Identification of the key stromal cell responsible for desmoplasia of pancreatic cancer, elucidation of the origin of it, and regulation of its function
| Project/Area Number |
24390319
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTSUKA Takao 九州大学, 大学病院, 助教 (20372766)
EGAMI Takuya 九州大学, 医学研究院, 共同研究員 (40507787)
NAGAI Eishi 九州大学, 医学研究院, 准教授 (30264021)
TOMINAGA Yohei 九州大学, 医学研究院, 共同研究員 (90304823)
OHUCHIDA Kenoki 九州大学, 大学病院, 助教 (20452708)
SHIRAHANE Kengo 九州大学, 医学研究院, 共同研究員 (10529803)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 膵癌 / desmoplasia / 膵星細胞 / CD51 / 間葉系幹細胞 / perivascular cell / 癌間質相互作用 |
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| Outline of Final Research Achievements |
The present study revealed the following. (1) Perivascular markers, NG2 and/or PDGFRβ, are expressed in the stroma of pancreatic tumor. (2) NG2/PDGFRβ-positive cancer-associated fibroblasts increase the migratory and invasive abilities of pancreatic cancer cells. (3) CD51 is widely expressed in the stroma of pancreatic tumor. (4) Knockdown of CD51 in activated pancreatic stellate cells decreases the production of extracellular matrix, such as collagenⅠand fibronectin. (5) Knockdown of CD51 suppresses the growth of pancreatic cancer cells in vivo.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Peritoneal myofibroblasts at metastatic foci promote dissemination of pancreatic cancer.2014
Author(s)
Akagawa S, Ohuchida K, Torata N, Hattori M, Eguchi D, Fujiwara K, Kozono S, Cui L, Ikenaga N, Ohtsuka T, Oishima S, Mizumoto K, Oda Y, Tanaka M
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Journal Title
Int J Oncol
Volume: 45
Issue: 1
Pages: 113-120
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] CD166/ALCAM expression is characteristic of tumorigenicity and invasive and migratory activities of pancreatic cancer cells.2014
Author(s)
Fujiwara K, Ohuchida K, Sada M, Horioka K, Ulrich CD 3rd, Shindo K, Ohtsuka T, Takahata S, Mizumoto K, Oda Y, Tanaka M.
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Journal Title
PLoS One
Volume: 9
Issue: 9
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
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