Chimeric antigen receptor gamma delta T cell immunotherapy for the treatment of malignant mesothelioma
| Project/Area Number |
24390326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Nakajima Jun 東京大学, 医学部附属病院, 教授 (90188954)
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| Co-Investigator(Kenkyū-buntansha) |
KAKIMI Kazuhiro 東京大学, 医学部附属病院, 特任教授 (80273358)
MURAKAWA Tomohiro 東京大学, 医学部附属病院, 登録研究員 (50359626)
MATSUSHITA Hirokazu 東京大学, 医学部附属病院, 特任講師 (80597782)
SANO Atsushi 東京大学, 医学部附属病院, 登録診療員 (20569834)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 胸膜中皮腫 / 細胞移入治療 / γδT細胞 / メソテリン / ＣＡＲ / NOGマウス / 細胞傷害活性 / 抗腫瘍効果 / αβT細胞 / メソテリン特異的受容体 / NOGマウス、抗腫瘍効果 / 免疫細胞治療 / CAR / メッセンジャーRNA / エレクトロポレーション(EP)法 / ACC-Meso4 / Chimeric Antigen Receptor(CAR) / メッセンジャーRNA(mRNA) |
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| Outline of Final Research Achievements |
To develop antigen-specific immunotherapy for malignant mesothelioma, we established mesothelin-specific chimeric antigen receptor (MesoCAR) inducedγδTcells. MesoCAR mRNA was transduced into γδTcells, and optimal conditions of MesoCAR+γδTcell adoptive therapy for in vivo and in vitro mesothelioma models were investigated. Anti-tumor effects of MesoCAR+γδTcells were observed, and the anti-tumor effects were comparable to or might be better than those of MesoCAR+ αβTcells. Off-tumor/on-target toxicity to normal tissues was not seen, and the graft-versus host disease was not induced. MesoCAR+ γδTcell adoptive therapy may be an effective treatment without causing major side-effects for mesothelioma or other mesothelin-positive tumors.
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Report
(5 results)
Research Products
(31 results)
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[Journal Article] Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer.2016
Author(s)
Karasaki T, Nagayama K, Kawashima M, Hiyama N, Murayama T, Kuwano H, Nitadori J, Anraku M, Sato M, Miyai M, Hosoi A, Matsushita H, Kikugawa S, Matoba R, Ohara O, Kakimi K, Nakajima J
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Journal Title
Journal of Thoracic Oncology
Volume: 11(3)
Issue: 3
Pages: 324-33
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] がん免疫治療新時代に向けて2014
Author(s)
垣見和宏
Organizer
第11回東レ先端融合研究シンポジウム
Place of Presentation
東レ先端融合研究所（神奈川県鎌倉市）
Year and Date
2014-07-02
Related Report
Invited
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