML-05 trial.
  • Author(s): Tokumasu M, Nagao M, Shimada A, Murata C, Ohki K, Hayashi Y, Saito A, Fujimoto J, Horibe K, Ito H, Nakayama H, Kinoshita A, Tomizawa D, Taga T, Yamaguchi H, Tawa A, Heike T, Adachi S.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] NUP98-NSD1 gene fusion is a strong poor prognostic factor in pediatric AML.
  • Author(s): Hara Y, Shiba N, Ichikawa H, Taki T, Shimada A, Kudo K, Tomizawa D, Taga T, Adachi S, Arakawa H, Tawa A, Hayashi Y.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] Clonal architecture in a case of acute myeloid leukemia with trisomy 8 and MLL-AF9.
  • Author(s): Ohki K, Kama Y, Shiba N, Arai K, Park MJ, Sotomatsu M, Hayashi Y.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] Genetic basisi of myeloid leukemogenesisi in Down syndrome.
  • Author(s): Yoshida K, Toki T, Okuno Y, Kanezaki R, Shiraishi Y, Sanada M, Park MJ, Terui K, Kon A, Nagata Y, Sato-Otsubo A, Sato Y, Wang R, Shiba N, Chiba K, Tanaka H, Hama A, Muramatsu H, Hasegawa D, Nakamura K, Kanegane H, Tsukamoto K, Adachi S, Kawakami K, Hayashi Y, Miyano S, Kojima S, Ito E, Ogawa S.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] 13q欠失を伴ったダウン症合併TAMとAMKLの遺伝子解析.
  • Author(s): 朴 明子, 吉田健一, 大木健太郎, 新井 心, 外松 学, 伊藤悦朗, 小川誠司, 林 泰秀.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] Gata2 mutations are found in pediatric AML but not in other leukemias including JMML.
  • Author(s): Hara Y, Shiba N, Funato M, Oki K, Park MJ, Mizushima Y, Adachi S, Kobayashi M, Kinoshita A, Sotomatsu M, Arakawa H, Tawa A, Horibe K, Tsukimoto I, Hayashi Y.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] Whole-exome resequencing reveals novel pathogenetic gene mutations in pediatric AML.
  • Author(s): Shiba N, Yoshida K, Okuno Y, Shiraishi Y, Nagata Y, Kon A, Chiba K, Tanaka H, Ohki K, Kato M, Terui K, Park MJ, Kanazawa T, Takita J, Kudo K, Arakawa H, Ito E, Sanada M, Miyano S, Ogawa S, Hayashi Y.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] Recurrent SETBP1 mutation in juvenile myelomonocytic leukemia and myelodysplastic syndrome.
  • Author(s): Shiba N, Hara Y, Park MJ, Ohki K, Fukushima K, Sako M, Kudo K, Arakawa H, Ito E, Hayashi Y.
  • Organizer: The 75th Annual Meeting of the Japanese Society of Hematolgy.
  • Place of Presentation: 札幌
• [Presentation] 児血液・腫瘍の染色体・分子遺伝学入門とその臨床応用.
  • Author(s): 林 泰秀
  • Organizer: 第55回日本小児血液・がん学会学術集会(meet the expert)
  • Place of Presentation: 福岡
• [Presentation] 全エクソーム解析による小児急性骨髄性白血病の新規原因遺伝子の同定.
  • Author(s): 柴 徳生, 林 泰秀.
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 小児白血病におけるSETBP1遺伝子変異の解析.
  • Author(s): 柴 徳生, 大木健太郎, 朴 明子, 工藤寿子, 福島啓太郎, 伊藤悦朗, 迫 正廣, 多和昭雄, 荒川浩一, 林 泰秀.
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 急性骨髄性白血病におけるWT1遺伝子変異の解析.
  • Author(s): 佐野弘純, 嶋田 明, 田渕 健, 滝 智彦, 村田知里, 朴 明子, 大木健太郎, 外松 学, 足立壮一, 多和昭雄, 小林良二, 堀部敬三, 土田昌宏, 花田良二, 月本一郎, 林 泰秀.
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 全エクソーム解析による肝芽腫における網羅的ゲノム解析.
  • Author(s): 星野諭子, 西村 力, 関 正史, 奥野友介, 吉田健一, 白石友一, 加藤元博, 宮野 悟, 岡 明, 林 泰秀, 岩中 督, 小川誠司, 滝田順子.
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 散発性胸膜肺芽腫におけるDICER1の両アレル変異.
  • Author(s): 関 正史, 吉田健一, 白石友一, 佐藤悠佑, 西村 力, 奥野友介, 千葉健一, 田中陽子, 加藤啓輔, 加藤元博, 花田良二, 野村優子, 朴 明子, 石田敏章, 岡 明, 宮野 悟, 林 泰秀, 小川誠司, 滝田順子.
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 小児骨髄造血器腫瘍におけるCSF3R遺伝子異常の解析.
  • Author(s): 佐野仁志, 大木健太郎, 朴 明子, 柴 徳生, 原 勇介, 外松 学, 足立壮一, 堀部敬三, 多和昭雄, 花田良二, 月本一郎, 林 泰秀.
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡