Screening and discovery of drug for severe heart failure with cardiac tissue sheet technology.
| Project/Area Number |
24390327
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKATA Ryuzo 京都大学, 医学(系)研究科(研究院), 教授 (20325781)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Tadashi 京都大学, 大学院医学研究科, 准教授 (40281092)
YAMASHITA Zyun 京都大学, iPS細胞研究所, 教授 (50335288)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 再生医療 / 細胞移植 / ヒトiPS細胞 / 心不全治療 / 多能性幹細胞 |
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| Outline of Final Research Achievements |
We have conducted a transplantation study in a rat myocardial infarction model using the cardiac tissue sheets bioengineered with mouse ES cells-derived defined cardiac cell populations with cardiomyocytes, endothelial cells, and mural cells. Male nude rats were treated with sheet transplantation (treatment group) or sham operation. We analyzed the sheets or recipient heart with real-time qPCR and DNA micro array. These results suggested that b-FGF and other factors are potential treatment drugs. We administrated b-FGF with slow release system to a rat chronic MI model, and found that slow release b-FGF significantly improved cardiac function. Herein, we were able to establish the screening system, and find candidate drugs for heart failure treatment.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration.2014
Author(s)
Masumoto H, Ikuno T, Takeda M, Fukushima H, Marui A, Katayama S, Shimizu T, Ikeda T, Okano T, Sakata R, Yamashita JK.
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Journal Title
Sci Rep
Volume: 4
Issue: 1
Pages: 6716-6716
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells2013
Author(s)
Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK
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Journal Title
Circ Cardiovasc Genet
Volume: 6(6)
Issue: 6
Pages: 624-33
DOI
Related Report
Peer Reviewed
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