| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
In the present study, we aimed to elucidate the physiological roles of a novel signaling pathway called RANKL reverse signaling. Recently, it has been reported that osteocytes are the major provider of RANKL during physiological osteoclastogenesis. Considering this, we firstly analyzed the roles of RANKL reverse signaling in osteocytes, and showed that the secretion of lysosomal RANKL to the osteocytic cell surface is triggered by RANKL reverse signaling. Next, we analyzed the roles of RANKL reverse signaling in osteoblasts, and showed that osteoblastic RANKL acts as a coupling signal acceptor for RANK incorporated into osteoclastic exosomes.
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