• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of infant lung transplantation technology applying regenerative medicine

Research Project

Project/Area Number 24390332
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionKagawa University

Principal Investigator

Yokomise Hiroyasu  香川大学, 医学部, 教授 (80231728)

Co-Investigator(Kenkyū-buntansha) 松浦 奈都美  香川大学, 医学部附属病院, 助教 (20572853)
劉 大革  香川大学, 医学部, 助教 (30314941)
後藤 正司  香川大学, 医学部附属病院, 助教 (40398029)
笠井 由隆  香川大学, 医学部附属病院, 助教 (40610085)
呉 哲彦  香川大学, 医学部附属病院, 講師 (50313656)
奥田 昌也  香川大学, 医学部附属病院, 助教 (60448355)
中野 淳  香川大学, 医学部, 助教 (80437673)
石川 真也  香川大学, 医学部附属病院, 講師 (20363210)
垂水 晋太郎  香川大学, 医学部, 助教 (30550082)
藤原 敦史  香川大学, 医学部, 助手 (00748642)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywords肺移植 / サイトカイン徐放 / 乳幼児肺移植 / 再生医療 / サイトカイン / 成長因子 / DDS / 長期生存 / 薬剤投与プロトコル / 増殖因子 / DDS
Outline of Final Research Achievements

The left lower lobe removed from the adult dog was transplanted into the left thoracic cavity of the puppy, and after the transplantation, cytokine sustained release gelatin beads were administered in the pulmonary artery. Changing the drug administration schedule after transplantation, it became possible for long-term survival with high probability. Although image evaluation was done with CT, the transplanted lungs were thought to be steadily engrafted although some organizing segment was seen. However, overexpansion of the healthy lung was seen in both models, and it seemed that growth and expansion of the transplanted lung were hindered.
Although this study is terminated once. If this method is clinically applied there is a possibility that common sense of childhood lung transplantation can be changed drastically. I would like to continue this research in the future.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report

URL: 

Published: 2012-04-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi