| Project/Area Number |
24390303
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
KATANO Mitsuo 九州大学, 医学(系)研究科(研究院), 教授 (10145203)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ONISHI Hideya 九州大学, 大学院医学研究院, 准教授 (30553276)
NAKANO Kenji 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061)
TANAKA Masao 九州大学, 大学院医学研究院, 教授 (30163570)
ODA Yoshinao 九州大学, 大学院医学研究院, 教授 (70291515)
NOMURA Masatoshi 九州大学, 大学病院, 講師 (30315080)
NAKAMURA Katsuya 九州大学, 大学病院, 助教 (60585743)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|
|---|
| Keywords | Hedgehogシグナル / 悪性形質誘導 / Gli1 / ＴｒｋＢ／ＢＤＮＦシグナル / CD24分子 / 低酸素環境 / 増殖能 / 浸潤能 / ネットワーク形成 / TrkB/BDNF / ＣＤ２４ / HIF-1a / Gli3 / シグナルネットワーク / 治療標的 / 肺がん / 膵がん / 乳がん / 胆嚢がん / 癌悪性化 / 大腸がん |
|---|
| Outline of Final Research Achievements |
1)Lung cancer:In Large cell neuroendocrine carcinoma(LCNEC) which is one of neuroendocrine tumors, has high potential of malignancy and there is no standard chemothrapy, TrkB/BDNF signaling is highly activated and can be a therapeutic target. 2)breast cancer:we showed that CD24 molecule regulates Shh that is a ligand of Hh signaling pathway and induces malignant phenotype in breast cancer.3)gallbladder cancer:we confirmed that Hh signaling is activated and it can be a therapeutic target.4)pancreatic cancer:Hh signaling contributes to the reoxygenation-related malignant phenotype induction.5)colon cancer:we revealed that Gli3 pathway can be a new therapeutic target for colon cancer.
|
