Protective effect of ischemic preconditioning for spinal cord ischemia
Project/Area Number |
24390330
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Thoracic surgery
|
Research Institution | Yamaguchi University |
Principal Investigator |
MIKAMO Akihito 山口大学, 医学(系)研究科(研究院), 准教授 (30372709)
|
Co-Investigator(Kenkyū-buntansha) |
HAMANO Kimikazu 山口大学, 大学院医学系研究科, 教授 (60263787)
LI Tao-sheng 長崎大学, 原爆後障害医療研究所, 教授 (50379997)
KUBO Masayuki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60420519)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
Keywords | 虚血プレコンディショニング / 骨髄由来幹細胞 / 下肢虚血プレコンディショニング / 脊髄傷害 |
Outline of Final Research Achievements |
A remote IPC (ischemic pre-conditioning) model was carried out in C57BL/6 followed by SCI (spinal cord ischemia). A remote IPC showed protective effect on SCI. Expression levels of DKK1, IL10 and FGF9 RNA in CD34-positive bone marrow cells were 10-times higher compared to CD34-negative bone marrow cells. Our data suggested that ischemic protective factors and anti-inflammatory cytokine secreted by bone marrow stem cells had a functional role in SCI.
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Report
(4 results)
Research Products
(4 results)