A role of Lotus, a novel axon growth promoting factor, in post-ischemic neuronal regeneration

Research Project

Project/Area Number	24390346
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Partial Multi-year Fund
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	Yokohama City University
Principal Investigator	KAWAHARA Nobutaka 横浜市立大学, 医学(系)研究科(研究院), 教授 (60214673)
Co-Investigator(Renkei-kenkyūsha)	TAKEI Koutarou 横浜市立大学, 医学研究科, 教授 (40202163)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000) Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2013: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords	脳虚血 / 神経再生 / 軸索 / 脳梗塞 / 機能回復 / brain ischemia / infarction / Lotus / transgenic mouse / regeneration / 軸索再生
Outline of Final Research Achievements	We investigated a role of a novel axon growth promoting factor Louts in neurogenesis and functional recovery after Stroke. Lotus knockout mouse exhibited inhibition of neural progenitor migration in the hippocampus, suggesting a role in neurogenesis. In the stoke model, Lotus transgenic mouse exhibited better recover of motor function compared with wild type, suggesting a new therapeutic regenerative strategy for ischemic stroke.

Report

(4 results)