| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
Bone homeostasis is regulated in a delicate balance between bone resorbing osteoclasts and bone forming osteoblasts. In this study, we found that B lymphocyte induced maturation protein 1 (Blimp1) plays a crucial role in regulating osteoclastogenesis and bone mass at an adult stage, and targeting Blimp1 in adult mice resulted in significant inhibition of osteoclast formation followed by increased bone mass. We also found that osteoclast stimulatory transmembrane protein (OC-STAMP) is required for osteoclast cell-cell fusion, and OC-STAMP-deficient mice exhibited complete abrogation of osteoclast cell-cell fusion. We further found that B cell lymphoma 6 (Bcl6) plays a role in regulating osteoblastogenesis via suppressing expression of signal transducer and activator of transcription 1 (Stat1), and Bcl6-deificient osteoblasts showed altered differentiation owing to Stat1 elevation. Bcl6/Stat1 doubly deficient mice exhibited reversed osteoblastogenesis compared with Bcl6-deficient mice.
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