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Investigation of state-of-the art functional MR imaging supporting fertility sparing and minimal-invasive operation

Research Project

Project/Area Number 24390291
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

TOGASHI Kaori  京都大学, 医学(系)研究科(研究院), 教授 (90135484)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Koji  京都大学, 医学研究科, 助教 (10580110)
KATAOKA Masako  京都大学, 医学研究科, 助教 (10611577)
KIDO Aki  京都大学, 医学研究科, 助教 (80595710)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
KeywordsMRI / 低侵襲治療 / 生殖医療 / 機能温存治療
Outline of Final Research Achievements

We visualized uterine peristalsis both sagittal and coronal images. Each direction of the image may have its merit and demerit for evaluating the peristalsis. In addition, automatic evaluation system has been promoted. Non-contrast enhanced MRA of the uterine artery could indicate the difference between pre and after menopausal state, which correspond to the previous reports by Doppler US. As for cervical cancer, treatment effect of neoajuvant chemotherapy was well correlated with the tumor size rather than ADC value obtained from DWI and quantitative values from perfusion images. Regarding the event free survival and overall survival, mean ADC value was an independent biomarker for event free survival in patients with SCC in the multivariate analysis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (30 results)

All 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 9 results,  Acknowledgement Compliant: 9 results) Presentation (10 results) (of which Invited: 3 results)

  • [Journal Article] Peritumoral enhancement in endometrial cancer on dynamic contrast-enhanced imaging: radiologic-pathologic correlation2014

    • Author(s)
      Shinya Fujii, Aki Kido, Yoshiki Mikami, Noriomi Matsumura, Ikuo Konishi, Kaori Togashi
    • Journal Title

      The Journal of Obstetrics and Gynaecology Research

      Volume: 40 Pages: 1445-1449

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 3.0T Uterine Peristalsis: Comparison of Symptomatic Fibroid Patients versus Controls2014

    • Author(s)
      Aki Kido, Susan M.Ascher, Winnie Hahn, Keiko Kishimoto, Naoko Kashitani, Reena C. Jha, Kaori Togashi, James B. Spies
    • Journal Title

      Clinical Radiology

      Volume: 69 Pages: 468-472

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-contrast-enhanced MR angiography of uterine arteries with balanced steady-state free precession and time-space labeling inversion pulse: technical optimization and preliminary results2014

    • Author(s)
      Kayo Kiguchi, Aki Kido, Koji Fujimoto, Fuki Shitano, Kyoko Takakura, Sayaka Daido, Yuki Himoto, Ayako Ninomiya, Hiroshi Kusahara, Yasutaka Fushimi, Tomohisa Okada, Kaori Togashi
    • Journal Title

      Clinical Radiology

      Volume: 69 Pages: 669-673

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Assessment of Early Predictive Power of Magnetic Resonance Imaging Parameters during Neoadjuvant Chemotherapy for Uterine Cervical Cancer2014

    • Author(s)
      Yuki Himoto, Koji Fujimoto, Aki Kido, Noriomi Matsumura, Tsukasa Baba, Sayaka Daido, Kayo Kiguchi, Fuki Shitano, Ikuo Konishi, Kaori Togashi
    • Journal Title

      International Journal of Gynecological Cancer

      Volume: 24 Pages: 751-754

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prenatal Differential Diagnosis of Complete Hydatidiform Mole with a Twin Live Fetus and Placental Mesenchymal Dysplasia by Magnetic Resonance Imaging2014

    • Author(s)
      Yuki Himoto, Aki Kido, Sachiko Minamiguchi, Yusaku Moribata, Ryosuke Okumura, Harta Mogami, Tadayoshi Nagano, Ikuo Konishi, Kaori Togashi
    • Journal Title

      The Journal of Obstetrics and Gynaecology Research

      Volume: 40 Pages: 1894-1900

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MR imaging manifestations of decidualized endometriotic cysts: comparative study with ovarian cancers associated with endometriotic cysts2014

    • Author(s)
      Nobuko Morisawa, Aki Kido, Masako Kataoka, Sachiko Minamiguchi, Ikuo Konishi, Kaori Togashi
    • Journal Title

      J Comput Assist Tomogr

      Volume: 38 Pages: 879-884

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MR Appearance of gastric-type adenocarcinoma of the uterine cervix comparison with those of usual type endocervical adenocarcinoma:A pitfall of newly described unusual subtype of endocervical adenocarcinoma2014

    • Author(s)
      Aki Kido, Yoshiki Mikami, Takashi Koyama, Masako Kataoka, Fuki Shitano, Ikuo Konishi, and Kaori Togashi
    • Journal Title

      Int J Gynecol Cancer

      Volume: 24 Pages: 1474-1479

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clear cell carcinoma arising from a uterus-like mass2014

    • Author(s)
      Nakakita B, Abiko K, Mikami Y, Kido A, Baba T, Yoshioka Y, Yamaguchi K, Matsumura N, Konishi I
    • Journal Title

      Pathol Int

      Volume: 64 Pages: 576-580

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical approaches to treating papillary squamous cell carcinoma of the uterine cervix2014

    • Author(s)
      Michikazu Nagura, Masafumi Koshiyama, Noriomi Matsumura, Aki Kido, Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Yoshiki Mikami, Ikuo Konishi
    • Journal Title

      BMC Cancer

      Volume: 27 Pages: 784-784

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Diffusion tensor imaging(DTI) of the normal human uterus in vivo at 3 tesla: comparison of DTI parameters in the different uterine layers.2013

    • Author(s)
      Fujimoto K, Kido A, Okada T, Uchikoshi M, Togashi K.
    • Journal Title

      J Magn Reson Imaging

      Volume: 38 Pages: 1494-1500

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decidualized adenomyosis during pregnancy and post delivery: three cases of magnetic resonance imaging findings.2013

    • Author(s)
      Shitano F, Kido A, Fujimoto K, Umeoka S, Himoto Y, Kiguchi K, Kondoh E,
    • Journal Title

      Abdom Imaging

      Volume: 38 Pages: 851-857

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimizing cine MRI for uterine peristalsis: A comparison of three different single shot fast spin echo techniques.2013

    • Author(s)
      Nakai A, Reinhold C, Noel P, Kido A, Rafatzand K, Ito I, Togashi K.
    • Journal Title

      J Magn Reson Imaging

      Volume: 38 Pages: 1196-1202

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel diagnostic criterion for lymph node metastasis in cervical cancer using multi-detector computed tomography.2013

    • Author(s)
      Yamanoi K, Matsumura N, Kido A, Baba T, Hamanishi J, Yamaguchi K, Yoshioka Y,
    • Journal Title

      Gynecol Oncol

      Volume: 131 Pages: 701-707

    • NAID

      120005357243

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced MRI in malignant neoplasms of the uterus.2013

    • Author(s)
      Kido A., et al
    • Journal Title

      J Magn Reson Imaging

      Volume: 37 Pages: 249-264

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decidualized adenomyosis during pregnancy and post delivery : three cases of magnetic resonance imaging findings2013

    • Author(s)
      Shitano F., et al
    • Journal Title

      Abdom Imaging

      Volume: (印刷中)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticholinergic agents result in weaker and shorter suppression of uterine contractility compared with intestinal motion : time course observation with cine MRI.2013

    • Author(s)
      Daido S., et al
    • Journal Title

      J Magn Reson Imaging

      Volume: (印刷中)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes of the normal ovary during menstrual cycle in reproductive age on the diffusion-weighted image.2012

    • Author(s)
      Morisawa N., et al
    • Journal Title

      Journal of Computer assisted Tomography

      Volume: VOL.36 Pages: 319-322

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimizing cine MRI for uterine peristalsis : A comparison of three different single shot fast spin echo techniques.2012

    • Author(s)
      Nakai A., et al
    • Journal Title

      J Magn Reson Imaging

      Volume: (印刷中)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-contrast-enhanced MR venography of the upper limb : a comparative study of acauisitions with fresh blood imaging vs. time-of-flight methods.2012

    • Author(s)
      Harigai M., et al
    • Journal Title

      Clin Imaging

      Volume: VOL.36 Pages: 496-501

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic imaging of the endometrial carcinoma.2012

    • Author(s)
      Kido A., et al
    • Journal Title

      Nihon Rinsho

      Volume: VOL.70 Pages: 377-380

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Diagnostic Imaging of Uterine sarcoma2014

    • Author(s)
      木戸晶
    • Organizer
      The 15th Asian Oceanian Congress of Radiology
    • Place of Presentation
      神戸コンベンションセンター(神戸市)
    • Year and Date
      2014-09-24 – 2014-09-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 婦人科疾患のMR診断最先端2014

    • Author(s)
      富樫 かおり
    • Organizer
      第56回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      栃木県総合文化センター(宇都宮市)
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 画像診断における統計学2014

    • Author(s)
      片岡 正子
    • Organizer
      第107回日本医学物理学会学術大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-04-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] MR imaging appearance of gastric type adenocarcinoma of cervix comparison with usual-type mucinous adenocarcinoma and squamous cell carcinoma2014

    • Author(s)
      木戸晶、小山貴、三上芳喜、片岡正子、小西郁生、富樫かおり
    • Organizer
      第73回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-04-10 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cine MR : as a new tool to evaluate uterine function2013

    • Author(s)
      Kaori Togashi
    • Organizer
      The 4th Asian Congress of Abdominal Radiology (ACAR2013)
    • Place of Presentation
      Kaohsiung Medical University(台湾)(招待講演)
    • Year and Date
      2013-03-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] がんと画像診断2012

    • Author(s)
      富樫 かおり
    • Organizer
      非感染性疾患(NCDs)シンポジウム2012
    • Place of Presentation
      京都大学芝蘭会館(京都市)(招待講演)
    • Year and Date
      2012-09-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] 婦人科画像の形態から機能へ2012

    • Author(s)
      富樫 かおり
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cervical Cancer : Role of MRI in Patient Management2012

    • Author(s)
      Kaori Togashi
    • Organizer
      The 20th International Society for Magnetic Resonance in Medicine (ISMRM2012)
    • Place of Presentation
      メルボルン会議場(オーストラリア)(招待講演)
    • Year and Date
      2012-05-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Woman in MRI-Networking & Panel Discussion

    • Author(s)
      Kaori Togashi
    • Organizer
      The 21th International Society for Magnetic Resonance in Medicine (ISMRM2013)
    • Place of Presentation
      Salt Palace Convention Center (米国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 医療における画像診断,放射線科分科会 自治体病院における放射線治療の在り方

    • Author(s)
      富樫 かおり
    • Organizer
      第52回全国自治体病院学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2012-04-24   Modified: 2019-07-29  

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