| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
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| Outline of Final Research Achievements |
Electrocortical stimulation (ECS) is the gold standard for functional brain mapping.High gamma activity (HGA) between 80 and 140 Hz on electrocorticogram (ECoG) is assumed to reflect localized cortical processing, while cortico-cortical evoked potential (CCEP) can reflect bidirectional responses on the language cortices.We propose the use of HGA mapping and CCEP recording during conscious resections of brain tumors.We performed functional localization for the receptive language area, using real-time HGA mapping by listening passively to linguistic sounds. Furthermore, single electric pulses were delivered to the identified receptive temporal language area to detect CCEP in the frontal lobe. Electric stimulation by linguistic HGA mapping to the identified temporal receptive language area evoked CCEP on the frontal lobe. The combination of linguistic HGA and frontal CCEP did not need any patient cooperation or effort. The sensitivity and specificity were 93.8% and 89%, respectively.
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