| Project/Area Number |
24390284
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Yasumasa 広島大学, 大学院医歯薬保健学研究院, 准教授 (70314763)
YOSHINO Atsuo 広島大学, 大学院医歯薬保健学研究院, 助教 (90633727)
NAKAO Takashi 広島大学, 大学院教育学研究科, 准教授 (40432702)
MORINOBU Shigeru 高知大学, 医学部, 教授 (30191042)
YAMASAHITA Hidehisa 広島大学病院, 講師 (50294591)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 精神生理学 / Self-Referential Task / うつ傾向 / ストレス / BDNF / 自己関連付け課題 / うつ / CBT / 痛み / 情動 / MRI |
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| Outline of Final Research Achievements |
We examined the brain mechanisms of emotional control and restoring mechanisms to their disturbance in healthy controls, depression, and pain disorder. We conducted various cognitive-emotional tasks and functional magnetic resonance imaging in healthy controls or pain disorder, and examined the comparison of brain activities between pre and post cognitive behavior therapy (CBT) in patients with depression. These studies have shown that the pathology of depression and pain disorder or the restoring brain mechanism of depression modulated by CBT might be associated with the specific brain regions such as medial prefrontal cortex, anterior cingulate cortex, and insula.
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