• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Novel autoantibody markers for ACPA negative RA patients

Research Project

Project/Area Number 24390360
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

MOMOHARA Shigeki  東京女子医科大学, 医学部, 教授 (00190984)

Co-Investigator(Renkei-kenkyūsha) IKARI Katsunori  東京女子医科大学, 医学部, 准教授 (80343557)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Keywords自己抗体 / 関節リウマチ / ACPA陰性
Outline of Final Research Achievements

We tried to define novel autoantibody markers for ACPA negative RA patients using the ProtoArray human protein microarray and ProtoPlex. Candidates were as follows: pogo transposable element with ZNF domain (POGZ), transcript variant 3, Aryl hydrocarbon receptor nuclear translocator, TIMELESS interacting protein (TIPIN), serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (SERPINE1), interferon regulatory factor 3 (IRF3), protein kinase C and casein kinase substrate in neurons 1 (PACSIN1), toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), transcript variant 1, RUN and FYVE domain containing 3 (RUFY3), TBC1 domain family member 22B, hypothetical protein MGC13057 (MGC13057), transcript variant 4, chromosome 16 open reading frame 53 (C16orf53), solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (SLC9A3R1), MRG-binding protein, tec protein tyrosine kinase (TEC), KIAA0513 (KIAA0513).

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (10 results)

All 2015 2014 2012

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results)

  • [Journal Article] An association between the 74th amino acid position of HLA-DRB1 and ACPA levels of Japanese ACPA-positive RA.2015

    • Author(s)
      Terao C, Suzuki A, Ikari K, Kochi Y, Ohmura K, Katayama M, Nakabo S, Yamamoto N, Suzuki T, Iwamoto T, Yurugi K, Miura Y, Maekawa T, Takasugi K, Kubo M, Saji H,Taniguchi A, Momohara S, Yamamoto K, Yamanaka H, Mimori T, Matsuda F.
    • Journal Title

      Arthritis Rheumatol.

      Volume: X Issue: 8 Pages: 2038-2045

    • DOI

      10.1002/art.39133

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A main contribution of DRB1*04:05 among shared epitope and involvement of 57th DRB1 amino acid in association with joint destruction in ACPA(+) RA.2015

    • Author(s)
      Terao C, Yano K, Ikari K, Furu M, Yamakawa N, Yoshida S, Hashimoto M, Ito H,Fujii T, Ohmura K, Yurugi K, Miura Y, Maekawa T, Taniguchi A, Momohara S,Yamanaka H, Mimori T, Matsuda F.
    • Journal Title

      Arthritis Rheumatol.

      Volume: X Issue: 7 Pages: 1744-1750

    • DOI

      10.1002/art.39105

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Smoking on Remission Proportions Differs Between Male and Female Patients with Rheumatoid Arthritis: A Study Based on the IORRA Survey.2015

    • Author(s)
      Inoue Y, Nakajima A, Tanaka E, Inoue E, Kobayashi A, Hoshi D, Sugimoto N, SetoY, Taniguchi A, Momohara S, Yamanaka H.
    • Journal Title

      J Rheumatol.

      Volume: X

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An osteoprotegerin gene polymorphism is associated with an increased risk of hip fracture in Japanese patients with rheumatoid arthritis: results from the IORRA Observational Cohort Study.2014

    • Author(s)
      Yoshida S, Ikari K, Furuya T, Toyama Y, Taniguchi A, Yamanaka H, Momohara S.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e104587-e104587

    • DOI

      10.1371/journal.pone.0104587

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ffects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adultpopulation.2014

    • Author(s)
      Terao C, Ohmura K, Ikari K, Kawaguchi T, Takahashi M, Setoh K, Nakayama T,Kosugi S, Sekine A, Tabara Y, Taniguchi A, Momohara S, Yamanaka H, Yamada R,Matsuda F, Mimori T; Nagahama Study Group
    • Journal Title

      Arthritis Care Res (Hoboken)

      Volume: 66 Issue: 12 Pages: 1818-27

    • DOI

      10.1002/acr.22385

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetics of rheumatoid arthritis contributes to biology and drug discovery.2014

    • Author(s)
      Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, (省略), GARNET consortium, (以下省略).
    • Journal Title

      Nature

      Volume: 506 Issue: 7488 Pages: 376-381

    • DOI

      10.1038/nature12873

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-synonymous variant (Gly307Ser) in CD226 is associated with susce ptibility in Japanese rheumatoid arthritis patients2012

    • Author(s)
      Suzuki T, Ikari K, et al
    • Journal Title

      Modern rheumatology

      Volume: (e-pub) Issue: 1 Pages: 200-202

    • DOI

      10.1007/s10165-012-0609-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACPA-negative RA consists of two genetically distinct subsets based on RF positivity in Japanese.2012

    • Author(s)
      Terao C, Mimori T, et al (21人中21人目)
    • Journal Title

      PLoS One

      Volume: 7 Issue: 7 Pages: e40067-e40067

    • DOI

      10.1371/journal.pone.0040067

    • NAID

      120004754351

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis : no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1^*09:012012

    • Author(s)
      Terao C, Ikari K, et al
    • Journal Title

      Annals of the rheumatic diseases

      Volume: (e-pub) Issue: 6 Pages: 1095-1097

    • DOI

      10.1136/annrheumdis-2011-200907

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2012-04-24   Modified: 2025-11-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi