Basic research for particle therapy using high enrgy proton in next generation

• Project/Area Number: 24390286
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: SAKURAI Hideyuki 筑波大学, 医学医療系, 教授 (50235222)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377) ; ISHIKAWA Hitoshi 筑波大学, 医学医療系, 准教授 (70344918)
• Co-Investigator(Renkei-kenkyūsha): OKUMURA Toshiyuki 筑波大学, 医学医療系, 准教授 (50241815) ; MORITAKE Takashi 産業医科大学, 産業生態科学研究所, 准教授 (50450432) ; HASHIMOTO Takayuki 北海道大学, 医学研究科, 特任准教授 (60400678) ; MIZUMOTO Masashi 筑波大学, 医学医療系, 講師 (20512388) ; MATSUMOTO Yoshitaka 筑波大学, 医学医療系, 助教 (70510395)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 粒子線治療 / 放射線治療 / 陽子線治療

Outline of Final Research Achievements

There is high possibility to increase cure rate of cancer by using new radiation therapy, proton beam therapy and boron neutron capture therapy (BNCT). We performed not only basic research of these two particle therapy, but also clinical studies of chemoproton therapy for esophageal cancer, locally advanced lung cancer, and cholangiocarcinoma. As a result, chemoproton therapy, which was new field of cancer therapy, showed high treatment effect with less toxicity for the heart and lung. We also carried out clinical study of proton for pediatric cancer, and started long term to follow up of 150 patients. For clinical study of BNCT, the treatments were finalized in 4 patients.

Research Products

• [Journal Article] Comparison of dose-volume histograms between proton beam and X-ray conformal radiotherapy for locally advanced non-small-cell lung cancer. (2015)
  • Author(s): Ohno T, Oshiro Y, Mizumoto M, Numajiri H, Ishikawa H, Okumura T, Terunuma T, Sakae T, Sakurai H.
  • Journal Title: J Radiat Res Volume: 56 Issue: 1 Pages: 128-133
  • DOI: 10.1093/jrr/rru082
  • NAID: 120007130349
  • Peer Reviewed / Open Access
• [Journal Article] Preparation of pediatric patients for treatment with proton beam therapy. (2015)
  • Author(s): Mizumoto M, Oshiro Y, Ayuzawa K, Miyamoto T, Okumura T, Fukumitsu N, Fukushima T, Ishikawa H, Sakurai H
  • Journal Title: Radiather Oncol Volume: 114 Issue: 2 Pages: 245-248
  • DOI: 10.1016/j.radonc.2015.01.007
  • Peer Reviewed / Open Access
• [Journal Article] [Concurrent proton therapy and chemotherapy for locally advanced cancers]. (2015)
  • Author(s): Ishikawa H, Fukumitsu N, Ohnishi K, Mizumoto M, Murofushi K, Numajiri H, Aihara T, Okumura T, Sakurai H.
  • Journal Title: Gan To Kagaku Ryoho Volume: 42 Pages: 148-153
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy combined with concurrent chemotherapy for esophageal cancer. (2015)
  • Author(s): Ishikawa H, Hashimoto T, Moriwaki T, Hyodo I, Hisakura K, Terashima H, Ohkohchi N, Ohno T, Makishima H, Mizumoto M, Ohnishi K, Okumura T, Sakurai H.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 1757-1762
  • Peer Reviewed / Open Access
• [Journal Article] High-dose concurrent chemo-proton therapy for Stage III NSCLC: preliminary results of a Phase II study (2014)
  • Author(s): Oshiro Y, Okumura T, Kurishima K, Homma S, Mizumoto M, Ishikawa H,Onizuka M, Sakai M, Goto Y, Hizawa N, Sato Y, Sakurai H.
  • Journal Title: J Radiat Res. Volume: 55 Pages: 959-965
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] RBE and OER within the spread-out Bragg peak for proton beam therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba (2014)
  • Author(s): Kanemoto A, Hirayama R, Moritake T, Furusawa Y, Sun L, Sakae T, Kuno A, Terunuma T, Yasuoka K, Mori Y, Tsuboi K, Sakurai H.
  • Journal Title: J Radiat Res. Volume: 55 Issue: 5 Pages: 1028-1032
  • DOI: 10.1093/jrr/rru043
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for a patient with a giant thymic carcinoid tumor and severe superior vena cava syndrome. (2014)
  • Author(s): Sugawara K, Mizumoto M, Numajiri H, Ohno T, Ohnishi K, Ishikawa H, Okumura T, Sakurai H.
  • Journal Title: Rare Tumors Volume: 13 Issue: 2 Pages: 5177-5177
  • DOI: 10.4081/rt.2014.5177
  • Peer Reviewed / Open Access
• [Journal Article] Dose distribution resulting from changes in aeration of nasal cavity or paranasal sinus cancer in the proton therapy. (2014)
  • Author(s): Fukumitsu N, Ishikawa H, Ohnishi K, Terunuma T, Mizumoto M, Numajiri H, Aihara T, Okumura T, Tsuboi K, Sakae T, Sakurai H.
  • Journal Title: Radiother Oncol. Volume: 113 Issue: 1 Pages: 72-76
  • DOI: 10.1016/j.radonc.2014.08.024
  • NAID: 120007136377
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proton beam therapy for unresectable intrahepatic cholangiocarcinoma. (2014)
  • Author(s): Ohkawa A, Mizumoto M, Ishikawa H, Abei M, Fukuda K, Hashimoto T, Sakae T, Tsuboi K, Okumura T, Sakurai H.
  • Journal Title: J Gastroenterol Hepatol Volume: 30 Issue: 5 Pages: 957-963
  • DOI: 10.1111/jgh.12843
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Total skin electron beam therapy using an inclinable couch on motorized table and a compensating filter. (2014)
  • Author(s): Fuse H, Suzuki K, Shida K, Mori Y, Takahashi H, Kobayashi D, Seki M, Isobe T, Okumura T, Sakae T, Sakurai H.
  • Journal Title: Rev Sci Instrum Volume: 85 Issue: 6 Pages: 064301-064301
  • DOI: 10.1063/1.4882336
  • NAID: 120007136654
  • Peer Reviewed / Open Access
• [Journal Article] Association between pretreatment retention rate of indocyanine green 15min after administration and life prognosis in patients with HCC treated by proton beam therapy. (2014)
  • Author(s): Mizumoto M, Oshiro Y, Okumura T, Fukuda K, Fukumitsu N, Abei M, et al.
  • Journal Title: Radiother Oncol Volume: 113 Issue: 1 Pages: 54-59
  • DOI: 10.1016/j.radonc.2014.08.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Outcomes and prognostic factors for recurrence after high-dose proton beam therapy for centrally and peripherally located stage I non-small-cell lung cancer (2014)
  • Author(s): Kanemoto A, Okumura T, Ishikawa H, Mizumoto M, Oshiro Y, Kurishima K, Homma S, Hashimoto T, Ohkawa A, Numajiri H, Ohno T, Moritake T, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Clin Lung Cancer Volume: 15 Issue: 2 Pages: e7-e12
  • DOI: 10.1016/j.cllc.2013.11.002
  • Peer Reviewed
• [Journal Article] A phase I study on combined therapy with proton-beam radiotherapy and in situ tumor vaccination for locally advanced recurrent hepatocellular carcinoma (2013)
  • Author(s): Abei M, Okumura T, Fukuda K, Hashimoto T, Araki M, Ishige K, Hyodo I, Kanemoto A, Numajiri H, Mizumoto M, Sakae T, Sakurai H, Zenkoh J, Ariungerel G, Sogo Y, Ito A,Ohno T, Tsuboi K
  • Journal Title: Radiat Oncol Volume: 16 Issue: 1 Pages: 239-239
  • DOI: 10.1186/1748-717x-8-239
  • Peer Reviewed
• [Journal Article] Dose-volume histogram analysis for risk factors of radiation-induced rib fracture after hypofractionated proton beam therapy for hepatocellular carcinoma (2013)
  • Author(s): Kanemoto A, Mizumoto M, Okumura T, Takahashi H, Hashimoto T, Oshiro Y, Fukumitsu N, Moritake T, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Acta Oncol Volume: 52(3) Issue: 3 Pages: 538-44
  • DOI: 10.3109/0284186x.2012.718094
  • Peer Reviewed
• [Journal Article] Evaluation of vegetables in Tsukuba for contamination with radioactive materials from the accident at Fukushima Daiichi nuclear power pl (2013)
  • Author(s): Isobe T, Mori Y, Takada K, Sato E, Takahashi H, Sekiguchi T, Yoshimura Y, Sakurai H, Sakae T
  • Journal Title: Health Phys Volume: 105 Issue: 4 Pages: 311-317
  • DOI: 10.1097/hp.0b013e3182895759
  • Peer Reviewed
• [Journal Article] Clinical results of proton beam therapy for advanced neuroblastoma (2013)
  • Author(s): Oshiro Y, Mizumoto M, Okumura T, Sugahara S, Fukushima T, Ishikawa H, Nakao T, Hashimoto T, Tsuboi K, Ohkawa H, Kaneko M, Sakurai H
  • Journal Title: Radiat Oncol Volume: 12 Issue: 1 Pages: 142-142
  • DOI: 10.1186/1748-717x-8-142
  • NAID: 120007136889
  • Peer Reviewed
• [Journal Article] Multidisciplinary therapy including proton beam radiotherapy for a Ewing sarcoma family tumor of maxillary sinus in a 4-year-old girl (2013)
  • Author(s): Yamaoka M, Akiyama M, Yokokawa Y, Terao Y, Yokoi K, Kato T, Fukushima T, Sakurai H, Ida H
  • Journal Title: Head Neck Volume: 35 Issue: 12
  • DOI: 10.1002/hed.23352
  • Peer Reviewed
• [Journal Article] Proton beam therapy for malignancy in Bloom syndrome (2013)
  • Author(s): Mizumoto M, Hashii H, Senarita M, Sakai S, Wada T, Okumura T, Tsuboi K, Sakurai H
  • Journal Title: Strahlenther Onkol Volume: 189 Issue: 4 Pages: 335-338
  • DOI: 10.1007/s00066-012-0274-1
  • Peer Reviewed
• [Journal Article] Reirradiation for recurrent malignant brain tumor with radiotherapy or proton beam therapy. Technical considerations based on experience at a single institution (2013)
  • Author(s): Mizumoto M, Okumura T, Ishikawa E, Yamamoto T, Takano S, Matsumura A, Oshiro Y, Ishikawa H, Sakurai H, Tsuboi K
  • Journal Title: Strahlenther Onkol Volume: 189 Issue: 8 Pages: 656-663
  • DOI: 10.1007/s00066-013-0390-6
  • Peer Reviewed
• [Journal Article] Comparison of the effects of high-energy photon beam irradiation (10 and 18 MV) on 2 types of implantable cardioverter-defibrillators (2013)
  • Author(s): Hashii H, Hashimoto T, Okawa A, Shida K, Isobe T, Hanmura M, Nishimura T, Aonuma K, Sakae T, Sakurai H
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 85 Issue: 3 Pages: 840-845
  • DOI: 10.1016/j.ijrobp.2012.05.043
  • Peer Reviewed
• [Journal Article] Comparison of adverse effects of proton and X-ray chemoradiotherapy for oesophageal cancer using an adaptive dose-volume histogram analysis (2013)
  • Author(s): Makishima H, Ishikawa H, Terunuma T, Hashimoto T, Yamanashi K, Sekiguchi T, Mizumoto M, Okumura T, Tsuboi K, Sakurai H
  • Journal Title: Eur J Cancer Volume: 49
  • Peer Reviewed
• [Journal Article] Proton beam therapy for a patient with large rhabdomyosarcoma of the body trunk (2013)
  • Author(s): Takizawa D, Oshiro Y, Okumura T, Mizumoto M, Fukushima T, Ishikawa H, Tsuboi K, Kaneko M, Sakurai H
  • Journal Title: Pediatr Blood Cancer Volume: 60 Pages: 93-93
  • Peer Reviewed
• [Journal Article] Incidence of venous thromboembolism before treatment in cervical cancer and the impact of management on venous thromboembolism after commencement of treatment. (2013)
  • Author(s): Toyomi Satoh, Koji Matsumoto, Yumiko O Tanaka, Azusa Akiyama, Sari Nakao, Manabu Sakurai, Hiroyuki Ochi, Mamiko Onuki, Takeo Minaguchi, Hideyuki Sakurai, Hiroyuki Yoshikawa.
  • Journal Title: Thrombosis Research Volume: 131(4) Issue: 4 Pages: e127-e132
  • DOI: 10.1016/j.thromres.2013.01.027
  • Peer Reviewed
• [Journal Article] Prognosis was not deteriorated by multiple primary cancers in esophageal cancer patients treated by radiotherapy (2013)
  • Author(s): Shirai K, Tamaki Y, Kitamoto Y, et al
  • Journal Title: Appl Radiat Isot Volume: (In press) Issue: 4 Pages: 706-711
  • DOI: 10.1093/jrr/rrt002
  • Peer Reviewed
• [Journal Article] Proton beam therapy for unresectable hepatoblastoma in children: survival in one case (2013)
  • Author(s): Oshiro Y, Okumura T, Mizumoto M, Fukushima T, Ishikawa H, Hashimoto T, Tsuboi K, Kaneko M, Sakurai H
  • Journal Title: Acta Oncol Volume: 52(3) Issue: 3 Pages: 600-3
  • DOI: 10.3109/0284186x.2012.760849
  • Peer Reviewed
• [Journal Article] Proton beam therapy for malignancy in bloom syndrome (2013)
  • Author(s): Mizumoto M, Hashii H, et al
  • Journal Title: Strahlentherapie und Onkologie Volume: 4 Pages: 335-7
  • Peer Reviewed
• [Journal Article] Lineal energy-based evaluation of oxidative DNA damage induced by proton beams and X-rays (2013)
  • Author(s): Zhengshan Hong, Yuki Kase, Takashi Moritake, Ariungerel Gerelchuluun, Lue Sun, Kenshi Suzuki, Toshiyuki Terunuma, Kiyoshi Yasuoka, Hiroaki Kumada, Kazunori Anzai, Hideyuki Sakurai, Takeji Sakae and Koji Tsuboi
  • Journal Title: Int. J. Radiat. Biol. Volume: Vol.89 Issue: 1 Pages: 36-43
  • DOI: 10.3109/09553002.2012.715791
  • Peer Reviewed
• [Journal Article] Comparison of the effects of high-energy photon beam irradiation (10 and 18 mv) on 2 of implantable cardioverter-defibrillators (2013)
  • Author(s): Hashii H, Hashimoto T, Okawa A, et al
  • Journal Title: Int J Radiat Oncol Volume: 85 Pages: 840-45
  • Peer Reviewed
• [Journal Article] The use of proton-beam therapy in the treatment of non-small-cell lung cancer (2013)
  • Author(s): Oshiro Y, Sakurai H
  • Journal Title: Expert Rev Med Devices Volume: 10(2) Issue: 2 Pages: 239-45
  • DOI: 10.1586/erd.12.81
  • Peer Reviewed
• [Journal Article] Dose response of soft x-ray-induced bystander cell killing affected by p53 status. (2012)
  • Author(s): Tomita、M., Maeda, M., Kobayashi, K., Matsumoto, H.
  • Journal Title: Radiat. Res. Volume: 179 Issue: 2 Pages: 200-207
  • DOI: 10.1667/rr3010.1
  • Peer Reviewed
• [Journal Article] Evaluation of liver function after proton beam therapy for hepatocellular carcinoma (2012)
  • Author(s): Mizumoto M, Okumura T, 他15名
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82 Issue: 3 Pages: e529-e535
  • DOI: 10.1016/j.ijrobp.2011.05.056
  • Peer Reviewed
• [Journal Article] The combination of olaparib and camptothecin for effective radiosensitization (2012)
  • Author(s): Katsutoshi Miura
  • Journal Title: Radiation Oncology Volume: 7 Issue: 1 Pages: 62-62
  • DOI: 10.1186/1748-717x-7-62
  • Peer Reviewed
• [Journal Article] Comparison of efficacy and safety of low-dose-rate vs. high-dose-rate intraluminal brachytherapy boost in patients with superficial esophageal cancer. (2012)
  • Author(s): Tamaki T, Ishikawa H, Takahashi T, et al
  • Journal Title: Brachytherapy Volume: 11 Issue: 2 Pages: 130-6
  • DOI: 10.1016/j.brachy.2011.05.008
  • Peer Reviewed
• [Journal Article] Results of proton beam therapy without concurrent chemotherapy for patients with unresectable stage iii non-small cell lung cancer (2012)
  • Author(s): Oshiro Y, Mizumoto M, Okumura T, et al
  • Journal Title: J Thorac Oncol Volume: 7 Pages: 370-75
  • Peer Reviewed
• [Journal Article] Analysis of Intravesical Recurrence After Bladder-preserving Therapy for Muscle-invasive Bladder Cancer (2012)
  • Author(s): Onozawa M, Miyazaki J, Kawai K, Nishiyama H
  • Journal Title: JJCO Volume: 42(9) Issue: 9 Pages: 30-825
  • DOI: 10.1093/jjco/hys105
  • Peer Reviewed
• [Journal Article] Long-term results of curative intraluminal high dose rate bachytherapy for endobronchial carcinoma (2012)
  • Author(s): Kawamura H, Ebara T, Katoh H., et al
  • Journal Title: Radiat Oncol Volume: 7 Issue: 1 Pages: 112-17
  • DOI: 10.1186/1748-717x-7-112
  • Peer Reviewed
• [Journal Article] Proton beam therapy for inoperable recurrence of bronchial high-grade mucoepidermoid carcinoma (2012)
  • Author(s): Kanemoto A, Oshiro Y, Sugahara S, Kamagata S, Hirobe S, Toma M, Okumura T, Sakurai H
  • Journal Title: Jpn J Clin Oncol Volume: 42(6) Issue: 6 Pages: 552-5
  • DOI: 10.1093/jjco/hys047
  • Peer Reviewed
• [Journal Article] Proton beam therapy for liver metastasis from breast cancer : Five case reports and a review of the literatures (2012)
  • Author(s): Kanemoto A, Ishikawa H, Mizumoto M, et al
  • Journal Title: International Cancer Conference Journal Volume: 1 Pages: 210-14
  • Peer Reviewed
• [Journal Article] Verification of beam delivery using fibrosis after proton beam irradiation to the lung tumor. (2012)
  • Author(s): Fukumitsu N, Oshiro Y, 他7名
  • Journal Title: Lung Cancer Volume: (in press) Issue: 1 Pages: 83-8
  • DOI: 10.1016/j.lungcan.2012.01.007
  • Peer Reviewed
• [Journal Article] Reproducibility of image quality for moving objects using respiratory-gated computed tomography-a study using phantom model (2012)
  • Author(s): Fukumitsu N, Ishida M, Terunuma T., et al
  • Journal Title: Radiation Research Volume: 53 Issue: 6 Pages: 945-63
  • DOI: 10.1093/jrr/rrs039
  • Peer Reviewed
• [Journal Article] Carbon-ion radiation for prostate cancer (2012)
  • Author(s): Ishikawa H, Tsuji H, Kamada T, Akakura K, Suzuki H, et al
  • Journal Title: Int J Urol Volume: 19 Issue: 4 Pages: 296-305
  • DOI: 10.1111/j.1442-2042.2012.02961.x
  • Peer Reviewed
• [Journal Article] A seven-year disease-free survivor of malignant pleural mesothelioma treated with hyperthermia and chemotherapy: a case report (2012)
  • Author(s): Okonogi N, Ebara T, Ishikawa H, et al
  • Journal Title: J Med Case Rep Volume: 28 Pages: 427-427
  • Peer Reviewed
• [Journal Article] Risk factors for rectal bleeding associated with I-125 brachytherapy for prostate cancer (2012)
  • Author(s): Harada K, Ishikawa H, Saito Y, et al
  • Journal Title: J Radiat Res Volume: 1 Issue: 6 Pages: 923-9
  • DOI: 10.1093/jrr/rrs059
  • Peer Reviewed
• [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model (2011)
  • Author(s): Kumada H, Saito K, Nakamura T, Sakae T, Sakurai H, Matsumura A, Ono K.
  • Journal Title: Appl Radiat Isot Volume: 69 Issue: 12 Pages: 1866-1869
  • DOI: 10.1016/j.apradiso.2011.03.023
  • NAID: 120007137344
  • Peer Reviewed
• [Presentation] Preparation and behavioral training for pediatric patients treated by ptoton therapy (2014)
  • Author(s): Mizumoto M, Ayuzawa K, Miyamoto T, Oshiro Y, Okumura T, Fukushima T, Ishikawa H, Tsuboi K, Sakurai H
  • Organizer: 46th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] The current status for linac based BNCT project in University of Tsukuba (2014)
  • Author(s): Kumada H, Matsumura A, Sakurai H, Sakae T, Takada K, Yoshioka M, Kobayashi H, Matsumoto H, Kurihara T, Nakashima H, Nakamura T, Sugano T, Ikeda N
  • Organizer: 7th Korea-Japan Meeting on Medical Physics
  • Place of Presentation: Busan, Korea
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Proton beam herapy for hepatocllular carcinoma (2014)
  • Author(s): Sakurai H, Okumura T, Fukumitsu N, Ishikawa H, Ohnishi K, Mizumoto M.
  • Organizer: The 15th Asian Oceania Congress of Radiology（AOCR2014)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2014-09-24 – 2014-09-28
  • Invited
• [Presentation] Proton beam therapy combined with concurrent chemotherapy for esophageal cancer (2014)
  • Author(s): Ishikawa H, Okumura T, Ohno T, Makishima H, Ohnishi K, Mizumoto M, Aihara T, Numajiri H, Hashimoto T, Sakurai H
  • Organizer: The 56th American Society for Therapeutic Radiology and Oncology Annual Meeting
  • Place of Presentation: San Francisco
  • Year and Date: 2014-09-14 – 2014-09-17
  • Invited
• [Presentation] A simple strategy to decrease the incidence of fatal carotid blowout syndrome after BNCT for head and neck cancers (2014)
  • Author(s): Aihara T, Morita N, Kamitani N, Kumada H, Ohnishi K, Suzuki M, Hiratsuka J, Sakurai H
  • Organizer: 16th International Congress Neutron Capture Therapy
  • Place of Presentation: Helsinki, Finland
  • Year and Date: 2014-06-14 – 2014-06-19
• [Presentation] Comparison of adverse effects of proton and X-ray CRT for esophageal cancer using an adaptive DVH analysis (2014)
  • Author(s): Makishima H, Ishibashi H, Terunuma T, Hashimoto T, Yamanashi K, Sekiguchi T, Mizumoto M, Okumura T, Sakae T, Sakurai H
  • Organizer: 53rd Annual Conference of the Particle Therapy Co-Operative Group(PTCOG53)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2014-06-08 – 2014-06-14
• [Presentation] Preliminary results using proton beam therapy with a surgical spacer (2014)
  • Author(s): Saito T, Numajiri H, Mizumoto M, Ohnishi K, Ishikawa H, Fukumitsu N, Aihara T, Okumura T, Sakurai H
  • Organizer: 53rd Annual Conference of the Particle Therapy Co-Operative Group(PTCOG53)
  • Place of Presentation: Shanghai, China
  • Year and Date: 2014-06-08 – 2014-06-14
• [Presentation] Association between life prognosis and pretreatment ICG 15 for the patients with HCC treated by proton beam therapy (2014)
  • Author(s): Mizumoto M, Oshiro Y, Okumura T, Fukumitsu N, Ishikawa H, Ohnishi K, Numajiri H, Aihara T, Tsuboi K, Sakurai H
  • Organizer: ESTRO 33
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-04-04 – 2014-04-08
• [Presentation] Overview of Proton beam therapy -present & future (2014)
  • Author(s): 櫻井英幸
  • Organizer: The 2nd International Symposium of Gunma University Program for Leading Granduate Schools
  • Place of Presentation: 前橋
  • Invited
• [Presentation] 陽子線治療の臨床と今後の動向 (2014)
  • Author(s): 櫻井英幸
  • Organizer: 第3回岡山粒子線治療研究会
  • Place of Presentation: 岡山
  • Invited
• [Presentation] 腸子線治療の立場からみた癌治療増感研究 (2013)
  • Author(s): 横井英幸, 奥村敏之, 石川仁, ほか
  • Organizer: 第15回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
  • Year and Date: 2013-02-09
• [Presentation] Verfication of the new BNCT treatment planning system in Tokyo (2013)
  • Author(s): K Yamanashi,H Kumada,K Takada,H Sakurai,T Sakae
  • Organizer: 7th Young Researchers' Boron Neutron Capture Therapy Meeting
  • Place of Presentation: Granada, Spain
• [Presentation] Proton beam therapy for a patient with large rhabdomyosarcoma of the body trunk (2013)
  • Author(s): Daichi Takizawa,Y Oshiro,T Okumura,M Mizumoto,N Fukumitsu,H Ishikawa,K Tsuboi,M Kaneko,H Sakurai
  • Organizer: 45th Congress of the International Society of Paediatric Oncology. Hong Kong
  • Place of Presentation: Hong Kong, China
• [Presentation] The basic evaluation of radiation exposure dose for whole body in clinical boron neutron capture therapy (2013)
  • Author(s): K Takada,T Isobe,H Kumada,K Yamanashi,H Sakurai,T Sakae
  • Organizer: 日本放射線技術学会第69回総会学術大会
  • Place of Presentation: 横浜
• [Presentation] Multidisciplinary therapy including proton beam therapy for Ewing's sarcoma family of tumors (2013)
  • Author(s): Ryoko Suzuki,Takashi Fukushima,Chie Kobayashi,Hiroko Fukushima,Aiko Sakai,Toshiaki Ishida,Tomoki Ohsumi,Hidemasa Ochiai,Seiji Kishimoto,Motoaki Chin,Ryosuke Hosogai,Yousuke Hosoya,Atsuko Watanabe,Chikashi Goto,Kouji Masumoto,M Mizumoto,H Sakurai,R Sumazaki
  • Organizer: 第55回日本小児血液・がん学会学術集会/第11回日本小児がん看護学会/第18回公益財団法人がんの子どもを守る会公開シンポジウム
  • Place of Presentation: 福岡
• [Presentation] Suprasellar GCT and endocrinopathy;duration of symptoms and outcome (2013)
  • Author(s): Hiroko Fukushima,Takashi Fukushima,Syo Hosaka,Aiko Sakai,Ryoko Suzuki,Chie Kobayashi,Atsushi Iwabuchi,Tomohiro Kamoda,Keisuke Kato,Kazutoshi Koike,Kai Yamazaki,Hiroyuki Fujisaki,Junichi Hara,Satoshi Ihara,Tetsuya Yamamoto,Shingo Takano,Tomohiko Masumoto,Masashi Mizumoto,Hideyuki Sakurai,Ryo Sumazaki
  • Organizer: 第55回日本小児血液・がん学会学術集会/第11回日本小児がん看護学会/第18回公益財団法人がんの子どもを守る会公開シンポジウム
  • Place of Presentation: 福岡
• [Presentation] Long-term survival in patients with hepatocellular carcinoma initially treated with definitive proton beam therapy (2013)
  • Author(s): T Okumura,K Fukuda,T Hashimoto,M Mizumoto,H Ishikawa,T Sakae,M Abei,K Tsuboi,H Sakurai
  • Organizer: 55th Anuual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: Atlanta, USA
• [Presentation] Quantitative assessment of 131-1 in soil originating from the Fukushima Daiichi Nuclear Power Plant Disaster using a germanium semiconductor detector (2013)
  • Author(s): Y Mori,T Isobe,K Takada,S Kamizawa,E Sato,H Sakurai,T Sakae
  • Organizer: The Fourth International Symposium on Innovative Nuclear Energy Systems(INES-4)
  • Place of Presentation: Tokyo
• [Presentation] Comparison of adverse effects proton and X-ray chemoradiotherapy for oesophageal cancer using an adaptive dose-volume histogram (2013)
  • Author(s): H Makishima,H Ishikawa,T Terunuma,T Hashimoto,K Yamanashi,T Sekiguchi,M Mizumoto,T Okumura,K Tsuboi,H Sakurai
  • Organizer: The European Cancer Congress 2013
  • Place of Presentation: Amsterdam, Holland
• [Presentation] Preliminary results of concurrent chemoradiation therapy using proton beam therapy for esophageal cancer (2013)
  • Author(s): H Ishikawa,T Hashimoto,M Mizumoto,H Makishima,D Takizawa,Kaori Sugawara,T Okumura,H Sakurai
  • Organizer: 55th Anuual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: Atlanta, USA
• [Presentation] Boron-neutron capture therapy for advanced maxillary sinus cancer: two case reports (2013)
  • Author(s): Teruhito Aihara,Norimasa Morita,Hiroaki Kumada,Hitoshi Ishikawa,Nobuhiko Kamitani,Nobuyoshi Fukumitsu,Yoshinori Sakurai,Junichi Hitatsuka,Hideyuki Sakurai
  • Organizer: 16th Asian Research Symposium in Rhinology
  • Place of Presentation: Tokyo
• [Presentation] Boron-neutron capture therapy for newly diagnosed head and neck cancer in initial treatment (2013)
  • Author(s): Teruhito Aihara,Norimasa Morita,Nobuhiko Kamitani,H Kumada,N Fukumitsu,Yoshinori Sakurai,Kayoko Ohnishi,Junichi Hiratsuka,Hideyuki Sakurai
  • Organizer: 7th Young Researchers BNCT Meeting
  • Place of Presentation: Guranada, Spain
• [Presentation] スペーサー手術後の放射線治療の初期経験 (2013)
  • Author(s): 櫻井英幸
  • Organizer: 第2回スペーサー治療研究会
  • Place of Presentation: 京都
  • Invited
• [Presentation] 子宮頸癌：画像誘導ブラキセラピーの動向 (2013)
  • Author(s): 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 当院における前立腺癌高リスク群に対する３DCRTの治療成績 (2013)
  • Author(s): 牧島弘和,林靖孝,新田和範,清水誠,青木誠,相澤健太郎,海老根聖子,奥村敏之,櫻井英幸,玉木義雄
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 転移性肺腫瘍に対する陽子線治療成績 (2013)
  • Author(s): 大西かよ子,奥村敏之,石川仁,水本斉志,沼尻晴子,福光延吉,粟飯原輝人,坪井康次,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 頸部のデスモイド腫瘍に対して陽子線治療を施行した一例 (2013)
  • Author(s): 田中圭一,奥村敏之,水本斉志,大西かよ子,石川仁,粟飯原輝人,沼尻晴子,福光延吉,坪井康次,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 局所進行非小細胞肺癌に対する化学療法併用陽子線治療の安全性、有効性試験の初期報告 (2013)
  • Author(s): 大城佳子,奥村敏之,水本斉志,栗島浩一,石川仁,大川綾子,沼尻晴子,金本彩恵,大野豊然貴,牧島弘和,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 陽子線治療と中性子捕捉療法の過去、現在、未来 －難治癌克服に向けて－ (2013)
  • Author(s): 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 食道扁平上皮癌に対する同時化学療法併用陽子線治療成績 (2013)
  • Author(s): 石川仁,大野豊然貴,橋本孝之,水本斉志,大西かよ子,粟飯原輝人,沼尻晴子,福光延吉,奥村敏之,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 小児頭蓋内上衣腫に対する陽子線治療 (2013)
  • Author(s): 水本斉志,瀧澤大地,大城佳子,沼尻晴子,大西かよ子,福光延吉,石川仁,奥村敏之,坪井康次,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 婦人科領域癌の骨盤内再発腫瘍に対する組織内照射 (2013)
  • Author(s): 沼尻晴子,大川綾子,瀧澤大地,牧島弘和,大野豊然貴,水本斉志,大西かよ子,石川仁,奥村敏之,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] シスプラチンを併用した外部照射と組織内照射をおこなった女性尿道癌の１例 (2013)
  • Author(s): 加沼玲子,石川仁,沼尻晴子,大川綾子,大野豊然貴,斎藤高,奥村敏之,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 前立腺がん陽子線治療におけるリスク臓器線量低下を目的としたビーム方向の検討 (2013)
  • Author(s): 瀬川達矢,神澤聡,布施拓,照沼利之,榮武二,石川仁,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 小児固形がんに対する陽子線治療 (2013)
  • Author(s): 大城佳子,水本斉志,石川仁,奥村敏之,坪井康次,榮武二,福島敬,須磨埼亮,増本幸二,金子道夫,櫻井英幸
  • Organizer: 第54回日本小児血液・がん学会学術集会
  • Place of Presentation: 横浜
• [Presentation] 陽子線治療を施行した前立腺基底細胞癌の１例 (2013)
  • Author(s): 中村智則,石川仁,瀧澤大地,沼尻晴子,水本斉志,大西かよ子,粟飯原輝人,福光延吉,坪井康次,奥村敏之,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 進行頭頸部癌に対する初期治療としての硼素中性子捕捉療法の有効性と問題点 (2013)
  • Author(s): 粟飯原輝人,森田倫正,神谷伸彦,櫻井良憲,熊田博明,石川仁,福光延吉,奥村敏之,鈴木実,平塚純一,櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
• [Presentation] 筑波大学の陽子線治療の現状と目指すべきもの (2013)
  • Author(s): 櫻井英幸,石川仁,奥村敏之
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] 食道扁平上皮癌に対する同時化学療法併用陽子線治療成績 (2013)
  • Author(s): 石川仁,橋本孝之,奥村敏之,大野豊然貴,森脇俊和,久倉勝治,寺島秀夫,櫻井英幸
  • Organizer: 第67回日本食道学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 有限要素法を用いたシミュレーションによるＲＦ誘導加温の3次元温度分布取得の可能性 (2013)
  • Author(s): 小林大輔,高田健太,磯辺智範,鈴木慶史,高橋英希,森祐太郎,志田晃一,関正志,横田浩,櫻井英幸,榮武二
  • Organizer: 日本ハイパーサーミア学会第30回大会
  • Place of Presentation: 横浜
• [Presentation] 筑波大学のＢＮＣＴ臨床研究再開計画について (2013)
  • Author(s): 粟飯原輝人,山本哲哉,熊田博明,中井啓,石川仁,福光延吉,奥村敏之,大西かよ子,水本斉志,沼尻晴子,大野豊然貴,瀧澤大地,菅原香織,松村明,櫻井英幸
  • Organizer: 第10回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 岡山
• [Presentation] 頭頸部進行がんに対する初期治療としての硼素中性子捕捉療法 (2013)
  • Author(s): 粟飯原輝人,森田倫正,神谷伸彦,熊田博明,福光延吉,櫻井良憲,鈴木実,平塚純一,櫻井英幸
  • Organizer: 第51回日本癌治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] 頭頸部進行癌における初期治療としての硼素中性子捕捉療法 (2013)
  • Author(s): 粟飯原輝人,森田倫正,神谷伸彦,熊田博明,福光延吉,鈴木実,櫻井良憲,小野公二,櫻井英幸,平塚純一
  • Organizer: 第10回日本中性子捕捉療法学会学術大会
  • Place of Presentation: 岡山
• [Presentation] Proton beam therapy for cancer treatment at University of Tsukuba-present & future (2012)
  • Author(s): Sakurai H
  • Organizer: The 2nd Symposium of Gunma University Leading PhD Program/Gunma University Global Leader Training Program for Heavy Ion Medicine and Engineering
  • Place of Presentation: Maebashi, Gunma(招待講演)
  • Year and Date: 2012-12-07
• [Presentation] 小児固形がんに対する陽子線治療 (2012)
  • Author(s): 襖井英幸, 水本斉志, 大城佳子, ほか
  • Organizer: 第54回日本小児血液-がん学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] 加速器中性子源によるBNCTの実現 (2012)
  • Author(s): 熊田博明, 松村明, 横井英幸, ほか
  • Organizer: 第104回日本医学物理学会学術大会
  • Place of Presentation: つくば(招待講演)
  • Year and Date: 2012-09-15
• [Presentation] Project of development of the linac based NCT facility in University of Tsukuba (2012)
  • Author(s): Kumada H, Matsumura A, Sakurai H, et al
  • Organizer: 5th International Congress on Neutron Capture Therapy
  • Place of Presentation: Tsukuba Japan(招待講演)
  • Year and Date: 2012-09-15
• [Presentation] Cell inactivation ability and mechanish of clinical high-energy proton beams (2012)
  • Author(s): Tsuboi K, Sakae T, Sakurai H
  • Organizer: The 31st Sapporo International Cancer Symposium 2012
  • Place of Presentation: Sapporo, Japan(招待講演)
  • Year and Date: 2012-07-23
• [Presentation] Evaluation of the radiation dose for whole body in boron neutron capture therapy (2012)
  • Author(s): Takada K, Isobe l; Kumada H, et al
  • Organizer: 12th International Conference Oil Radiation Shielding & 17th Topical Meeting of the Radiation Protection and Shielding Division of ANS
  • Place of Presentation: Nara, Japan
• [Presentation] Reirradiation for recurrent malignant brain tumor with X-ray radiotherapy or proton beam therapy (2012)
  • Author(s): Tsuboi K, Mizumoto M, Okumura T, et al
  • Organizer: ESTRO31
  • Place of Presentation: Barcelona, Spain
• [Presentation] Association between life prognosis and pre treatment liver function of proton beam therapy for the patients with HCC (2012)
  • Author(s): Mizumoto M, Okumura T, Hashimoto T, et al
  • Organizer: ESTR031
  • Place of Presentation: Barcelona, Spain
• [Presentation] Preliminary clinical results of proton beam therapy for advanced neuroblastoma (2012)
  • Author(s): Oshiro y; Mizumoto M, Fukushima T, et al
  • Organizer: ESTR031
  • Place of Presentation: Barcelona, Spain
• [Presentation] Dose-volume histogram comparison of the lung between proton and X-ray therapy for lung cancer (2012)
  • Author(s): Ohno T, Mizumoto M, Oshiro Y, et al
  • Organizer: PTC0G51
  • Place of Presentation: Seoul Korea
• [Presentation] Development of a new linac based neutron capture therapy device in University of Tsukuba (2012)
  • Author(s): Kumada H, Matsumura A, et al
  • Organizer: PTC0G51
  • Place of Presentation: Seoul Korea
• [Remarks] 筑波大学附属病院 放射線腫瘍科
• [Remarks] 筑波大学附属病院にて 陽子線治療をお考えの方へ