Protective effect of ischemic preconditioning for spinal cord ischemia

• Project/Area Number: 24390330
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: MIKAMO Akihito 山口大学, 医学(系)研究科(研究院), 准教授 (30372709)
• Co-Investigator(Kenkyū-buntansha): HAMANO Kimikazu 山口大学, 大学院医学系研究科, 教授 (60263787) ; LI Tao-sheng 長崎大学, 原爆後障害医療研究所, 教授 (50379997) ; KUBO Masayuki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60420519)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
• Keywords: 虚血プレコンディショニング / 骨髄由来幹細胞 / 下肢虚血プレコンディショニング / 脊髄傷害

Outline of Final Research Achievements

A remote IPC (ischemic pre-conditioning) model was carried out in C57BL/6 followed by SCI (spinal cord ischemia). A remote IPC showed protective effect on SCI. Expression levels of DKK1, IL10 and FGF9 RNA in CD34-positive bone marrow cells were 10-times higher compared to CD34-negative bone marrow cells. Our data suggested that ischemic protective factors and anti-inflammatory cytokine secreted by bone marrow stem cells had a functional role in SCI.

Research Products

• [Journal Article] Aortic arch surgery in octogenarians: is it justified? (2014)
  • Author(s): Kurazumi H, Mikamo A, Kudo T, Suzuki R, takahashi M, Shirasawa B, Zempo N, Hamano K
  • Journal Title: Eur J Cardiothorac Surg Volume: Epub ahead of print Issue: 4 Pages: 1-6
  • DOI: 10.1093/ejcts/ezu056
  • Peer Reviewed
• [Journal Article] Mortality and morbidity after total aortic arch replacement (2014)
  • Author(s): Tanaka Y, Mikamo A, Suzuki R, Kurazumi H, Kudo T, Takahashi M, Ikenaga S, Shirasawa B, Hamano K
  • Journal Title: Ann Thorac Surg Volume: 97 Issue: 5 Pages: 1569-1575
  • DOI: 10.1016/j.athoracsur.2014.01.014
  • Peer Reviewed
• [Presentation] 胸腹部大動脈瘤の術中脊髄保護戦略―脊髄循環血液量維持とCritical肋間動脈同定再建の初期成績― (2013)
  • Author(s): 美甘章仁、国居由香、工藤智明、藏澄宏之、鈴木 亮、高橋雅弥、白澤文吾、濱野公一
  • Organizer: 第６６回日本胸部外科学会定期学術集会
  • Place of Presentation: 仙台（仙台国際センター）
• [Presentation] 経カテーテル大動脈弁植え込み術 (TAVI) について (2013)
  • Author(s): 美甘章仁
  • Organizer: 山陽小野田地区 循環器疾患講演会
  • Place of Presentation: 山陽小野田（小野田セントラルホテル）
  • Invited