Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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Outline of Final Research Achievements |
Crosstalk between tumor cells and cells composed of tumor microenvironment as well as endothelial cells is important for glioma angiogenesis. Glioma angiogenesis evaluated by endothelial cell tube formation induced by glioma conditioned medium. Glioma tube formation was stimulated by tumor stem cell, mesenchymal stem cell and pericyte. The target molecules for stimulation of tube formation were determined RANTES, but not SDF-1. Further studies, such as RANTES targeted animal study and new crosstalk molecule, neurovascular wiring molecule are needed for clinical use of these molecules as antiangiogenic agent.
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