macro-cosmos in interaction between cancer and host microenvironments.
| Project/Area Number |
24390315
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Hirofumi 大阪大学, 医学(系)研究科(研究院), 准教授 (30322184)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masaki 大阪大学, 大学院医学系研究科, 教授 (70190999)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | hypoxia / microRNA / micrometastasis / C4.4A / invasion / disease recurrence / 微小転移 / 低酸素 / 核酸医薬 / ナノデリバリーシステム / 骨髄DTC / 腫瘍血管分化 / ナノデリバリー / 大腸癌のmicroRNA / 癌・間質転換 / 骨髄のmicroRNA |
|---|
| Outline of Final Research Achievements |
Cancer progression should be understood with respect to cancer features as well as the biological response of the patient’ body. To concur cancers we need to understand tumor behaviors from early cancers to advanced ones. In this project we successfully clarified clinical significance of very early tumor cells, role of a key molecule involved in EMT, role of a hypoxic condition surrounding tumor cells in tumor progression, and we developed a novel nucleic acid medicine against therapy-resistant cancers.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] A glucose carbonate apatite complex exhibits in vitro and in vivo anti- tumour effects.2015
Author(s)
Yamamoto H, Wu X, Nakanishi H, Yamamoto Y, Uemura M, Hata T, Nishimura J, Takemasa I, Mizushima T, Sasaki J, Imazato S, Matsuura N, Doki Y, Mori M.
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Journal Title
Sci Rep.
Volume: 5
Pages: 7742-7742
Related Report
Peer Reviewed
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[Journal Article] Innovative Delivery of siRNA to Solid Tumors by Super Carbonate Apatite.2015
Author(s)
Wu X, Yamamoto H, Nakanishi H, Yamamoto Y, Inoue A, Tei M, Hirose H, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Hossain S, Akaike T, Matsuura N, Doki Y, Mori M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer.2015
Author(s)
Hiraki M, Nishimura J, Takahashi H, Wu X, Takahashi Y, Miyo M, Nishida N, Uemura M, Hata T, Takemasa I, Mizushima T, Soh JW, Doki Y, Mori M, Yamamoto H.
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Journal Title
Mol Ther Nucleic Acids
Volume: 4
NAID
Related Report
Peer Reviewed
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[Journal Article] A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer : Research for Reprogramming of Cancer Cells by MicroRNAs.2014
Author(s)
Miyazaki S, Yamamoto H, Miyoshi N, Wu X, Ogawa H, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Konno M, Doki Y, Mori M, Ishii H.
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Journal Title
A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer : Research for Reprogramming of Cancer Cells by MicroRNAs.
Volume: Nov 11. [Epub ahead of print]
Related Report
Peer Reviewed
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[Journal Article] MicroRNA-29b is a Novel Prognostic Marker in Colorectal Cancer.2014
Author(s)
Inoue A, Yamamoto H, Uemura M, Nishimura J, Hata T, Takemasa I, Ikenaga M, Ikeda M, Murata K, Mizushima T, Doki Y, Mori M.
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Journal Title
Ann Surg Oncol.
Volume: Dec 4. [Epub ahead of print]
Related Report
Peer Reviewed
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[Journal Article] SCGB2A1 is a novel prognostic marker for colorectal cancer associated with chemoresistance and radioresistance.2014
Author(s)
Munakata K, Uemura M, Takemasa I, Ozaki M, Konno M, Nishimura J, Hata T, Mizushima T, Haraguchi N, Noura S, Ikenaga M, Okamura S, Fukunaga M, Murata K, Yamamoto H, Doki Y, Mori M.
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Journal Title
Int J Oncol
Volume: 44(5)
Pages: 1521-1528
Related Report
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