| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Neurodevelopmental disorders contain many systemic-epigenome disrupted diseases, like Rett syndrome (RTT). As well-known, epigenome-system in brain plays an important role in control of mental state. On the other hand, the abnormality of MECP2 gene, that is major causative gene of RTT and its product mainly works transcription repressor, presents two different phenotypes of RTT and Angelman syndrome. Moreover, it has been reported strongly functional relationship of MECP2 gene and chromosome 15q11-q13 (AS-PWS imprinting region).
In the present study, we performed MeCP2 functional analyses and recovery study, using original mecp2-expression control mice and multiple approaches. As the results, we revealed that molecular pathophysiology of abnormal MeCP2 gene and discovered some candidate factors to be mild phenotypes of RTT and critical period for any treatment. From the study, we could learn the important factors of epigemone system in developmental disorders.
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