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Comparison of the cerebral function before and after the oxytocin administration for patients with autism spectrum disorder.

Research Project

Project/Area Number 24390282
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

MINABE Yoshio  金沢大学, 医学系, 教授 (60181947)

Co-Investigator(Kenkyū-buntansha) MUNESUE Toshio  金沢大学, 子どものこころの発達研究センター, 特任教授 (50293353)
KIKUCHI Mitsuru  金沢大学, 子どものこころの発達研究センター, 特任教授 (00377384)
OUCHI Yasuomi  浜松医科大学, 分子イメージング先端研究センター, 教授 (40436978)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsオキシトシン / 自閉症スペクトラム / セロトニン / PET / 自閉症スペクトラム障害 / MEG / 脳画像研究 / セロトニン系システム / 広汎性発達障害 / 遺伝子研究 / GABA系ニューロン
Outline of Final Research Achievements

With chronic administration of the oxytocin to the patients with autism spectrum disorder who does not have intelligence impairment, we investigated the influence on the serotonin system and the influence on a social cognitive function. The neurophysiological characterization of the patient who improves with oxytocin administration was also explored. We investigated the changes of the serotonin transporter density after the drug treatment (ten weeks), and we also investigated the changes in brain response to social stimuli recorded by MEG. Study desing: Non-randomized, open and uncontrolled.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (49 results)

All 2015 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 5 results) Presentation (25 results) (of which Invited: 5 results) Remarks (4 results)

  • [Journal Article] Attentional control and interpretation of facial expression after oxytocin administration to typically developed male adults.2015

    • Author(s)
      Hirosawa T, Kikuchi M, Okumura E, Yoshimura Y, Hiraishi H, Munesue T, Takesaki N, Furutani N, Ono Y, Higashida H, Minabe Y
    • Journal Title

      PLoS One

      Volume: 6 Issue: 2 Pages: e0116918-e0116918

    • DOI

      10.1371/journal.pone.0116918

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced long-range functional connectivity in young children with autism spectrum disorder.2015

    • Author(s)
      Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Hashimoto T, Tsubokawa T, Takahashi T, Suzuki M, Higashida H, Minabe Y.
    • Journal Title

      Soc Cogn Affect Neurosci.

      Volume: 10 Issue: 2 Pages: 248-254

    • DOI

      10.1093/scan/nsu049

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unusual developmental pattern of brain lateralization in young boys with autism spectrum disorder: Power analysis with child-sized magnetoencephalography.2015

    • Author(s)
      Hiraishi H, Kikuchi M, Yoshimura Y, Kitagawa S, Hasegawa C, Munesue T, Takesaki N, Ono Y, Takahashi T, Suzuki M, Higashida H, Asada M, Minabe Y.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 69 Issue: 3 Pages: 153-160

    • DOI

      10.1111/pcn.12261

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Broader autism phenotype in mothers predicts social responsiveness in young children with autism spectrum disorders.2015

    • Author(s)
      Hasegawa C, Kikuchi M, Yoshimura Y, Hiraishi H, Munesue T, Nakatani H, Higashida H, Asada M, Oi M, Minabe Y.
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 69 Issue: 3 Pages: 136-144

    • DOI

      10.1111/pcn.12210

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses.2014

    • Author(s)
      Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T.
    • Journal Title

      Biological Psychiatry

      Volume: 3223 Issue: 2 Pages: 00570-00578

    • DOI

      10.1016/j.biopsych.2014.07.025

    • NAID

      40020643113

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A longitudinal study of auditory evoked field and language development in young children2014

    • Author(s)
      Yoshimura Yuko, Kikuchi Mitsuru, Ueno Sanae, Shitamichi Kiyomi, Remijn Gerard, Hiraishi Hirotoshi, Hasegawa Chiaki, Furutani Naoki, Oi Manabu, Munesue Toshio, Tsubokawa Tunehisa, Higashida Haruhiro, Minabe Yoshio
    • Journal Title

      NeuroImage

      Volume: 1;101 Pages: 440-447

    • DOI

      10.1016/j.neuroimage.2014.07.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Somatosensory evoked field in response to visuotactile stimulation in 3- to 4-year-old children.2014

    • Author(s)
      Remijn GB, Kikuchi M, Shitamichi K, Ueno S, Yoshimura Y, Nagao K, Tsubokawa T, Kojima H, Higashida H, Minabe Y.
    • Journal Title

      Front Hum Neurosci

      Volume: 24 Pages: 170-170

    • DOI

      10.3389/fnhum.2014.00170

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia.2014

    • Author(s)
      Georgiev D, Arion D, Enwright JF, Kikuchi M, Minabe Y, Corradi JP, Lewis DA, Hashimoto T.
    • Journal Title

      Am J Psychiatry.

      Volume: 171 Pages: 62-71

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between brain network pattern and cognitive performance of children revealed by MEG signals during free viewing of video.2014

    • Author(s)
      Duan F, Watanabe K, Yoshimura Y, Kikuchi M, Minabe Y, Aihara K.
    • Journal Title

      Brain Cogn

      Volume: 86 Pages: 10-16

    • DOI

      10.1016/j.bandc.2014.01.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lower gene expression for KCNS3 potassium channel subunit in parvalbumin-containing neurons in the prefrontal cortex in schizophrenia.2014

    • Author(s)
      Georgiev D
    • Journal Title

      Am J Psychiatry

      Volume: 1 Issue: 1 Pages: 62-71

    • DOI

      10.1176/appi.ajp.2013.13040468

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered brain connectivity in 3-to-7-year-old children with autism spectrum disorder.2013

    • Author(s)
      Kikuchi, M., Shitamichi, K., Yoshimura, Y., Ueno, S., et al., Remijn, G.B., Takahashi, T., Suzuki, M., Higashida, H., Minabe, Y.
    • Journal Title

      Neuroimage: Clinical

      Volume: 2 Pages: 394-401

    • DOI

      10.1016/j.nicl.2013.03.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The brain's response to the human voice depends on the incidence of autistic traits in the general population2013

    • Author(s)
      Y Yoshimura, M Kikuchi, S Ueno, E Okumura, H Hiraishi, C Hasegawa, G B Remijn, K Shitamichi, T Munesue, T Tsubokawa, H Higashida, Y Minabe
    • Journal Title

      PLoS One

      Volume: 20巻 Issue: 11 Pages: e80126-e80126

    • DOI

      10.1371/journal.pone.0080126

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atypical brain lateralisation in the auditory cortex and language performance in 3- to 7-year-old children with high-functioning autism spectrum disorder : a child-customised magnetoencephalography (MEG) study2013

    • Author(s)
      Y Yoshimura, M Kikuchi, K Shitamichi, S Ueno, T Munesue, Y Ono, T Tsubokawa, Y Haruta, M Oi, Y Niida, GB Remijn, T Takahashi, M Suzuki, H Higashida, Y Minabe
    • Journal Title

      Mol Autism

      Volume: 8巻 Issue: 1 Pages: 38-38

    • DOI

      10.1186/2040-2392-4-38

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior prefrontal hemodynamic connectivity in conscious 3- to 7-year-old children with typical development and autism spectrum disorder.2013

    • Author(s)
      Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S., et al., Remijn, G.B., Takahashi, T., Suzuki, M., Higashida, H., Minabe, Y.
    • Journal Title

      PloSONE

      Volume: 8 Issue: 2 Pages: 56087-56087

    • DOI

      10.1371/journal.pone.0056087

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A custom magnetoencephalography device reveals brain connectivity and high reading/decoding ability in children with autism.2013

    • Author(s)
      Kikuchi M.
    • Journal Title

      Scientific Reports

      Volume: 3 Pages: 1139-1139

    • NAID

      120005821068

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal frequency characteristics of cerebral oscillations during the perception of fundamental frequency contour changes in one-syllable intonation2012

    • Author(s)
      Ueno S, Okumura E, Remijn GB, YoshimuraY, Kikuchi M, Shitamichi K, Nagao K, Mochiduki M, Haruta Y, Hayashi N, Munesue T, Tsubokawa T, Oi M, NakataniH, Higashida H, MinabeY.
    • Journal Title

      Neurosci Lett

      Volume: (in press) Issue: 2 Pages: 141-146

    • DOI

      10.1016/j.neulet.2012.03.031

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin attenuates feelings of hostility depending on emotional context and individuals' characteristics2012

    • Author(s)
      Tetsu Hirosawa1, Mitsuru Kikuchi, Haruhiro Higashida, Eiichi Okumura, Sanae Ueno, Kiyomi Shitamichi, YukoYoshimura, Toshio Munesue, TsunehisaTsubokawa, Yasuhiro Haruta, Hideo Nakatani, Takanori Hashimoto, Yoshio Minabe
    • Journal Title

      Scientific Reports

      Volume: (in press) Issue: 1 Pages: 384-384

    • DOI

      10.1038/srep00384

    • NAID

      120005821069

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lateralized theta wave connectivity and language performance in 2- to 5-old children2012

    • Author(s)
      三邉義雄
    • Journal Title

      子どものこころと脳の発達

      Volume: 3 Pages: 52-53

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自閉症スペクトラム障害を対象としたオキシトシン臨床試験の国内外での状況2012

    • Author(s)
      芦村和美
    • Journal Title

      北陸神経精神医学雑誌

      Volume: 26 Pages: 37-39

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social memory, amnesia, and autism : brain oxytocin secretion is regulated by NAD+ and single nucleotide polymorphism of CD382012

    • Author(s)
      Higashida, H
    • Journal Title

      Neurochem Int

      Volume: (in press) Issue: 6 Pages: 828-838

    • DOI

      10.1016/j.neuint.2012.01.030

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 自閉症スペクトラム障害の認知特性と脳機能の特徴2014

    • Author(s)
      菊知 充
    • Organizer
      第14回、「精神疾患と認知機能研究会」
    • Place of Presentation
      海運クラブ(東京都)
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neuroimaging for brain development in young children2014

    • Author(s)
      菊知 充、三邉義雄
    • Organizer
      第4回 賀戸久先生記念研究会
    • Place of Presentation
      TOKYO REIT虎ノ門ビル(東京都)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 広汎性発達障害の早期診断のための診断システム開発,2014

    • Author(s)
      菊知 充
    • Organizer
      第45回公益財団法人アステラス病態代謝研究会
    • Place of Presentation
      日本工業倶楽部(東京都)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子どものこころの生物学2014

    • Author(s)
      三邉義雄
    • Organizer
      第1回大阪大学COIワークショップ
    • Place of Presentation
      大阪大学中ノ島センター10F
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自閉症スペクトラム障害の幼児期における脳機能結合低下:MEG長距離センサー間の検討2013

    • Author(s)
      三邉義雄
    • Organizer
      第40回日本脳科学会
    • Place of Presentation
      アクトシティ浜松 コングレスセンター(浜松市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳科学から見た発達障がいと音楽2013

    • Author(s)
      菊知充
    • Organizer
      ミュージックケア学会
    • Place of Presentation
      加佐ノ岬倶楽部 (加賀市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 招待シンポジウム:発達障害児の行動をもっと理解する:最先端の脳科学研究から2013

    • Author(s)
      菊知充
    • Organizer
      独立行政法人 国立精神・神経医療研究センター
    • Place of Presentation
      イイノホール(東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 自閉症スペクトラム障害児の理解を目指して:脳科学研究から2013

    • Author(s)
      菊知充
    • Organizer
      第3回福井県精神科治療研究会
    • Place of Presentation
      バードグリーンホテル(福井市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Brain connectivity in young children with autism2013

    • Author(s)
      菊知充
    • Organizer
      International Society for the Advancement of Clinical Magnetoencephalography meeting 2013
    • Place of Presentation
      Tokyo Dome Hotel Sapporo (札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自閉症スペクトラム障害幼児期における、脳機能結合低下と認知特性2013

    • Author(s)
      菊知充
    • Organizer
      第46回 精神神経系薬物治療研究報告会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] シンポジウム:幼児用MEGをもちいた広汎性発達障害の脳機能評価2013

    • Author(s)
      菊知充
    • Organizer
      第28回日本生体磁気学会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Brain connectivity and high reading/decoding ability in young children with autism.2013

    • Author(s)
      Mitsuru Kikuchi
    • Organizer
      Neuro2013
    • Place of Presentation
      国立京都国際会館 (京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] An approach with a new neuroimaging methods for young children.2013

    • Author(s)
      Mitsuru Kikuchi
    • Organizer
      IEEE ICDL-EpiRob2013 Special Session
    • Place of Presentation
      Oosaka Central Public Hall (大阪市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel method of creating a brain template for mapping in MEG without the need of an MRI2012

    • Author(s)
      Hachiman Y.
    • Organizer
      Radiological Society of North America 2012 98th Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place(米)
    • Year and Date
      2012-11-26
    • Related Report
      2012 Annual Research Report
  • [Presentation] Toward Diagnosis and Therapy of Autism: MEG and Oxytocin2012

    • Author(s)
      Minabe Y
    • Organizer
      Japan-Korea Joint symposium
    • Place of Presentation
      金沢大学医学部記念館(石川県)
    • Year and Date
      2012-11-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発達障害の早期発見に向けた研究2012

    • Author(s)
      菊知充
    • Organizer
      第47回北陸心理学会
    • Place of Presentation
      金沢大学サテライト・プラザ(石川県)(招待講演)
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 未就学広汎性発達障害児の認知機能および脳機能結合の特性2012

    • Author(s)
      菊知充
    • Organizer
      第21回海馬と高次脳機能学会
    • Place of Presentation
      湯涌創作の森(石川県)
    • Year and Date
      2012-10-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] 未就学広汎性発達障害児の大脳半球側性化:幼児用MEGによる検討2012

    • Author(s)
      三邉義雄
    • Organizer
      第39回日本脳科学会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県)
    • Year and Date
      2012-10-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] MEGによる定型発達児と自閉症児の自発脳活動の比較2012

    • Author(s)
      平石博敏
    • Organizer
      第39回日本脳科学会
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡県)
    • Year and Date
      2012-10-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小児MEG検査におけるマツピング用MR画像作成手法に関する研究:テンプレート選択手法の最適化2012

    • Author(s)
      八幡優希
    • Organizer
      第40回日本放射線技術学会秋季学術大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2012-10-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] 幼児用MEGによる未就学広汎性発達障害児の生理学的検討2012

    • Author(s)
      三邉義雄
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議(兵庫県)
    • Year and Date
      2012-09-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 幼児の脳機能測定2012

    • Author(s)
      菊知充
    • Organizer
      神経ダイナミクスから社会的相互作用へ至る過程の理解と構築による構成的発達科学研究会
    • Place of Presentation
      大阪大学(大阪府)(招待講演)
    • Year and Date
      2012-09-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] Oxytocin attenuates feelings of hostility depending on emotional context and individuals? characteristics.2012

    • Author(s)
      Hirosawa Tetsu
    • Organizer
      18th International Conference on Biomagnetism
    • Place of Presentation
      MAISON DE LA CHIMIE (仏)
    • Year and Date
      2012-08-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] MEG-NIRS統合機の開発:幼児への応用2012

    • Author(s)
      菊知充
    • Organizer
      第14回ヒト脳機能マッピング学会
    • Place of Presentation
      京王プラザホテル札幌(北海道)(招待講演)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] 幼児の言語発達と脳機能結合:コピーレンズ解析による試み2012

    • Author(s)
      菊知充
    • Organizer
      第27回 日本生体磁気学会大会
    • Place of Presentation
      東京電機大学(東京都)
    • Year and Date
      2012-05-31
    • Related Report
      2012 Annual Research Report
  • [Remarks] 子どものこころの発達研究センター

    • URL

      http://kodomokokoro.w3.kanazawa-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 金沢大学附属病院神経科精神科

    • URL

      http://psychiatry.w3.kanazawa-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] バンビプラン

    • URL

      http://bambiplan.w3.kanazawa-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 連合小児発達学研究科 金沢校

    • URL

      http://rengou.w3.kanazawa-u.ac.jp/

    • Related Report
      2014 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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