| Project/Area Number |
24390356
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Kubo Toshikazu 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20178031)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI YUJI 京都府立医科大学, 医学研究科, 講師 (50347449)
Terauchi Ryu 京都府立医科大学, 医学研究科, 講師 (20575154)
Fujiwara Hiroyoshi 京都府立医科大学, 医学研究科, 准教授 (90381962)
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| Co-Investigator(Renkei-kenkyūsha) |
Mazda Osam 京都府立医科大学, 医学研究科, 教授 (00271164)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 変形性関節症 / ストレス応答機構 / 関節軟骨 / 軟骨細胞 / メカニカルストレス / 軟骨代謝 / ストレス応答 / HSP70 |
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| Outline of Final Research Achievements |
We showed that expression of HIF-2α in cultured chondrocytes is induced independent of NF-κB expression under a hydrostatic pressure of 5 MPa. These results may help in elucidation of the pathology of OA because HIF-2α and MMPs, acting downstream of HIF-2α, are involved in initiation and progression of OA. Further, as compared to 10 m/min group and 12m/min group, 20 m/min group exercise was found to be excessive, since OA had progressed in 20 m/min group. We considered that excessive forced running caused the progression of OA.
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