| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
We performed a basic research on the method to enhance the efficacy of polymeric nanomicelles as a drug and gene delivery system. The polymeric nanomicelles consist of block polymers which were designed to achieve selective and efficient accumulation to solid tumors including brain tumors. In order to use the polymeric nanomicelles in combination with oncolytic HSV-1 virus therapy, several in vivo mice tumor models were studied, mainly using marker gene expressing HSV-1. When RGD peptide was used as a ligand to αvβ3 and αvβ5 integrins, the functional micelle showed improved accumulation to αvβ3 and αvβ5 integrin expressing tumor tissue and enhanced antitumor effect in vivo
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