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Translational and clinical studies for sophistication of heavy ion therapy for cancer

Research Project

Project/Area Number 24390288
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionGunma University

Principal Investigator

Nakano Takashi  群馬大学, 医学(系)研究科(研究院), 教授 (20211427)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yoshiyuki  群馬大学, 大学院医学系研究科, 教授 (60334116)
OHNO Tatsuya  群馬大学, 重粒子線医学推進機構, 教授 (10344061)
NODA Shin-ei  群馬大学, 医学部, 講師 (60396645)
KATOH Hiroyuki  群馬大学, 重粒子線医学推進機構, 助教 (30334121)
SAITO Junichi  群馬大学, 大学院医学系研究科, 准教授 (70572816)
TAMAKI Tomoaki  福島医科大学, 大学院医学系研究科, 准教授 (20400749)
SHIRAI Katsuyuki  群馬大学, 大学院医学系研究科, 講師 (10400748)
YOSHIDA Yukari  群馬大学, 重粒子線医学推進機構, 助教 (90431717)
清原 浩樹  群馬大学, 医学部附属病院, 助教 (10344920)
尾池 貴洋  群馬大学, 医学部附属病院, 助教 (10643471)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords重粒子線 / 放射線治療 / 放射線生物学 / 粒子線治療 / 放射線腫瘍学 / 放射線生物 / 重粒子線治療 / 治療計画 / 放射線免疫学
Outline of Final Research Achievements

This study promoted translational research for innovative heavy ion therapy to elucidate characteristic biological effects of carbon ions and preferable cancers for carbon therapy and also to develop optimal methods of the treatment. Results of the research were strong biological effect of heavy ions being related to NHEJ gene repair mechanism, carbon beam therapy for locally advanced lung cancer enhance local control with combination with anti-cancer drugs, carbons increase the cell migration ability of A549 lung cancer cells through the Rho signaling pathway, antigen-specific anti-tumor immunity being activated in cancer patients with radiation therapy, intravenous administration of dendritic cells augment anti-tumor immune with combination of carbon therapy to suppress the lung metastasis, greater enhanced effect of carbon therapy being expected for EGFR mutation-negative lung cancers, the combination of radiation and mTOR inhibitors sensitizing radiation effect under hypoxia.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (89 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (64 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 23 results,  Open Access: 12 results,  Acknowledgement Compliant: 5 results) Presentation (24 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Concurrent chemoradiotherapy for T3–4 and N0–1 nasopharyngeal cancer: Asian multicenter trial of the Forum for Nuclear Cooperation in Asia2016

    • Author(s)
      Tatsuya Ohno, Masaru Wakatsuki, Dang Huy Quoc Thinh, Ngo Thanh Tung, Dyah Erawati, Nana Supriana, C.R. Beena Devi, Shingo Kato, Kullathorn Thephamongkhol, Yaowalak Chansilpa, Miriam Joy C. Calaguas, Xu Xiaoting, Cao Jianping, Parvin Akhter Banu, Chul-Koo Cho, Kumiko Karasawa, Takashi Nakano and Hirohiko Tsujii
    • Journal Title

      J Radiat Res

      Volume: 57 Issue: 1 Pages: 44-49

    • DOI

      10.1093/jrr/rrv046

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Incidence, risk factors, and dose-volume relationship of radiation-induced rib fracture after carbon ion radiotherapy for lung cancer2016

    • Author(s)
      Abe T, Shirai K, Saitoh J, Ebara T, Shimada H, Tashiro M, Okano N, Ohno T, Nakano T
    • Journal Title

      Acta Oncol.

      Volume: 55 Issue: 2 Pages: 163-166

    • DOI

      10.3109/0284186x.2015.1088169

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy2016

    • Author(s)
      Takahiro Oike, Atsuko Niimi, Noriyuki Okonogi, Kazutoshi Murata, Akihiko Matsumura, Shin-Ei Noda, Daijiro Kobayashi, Mototaro Iwanaga, Keisuke Tsuchida, Tatsuaki Kanai, Tatsuya Ohno, Atsushi Shibata, Takashi Nakano
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 22275-22275

    • DOI

      10.1038/srep22275

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Difference in distant failure site between locally advanced squamous cell carcinoma and adenocarcinoma of the uterine cervix after C-ion RT.2015

    • Author(s)
      Masaru Wakatsuki, Shingo Kato, Tatsuya Ohno, Hiroki Kiyohara, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Daisuke Irie, Shintaro Shiba, Hirohiko Tsujii, Takashi Nakano, Tadashi Kamada, Makio Shozu
    • Journal Title

      Journal of radiation research

      Volume: 56 Issue: 3 Pages: 523-528

    • DOI

      10.1093/jrr/rru117

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation.2015

    • Author(s)
      Yoshimoto Y, Oike T, Okonogi N, Suzuki Y, Ando K, Sato H, Noda SE, Isono M, Mimura K, Kono K, Nakano T
    • Journal Title

      J Radiat Res

      Volume: 56 Issue: 3 Pages: 509-514

    • DOI

      10.1093/jrr/rrv007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Topics in Chemotherapy, Molecular-targeted Therapy, and Immunotherapy for Newly-diagnosed Glioblastoma Multiforme.2015

    • Author(s)
      Okonogi N, Shirai K, Oike T, Murata K, Noda SE, Suzuki Y, Nakano T
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1229-1235

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460.2015

    • Author(s)
      Kubo N, Noda SE, Takahashi A, Yoshida Y, Oike T, Murata K, Musha A, Suzuki Y, Ohno T, Takahashi T, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 56 Issue: 2 Pages: 229-238

    • DOI

      10.1093/jrr/rru085

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The EGFR mutation status affects the relative biological effectiveness of carbon-ion beams in non-small cell lung carcinoma cells.2015

    • Author(s)
      Amornwichet N, Oike T, Shibata A, Nirodi CS, Ogiwara H, Makino H, Kimura Y, Hirota Y, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T.
    • Journal Title

      Sci Rep.

      Volume: 11 Issue: 1 Pages: 11305-11305

    • DOI

      10.1038/srep11305

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polymyositis and fatal interstitial pneumonia following pelvic irradiation that led to unexpectedly severe adverse effects: a case report.2015

    • Author(s)
      Oike Takahiro, Ohno Tatsuya, Shirai Katsuyuki, Inoue Takashi, Nakano Takashi.
    • Journal Title

      Clinical Case Reports

      Volume: 8 Issue: 8 Pages: 710-713

    • DOI

      10.1002/ccr3.322

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.2015

    • Author(s)
      Ushijima H, Suzuki Y, Oike T, Komachi M, Yoshimoto Y, Ando K, Okonogi N, Sato H, Noda SE, Saito J, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 56 Issue: 4 Pages: 663-668

    • DOI

      10.1093/jrr/rrv021

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.2015

    • Author(s)
      Isono M, Yoshida Y, Takahashi A, Oike T, Shibata A, Kubota Y, Kanai T, Ohno T, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 56 Issue: 5 Pages: 856-861

    • DOI

      10.1093/jrr/rrv033

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Filling the gap in central shielding: three-dimensional analysis of the EQD2 dose in radiotherapy for cervical cancer with the central shielding technique.2015

    • Author(s)
      Tamaki T, Ohno T, Noda SE, Kato S, Nakano T.
    • Journal Title

      J Radiat Res.

      Volume: 56 Issue: 5 Pages: 804-10

    • DOI

      10.1093/jrr/rrv029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an automatic evaluation method for patient positioning error2015

    • Author(s)
      Kubota Y, Tashiro M, Shinohara A, Abe S, Souda S, Okada R, Ishii T, Kanai T, Ohno T, Nakano T
    • Journal Title

      J Appl Clin Med Phys

      Volume: 16 Issue: 4 Pages: 100-111

    • DOI

      10.1120/jacmp.v16i4.5400

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Trial of Prophylactic Extended-Field Carbon-Ion Radiotherapy for Locally Advanced Uterine Cervical Cancer (Protocol 0508)2015

    • Author(s)
      Masaru Wakatsuki, Shingo Kato, Hiroki Kiyohara, Tatsuya Ohno, Kumiko Karasawa, Tomoaki Tamaki, Ken Ando, Hirohiko Tsujii, Takashi Nakano, Tadashi Kamada, Makio Shozu,
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0127587-e0127587

    • DOI

      10.1371/journal.pone.0127587

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Clinical outcomes of helical tomotherapy for super-elderly patients with localized and locally advanced prostate cancer: comparison with patients under 80 years of age2015

    • Author(s)
      Noriyuki Okonogi, Hiroyuki Katoh, Hidemasa Kawamura, Tomoaki Tamaki, Takuya Kaminuma, Kazutoshi Murata, Yu Ohkubo, Yosuke Takakusagi, Masahiro Onishi, Tetsuo Sekihara, Atsushi Okazaki and Takashi Nakano
    • Journal Title

      J Radiat Res

      Volume: 56 Issue: 6 Pages: 889-896

    • DOI

      10.1093/jrr/rrv040

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: a multi-institutional retrospective research study2015

    • Author(s)
      ArigaT., Numasaki H., Teshima T., et al.
    • Journal Title

      Journal of Radiation Research

      Volume: 56(5) Issue: 5 Pages: 841-848

    • DOI

      10.1093/jrr/rrv036

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair2015

    • Author(s)
      Nakako Izumi Nakajima, Yoshihiko Hagiwara, Takahiro Oike, Ryuichi Okayasu, Takeshi Murakami, Takashi Nakano, and Atsushi Shibata
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 3 Pages: e0122582-e0122582

    • DOI

      10.1371/journal.pone.0122582

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] "Dosimetric comparison of carbon ion radiotherapy and stereotactic body radiotherapy with photon beams for the treatment of hepatocellular carcinoma"2015

    • Author(s)
      Takanori Abe, Jun-ichi Saitoh, Daijiro Kobayashi, Kei Shibuya, Yoshinori Koyama, Hirohumi Shimada, Katsuyuki Shirai, Tatsuya Ohno and Takashi Nakano
    • Journal Title

      Radiat Oncol

      Volume: 10 Issue: 1 Pages: 187-187

    • DOI

      10.1186/s13014-015-0491-8

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Carbon-ion Radiotherapy for Prostate Cancer: Analysis of Morbidities and Change in Health-related Quality of Life2015

    • Author(s)
      Ishikawa H, Katoh H, Kaminuma T, Kawamura H, Ito K, Matsui H, Hirato J, Shimizu N, Takezawa Y, Tsuji H, Suzuki K, Ohno T, Nakano T
    • Journal Title

      Anticancer Res

      Volume: 35 Pages: 5559-5566

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Prediction of acute radiation mucositis using an oral mucosal dose surface model in carbon ion radiotherapy for head and neck tumors.2015

    • Author(s)
      Musha A, Shimada H, Shirai K, Saitoh J, Yokoo S, Chikamatsu K, Ohno T, Nakano T.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 10 Pages: e0141734-e0141734

    • DOI

      10.1371/journal.pone.0141734

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leptomeningeal metastasis of uterine cervical cancer 17 years after primary tumor treatment.2015

    • Author(s)
      Oike T, Ohno T, Noda SE, Murata T, Hirakawa T, Hirato J, Furuya M, Sato H, Hirota Y, Minegishi T, Nakano T.
    • Journal Title

      Clin Case Rep

      Volume: 18 Issue: 1 Pages: 54-61

    • DOI

      10.1002/ccr3.445

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.2015

    • Author(s)
      Ma H, Takahashi A, Yoshida Y, Adachi A, Kanai T, Ohno T, Nakano T.
    • Journal Title

      Radiat Oncol

      Volume: 10 Issue: 1 Pages: 225-225

    • DOI

      10.1186/s13014-015-0536-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775.2015

    • Author(s)
      Ma H, Takahashi A, Sejimo Y, Adachi A, Kubo N, Isono M, Yoshida Y, Kanai T, Ohno T, Nakano T.
    • Journal Title

      Radiat Res

      Volume: 184 Issue: 6 Pages: 660-669

    • DOI

      10.1667/rr14171.1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of an empirical monitor output estimation in carbon ion radiotherapy2015

    • Author(s)
      Akihiko Matsumura, Ken Yusa, Tatsuaki Kanai, Manabu Mizota, Tatsuya Ohno, and Takashi Nakano
    • Journal Title

      Med Phys

      Volume: 42 Pages: 5188-5194

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Evaluation of therapeutic gain for fractionated carbon-ion radiotherapy using the tumor growth delay and crypt survival assays2015

    • Author(s)
      Yoshida Y, Ando K, Ando K, Murata K, Yoshimoto Y, Musha A, Kubo N, Kawamura H, Koike S, Uzawa A, Takahashi T, Ohno T, Nakano T
    • Journal Title

      Radiother Oncol

      Volume: 117 Pages: 351-357

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Monitoring bone and soft-tissue tumors after carbon-ion radiotherapy using (18)F-FDG positron emission tomography: a retrospective cohort study2015

    • Author(s)
      Yanagawa T, Saito K, Kiyohara H, Ohno T, Nakano T, Takagishi K
    • Journal Title

      Radiat Oncol

      Volume: 10 Issue: 1 Pages: 259-259

    • DOI

      10.1186/s13014-015-0571-9

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.2015

    • Author(s)
      Nakajima I, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, Shibata A.
    • Journal Title

      Plos One

      Volume: 10

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Topics in Chemotherapy, Molecular-targeted Therapy, and Immunotherapy for Newly Diagnosed Glioblastoma Multiforme.2015

    • Author(s)
      Okonogi N, Shirai K, Oike T, Murata K, Noda S, Suzuki Y, NakanoT.
    • Journal Title

      Anticancer Res.

      Volume: 35 Pages: 1229-1235

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastrophe.2014

    • Author(s)
      Amornwichet N, Oike T, Shibata A, Ogiwara H, Tsuchiya N, Yamauchi M, Saitoh Y, Sekine R, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T.
    • Journal Title

      Plos One

      Volume: 9

    • NAID

      120006986291

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Can combined intracavitary/interstitial approach be an alternative to interstitial brachytherapy with the Martinez Universal Perineal Interstitial Template (MUPIT) in computed tomography-guided adaptive brachytherapy for bulky and/or irregularly shaped gynecological tumors?2014

    • Author(s)
      Oike T, Ohno T, Noda SE, Kiyohara H, Ando K, Shibuya K, Tamaki T, Takakusagi Y, Sato H, Nakano T.
    • Journal Title

      Radiation Oncology

      Volume: 9 Pages: 9-222

    • Related Report
      2014 Annual Research Report
  • [Journal Article] HLA class I expression and its alteration by preoperative hyperthermo-chemoradiotherapy in patients with rectal cancer.2014

    • Author(s)
      Sato H, Suzuki Y, Ide M, Katoh T, Noda SE, Ando K, Oike T, Yoshimoto Y, Okonogi N, Mimura K, Asao T, Kuwano H, Nakano T.
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small cell lung cancer cell line H460.2014

    • Author(s)
      Kubo N, Noda SE, Takahashi A, Yoshida Y, Oike T, Murata K, Musha A, Suzuki Y, Ohno T, Takahashi T, Nakano T.
    • Journal Title

      Journal of Radiation Research

      Volume: 56 Pages: 229-238

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by CTLA-4 blockade in a mouse model.2014

    • Author(s)
      Yoshimoto Y, Suzuki Y, Mimura K, Ando K, Oike T, Sato H, Okonogi N, Maruyama T, Izawa S, Noda SE, Fujii H, Kono K, Nakano T.
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Proposal for a synthetic lethality therapy using the paralog dependence of cancer cells--response.2014

    • Author(s)
      Oike T, Ogiwara H, Nakano T, Kohno T.
    • Journal Title

      Cancer Research

      Volume: 74 Pages: 4948-4949

    • Related Report
      2014 Annual Research Report
  • [Journal Article] C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe.2014

    • Author(s)
      Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N, Nakano T, Kohno T.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 111 Pages: 222-227

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Current Advances in Radiotherapy for Newly Diagnosed Glioblastoma Multiforme.2014

    • Author(s)
      Okonogi N, Oike T, Shirai K, Tamaki T, Noda SE, Suzuki Y, Nakano T.
    • Journal Title

      Journal of Neurology and Neurophysiology

      Volume: 5 Pages: 186-186

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Increase in cell motility by carbon ion irradiation via the Rho signaling pathway and its inhibition by the ROCK inhibitor Y-27632 in lung adenocarcinoma A549 cells.2014

    • Author(s)
      Murata K, Noda SE, Oike T, Takahashi A, Yoshida Y, Suzuki Y, Ohno T, Funayama T, Kobayashi Y, Takahashi T, Nakano T.
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Pages: 658-664

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Chromatin-regulating proteins as targets for cancer therapy.2014

    • Author(s)
      Oike T, Ogiwara H, Amornwichet N, Nakano T, Kohno T.
    • Journal Title

      Journal of Radiation Research

      Volume: 55 Pages: 613-628

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Current Advances in Radiotherapy for Newly Diagnosed Glioblastoma Multiforme.2014

    • Author(s)
      Okonogi N, Oike T, Shirai K, Tamaki T, Noda S, Suzuki Y, NakanoT.
    • Journal Title

      J Neurol Neurophysiol.

      Volume: 5 Pages: 4-4

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue.2014

    • Author(s)
      Okonogi N, Nakamura K, Suzuki Y, Suto N, Suzue K, Kaminuma T, Nakano T, Hirai H.
    • Journal Title

      J Radiat Res.

      Volume: 55 Pages: 713-719

    • Related Report
      2014 Annual Research Report
  • [Journal Article] HLA class I expression and its alteration by preoperative hyperthermo-chemoradiotherapy in patients with rectal cancer.2014

    • Author(s)
      Sato H, Suzuki Y, Ide M, Katoh T, Noda SE, Ando K, Oike T, Yoshimoto Y, Okonogi N, Mimura K, Asao T, Kuwano H, Nakano T.
    • Journal Title

      PLoS One.

      Volume: 9

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by CTLA-4 blockade in a mouse model.2014

    • Author(s)
      Yoshimoto Y, Suzuki Y, Mimura K, Ando K, Oike T, Sato H, Okonogi N, Maruyama T, Izawa S, Noda SE, Fujii H, Kono K, Nakano T.
    • Journal Title

      PLoS One.

      Volume: 9

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Prognosis was not deteriorated by multiple primary cancers in esophageal cancer patients treated by radiotherapy.2013

    • Author(s)
      Shirai K, Tamaki Y, Kitamoto Y, Murata K, Satoh Y, Higuchi K, Ishikawa H, Nonaka T, Takahashi T, Nakano T.
    • Journal Title

      J Radiat Res,

      Volume: 54 Pages: 706-711

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Three-fraction CyberKnife radiotherapy for brain metastases in critical areas: referring to the risk evaluating radiation necrosis and the surrounding brain volumes circumscribed with a single dose equivalence of 14 Gy (V14).2013

    • Author(s)
      Inoue HK, Seto K, Nozaki A, Torikai K, Suzuki Y, Saitoh J, Noda SE, Nakano T.
    • Journal Title

      J Radiat Res,

      Volume: 54 Pages: 727-735

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Usefulness of double dose contrast-enhanced magnetic resonance imaging for clear delineation of gross tumor volume in stereotactic radiotherapy treatment planning of metastatic brain tumors: a dose comparison study.2013

    • Author(s)
      Subedi KS, Takahashi T, Yamano T, Saitoh J, Nishimura K, Suzuki Y, Ohno T, Nakano T.
    • Journal Title

      J Radiat Res,

      Volume: 54 Pages: 135-139

    • Related Report
      2013 Annual Research Report
  • [Journal Article] X irradiation changes dendritic spine morphology and density through reduction of cytoskeletal proteins in mature neurons.2013

    • Author(s)
      Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-jahdari WS, Chakravarti A, Shirao T, Nakano T.
    • Journal Title

      Radiat Res,

      Volume: 179 Pages: 630-636

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Carbon-ion radiotherapy for marginal lymph node recurrences of cervical cancer after definitive radiotherapy: a case report.2013

    • Author(s)
      Tamaki T, Ohno T, Kiyohara H, Noda SE, Ohkubo Y, Ando K, Wakatsuki M, Kato S, Kamada T, Nakano T.
    • Journal Title

      Radiat Oncol,

      Volume: 8 Pages: 79-79

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Comparison of hematological toxicities between innovator and generic cisplatin formulations in cervical cancer patients treated with concurrent chemoradiotherapy.2013

    • Author(s)
      Oike T, Ohno T, Noda SE, Sato H, Tamaki T, Kiyohara H, Ando K, Nakano T.
    • Journal Title

      J Radiat Res

      Volume: 54 Pages: 474-478

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Inactivating mutations in SWI/SNF chromatin remodeling genes in human cancer.2013

    • Author(s)
      Oike T, Ogiwara H, Nakano T, Yokota J, Kohno T.
    • Journal Title

      Jpn J Clin Oncol,

      Volume: 43 Pages: 849-855

    • Related Report
      2013 Annual Research Report
  • [Journal Article] A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.2013

    • Author(s)
      Oike T, Ogiwara H, Tominaga Y, Ito K, Ando O, Tsuta K, Mizukami T, Shimada Y, Isomura H, Komachi M, Furuta K, Watanabe S, Nakano T, Yokota J, Kohno T.
    • Journal Title

      Cancer Res,

      Volume: 73 Pages: 5508-5518

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for N2-3 nasopharyngeal cancer: a multicenter trial of the Forum for Nuclear Cooperation in Asia.2013

    • Author(s)
      Ohno T, Thinh DH, Kato S, Devi CR, Tung NT, Thephamongkhol K, Calaguas MJ, Zhou J, Chansilpa Y, Supriana N, Erawati D, Banu PA, Koo CC, Kobayashi K, Nakano T, Tsujii H.
    • Journal Title

      J Radiat Res,

      Volume: 54 Pages: 467-473

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Radiotherapy plus concomitant adjuvant temozolomide for glioblastoma: Japanese mono-institutional results.2013

    • Author(s)
      Oike T, Suzuki Y, Sugawara K, Shirai K, Noda SE, Tamaki T, Nagaishi M, Yokoo H, Nakazato Y, Nakano T.
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Interfractional change of high-risk CTV D90 during image-guided brachytherapy for uterine cervical cancer.2013

    • Author(s)
      Ohkubo Y, Ohno T, Noda SE, Kubo N, Nakagawa A, Kawahara M, Abe T, Kiyohara H, Wakatsuki M, Nakano T.
    • Journal Title

      J Radiat Res,

      Volume: 54 Pages: 1138-1145

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Long-term follow-up results of a multi-institutional phase 2 study of concurrent chemoradiation therapy for locally advanced cervical cancer in east and southeast Asia.2013

    • Author(s)
      Kato S, Ohno T, Thephamongkhol K, Chansilpa Y, Cao J, Xu X, Devi CR, Swee TT, Calaguas MJ, de Los Reyes RH, Cho CK, Dung TA, Supriana N, Erawati D, Mizuno H, Nakano T, Tsujii H.
    • Journal Title

      Int J Radiat Oncol Biol Phys,

      Volume: 87 Pages: 100-105

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Three-dimensional and multienergy gamma-ray simultaneous imaging by using a Si/CdTe Compton camera.2013

    • Author(s)
      Suzuki Y, Yamaguchi M, Odaka H, Shimada H, Yoshida Y, Torikai K, Satoh T, Arakawa K, Kawachi N, Watanabe S, Takeda S, Ishikawa SN, Aono H, Watanabe S, Takahashi T, Nakano T.
    • Journal Title

      Radiology

      Volume: 267 Pages: 941-947

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Granulocyte-colony stimulating factor-producing cervical cancers treated with carbon-ion irradiation.2013

    • Author(s)
      Ohkubo Y, Kato S, Kiyohara H, Suzuki Y, Nakano T, Kamada T.
    • Journal Title

      J Obstet Gynaecol Res,

      Volume: 39 Pages: 1111-1115

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Changes in bone mineral density in uterine cervical cancer patients after radiation therapy.2013

    • Author(s)
      Okonogi N, Saitoh J, Suzuki Y, Noda SE, Ohno T, Oike T, Ohkubo Y, Ando K, Sato H, Nakano T.
    • Journal Title

      Int J Radiat Oncol Biol Phys,

      Volume: 87 Pages: 968-974

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Sunaga N. Phase II study of oral S-1 and cisplatin with concurrent radiotherapy for locally advanced non-small-cell lung cancer.2013

    • Author(s)
      Kaira K, Tomizawa Y, Yoshino R, Yoshii A, Matsuura M, Iwasaki Y, Koga Y, Ono A, Nishioka M, Kamide Y, Hisada T, Ishizuka T, Shirai K, Ebara T, Saitoh J, Nakano T,
    • Journal Title

      Lung Cancer,

      Volume: 82 Pages: 449-454

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Technical approach to individualized respiratory-gated carbon-ion therapy for mobile organs.2013

    • Author(s)
      Tashiro M, Ishii T, Koya J, Okada R, Kurosawa Y, Arai K, Abe S, Ohashi Y, Shimada H, Yusa K, Kanai T, Yamada S, Kawamura H, Ebara T, Ohno T, Nakano T.
    • Journal Title

      Radiol Phys Technol,

      Volume: 6 Pages: 356-366

    • Related Report
      2013 Annual Research Report
  • [Journal Article] KIF5B-RET fusions in lung adenocarcinoma2012

    • Author(s)
      Takashi Kohno
    • Journal Title

      Nature Medicine

      Volume: 18 Issue: 3 Pages: 375-7

    • DOI

      10.1038/nm.2644

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiangiogenic therapy for patients with recurrent and newly diagnosed malignant gliomas.2012

    • Author(s)
      Shirai K
    • Journal Title

      J Oncol.

      Volume: 2012 Pages: 193436-193436

    • DOI

      10.1155/2012/193436

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunogenic tumor cell death induced by chemoradiotherapy in patients with esophageal squamous cell carcinoma2012

    • Author(s)
      Yoshiyuki Suzuki
    • Journal Title

      Cancer Research

      Volume: 72 Issue: 16 Pages: 3967-3976

    • DOI

      10.1158/0008-5472.can-12-0851

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of efficacy and safety of low-dose-rate vs. high-dose-rate intraluminal brachytherapy boost in patients with superficial esophageal cancer.2012

    • Author(s)
      Tamaki T, Ishikawa H, Takahashi T, et al
    • Journal Title

      Brachytherapy

      Volume: 11 Issue: 2 Pages: 130-6

    • DOI

      10.1016/j.brachy.2011.05.008

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Relative Biological Effectiveness of Carbon Ion Beams in the Cerebellum Using the Rat Organotypic Slice Culture System2012

    • Author(s)
      Yoshida Y
    • Journal Title

      Journal of Radiation Research

      Volume: 53 Issue: 1 Pages: 87-92

    • DOI

      10.1269/jrr.11139A

    • NAID

      10030023646

    • ISSN
      0449-3060, 1349-9157
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射線腫瘍学の温故知新と放射線腫瘍医養成そして国際展開へ2015

    • Author(s)
      中野 隆史
    • Organizer
      日本放射線腫瘍学会第28回学術大会
    • Place of Presentation
      前橋市
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 放射線治療により誘導される抗腫瘍免疫と治療効果に関する実験的検討2014

    • Author(s)
      鈴木義行,吉本由哉,三村耕作,安藤謙,尾池貴洋,丸山孝教,藤井秀樹,河野浩二,中野隆史
    • Organizer
      日本放射線腫瘍学会第27回学術大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-12-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経幹細胞および神経膠芽腫細胞における増殖率を指標としたX線および炭素線の感受性2014

    • Author(s)
      磯野真由,吉田由香里,八高知子,高橋昭久,尾池貴洋,柴田淳史,金井達明,大野達也,中野隆史
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島県民交流センター
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 群馬大学の重粒子線治療プロジェクトの現状と将来2014

    • Author(s)
      中野 隆史
    • Organizer
      日本放射線影響学会第57回大会
    • Place of Presentation
      鹿児島県民交流センター
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 重粒子線治療について2014

    • Author(s)
      中野 隆史
    • Organizer
      富山癌治療研究会
    • Place of Presentation
      富山大学
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 陽子線治療の臨床使用について2013

    • Author(s)
      中野隆史
    • Organizer
      第4回日本放射線外科学会
    • Place of Presentation
      名古屋(特別講演)
    • Year and Date
      2013-01-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 群馬大学における重粒子線マイクロサージェリィ治療技術の開発について2012

    • Author(s)
      中野隆史
    • Organizer
      第9回日本粒子線治療臨床研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] セッションA「臨床1」2012

    • Author(s)
      中野隆史
    • Organizer
      第9回日本粒子線治療臨床研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Radiotherapy(放射線治療)2012

    • Author(s)
      中野隆史
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌(English Oral Sessions)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮頸がんの放射線治療における現状と将来2012

    • Author(s)
      中野隆史
    • Organizer
      第52回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-07-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 粒子線治療のための物理学、化学、生物学2012

    • Author(s)
      中野隆史
    • Organizer
      第41回放射線による制癌シンポジウム
    • Place of Presentation
      沖縄(シンポジウムII)
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 研究II2012

    • Author(s)
      中野隆史
    • Organizer
      第66回日本食道学会学術集会
    • Place of Presentation
      長野(一般口演)
    • Year and Date
      2012-06-22
    • Related Report
      2012 Annual Research Report
  • [Presentation] 放射線感受性におよぼすDNA二本鎖切断修復のLET依存的な効果

    • Author(s)
      高橋昭久, 吉田由香里, 古澤佳也, 大野達也, 中野隆史.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 非小細胞肺癌に対する炭素線照射とカルボプラチン、パクリタキセル併用の基礎的検討.

    • Author(s)
      久保亘輝、野田真永、高橋昭久、村田和俊、武者篤、永島潤、吉田由香里、大野達也、高橋健夫、中野隆史.
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 殺細胞効果におよぼすDNA二本鎖切断修復のLET依存性.

    • Author(s)
      高橋昭久, 久保誠, 馬洪玉, 中川彰子, 吉田由香里, 磯野真由, 古澤佳也, 小林泰彦, 舟山知夫, 金井達明, 大野達也, 中野隆史
    • Organizer
      第51回日本放射線腫瘍学会生物部会学術大会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] LET依存的な標的増感候補としてのNHEJ修復およびHR修復

    • Author(s)
      久保 誠、高橋昭久、馬 洪玉、中川彰子、吉田由香里、磯野真由、古澤佳也、小林泰彦、舟山知夫、金井達明、大野達也、中野隆史
    • Organizer
      第19回癌治療増感研究会
    • Place of Presentation
      高知市
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト肺がん細胞の炭素線治療における標的増感候補としてのNHEJ修復および細胞周期調節

    • Author(s)
      馬洪玉、高橋昭久、久保誠、中川彰子、吉田由香里、磯野真由、金井達明、大野達也、中野隆史
    • Organizer
      第19回癌治療増感研究会
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Combination effect of carbon-ion beams and DNA repair inhibitor and/or cell cycle regulation inhibitor on cell killing in lung cancer cells.

    • Author(s)
      Ma H, Takahashi A, Kubo M, Nakagawa A, Yoshida Y, Kanai T, Ohno T, Nakano T.
    • Organizer
      PTCOG52
    • Place of Presentation
      Essen, Germany,
    • Related Report
      2013 Annual Research Report
  • [Presentation] LET-dependent biological effect of DNA double-strand break repair on radiosensitivity.

    • Author(s)
      Takahashi A, Kubo M, Ma H, Nakagawa A, Yoshida Y, Kanai T, Ohno T, Funarama T, Kobayashi Y, Furusawa Y, Nakano T.
    • Organizer
      PTCOG52
    • Place of Presentation
      Essen, Germany,
    • Related Report
      2013 Annual Research Report
  • [Presentation] LET-dependent biological effect of DNA DSB repair on cell killing.

    • Author(s)
      Takahashi A, Kubo M, Ma H, Nakagawa A, Yoshida Y, Funarama T, Kobayashi Y, Furusawa Y, Nakano T.
    • Organizer
      Ion Therapy and Space Radiation Symposium 2013 (HITSRS2013)
    • Place of Presentation
      千葉県
    • Related Report
      2013 Annual Research Report
  • [Presentation] 局所進行子宮頸癌においてCT画像誘導・組織内刺入針併用腔内照射は組織内照射の代替手法となりうるか?

    • Author(s)
      尾池貴洋, 大野達也, 野田真永, 清原浩樹, 安藤謙, 渋谷圭, 田巻倫明, 高草木陽介, 佐藤浩央, 中野隆史.
    • Organizer
      日本放射線腫瘍学会第26回学術大会
    • Place of Presentation
      青森市
    • Related Report
      2013 Annual Research Report
  • [Presentation] Can combined intracavitary/interstitial approach be an alternative to interstitial brachytherapy with the MUPIT in CT-guided adaptive brachytherapy for bulky and/or irregularly shaped gynecological tumors? - A dosimetric study

    • Author(s)
      Oike T, Ohno T, Noda S-E, Kiyohara H, Ando K, Shibuya K, Tamaki T, Takakusagi Y, Sato H, Nakano T.
    • Organizer
      ASTRO’s 55th Annual Meeting.
    • Place of Presentation
      ジョージア州 米国
    • Related Report
      2013 Annual Research Report
  • [Presentation] Histon acetyltransferase p300の低分子選択的阻害剤C646はがん細胞において照射後に誘導されるmitotic catastropheを増強することで放射線増感効果を示す.

    • Author(s)
      尾池貴洋, 小町麻由美, 荻原秀明, 鳥飼幸太, 久保亘輝, 中野隆史, 河野隆志.
    • Organizer
      第42回放射線による制癌シンポジウム・第51回日本放射線腫瘍学会生物部会学術大会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Annual Research Report
  • [Presentation] C646, a selective small molecule inhibitor of p300, radiosensitizes cancer cells through enhancement of mitotic catastrophe

    • Author(s)
      Oike T, Komachi M, Ogiwara H, Nakano T, Yokota J, Kohno T.
    • Organizer
      AACR Annual Meeting.
    • Place of Presentation
      ワシントンD.C. 米国
    • Related Report
      2013 Annual Research Report
  • [Book] Frontiers in Radiation Oncology,2013

    • Author(s)
      Oike T, Ogiwara H, Nakano T, Kohno T.
    • Publisher
      Histone Acetyltransferases (HATs) Involved in Non-Homologous End Joining as a Target for Radiosensitization.
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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